Article
Clinical Neurology
Si-Lei Fong, Minh-An Thuy Le, Kheng-Seang Lim, Herlyani Khosama, Ohnmar Ohnmar, Say Savath, Zarine Mogal, Leonor Cabral-Lim, Stefanie Kar-Yan Hung, Ajay Asranna, Mohammad Enayet Hussain, Chiu-Wan Ng, Chong-Tin Tan
Summary: The objective of the study was to determine the affordability of newer antiseizure medications in resource-limited countries in Asia. The majority of these medications were found to be unaffordable, with the median cost ranging from 5.6 to 14.8 days' wages for a 30-day supply.
Article
Clinical Neurology
Pavel Klein, Orrin Devinsky, Jacqueline French, Cynthia Harden, Gregory L. Krauss, Robert McCarter, Michael R. Sperling
Summary: This study analyzed the risk of suicidality for five antiseizure medications approved since 2008, finding no increased risk of suicidal ideation or attempts compared to placebo. Therefore, these medications do not warrant a class warning for suicidality.
Review
Clinical Neurology
Rebecca Knight, Anja Wittkowski, Rebecca Louise Bromley
Summary: Recent research has shown that exposure to certain newer antiseizure medications (ASMs) such as lamotrigine and levetiracetam during pregnancy does not appear to have a significant impact on child neurodevelopment. However, due to limitations in study quality and data availability, further research is needed to fully understand the effects of other ASMs on child neurodevelopment.
Article
Oncology
Erin K. Biringen, Emily Cox-Martin, Sierra Niemiec, Cheyret Wood, W. Thomas Purcell, Elissa Kolva
Summary: Oncology providers displayed both comfort and discomfort with prescribing psychotropic medications, with benzodiazepines being the most commonly prescribed class and mood stabilizers being the least prescribed. Barriers to comfort included difficulties in connecting patients to mental health professionals for follow-up care and inadequate mental health education for providers. Continuing mental health education and improving patient access to mental health resources were suggested to increase providers' comfort in prescribing psychotropic medications.
SUPPORTIVE CARE IN CANCER
(2021)
Editorial Material
Green & Sustainable Science & Technology
Jerry Glover
Summary: A new study suggests that switching to high-yield perennial rice crops can help maintain key ecosystem functions while supporting livelihoods.
NATURE SUSTAINABILITY
(2023)
Article
Pharmacology & Pharmacy
Zhenzhen Deng, Shengfeng Wang, Cuifang Wu
Summary: This study identified 7 newer-generation ASMs with significant associations with rhabdomyolysis. Prescribers should be more aware of this risk and teach patients to recognize signs/symptoms of rhabdomyolysis early.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
M. Ramesh, Krishnan Anand, Mohd Shahbaaz, Magda H. Abdellattif
Summary: The COVID-19 pandemic caused by the rapid spread of SARS-CoV-2 has resulted in a range of respiratory illnesses, from mild symptoms to severe cases that can lead to death. Targeting the spike protein to prevent viral entry into the host has been suggested as an effective treatment strategy for COVID-19.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Laurel A. Copeland, Rebecca L. Kinney, Aimee R. Kroll-Desrosiers, Geetha Shivakumar, Kristin M. Mattocks
Summary: The study found that women service members in the VHA were prescribed numerous medications during pregnancy, with a concerning rate of discontinuation of antidepressants. Counseling should be provided to women veterans of childbearing potential about medication use after pregnancy is detected and after pregnancy concludes, and information should be shared between their non-VHA obstetricians and VHA providers to optimize outcomes.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Clinical Neurology
Irene Aicua-Rapun, Pascal Andre, Andrea O. Rossetti, Laurent A. Decosterd, Thierry Buclin, Jan Novy
Summary: This study assessed the correlation between plasma levels of newer generation antiseizure medications and efficacy in patients with epilepsy. The results indicated that seizure-free patients generally had lower medication plasma levels compared to those with ongoing seizures, suggesting that the efficacy of these medications may be achieved at lower levels than previously thought.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Neurosciences
Brian Shiner, Jenna A. Forehand, Luke Rozema, Martin Kulldorff, Bradley Watts, Marina Trefethen, Tammy Jiang, Krista F. Huybrechts, Paula P. Schnurr, Matthew Vincenti, Jiang Gui, Jaimie L. Gradus
Summary: This study used electronic health record data to identify existing medications that may be repurposed as treatments for posttraumatic stress disorder (PTSD). They found that some direct-acting antivirals used in the treatment of hepatitis C virus are strongly associated with improvement in PTSD symptoms.
BIOLOGICAL PSYCHIATRY
(2022)
Review
Pediatrics
Samata Singhi, Ajay Gupta
Summary: Newer antiseizure medications offer advantages in terms of tolerability, adverse effects, and drug interactions compared to conventional medications, but concerns remain regarding high cost and availability. Unique pharmacokinetic and pharmacodynamic considerations are important for the pediatric population, especially in the context of age-dependent electroclinical syndromes and precision-based medicine. This review aims to provide a comprehensive update on newer antiseizure medications.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Chandrashekar Janakiram, Ilya Okunev, Eric P. Tranby, Paul Fontelo, Timothy J. Iafolla, Bruce A. Dye
Summary: This study examines the prescription patterns of opioids for pain management in patients with depression and/or anxiety. It found that adults with mental health disorders are more likely to receive opioid prescriptions for pain management compared to those without mental health disorders.
Review
Psychology, Clinical
Harry Costello, Jonathan P. Roiser, Robert Howard
Summary: Depression in dementia is common and has negative effects on patients and carers. Antidepressants are widely used but lack evidence of efficacy, and may be harmful. More research is needed to understand why antidepressants are ineffective in dementia and to find new treatment targets. Clinicians continue to prescribe antidepressants, but novel approaches are needed to identify effective treatments for depression in dementia.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Harriet Ho, Naveed Z. Janjua, Kimberlyn M. McGrail, Mark Harrison, Michael R. Law
Summary: After studying the impact of public prescription drug coverage for sofosbuvir and ledipasvir-sofosbuvir in British Columbia, Canada, it was found that public coverage dramatically increased the use of these drugs without reducing adherence. Public expenditure increased following the policy change, crowding out some private expenditure.
Article
Clinical Neurology
Gabriela K. Khazanov, Colin Xu, Steven D. Hollon, Robert J. DeRubeis, Michael E. Thase
Summary: This study found that adding cognitive therapy to antidepressant medications can further reduce suicidal ideation during treatment, relative to medications alone. This effect was consistent when measured with both the Beck Depression Inventory and the Hamilton Depression Rating Scale, particularly for patients with more severe suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2021)