Article
Psychiatry
Yue Feng Quek, Zixu Yang, Justin Dauwels, Jimmy Lee
Summary: This study compared the impact of negative symptoms and neurocognitive deficits on functioning in individuals with MDD and SCZ, finding that they play different roles in the two disorders. In SCZ, both negative symptoms and neurocognitive deficits were significantly correlated with social and occupational functioning, while in MDD, negative symptoms, neurocognitive deficits, and depressive symptoms were associated with functioning.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Maria Paz Garcia-Portilla, Leticia Garcia-Alvarez, Leticia Gonzalez-Blanco, Francesco Dal Santo, Teresa Bobes-Bascaran, Clara Martinez-Cao, Ainoa Garcia-Fernandez, Pilar A. Saiz, Julio Bobes
Summary: This study aimed to identify factors that contribute significantly to real-world functioning in patients with schizophrenia, and ultimately found that 66.0% of the variance was explained. The results indicate that certain psychopathological symptoms, functional abilities, and cognitive functions are closely related to patients' real-world functioning.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Xiaowei Tan, Donel Martin, Jimmy Lee, Phern Chern Tor
Summary: This study examined the efficacy of electroconvulsive therapy (ECT) on negative symptoms in schizophrenia. The results showed that ECT was associated with improvements in negative symptoms, as well as overall function and cognition. Additionally, several clinical factors were identified as potential predictors of negative symptom improvement.
Article
Psychology, Clinical
Tim B. Ziermans, Frederike Schirmbeck, Floor Oosterwijk, Hilde M. Geurts, Lieuwe de Haan
Summary: The study found significantly elevated levels of autistic traits in individuals with psychotic disorders, which are closely related to social functioning. Individuals with a familial risk for psychosis did not show high levels of autistic traits, indicating the need for specific clinical guidelines for psychotic patients with comorbid autism to address their social needs.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Na Hu, Wei Li, Hu Deng, Jiaqi Song, Hanxue Yang, Jiabao Chai, Wenqian Huang, Hong Wang, Xuanzi Zhou, Pan Zhang, Sushuang He, Yonghua Cui, Tengteng Fan, Ying Li
Summary: This study evaluated the clinical symptoms, antipsychotic adverse reactions, and social functioning of 283 hospitalized patients with chronic schizophrenia. Depressive symptoms, extrapyramidal symptoms, and positive symptoms were found to be significant contributors to secondary negative symptoms. Negative symptoms were found to play a significant mediating role in the effect of depressive and positive symptoms on social functioning.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Zixu Yang, Soon Hong Lee, Nur Amirah Abdul Rashid, Yuen Mei See, Justin Dauwels, Bhing Leet Tan, Jimmy Lee
Summary: The study found that negative symptoms play an important role in predicting real-world functioning and employment outcomes after considering neurocognition and functional capacity. DE and AA are considered important treatment targets in functional recovery for people with schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Giulia M. Giordano, Luigi Giuliani, Andrea Perrottelli, Paola Bucci, Giorgio Di Lorenzo, Alberto Siracusano, Francesco Brando, Pasquale Pezzella, Michele Fabrazzo, Mario Altamura, Antonello Bellomo, Giammarco Cascino, Anna Comparelli, Palmiero Monteleone, Maurizio Pompili, Silvana Galderisi, Mario Maj
Summary: Impairment in functioning over time is a key aspect of subjects with schizophrenia. MMN and P3a, indices of early attention processing often impaired in schizophrenia, may represent optimal electrophysiological candidate biomarkers. Our results suggest that MMN amplitude reduction might serve as a biomarker for poor functioning in schizophrenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Cristian Petrescu, Ioana R. R. Papacocea, Crisanda Vilciu, Oana A. A. Mihalache, Diana M. M. Vlad, Gabriela Marian, Brindusa E. E. Focseneanu, Cristian T. T. Sima, Constantin A. A. Ciobanu, Sorin Riga, Adela M. M. Ciobanu
Summary: This study aims to compare the profile of neurological soft signs in patients with predominantly negative symptoms of schizophrenia with patients who do not present a predominance of negative symptoms, as well as to assess the impact of treatment on the neurological function of these patients.
Article
Psychiatry
Yanhui Li, Gurpreet Rekhi, Mei San Ang, Jimmy Lee
Summary: This study examines the association between Negative Symptoms (NS) dimensions and Health-related Quality of Life (HRQoL) in schizophrenia. The results show that lower severity of NS, specifically in the Motivation and Pleasure (MAP) dimension, and the asociality domain, is associated with higher HRQoL. Therefore, targeting NS, particularly MAP and asociality, is important for improving HRQoL in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Lorena Garcia-Fernandez, Veronica Romero-Ferreiro, Luis Sanchez-Pastor, Monica Dompablo, Isabel Martinez-Gras, Juan Manuel Espejo-Saavedra, David Rentero, Ana Isabel Aparicio, Miguel Angel Alvarez-Mon, Guillermo Lahera, Jimmy Lee, Jose Luis Santos, Roberto Rodriguez-Jimenez
Summary: This study aimed to explore the relationships between the two different domains of negative symptoms (diminished expression and avolition-apathy) and psychosocial functioning and quality of life in individuals with a first episode of schizophrenia. The results showed that the domain of diminished expression had a stronger predictive relationship with functionality and quality of life.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Dominique L. G. Van Praag, Filip van den Eede, Kristien Wouters, Lindsay Wilson, Andrew I. R. Maas
Summary: The study found that neurocognitive functioning plays a role in the course of PTSD symptoms after TBI, with sustained attention being associated with symptom improvement. Assessing cognitive performance may help identify individuals at risk of developing PTSD post-TBI and offer opportunities for informing treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Donal O'Keeffe, Anthony Kinsella, John L. Waddington, Mary Clarke
Summary: Determining the relationship between the duration of untreated psychosis (DUP) and long-term outcomes requires prospective studies of incidence cohorts over several decades. This study followed an Irish first-episode psychosis cohort for 20 years and found that shorter DUP was associated with improved symptoms, functioning, and quality of life, although the associations differed across outcome domains.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Review
Psychiatry
Sharon Weber, James G. Scott, Mary Lou Chatterton
Summary: This study aims to investigate the economic burden associated with negative symptoms of schizophrenia. Through searching and analyzing relevant literature, it is found that there is a positive relationship between negative symptoms and healthcare costs and resource utilization in patients. It should be noted that the cost variation associated with negative symptoms is wide, depending on factors such as patient characteristics, included costs, and country of study.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychology, Clinical
Kristin M. Mignogna, Fernando S. Goes
Summary: In this study using the STEP-BD study, trajectories of bipolar disorder were identified in terms of depressive symptoms, manic symptoms, and psychosocial functioning. Different trajectories showed varying degrees of association with negative clinical risk factors.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Gonzalo Salazar de Pablo, Filippo Besana, Vincenzo Arienti, Ana Catalan, Julio Vaquerizo-Serrano, Anna Cabras, Joana Pereira, Livia Soardo, Francesco Coronelli, Simi Kaur, Josette da Silva, Dominic Oliver, Natalia Petros, Carmen Moreno, Ana Gonzalez-Pinto, Covadonga M. Diaz-Caneja, Jae Il Shin, Pierluigi Politi, Marco Solmi, Renato Borgatti, Martina Maria Mensi, Celso Arango, Christoph U. Correll, Philip McGuire, Paolo Fusar-Poli
Summary: The meta-analysis study revealed that CHR-P individuals show improvements in symptoms and functional outcomes over time, but sustaining these improvements in the long term is challenging, with less than half of patients achieving full remission.
