Article
Neurosciences
Ying Chen, Hengyi Cao, Nanfang Pan, Yajing Long, Jinbo Zhou, Chunfeng Zhou, Yi Wang, Qiyong Gong
Summary: The ADRA2A-1291 C > G polymorphism is associated with visual memory and inhibitory control deficits in ADHD. This study found that the ADRA2A G/G genotype affects gray matter networks in ADHD and that these gene-brain modulations are associated with cognitive function.
Article
Biochemistry & Molecular Biology
Annika M. A. Berends, Mathieu S. Bolhuis, Ilja M. Nolte, Edward Buitenwerf, Thera P. Links, Henri J. L. M. Timmers, Richard A. Feelders, Elisabeth M. W. Eekhoff, Eleonora P. M. Corssmit, Peter H. Bisschop, Harm R. Haak, Ron H. N. van Schaik, Samira El Bouazzaoui, Bob Wilffert, Michiel N. Kerstens
Summary: Genetic variability of alpha-adrenergic receptor genes might be associated with the clinically observed variation in beneficial and adverse therapeutic drug responses to alpha-adrenergic receptor blockers. Further studies are needed to confirm these observations.
Article
Behavioral Sciences
Yasuko Tobari, Ami Masuzawa, Norika Harada, Kenta Suzuki, Simone L. Meddle
Summary: The study found that the crowing vocalization of male Japanese quails can be immediately suppressed by the intracerebroventricular injection of clonidine, a specific agonist for alpha 2-adrenergic receptor. This suppression was accompanied by a reduction of immediate early gene, zenk mRNA, in the ICo. Further experiments suggested that noradrenaline may regulate courtship vocalization in quails through the alpha 2A-adrenergic receptors expressed on ICo neurons.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xin Xu, Guangyu Wu
Summary: C1orf27 plays an important role in the surface transport of G protein-coupled receptors (GPCRs), specifically in the ER-to-Golgi transport of α2A-adrenergic receptor (α2A-AR). Its depletion inhibits the export of α2A-AR and other GPCRs, providing insights into the regulation of GPCR biosynthesis and anterograde transport.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Kim Zillo Rokamp, Jens Juul Holst, Niels Olsen, Flemming Dela, Niels H. Secher, Anders Juul, Jens Faber, Sebastian Wiberg, Birger Thorsteinsson, Ulrik Pedersen-Bjergaard
Summary: The study suggests that the Arg(16) variant may lead to decreased metabolic and symptomatic responses to recurrent hypoglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Neurosciences
Hiroki Toyoda, Jonghwa Won, Wheedong Kim, Hayun Kim, Oscar Davy, Mitsuru Saito, Doyun Kim, Takuma Tanaka, Youngnam Kang, Seog Bae Oh
Summary: Noradrenergic neurons in the locus coeruleus release noradrenaline via volume transmission to activate extrasynaptic G-protein coupled receptors in target cells, affecting the currents in MTN neurons. The different modes of LC activation lead to varying degrees of current inhibition in MTN neurons.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Tonghui Su, Yi Lu, Chaoying Fu, Yang Geng, Yelin Chen
Summary: This study demonstrates that the loss of GluN2A in adult mouse brains can elicit strong antidepressant-like responses without causing psychomimetic effects similar to Ketamine. The antidepressant effects of Ketamine and MK-801 are mainly mediated by the suppression of GluN2A rather than GluN2B.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Tonghui Su, Yi Lu, Chaoying Fu, Yang Geng, Yelin Chen
Summary: The study found that the loss of GluN2A in adult mice elicits antidepressant-like responses without causing psychomimetic effects similar to ketamine. The antidepressant effects of ketamine and MK-801 are mediated by the suppression of GluN2A, not GluN2B. Additionally, these drugs increase the excitability of hippocampal neurons through GluN2A.
NATURE NEUROSCIENCE
(2023)
Article
Immunology
Xiangxu Tang, Chanjuan Zhang, Tian Tian, Xiaomeng Dai, Yun Xing, Yingwei Wang, Duomeng Yang, Hongmei Li, Yiyang Wang, Xiuxiu Lv, Huadong Wang
Summary: DEX posttreatment may aggravate septic cardiomyopathy in the presence of organ dysfunction, possibly through activating the α2A-AR-mediated PKC signal pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Leonardo Sandrini, Patrizia Amadio, Alessandro Ieraci, Alessandro Malara, Jose P. Werba, Paolo M. Soprano, Alessandra Balduini, Marta Zara, Alice Bonomi, Fabrizio Veglia, Gualtiero Colombo, Maurizio Popoli, Francis S. Lee, Elena Tremoli, Silvia S. Barbieri
Summary: Depression is associated with thrombotic risk and arterial events, and its management is recommended in coronary artery disease patients. The BDNF Val66Met polymorphism, related to depression, is associated with arterial thrombosis in mice and acute myocardial infarction in humans. Finding show desipramine rescues behavioral impairments and reduces arterial thrombosis risk by normalizing norepinephrine levels in BDNFMet/Met mice, suggesting the potential use of alpha(2A)-ADR inhibitors in treating depression-associated thrombotic conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Jeffrey J. Sutherland, Dimitar Yonchev, Alexander Fekete, Laszlo Urban
Summary: The authors introduce a new database to predict the adverse event risks of new drugs, identify the most accurate assays, and propose potential mechanisms to explain observed risks.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Povilas Aniulis, Aurelija Podlipskyte, Alina Smalinskiene, Rosita Aniuliene, Mindaugas Jievaltas
Summary: The study aimed to investigate the association between genes and female urinary incontinence, and found that the HTR2A T102C gene polymorphism affected the development of urge urinary incontinence.
Article
Biochemistry & Molecular Biology
Aneta Archala, Wojciech Plazinski, Anita Plazinska
Summary: The study found that different polymorphisms have minimal impact on the beta 2-AR protein, with the Ser220Cys polymorphism affecting G-protein binding and treatment responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rong-Fu Chen, Po-Ming Chen, Chau-Shiung Pan, Chieh-Cheng Huang, En-Pei Isabel Chiang
Summary: Human metallothionein-2A (MT2A) protein plays important roles in metal homeostasis, detoxification, oxidative stress reduction, and immune defense. Genetic variations of MT2A rs10636 and rs28366003 are associated with erythropoiesis in the Taiwanese general population. MT2A expression is correlated with genes involved in erythropoiesis, cholesterol synthesis, platelet synthesis, and insulin.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Mayara Cecile Nascimento Oliveira, Ikla Lima Cavalcante, Alana Natalicia de Araujo, Aline Matilde Ferreira dos Santos, Renata Priscila Barros de Menezes, Chonny Herrera-Acevedo, Natalia Ferreira de Sousa, Jailane de Souza Aquino, Jose Maria Barbosa-Filho, Ricardo Dias de Castro, Reinaldo Nobrega Almeida, Luciana Scotti, Marcus Tullius Scotti, Mirian Graciela Da Silva Stiebbe Salvadori
Summary: This study investigated the antidepressant activity of methyl eugenol (ME) in a stress model induced by dexamethasone and found that ME has antidepressant effects by modulating the dopaminergic, adrenergic, and serotonergic systems.
Letter
Biochemistry & Molecular Biology
Taro Kishi, Kenji Sakuma, Masakazu Hatano, Makoto Okuya, Yuki Matsuda, Masaki Kato, Nakao Iwata
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Masahiro Hata, Yusuke Watanabe, Takumi Tanaka, Kimihisa Awata, Yuki Miyazaki, Ryohei Fukuma, Daiki Taomoto, Yuto Satake, Takashi Suehiro, Hideki Kanemoto, Kenji Yoshiyama, Masao Iwase, Shunichiro Ikeda, Keiichiro Nishida, Yoshiteru Takekita, Masafumi Yoshimura, Ryouhei Ishii, Hiroaki Kazui, Tatsuya Harada, Haruhiko Kishima, Manabu Ikeda, Takufumi Yanagisawa
Summary: Developing accurate and universally available biomarkers for dementia is critical. This study utilized electroencephalography (EEG) and a deep learning algorithm to successfully discriminate patients with dementia from healthy volunteers, providing a potential tool for automatic screening and diagnosis of dementia diseases.
NEUROPSYCHOBIOLOGY
(2023)
Letter
Biochemistry & Molecular Biology
Masaki Kato, Hikaru Hori, Aran Tajika
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Masaki Kato, Kazuyuki Nakagome, Takamichi Baba, Takuhiro Sonoyama, Daiki Okutsu, Hideki Yamanaka, Ryosuke Shimizu, Tomoko Motomiya, Takeshi Inoue
Summary: This study evaluated the efficacy and safety of oral zuranolone in Japanese patients with major depressive disorder. The results showed significant improvements in depressive symptoms and demonstrated a good safety profile.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Neurosciences
Nobuhisa Kanahara, Hiroshi Kimura, Toshihiko Kinoshita, Masaomi Iyo, Yoshiteru Takekita
Summary: Dopamine supersensitivity psychosis (DSP) is an unstable clinical condition observed in individuals with schizophrenia treated with high doses and/or for a long time with antipsychotic medication. Up-regulation of dopamine D2 receptors (DRD2) is believed to play a role in DSP. Asenapine, a medication that binds to a broad range of dopamine and serotonin receptors, successfully controlled DSP symptoms in two patients who were resistant to other antipsychotics. The unique profile of asenapine may contribute to its effectiveness in treating severe DSP symptoms in schizophrenia patients.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Psychiatry
Keita Tokumitsu, Norio Yasui-Furukori, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Reiji Yoshimura
Summary: This study investigated bipolar disorder patients in psychiatric clinics in Japan and found that 3.06% of patients required hospitalization within a year. Predictors of hospitalization included bipolar I disorder, lower baseline GAF scores, unemployment, substance abuse, and baseline mood state. These findings provide valuable guidance for clinicians in preventing hospitalization for bipolar disorder.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Chikashi Takano, Masaki Kato, Naoto Adachi, Yukihisa Kubota, Takaharu Azekawa, Hitoshi Ueda, Kouji Edagawa, Eiichi Katsumoto, Eiichiro Goto, Seiji Hongo, Kazuhira Miki, Takashi Tsuboi, Norio Yasui-Furukori, Atsuo Nakagawa, Toshiaki Kikuchi, Koichiro Watanabe, Toshihiko Kinoshita, Reiji Yoshimura
Summary: This study investigated the progression of rapid cycling (RC) and euthymia (EUT) in patients with bipolar disorder (BD) and examined the influence of patient backgrounds and prescription patterns on these different progressions. The results showed that factors such as bipolar disorder type I, suicidal ideation, duration of illness, and the use of lithium carbonate and antipsychotic medications were associated with the occurrence of rapid cycling. Comorbid developmental disorders and the prescription of anxiolytics and sleep medication were identified as possible risk factors for switching to rapid cycling. Older age, employment, fewer psychotic symptoms and comorbid personality disorders, fewer antidepressants, antipsychotics, and anxiolytics, and more lithium prescriptions were identified as possible factors for achieving euthymia.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Toshihiko Kinoshita, Yoshiteru Takekita, Shuichi Hiraoka, Fumihiro Tamura, Yasuhiro Iwama
Summary: After a 6-week trial comparing asenapine sublingual tablets to placebo in Asian patients with acute exacerbation of schizophrenia, a 52-week open-label study was conducted to evaluate the long-term safety and efficacy of asenapine. The results showed that asenapine was well tolerated and provided sustained efficacy with minimal adverse events. No clinically significant abnormalities were observed in weight, body mass index, or blood measurements.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Toshiya Funatsuki, Haruhiko Ogata, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Shinpei Nonen, Koichiro Higasa, Toshihiko Kinoshita, Masaki Kato
Summary: Individual responses to antidepressant treatment varies, and understanding the factors contributing to this variability is important. This study investigated the correlation between changes in plasma miRNA levels and treatment outcomes of MIR and SSRI monotherapy in MDD patients. The results suggest that specific miRNAs may serve as potential biomarkers for predicting treatment response in depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Haruhiko Ogata, Koichiro Higasa, Yuki Kageyama, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Shinpei Nonen, Tadafumi Kato, Toshihiko Kinoshita, Masaki Kato
Summary: Specific miRNAs expression levels are associated with ccf-mtDNA copy number in untreated depressed patients and linked to antidepressant treatment outcomes. These findings are expected to lead to the elucidation of new pathological mechanisms of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Kazuyuki Nakagome, Manabu Makinodan, Mitsuhiro Uratani, Masaki Kato, Norio Ozaki, Seiko Miyata, Kunihiro Iwamoto, Naoki Hashimoto, Atsuhito Toyomaki, Kazuo Mishima, Masaya Ogasawara, Masahiro Takeshima, Kazumichi Minato, Toshikazu Fukami, Mari Oba, Kazuyoshi Takeda, Hideki Oi
Summary: This study investigated the feasibility of estimating mental health status using a wrist-worn wearable device that measures movement and optical pulse photoplethysmography (PPG). The results showed significant correlations between heart rate variability (HRV) and heart rate (HR) with mental health status in the wake after sleep onset stage within 3 days of assessment. The conclusion was that using a wearable device to measure HR and HRV can serve as an objective assessment of mental health status.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Yosuke Koshikawa, Ai Onohara, Masataka Wakeno, Yoshiteru Takekita, Toshihiko Kinoshita, Masaki Kato
Summary: This study aimed to investigate the factors associated with persistent depressive disorder, relapse, and changes in bipolar disorder diagnosis. The results showed that residual symptoms had an impact on long-term treatment outcomes, emphasizing the importance of addressing residual symptoms in early treatment and finding measures to improve them.
Article
Neurosciences
Taro Kishi, Kenji Sakuma, Masakazu Hatano, Yuki Matsuda, Satoru Esumi, Nobumi Miyake, Itaru Miura, Hikaru Hori, Masaki Kato, Nakao Iwata
Summary: Newer antidepressants approved in Japan are effective in improving depressive symptoms, treatment response, and remission rates for Japanese adults with MDD, although they may have a higher incidence of adverse events. Clinicians need to closely monitor the health conditions of these individuals.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Clinical Neurology
Masaki Kato, Toshiaki Kikuchi, Koichiro Watanabe, Tomiki Sumiyoshi, Yoshiya Moriguchi, Daniel Oudin Astrom, Michael Cronquist Christensen
Summary: This study confirms the good validity and reliability of the Japanese version of the Oxford Depression Questionnaire (ODQ), making it suitable for capturing the treatment effects on emotional blunting in people with major depressive disorder (MDD).
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Clinical Neurology
Masaki Kato, Hiroshi Tsuda, Yirong Chen, Toshinaga Tsuji, Nobuhiro Nishigaki
Summary: This study aims to investigate if diagnosed MDD patients are more likely to exhibit ADHD traits and if the presence of these traits increases the humanistic burden on MDD patients, including impairment of HRQoL, work productivity, and activity impairment, as well as healthcare resource utilization.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)