Article
Medicine, General & Internal
Ming-Huan Zhu, Zhen-Jing Liu, Qiong-Yue Hu, Jia-Yu Yang, Ying Jin, Na Zhu, Ying Huang, Dian-Hong Shi, Min-Jia Liu, Hong-Yang Tan, Lei Zhao, Qin-Yu Lv, Zheng-Hui Yi, Feng-Chun Wu, Ze-Zhi Li
Summary: This study aimed to investigate the efficacy of amisulpride augmentation therapy in treating patients with treatment-resistant schizophrenia. The results showed that amisulpride augmentation therapy improved psychiatric symptoms and cognitive function with tolerability and safety.
MILITARY MEDICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Dandan Wang, Ning Wei, Fangzhen Hu, Jianhua Li, Yucheng Wang, Zhiwei Qian, Miao Yang, Mingrong Yao, Yong Xia, Hong Yu, Wenzhen Tu, Minjie Ye, Cheng Qian, Jianbo Hu, Jingkai Chen, Chanchan Hu, Manli Huang, Yi Xu, Shaohua Hu
Summary: This study compared the efficacy and safety of paliperidone extended release (ER) and olanzapine in patients with treatment-resistant schizophrenia. The results showed that both drugs improved psychotic symptoms, but had no significant effect on cognitive functions. Both drugs also caused weight gain and increased waist circumference, with olanzapine having a greater impact on waist circumference. Overall, paliperidone ER could be a safe alternative for treatment-resistant schizophrenia.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Le Xiao, Qian Zhao, An-ning Li, Jushui Sun, Bin Wu, Lina Wang, Honggeng Zhang, Ruiling Zhang, Keqing Li, Xiaojin Xu, Tiebang Liu, Wenshun Zhang, Shiping Xie, Xiufeng Xu, Yunlong Tan, Kerang Zhang, Hongyan Zhang, Nianhong Guan, Mingji Xian, Motomichi Uki, Gang Wang
Summary: The study evaluated the efficacy and safety of aripiprazole once-monthly (AOM) compared to oral aripiprazole in treating acute schizophrenia. The results showed that AOM was non-inferior to oral aripiprazole in terms of efficacy and tolerability. These findings suggest that AOM could be a treatment option for patients experiencing an acute episode of schizophrenia.
PSYCHOPHARMACOLOGY
(2022)
Article
Critical Care Medicine
Elisa Perger, Luigi Taranto Montemurro, Debora Rosa, Stefano Vicini, Mariapaola Marconi, Lucia Zanotti, Paolo Meriggi, Ali Azarbarzin, Scott A. Sands, Andrew Wellman, Carolina Lombardi, Gianfranco Parati
Summary: The combination therapy of Reb-Oxy significantly reduces the severity of OSA and improves vigilance. These findings highlight the potential of pharmacologic treatment for OSA.
Article
Clinical Neurology
Marcos Gomez-Revuelta, Jose Maria Pelayo-Teran, Javier Vazquez-Bourgon, Victor Ortiz-Garcia de la Foz, Jacqueline Mayoral-van Son, Rosa Ayesa-Arriola, Benedicto Crespo-Facorro
Summary: This study compared the effectiveness of aripiprazole and risperidone in the acute-phase treatment of FEP and found no differences in treatment discontinuation rates and mean time until discontinuation between the two drugs. However, risperidone showed better performance in terms of clinical efficacy, but patients on risperidone were more likely to experience sex-related adverse events.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Masaomi Iyo, Jun Ishigooka, Masatoshi Nakamura, Reiko Sakaguchi, Keisuke Okamoto, Yongcai Mao, Joyce Tsai, Alison Fitzgerald, Tadashi Nosaka, Teruhiko Higuchi
Summary: The study evaluated the efficacy of lurasidone in acute schizophrenia patients in Japan and other countries, showing significant improvement in PANSS and CGI-S scores. Lurasidone was well-tolerated with a low rate of adverse events and discontinuation, making it a promising treatment option for acute schizophrenia.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Clinical Neurology
Masaomi Iyo, Jun Ishigooka, Masatoshi Nakamura, Reiko Sakaguchi, Keisuke Okamoto, Yongcai Mao, Joyce Tsai, Alison Fitzgerald, Tadashi Nosaka, Teruhiko Higuchi
Summary: The study evaluated the efficacy of lurasidone in acute schizophrenia in Japan and other countries. Results indicated significant improvement in PANSS and CGI-S scores with lower rates of adverse events, demonstrating that lurasidone was effective and well-tolerated in patients with acute schizophrenia.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Psychiatry
Meijuan Li, Ying Liu, Yuying Qiu, Jing Zhang, Yonghui Zhang, Yongping Zhao, Qiong Jia, Jie Li
Summary: This study showed that adjunctive treatment with berberine can reduce the risk of glycolipid metabolic disturbances in patients with schizophrenia, leading to significant declines in total cholesterol, low-density lipoprotein cholesterol, fasting serum insulin, and insulin resistance.
PSYCHIATRY RESEARCH
(2021)
Article
Neurosciences
Mahmoud S. Abdallah, Esraa M. Mosalam, Ahmed Hassan, Ahmed N. Ramadan, Hend Omara-Reda, Abdel-Aziz A. Zidan, Waad A. Samman, Eman El-Berri
Summary: This study aimed to investigate the effectiveness and safety of pentoxifylline as an adjuvant to risperidone in mitigating the negative symptoms in patients with chronic schizophrenia. The results showed that pentoxifylline adjunctive therapy had a significant effect in reducing PANSS-negative subscale scores, PANSS general psychopathology subscale scores, and PANSS total scores. Furthermore, it also led to an increase in cAMP serum level and a decrease in TNF-alpha and IL-6 serum levels.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Psychiatry
Richard A. Kanaan, Gina Oliver, Anita Dharan, Shahbaz Sendi, Alice Maier, Mohammadreza Mohebbi, Chee Ng, Sudie E. Back, Peter Kalivas, Michael Berk
Summary: This study investigated the efficacy of adjuvant N-acetylcysteine (NAC) treatment in patients with treatment-resistant PTSD. The results showed that there were no significant differences between NAC and placebo groups in CAPS-5 scores at 12 weeks, but significant differences were observed in craving duration and resistance at 64 weeks. Further research is needed to determine the efficacy of NAC for treatment-resistant PTSD.
PSYCHIATRY RESEARCH
(2023)
Article
Neurosciences
Young Sup Woo, Sung-Yong Park, Bo-Hyun Yoon, Won-Seok Choi, Sheng-Min Wang, Won-Myong Bahk
Summary: This study compared the efficacy and tolerability of continued olanzapine (OLA) versus amisulpride (AMI) augmentation in schizophrenic patients with poor response to OLA monotherapy. The results showed significant differences in PANSS total score and PANSS-positive subscale score between the OLA and AMI groups. However, there were no statistically significant differences between the two groups in PANSS-negative subscale, PANSS-general subscale, Brief Psychiatric Rating Scale, and Clinical Global Impression-Severity (CGI-S) scale scores.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Article
Psychiatry
Marco Aurelio Cigognini, Alia Garrudo Guirado, Denise van de Meene, Monica Andreia Schneider, Monica Sarah Salomon, Vinicius Santana de Alexandria, Juliana Pisseta Adriano, Ana Maria Thaler, Fernando dos Santos Fernandes, Adriana Carneiro, Ricardo Alberto Moreno
Summary: This study aims to evaluate the long-term use of ketamine in the treatment of treatment-resistant depression (TRD) and compare it with active treatment. By assessing efficacy, safety, and tolerability, the study may provide evidence for a new, low-cost, rapid, and feasible approach to depression treatment.
FRONTIERS IN PSYCHIATRY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Jeremy Pettus, Schafer C. Boeder, Mark P. Christiansen, Douglas S. Denham, Timothy S. Bailey, Halis K. Akturk, Leslie J. Klaff, Julio Rosenstock, Mickie H. M. Cheng, Bruce W. Bode, Edgar D. Bautista, Ren Xu, Hai Yan, Thai Dung, Satish K. Garg, Samuel Klein
Summary: This study evaluated the safety and efficacy of volagidemab, an antagonistic monoclonal glucagon receptor antibody, as an adjunct to insulin therapy in patients with type 1 diabetes. The results showed that volagidemab reduced daily insulin use and decreased HbA1c levels. However, further research is needed to confirm the long-term efficacy and safety of volagidemab.
Article
Pharmacology & Pharmacy
Dejan B. Budimirovic, Kelli C. Dominick, Lidia Gabis, Maxwell Adams, Mathews Adera, Linda Huang, Pamela Ventola, Nicole R. Tartaglia, Elizabeth Berry-Kravis
Summary: This study aimed to evaluate the safety, tolerability, efficacy, and optimal daily dose of the GABA(A) receptor agonist OV101 in patients with FXS. Results showed that OV101 was well tolerated across different treatment regimens and demonstrated potential efficacy in improving symptoms of FXS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yanhang Gao, Fei Kong, Xinwen Song, Jia Shang, Lvfeng Yao, Jinyu Xia, Yanzhong Peng, Weidong Liu, Huanyu Gong, Mao Mu, Hesong Cui, Tao Han, Wen Chen, Xiaolu Wu, Yongfeng Yang, Xuebing Yan, Zhenjing Jin, Peng Wang, Qingjing Zhu, Liang Chen, Caiyan Zhao, Dengke Zhang, Weili Jin, Daidi Wang, Xiuhong Wen, Chunmei Liu, Jidong Jia, Qing Mao, Yanhua Ding, Xueyuan Jin, Zong Zhang, Qianguo Mao, Guangming Li, Junqi Niu
Summary: In a phase 2 trial, pradefovir showed comparable antiviral activity against HBV and good safety profile to tenofovir disoproxil fumarate. Pradefovir at doses of 30, 45, 60, and 75 mg effectively reduced HBV DNA levels and resulted in more HBeAg loss compared to TDF.
CLINICAL INFECTIOUS DISEASES
(2022)