Article
Medicine, General & Internal
Jennifer Fontaine, Evelyn Chin, Jean-Francois Provencher, Anthony Rainone, Dana Wazzan, Carmella Roy, Soham Rej, Marie Lordkipanidze, Vincent Dagenais-Beaule
Summary: This study reveals suboptimal baseline cardiometabolic monitoring of patients taking antipsychotic drugs in a Canadian hospital. Improving collaboration within a multidisciplinary team may enhance cardiometabolic monitoring.
Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Neurosciences
Janusz K. Rybakowski
Summary: The narrative review focuses on mood stabilizers. It provides the author's definition of mood-stabilizing drugs and describes the two generations of drugs that meet this definition. The article presents the clinical experiences with first and second-generation mood stabilizers and discusses their use in preventing recurrences of bipolar mood disorder.
Article
Psychiatry
Feiyun Ouyang, Jun He, Xunjie Cheng, Wei Zhou, Shuiyuan Xiao, Junqun Fang
Summary: Among NBPHSP enrollees with schizophrenia in Hunan Province, regular and intermittent use of antipsychotics were associated with 117% and 53% increased risks of developing type 2 diabetes mellitus compared to antipsychotic-free patients. Furthermore, specific antipsychotics like clozapine, risperidone, chlorpromazine, and perphenazine were found to increase the risk of T2DM in this population.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Kelly A. Ryan, Peisong Han, Yuhua Zhang, David F. Marshall, Anastasia K. Yocum, Melvin G. McInnis, Sebastian Zollner
Summary: Individuals with bipolar disorder tend to have higher neuroticism and lower extraversion and consciousness compared to healthy controls. Personality traits show only small changes over time, with neuroticism being the only trait associated with changes in mood state. Other factors beyond mood changes may influence changes in personality traits.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Nicola Omlor, Maike Richter, Janik Goltermann, Lavinia A. Steinmann, Anna Kraus, Tiana Borgers, Melissa Klug, Verena Enneking, Ronny Redlich, Katharina Dohm, Jonathan Repple, Elisabeth J. Leehr, Dominik Grotegerd, Harald Kugel, Jochen Bauer, Udo Dannlowski, Nils Opel
Summary: This study examined the effect of the second-generation antipsychotic quetiapine on ACC activity in major depressive disorder patients. The results showed that patients taking quetiapine had significantly higher activity in the ACC during reward stimulation compared to those not taking antipsychotic medication. This suggests that the antidepressant effects of quetiapine may be mediated through increased ACC activity during reward processing.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Marta Ielmini, Ivano Caselli, Flavio Critelli, Michele Mattia, Alessandro Bellini, Camilla Callegari
Summary: This systematic review with meta-analysis evaluates the utility of pharmacogenetic tests (PGTs) in the routine clinical treatment of mood disorders. The results indicate that PGT suggestions can lead to better efficacy outcomes for patients with major depressive disorder (MDD), but not for patients with bipolar disorder (BD). However, PGTs show promising results in terms of setting up more tolerated therapies. Overall, PGTs are important in supporting clinicians' choices in psychopharmacological therapies.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Siqi Xue, John Hodsoll, Ameer Bukhsh Khoso, Muhammad Omair Husain, Imran B. Chaudhry, Allan H. Young, Juveria Zaheer, Nusrat Husain, Benoit H. Mulsant, Muhammad Ishrat Husain
Summary: This study investigated the prevalence and risk factors of suicidal ideation in bipolar depression in Pakistan, with findings suggesting that BMI, HAM-D score, CRP level, and number of inpatient hospitalizations are significant predictors of suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Tien-Wei Hsu, Che-Sheng Chu, Pao-Yuan Ching, Guan-Wei Chen, Chih-Chuan Pan
Summary: This study conducted a systematic review and meta-analysis to evaluate the antidepressant effects of memantine in patients with major mental diseases. The results showed that memantine effectively alleviates depressive symptoms in patients with mood disorders with a small effect size, but it does not have a significant effect in patients with schizophrenia.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Neurosciences
Janusz K. Rybakowski
Summary: Antipsychotic drugs have been widely used in the treatment of mood disorders in addition to schizophrenia since their first application in psychiatry seventy years ago. These drugs can be classified into three generations, and each generation has different effects on mood disorders. The second and third generations of antipsychotic drugs have shown efficacy in the treatment of bipolar disorder, including antimanic and antidepressant effects.
Review
Medicine, General & Internal
Andreas S. Lappas, Bartosz Helfer, Katarzyna Henke-Ciazynska, Myrto T. Samara, Nikos Christodoulou
Summary: This systematic review and meta-analysis assessed the efficacy, tolerability, and acceptability of Clonazepam in the treatment of acute mania. The results suggested that Clonazepam may be superior to a placebo in the acute phase of treatment and comparable to Lithium and Haloperidol in terms of efficacy, both acutely and in the medium to long term. Clonazepam may be an acceptable and well-tolerated treatment for acute mania, especially when used as an augmentation strategy. However, the limited sample sizes and underpowered comparisons restrict the generalizability of the findings and hinder firm clinical conclusions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Psychiatry
Heinz Grunze, Reka Csehi, Christoph Born, Agota Barabassy
Summary: The dopaminergic system plays a crucial role in SUD, BD, and refractory depression, with common genetic markers and underlying cellular processes linking these disorders with a high rate of comorbidity. Dopamine D-3 receptors are central in SUD and BD, suggesting that D-2/D-3 partial agonists/antagonists could be a potential target for both disorders in future therapeutic approaches.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Pediatrics
Jessica L. Roane, Megan Mio, Jacqueline Viner, Ariel Bettridge, Chinthaka Heyn, Idan Roifman, Beth Selkirk, Peter Kertes, Bradley J. MacIntosh, Vivekanandan Thayalasuthan, Garry Detzler, Ruby Endre, Laura Jimenez-Juan, Blair Henry, Brian J. Murray, Benjamin I. Goldstein
Summary: Incidental findings are common in research imaging of both healthy and clinical youth populations, requiring a standardized management strategy. This study documents the frequency and nature of incidental findings in a research group that utilizes multiple imaging modalities and describes the evolution of their approach to handling these findings. While most of the incidental findings were non-serious, there were exceptions that require follow-up. It emphasizes the importance of clinical review and collaborative planning in research imaging.
FRONTIERS IN PEDIATRICS
(2022)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Materials Science, Multidisciplinary
Agnieszka L. Kozub, Arno Schindlmayr, Uwe Gerstmann, Wolf Gero Schmidt
Summary: Density-functional theory within a Berry-phase formulation is used to determine the second-order susceptibility of lithium niobate. Defect-trapped polarons and bipolarons enhance the nonlinear susceptibility of the material, especially when localized at specific defect pairs. This enhancement is due to the formation of polaronic states inside the band gap, allowing for spatial and transient modification of second-harmonic generation in macroscopic samples through illumination.