Article
Biochemistry & Molecular Biology
Qingxia Yang, Qiaowen Xing, Qingfang Yang, Yaguo Gong
Summary: Schizophrenia, bipolar disorder, and major depressive disorder are the most common psychiatric disorders. Diagnosing these disorders is difficult due to overlaps in genetic epidemiology and molecular genetics. This study used transcriptomic data to identify key genes and construct a classification model for differentiating these disorders. The model showed potential for improving the diagnoses of these psychiatric disorders.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Clinical Neurology
Jianli Yang, Jiaqi Fan, Aobo Cheng, Wuji Zhao, Danting Wu, Wei Cui, Yunshu Zhang, Xiuling Liu
Summary: Appropriate task selection is crucial for fNIRS-based MDD diagnosis and treatment. This study investigated the hemodynamic characteristics of MDD under four different tasks and found that oxy-Hb was more significant in differentiating MDD subjects from healthy controls. The combinational task showed better discrimination than single tasks.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Yong-Ku Kim, Seon-Cheol Park
Summary: From 1780 to 1880, the conceptualization of melancholia shifted from an intellectual model to a mood model. The modern view of depression reflects changes in opinion on psychiatric taxonomy of individual melancholia. The diagnostic criteria for major depressive disorder have evolved from a neoKraepelinian approach rooted in disease essentialism in DSM-III to a more dimensional and categorical approach in DSM-5, reflecting the heterogeneity of major depressive disorder.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Benedicte Marie Finger, Annika Triller, Ashley M. Bourke, Gert Jan Lammers, Christian Veauthier, Merve Yildizli, Ulf Kallweit
Summary: This study investigated the frequency and characteristics of complementary and alternative medicine (CAM) use in German narcolepsy patients. 15% of patients were using CAM at the time of the survey, and an additional 18% reported past use. The most commonly used CAM treatments were vitamins/trace elements, homeopathy, and meditation. CAM users were more likely to experience side effects from medication and have low adherence to pharmacological treatment.
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: SUMOylation plays a significant role in maintaining neuronal function in the development of major depressive disorder (MDD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Hye-Bin Seung, Hui-Ju Kwon, Chan-Young Kwon, Sang-Ho Kim
Summary: This study conducted a systematic review of clinical studies and found that herbal medicine treatment for depression has significant effects on improving neurobiological outcomes, including increased concentrations of serotonin, brain-derived neurotrophic factor, and nerve growth factors, and decreased cortisol concentrations. However, caution should be exercised when interpreting these findings due to the low methodological quality and clinical heterogeneity of the included studies.
Article
Biochemistry & Molecular Biology
Wei Wei, Lihong Deng, Chunxia Qiao, Yubing Yin, Yamin Zhang, Xiaojing Li, Hua Yu, Lingqi Jian, Mingli Li, Wanjun Guo, Qiang Wang, Wei Deng, Xiaohong Ma, Liansheng Zhao, Pak C. Sham, Lena Palaniyappan, Tao Li
Summary: A shared disruption in brain physiology is suspected across major psychiatric disorders. The neural variability at rest, a behavior-relevant marker of brain function, was investigated in healthy controls and patients with schizophrenia, major depressive disorder, or bipolar disorders. The study revealed transdiagnostic disruptions in neural variability and its relationship with clinical symptoms and cognitive functions.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Chao Li, Mengshi Dong, Fay Y. Womer, Shaoqiang Han, Yi Yin, Xiaowei Jiang, Yange Wei, Jia Duan, Ruiqi Feng, Luheng Zhang, Xizhe Zhang, Fei Wang, Yanqing Tang, Ke Xu
Summary: The study utilized DFC analysis to investigate transdiagnostic dysconnectivity across SZ, BD, and MDD, revealing more common dysconnectivity than previously expected, with SZ showing the most pronounced changes.
HUMAN BRAIN MAPPING
(2021)
Review
Medical Laboratory Technology
Masoomeh Dadkhah, Mohsen Jafarzadehgharehziaaddin, Soheila Molaei, Morteza Akbari, Negin Gholizadeh, Farzaneh Fathi
Summary: Depressive disorders, characterized by loss of interest in previously enjoyed activities and a depressed mood, are highly heterogeneous psychiatric diseases. Diagnosis and treatment of major depressive disorder (MDD) remain challenging due to significant clinical presentation heterogeneity and lack of applicable biomarkers. Identification of relevant biomarkers would enhance disease classification and personalized treatment strategies. In this review, we discuss the current state of these biomarkers and diagnostic techniques specifically targeting these analytes using state-of-the-art biosensor technology.
CLINICA CHIMICA ACTA
(2023)
Article
Psychiatry
Linnea Stenmark, Charles H. Kellner, Mikael Landen, Irya Larsson, Mussie Msghina, Axel Nordenskjold
Summary: The study found that ECT may reduce the risk of psychiatric readmission in certain subgroups of patients with MDD, but there seems to be an increased readmission risk trend for patients under 35 years old.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Feng Gao, Jie Fan, Jie Xia, Tamini Soondrum, Wanting Liu, Hongyu Du, Jiang Zhu, Changlian Tan, Xiongzhao Zhu
Summary: The study found that in depressive patients, the left ventral stratum showed reduced modulation by risk levels, indicating inefficient reward processing in risky decision-making.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Natalie A. Bello, Hui Zhou, T. Craig Cheetham, Eliza Miller, Darios T. Getahun, Michael J. Fassett, Kristi Reynolds
Summary: This study compared the effects of using ACC/AHA and ACOG guidelines for defining hypertension in pregnant women. Results showed that using the ACC/AHA criteria led to better identification of women at risk for developing preeclampsia in the future.
Article
Behavioral Sciences
Zuxing Wang, Zhili Zou, Jun Xiao, Peijia Wang, Yuanyuan Luo, Wenjiao Min, Ying He, Cui Yuan, Yihan Su, Chenghui Yang, Fan Chang, Hongru Zhu
Summary: Patients with remitted depression show abnormal brain activation, particularly in areas involved in cognitive function, emotion regulation, and perception. These alterations may be the primary or secondary neurophysiological mechanisms underlying major depressive disorder and could serve as potential neuroimaging targets for early screening.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Medicine, General & Internal
Anjali Sankar, Simon C. Ziersen, Brice Ozenne, Emily E. Beaman, Vibeke H. Dam, Patrick M. Fisher, Gitte M. Knudsen, Lars V. Kessing, Vibe Frokjaer, Kamilla W. Miskowiak
Summary: This study found that severe verbal memory impairment is associated with an increased risk of future psychiatric hospitalization in individuals with affective disorders, while it is unrelated to the worsening of socio-demographic conditions.
Article
Psychiatry
Karabi Nandy, A. John Rush, Thomas J. Carmody, Alexandra Kulikova, Taryn L. Mayes, Graham Emslie, Madhukar H. Trivedi
Summary: This study evaluated the psychometric properties of the Concise Health Risk Tracking Self-Report (CHRT-SR) in assessing suicidal behavior risk among adolescents. The results showed that the CHRT-SR9 is an effective brief self-report measure that is sensitive to changes in suicidality over time.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Cynthia H. Y. Fu, Guray Erus, Yong Fan, Mathilde Antoniades, Danilo Arnone, Stephen R. Arnott, Taolin Chen, Ki Sueng Choi, Cherise Chin Fatt, Benicio N. Frey, Vibe G. Frokjaer, Melanie Ganz, Jose Garcia, Beata R. Godlewska, Stefanie Hassel, Keith Ho, Andrew M. McIntosh, Kun Qin, Susan Rotzinger, Matthew D. Sacchet, Jonathan Savitz, Haochang Shou, Ashish Singh, Aleks Stolicyn, Irina Strigo, Stephen C. Strother, Duygu Tosun, Teresa A. Victor, Dongtao Wei, Toby Wise, Rachel D. Woodham, Roland Zahn, Ian M. Anderson, J. F. William Deakin, Boadie W. Dunlop, Rebecca Elliott, Qiyong Gong, Ian H. Gotlib, Catherine J. Harmer, Sidney H. Kennedy, Gitte M. Knudsen, Helen S. Mayberg, Martin P. Paulus, Jiang Qiu, Madhukar H. Trivedi, Heather C. Whalley, Chao-Gan Yan, Allan H. Young, Christos Davatzikos
Summary: In this study, a consortium called "COORDINATE-MDD" was established to define patterns of brain alteration in major depressive disorder (MDD) using neuroanatomical and neurofunctional heterogeneity as dimensions. By harmonizing imaging data and using machine learning methods, the project aims to predict treatment response at the individual level. International datasets from various MDD populations are being shared, and novel predictors of treatment response are being identified and validated externally.
Review
Business
Tanushree Mahato, Manish Kumar Jha, Akhaya Kumar Nayak, Neelam Kaushal
Summary: This paper conducted a comprehensive bibliometric analysis and systematic review to explore the research landscape of women empowerment through participation in self-help groups (SHGs). The findings suggest that SHGs play a crucial role in empowering rural women, and India is the most contributing country in this field. In addition, the paper proposes a conceptual framework to understand the antecedents of women's empowerment achieved through SHGs. The practical implications of this study provide guidance for practitioners, government, policymakers, and researchers in the area of SHGs and women empowerment.
JOURNAL OF ENTERPRISING COMMUNITIES-PEOPLE AND PLACES IN THE GLOBAL ECONOMY
(2023)
Article
Substance Abuse
Ximena A. Levander, Thomas Carmody, Ryan R. Cook, Jennifer S. Potter, Madhukar H. Trivedi, Philip Todd Korthuis, Steven Shoptaw
Summary: This study aimed to investigate the treatment response of women with methamphetamine use disorder and the effect of contraception on treatment response. The results showed that women had a better treatment response compared to the placebo group. The use of contraception did not affect the treatment response.
Article
Psychiatry
Manish K. Jha, Abu Minhajuddin, Holli Slater, Taryn L. Mayes, Joseph Blader, Ryan Brown, Cynthia Garza, Beth D. Kennard, David Riddle, Eric A. Storch, Joseph Shotwell, Cesar A. Soutullo, Sarah M. Wakefield, Madhukar H. Trivedi
Summary: This study evaluated the psychometric properties of the Concise Associated Symptom Tracking (CAST) scale in children, adolescents, and young adults. The results showed that CAST-12 is a valid self-report measure for assessing irritability, anxiety, insomnia, and panic symptoms in youths and young adults.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Microbiology
Eva M. Medina-Rodriguez, Jowan Watson, Juliana Reyes, Madhukar Trivedi, Eleonore Beurel
Summary: This study found that certain bacteria known to induce Th17 cells are increased in depressed patients and mice exhibiting learned helplessness. Fecal transfers of human depressed patients' microbiomes into germ-free-like mice were sufficient to decrease sociability and increase susceptibility to the learned helplessness paradigm. The effect of the microbiome on depressive-like behaviors was dependent on the presence of Th17 cells in the recipient.
Article
Psychiatry
Karabi Nandy, A. John Rush, Thomas J. Carmody, Taryn L. Mayes, Madhukar H. Trivedi
Summary: This study aimed to evaluate the psychometric properties of a 9-item Concise Health Risk Tracking Self-Report (CHRT-SR9) for assessing suicidal risk in adult primary care outpatients. The CHRT-SR9 demonstrated excellent internal consistency, measurement invariance across sex and age groups, and concurrent validity with the Patient Health Questionnaire (PHQ-9) suicide item.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Shubham Kamal, Manish Kumar Jha, Rajiv Radhakrishnan
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2023)
Editorial Material
Psychiatry
Manish Kumar Jha, Madhukar H. Trivedi
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2023)
Article
Health Care Sciences & Services
Daniel K. Elledge, Simon Craddock Lee, Sunita M. Stewart, Radu Pop, Madhukar H. Trivedi, Jennifer L. Hughes
Summary: This study examined the feasibility and acceptability of a resilience app for adolescents. The findings suggest that youth are interested in using this type of app, and the current prototype is feasible. However, there were no significant changes in mental health outcomes after using the app.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychiatry
Adriane M. dela Cruz, Tara Karns-Wright, Farra Kahalnik, Robrina Walker, Holly J. Lanham, Jennifer Sharpe Potter, Madhukar H. Trivedi
Summary: The research found that systemic and attitudinal barriers to screening, diagnosing, and treating OUD continue to persist. Providers tended to view the software-based MBC program favorably, indicating that it may be a solution to increasing accessibility to OUD treatment; however, further interventions to combat stigma would likely be needed prior to implementation of these programs.
Meeting Abstract
Psychology, Developmental
Madhukar H. Trivedi, Tobi Fuller, Jennifer L. Hughes
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Meeting Abstract
Psychology, Developmental
Ozlem Hokelekli, Abu Minhajuddin, Ann Brindley House, Ellen Leibenluft, Madhukar H. Trivedi, Manish K. Jha
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Meeting Abstract
Psychology, Developmental
Sarah Mallard Wakefield, Madhukar H. Trivedi, Taryn L. Mayes
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Correction
Psychiatry
David B. Riddle, Andrew Guzick, Abu Minhajuddin, Orri Smarason, Gabrielle M. Armstrong, Holli Slater, Taryn L. Mayes, Lynnel C. Goodman, Denise L. Baughn, Sarah L. Martin, Sarah M. Wakefield, Joseph Blader, Ryan Brown, Silvina Tonarelli, Wayne K. Goodman, Madhukar H. Trivedi, Eric A. Storch
JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS
(2023)