Article
Medicine, General & Internal
Marc B. Stone, Zimri S. Yaseen, Brian J. Miller, Kyle Richardville, Shamir N. Kalaria, Irving Kirsch
Summary: This study analyzed a large amount of randomized controlled trial data and found that approximately 15% of patients with major depressive disorder showed significant antidepressant effects in drug treatment, surpassing the effects of a placebo. This highlights the need for predictive factors for targeted drug therapy.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Review
Clinical Neurology
Lauren G. Friedman, Nicholas McKeehan, Yuko Hara, Jeffrey L. Cummings, Dawn C. Matthews, Jian Zhu, Richard C. Mohs, Deli Wang, Suzanne B. Hendrix, Melanie Quintana, Lon S. Schneider, Michael Grundman, Samuel P. Dickson, Howard H. Feldman, Judith Jaeger, Elizabeth C. Finger, J. Michael Ryan, Debra Niehoff, Susan L-J Dickinson, Jessica T. Markowitz, Meriel Owen, Alessio Travaglia, Howard M. Fillit
Summary: Exploratory clinical trials play a crucial role in drug development for neurodegenerative dementias, helping to identify potential drugs and improve development efficiency.
Editorial Material
Clinical Neurology
Lauren G. Friedman, Nicholas Mckeehan, Yuko Hara, Jeffrey L. Cummings, Dawn C. Matthews, Jian Zhu, Richard C. Mohs, Deli Wang, Suzanne B. Hendrix, Melanie Quintana, Lon S. Schneider, Michael Grundman, Samuel P. Dickson, Howard H. Feldman, Judith Jaeger, Elizabeth C. Finger, J. Michael Ryan, Debra Niehoff, Susan L-J. Dickinson, Jessica T. Markowitz, Meriel Owen, Alessio Travaglia, Howard M. Fillit
Summary: Drug development for neurodegenerative dementias like Alzheimer's disease has faced challenges, but exploratory clinical trials offer a faster, cost-effective way to achieve proof of concept, optimizing study design and application to save resources and improve efficiency in clinical development.
Article
Clinical Neurology
Qiping Fan, Melissa J. DuPont-Reyes, Md Mahbub Hossain, Lei-Shih Chen, Jennifer Lueck, Ping Ma
Summary: The study found that the prevalence of depressive symptoms is gradually increasing among U.S. adolescents, while the utilization of mental health services remains low. Racial and ethnic minority adolescents are more likely to experience depression, but less likely to use mental health services. Participation in school, family, community, or faith-based activities is significantly associated with a lower incidence of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Roberto Gomeni, Francoise Bressolle-Gomeni, Maurizio Fava
Summary: Treatment effect in clinical trials for major depressive disorders is influenced by both treatment specific and non-specific effects. Individual propensity to respond non-specifically to any treatment can be a confounding effect. Current statistical methods for analyzing randomized controlled trials do not address potential imbalances in subject allocation due to heterogeneous distributions of propensity. Propensity weighting methodology can help reduce baseline imbalances and make patient data comparable across treatment arms. A case study using paroxetine CR showed that propensity weighting provided a more accurate estimate of treatment effect compared to non-weighted analysis.
TRANSLATIONAL PSYCHIATRY
(2023)
News Item
Oncology
Mary Beth Nierengarten
Summary: This news section provides timely information for cancer readers, covering events, public policy analysis, topical issues, and personalities. This issue explores the use of single-arm studies for accelerated drug approvals, the impact of evidence-based surgical metrics on early-stage lung cancer patients, and the cost-effectiveness of lung cancer screening based on personal risk factors.
Article
Biochemistry & Molecular Biology
Ting Zan, Yi-Tao He, Min Zhang, Takahiro Yonezawa, Hong Ma, Qiang-Min Zhao, Wen-Ju Zhang, Chien-Hsun Huang, Wen-Yu Kuo
Summary: In this study, a detailed analysis of the phylogeny of the Camellia genus was conducted using 95 transcriptomes and 1481 low-copy genes. The results showed that the 87 species were grouped into 8 main clades and two independent species, which was different from existing classification systems. The relationships among these clades were weakly supported and did not agree with the phylogeny from chloroplast genomes. The study also revealed reticulate evolution and a rapid evolutionary history of Camellia.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2023)
Article
Medicine, General & Internal
William U. Meyerson, Carl F. Pieper, Rick H. Hoyle
Summary: A secondary analysis of FDA clinical trial data showed that antidepressant therapy can effectively reduce depressive symptoms in patients with severe depression, but the response varies among individuals.
Article
Dermatology
Sophia Z. Shalhout, Romi Bloom, Lynn Drake, David M. Miller
Summary: The study evaluated the fragility of clinical trial data used to support FDA approval of therapies for psoriasis and found that pivotal trials in psoriasis appear quite robust to changes in outcomes compared with randomized controlled trials for FDA approval across various diseases.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Roy H. Perlis, Katherine Ognyanova, Mauricio Santillana, Jennifer Lin, James Druckman, David Lazer, Jon Green, Matthew Simonson, Matthew A. Baum, John Della Volpe
Summary: This survey study found that individuals with moderate or greater depressive symptoms were more likely to believe vaccine-related misinformation. These individuals were less willing to get vaccinated and more likely to express vaccine resistance. The presence of depression was also associated with an increase in endorsement of misinformation in a subsequent survey.
Article
Psychiatry
Pan Chen, Yuan Feng, Xiao-Hong Li, Jia-Xin Li, Yue-Ying Wang, Wan-Ying Zheng, Zhaohui Su, Teris Cheung, Gabor S. Ungvari, Chee H. Ng, Sha Sha, Yu-Tao Xiang
Summary: This study explored and mapped the research outputs of major depressive disorder (MDD)-related systematic reviews and meta-analyses (SR/MA) using a bibliometric approach. The results showed a rapid increase in the number of SR/MA in recent years, highlighting the importance of this research field. Psychiatric comorbidities, clinical interventions, and treatment of MDD were identified as hot topics, while biological mechanisms in MDD are likely to be an emerging research priority.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Huang Jia, Cai Yiyun, Wu Zhiguo, Su Yousong, Zhang Min, Shi Yifan, Zhu Na, Jin Feng, Fang Yiru, Peng Daihui
Summary: This study investigated the associations between gastrointestinal symptoms, medication use, and spontaneous drug discontinuation in patients with major depressive disorder (MDD). The results showed that GI symptoms were significantly associated with an increased risk of drug discontinuation in MDD patients. These findings have important implications for clinical treatment options and drug adherence management in MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Anthony L. Vaccarino, Sandra E. Black, Susan Gilbert Evans, Benicio N. Frey, Mojib Javadi, Sidney H. Kennedy, Benjamin Lam, Raymond W. Lam, Bianca Lasalandra, Emily Martens, Mario Masellis, Roumen Milev, Sara Mitchell, Douglas P. Munoz, Alana Sparks, Richard H. Swartz, Brian Tan, Rudolf Uher, Kenneth R. Evans
Summary: The study used Rasch Measurement Theory to evaluate the measurement properties of the Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) in neurodegenerative disorders (ND) and major depressive disorder (MDD). The results showed that the QIDS-SR is suitable for assessing and screening depressive symptoms in persons with ND, but there are limitations in differentiating participants at certain severity levels.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Gastroenterology & Hepatology
Juan M. Pericas, Frank Tacke, Quentin M. Anstee, Nicholas A. Di Prospero, Mette Skalshoj Kjaer, Peter Mesenbrink, Franz Koenig, Joan Genesca, Vlad Ratziu, EU-PEARL NASH Invest
Summary: Non-alcoholic fatty liver disease affects 25% of the population and non-alcoholic steatohepatitis (NASH) is a progressive form of the disease with severe complications. The traditional clinical trials in NASH pose challenges for drug development, and platform trials, utilizing a master protocol and adaptive randomization, offer an alternative approach to evaluate multiple investigational medicinal products concurrently or sequentially.
JOURNAL OF HEPATOLOGY
(2023)
Article
Psychiatry
Panqi Liu, Yanli Zhao, Hongzhen Fan, Yaxue Wu, Lei Liu, Jingguo Zhang, Dong Li, Yunlong Tan, Zhiren Wang, Shuping Tan
Summary: This study investigates the self-referential processing in patients with major depressive disorder (MDD). The results suggest that MDD patients tend to negatively evaluate self- and mother-referential information and show enhanced self-recognition during memory retrieval. These findings provide valuable insights into the information processing mechanisms underlying depression and have potential implications for clinical interventions.
ASIAN JOURNAL OF PSYCHIATRY
(2023)