Article
Clinical Neurology
Gernot Fugger, Lucie Bartova, Chiara Fabbri, Giuseppe Fanelli, Raffaella Zanardi, Markus Dold, Alexander Kautzky, Dan Rujescu, Daniel Souery, Julien Mendlewicz, Joseph Zohar, Stuart Montgomery, Alessandro Serretti, Siegfried Kasper
Summary: A study found that European patients who were prescribed NaSSAs as first-line antidepressant treatment had characteristics such as older age, male gender, unemployment, additional melancholic and catatonic features, inpatient treatment, lower dosages of antidepressants but higher rates of augmentation with low-potency antipsychotics, and greater reductions of depressive symptoms during their current major depressive episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Qi Zhou, Xiaozhen Lv, Shuzhe Zhou, Qi Liu, Hongjun Tian, Kerang Zhang, Jing Wei, Gang Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Cuixia An, Nan Zhang, Yu Huang, Tianmei Si, Xin Yu, Chuan Shi
Summary: Inflammation and cognition are related to major depressive disorder (MDD). Treatment response in MDD patients is associated with different cognitive defects, especially in speed of processing and executive function. Factors such as smoking, alcohol drinking, baseline cognitive performance, and cytokine levels may influence treatment response.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Clinical
Po-Chun Lin, Ta-Chuan Yeh, Ya-Mei Bai, Ju-Wei Hsu, Kai-Lin Huang, Nai-Ying Ko, Che-Sheng Chu, Hsuan-Te Chu, Shih-Jen Tsai, Tzeng-Ji Chen, Chih-Sung Liang, Mu-Hong Chen
Summary: The association between treatment resistance and physical and psychiatric comorbidities in elderly patients with late-onset major depressive disorder is still unclear. Approximately one-fourth of patients responded poorly to the first antidepressant treatment in the first year, with psychiatric comorbidities being more associated with the risk of early treatment-resistant tendency.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Psychiatry
Pablo Patricio Zarate-Garza, Jessica Alejandra Ortega-Balderas, Jose Alfonso Ontiveros-Sanchez de la Barquera, Roberto Alejandro Lugo-Guillen, Alejandro Marfil-Rivera, Alejandro Quiroga-Garza, Santos Guzman-Lopez, Rodrigo Enrique Elizondo-Omana
Summary: The study found that antidepressant-naive individuals with major depression disorder who achieved clinical remission had larger hippocampal volumes before treatment. The findings suggest that HV may serve as a predictor of treatment outcomes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Jingjing Zhou, Jia Zhou, Zuoli Sun, Lei Feng, Yuan Feng, Le Xiao, Xu Chen, Jian Yang
Summary: This study found that CRP levels in the blood are associated with remission and symptomatic improvement in patients receiving escitalopram treatment for depression. Patients with lower CRP levels are more likely to achieve remission, and baseline CRP levels are negatively correlated with treatment outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Lei Zhao, Donglin Wang, Shao-Wei Xue, Zhonglin Tan, Hong Luo, Yan Wang, Hanxiaoran Li, Chenyuan Pan, Sufen Fu, Xiwen Hu, Zhihui Lan, Yang Xiao, Changxiao Kuai
Summary: Deficits in emotion regulation are key features of major depressive disorder (MDD) and targeting the dynamic functional connectivity of emotion networks could be an important clinical intervention for treating MDD. The study found that antidepressant treatment led to a reconfiguration of emotion regulation networks in MDD patients, and stronger baseline dFC can predict a faster reduction in depression scores.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Le Li, Yun-Ai Su, Yan-Kun Wu, Francisco Xavier Castellanos, Ke Li, Ji-Tao Li, Tian-Mei Si, Chao-Gan Yan
Summary: This study found significant intrinsic functional connectivity decreases in extensive brain networks after antidepressant treatment, indicating considerable antidepressant effects. There were no significant differences in resting-state functional connectivity between treatment-naive MDD patients and healthy controls.
HUMAN BRAIN MAPPING
(2021)
Article
Psychiatry
Vibeke Hoyrup Dam, Dea Siggaard Stenbaek, Kristin Kohler-Forsberg, Cheng Ip, Brice Ozenne, Barbara Jacquelyn Sahakian, Gitte Moos Knudsen, Martin Balslev Jorgensen, Vibe Gedsoe Frokjaer
Summary: This study investigates the cognitive performance and its relationship with antidepressant treatment response in patients with major depressive disorder. The results show that cognitive performance improves during antidepressant treatment, independent of mood symptoms. However, patients with severe baseline cognitive disturbances may have poorer clinical response after 8 weeks of treatment. Hence, considering cognitive performance across different domains may be useful for stratifying patients with major depressive disorder.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
David P. Herzog, Stefanie Wagner, Jan Engelmann, Giulia Treccani, Nadine Dreimueller, Marianne B. Mueller, Andre Tadic, Harald Murck, Klaus Lieb
Summary: Major depressive disorder is a highly heterogeneous disorder, with onset of depression serving as a possible clinical marker for therapy response prediction. Patients with early onset depression have more severe symptoms and worse treatment outcomes, while patients with late onset respond faster to treatment. Early non-improvement in depression after 2 weeks of therapy is associated with a higher likelihood of non-remission in early onset patients. These findings suggest the need for individualized treatment approaches based on differences in autonomic regulation for different onset groups.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Behavioral Sciences
Daniele Cavaleri, Federico Moretti, Alessandra Bartoccetti, Stefano Mauro, Cristina Crocamo, Giuseppe Carra, Francesco Bartoli
Summary: Based on meta-analyses, this overview suggests that the brain-derived neurotrophic factor (BDNF) may serve as a potential biomarker for major depressive disorder (MDD) and antidepressant response. People with MDD show lower peripheral and central BDNF levels compared to non-depressed individuals, and blood BDNF levels are negatively correlated with symptom severity. Antidepressant treatment can lead to increased blood BDNF levels, proportional to symptom improvement, while non-pharmacological interventions do not affect BDNF concentrations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neuroimaging
Pedro L. Ballester, Jee Su Suh, Nikita Nogovitsyn, Stefanie Hassel, Stephen C. Strother, Stephen R. Arnott, Luciano Minuzzi, Roberto B. Sassi, Raymond W. Lam, Roumen Milev, Daniel J. Muller, Valerie H. Taylor, Sidney H. Kennedy, Benicio N. Frey
Summary: The study found an elevated brain age gap in older individuals with major depressive disorder (MDD). Additionally, body mass index (BMI) was significantly associated with brain age gap in the MDD group. However, the brain age gap was not significantly associated with treatment response.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
You -Ran Dai, Yan-Kun Wu, Xiao Chen, Ya-Wei Zeng, Ke Li, Ji-Tao Li, Yun-Ai Su, Lin -Lin Zhu, Chao-Gan Yan, Tian -Mei Si
Summary: A recent study found disrupted topological organization of whole-brain networks in patients with major depressive disorder (MDD), especially in recurrent MDD patients. However, there is a lack of research on first-episode drug-naive (FEDN) patients, as well as the effects of antidepressant therapy on brain networks.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Tomiki Sumiyoshi, Tatsuya Hoshino, Izumi Mishiro, Lene Hammer-Helmich, Holly Ge, Yoshiya Moriguchi, Keita Fujikawa, Jovelle L. Fernandez
Summary: Early improvement in depressive symptoms predicts better cognitive outcomes in patients with Major Depressive Disorder (MDD). Grouping patients by mood and cognition status in early stages of antidepressant treatments may help improve long-term functional outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Huifeng Zhang, Zhiguo Wu, Lan Cao, Yousong Su, Fan Wang, Wu Hong, Yiyun Cai, Daihui Peng, Yiru Fang
Summary: Despite numerous treatment options for major depressive disorder (MDD), the efficacy of treatment remains uncertain. Algorithm-guided treatments (AGTs) are proposed to address this issue. This study evaluated the clinical benefit of AGTs for MDD and identified specific moderators that influence treatment outcomes. AGTs were found to have advantages in quality of life and relapse rates compared to treatment-as-usual (TAU), with disease episode types and somatic symptoms playing a significant role in treatment outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Engineering, Biomedical
Yueheng Peng, Yang Huang, Baodan Chen, Mengling He, Lin Jiang, Yuqin Li, Xunan Huang, Changfu Pei, Shu Zhang, Cunbo Li, Xiabing Zhang, Tao Zhang, Yutong Zheng, Dezhong Yao, Fali Li, Peng Xu
Summary: This study analyzed resting-state electroencephalogram (EEG) data from patients with major depressive disorder (MDD) and found that the corresponding EEG networks weakened significantly after short-term antidepressant treatment. This change in network properties within one week of medication reliably predicted the eventual medication efficacy. Additionally, the baseline EEG networks accurately distinguished responders from non-responders with a high accuracy.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Bashkim Kadriu, Cristan A. Farmer, Peixiong Yuan, Lawrence T. Park, Zhi-De Deng, Ruin Moaddel, Ioline D. Henter, Bridget Shovestul, Elizabeth D. Ballard, Cristoph Kraus, Philip W. Gold, Rodrigo Machado-Vieira, Carlos A. Zarate
Summary: This study explored the impact of ketamine on the endogenous KYN pathway in individuals with bipolar depression and its relationship with depression-related behavioral and peripheral inflammatory markers. Results showed that post-ketamine IDO levels were significantly lower, while KYN and KynA levels were significantly increased. Inflammatory markers and behavioral measures predicted changes in the KYN pathway post ketamine treatment.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Gabriel Tortella, Bernardo Sampaio-Junior, Marina L. Moreno, Adriano H. Moffa, Adriano Fernandes da Silva, Beny Lafer, Paulo Andrade Lotufo, Wagner Gattaz, Lucas Borrione, Rodrigo Machado-Vieira, Stephan Goerigk, Isabela M. Bensenor, Andre R. Brunoni
Summary: The study found that cognitive performance of patients with bipolar depression did not significantly change during transcranial direct current stimulation (tDCS) treatment, and there was no decrease in cognitive function. These results need to be further replicated in larger studies.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Review
Neurosciences
Christopher R. K. Ching, Derrek P. Hibar, Tiril P. Gurholt, Abraham Nunes, Sophia I. Thomopoulos, Christoph Abe, Ingrid Agartz, Rachel M. Brouwer, Dara M. Cannon, Sonja M. C. de Zwarte, Lisa T. Eyler, Pauline Favre, Tomas Hajek, Unn K. Haukvik, Josselin Houenou, Mikael Landen, Tristram A. Lett, Colm McDonald, Leila Nabulsi, Yash Patel, Melissa E. Pauling, Tomas Paus, Joaquim Radua, Marcio G. Soeiro-de-Souza, Giulia Tronchin, Neeltje E. M. van Haren, Eduard Vieta, Henrik Walter, Ling-Li Zeng, Martin Alda, Jorge Almeida, Dag Alnaes, Silvia Alonso-Lana, Cara Altimus, Michael Bauer, Bernhard T. Baune, Carrie E. Bearden, Marcella Bellani, Francesco Benedetti, Michael Berk, Amy C. Bilderbeck, Hilary P. Blumberg, Erlend Boen, Irene Bollettini, Caterina del Mar Bonnin, Paolo Brambilla, Erick J. Canales-Rodriguez, Xavier Caseras, Orwa Dandash, Udo Dannlowski, Giuseppe Delvecchio, Ana M. Diaz-Zuluaga, Danai Dima, Edouard Duchesnay, Torbjorn Elvsashagen, Scott C. Fears, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Jose M. Goikolea, Melissa J. Green, Dominik Grotegerd, Oliver Gruber, Bartholomeus C. M. Haarman, Chantal Henry, Fleur M. Howells, Victoria Ives-Deliperi, Andreas Jansen, Tilo T. J. Kircher, Christian Knoechel, Bernd Kramer, Beny Lafer, Carlos Lopez-Jaramillo, Rodrigo Machado-Vieira, Bradley J. MacIntosh, Elisa M. T. Melloni, Philip B. Mitchell, Igor Nenadic, Fabiano Nery, Allison C. Nugent, Viola Oertel, Roel A. Ophoff, Miho Ota, Bronwyn J. Overs, Daniel L. Pham, Mary L. Phillips, Julian A. Pineda-Zapata, Sara Poletti, Mircea Polosan, Edith Pomarol-Clotet, Arnaud Pouchon, Yann Quide, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Aart H. Schene, Kang Sim, Jair C. Soares, Michael Staeblein, Dan J. Stein, Christian K. Tamnes, Georgios V. Thomaidis, Cristian Vargas Upegui, Dick J. Veltman, Michele Wessa, Lars T. Westlye, Heather C. Whalley, Daniel H. Wolf, Mon-Ju Wu, Lakshmi N. Yatham, Carlos A. Zarate, Paul M. Thompson, Ole A. Andreassen
Summary: MRI-derived brain measures have been widely studied in bipolar disorder (BD) and provide insights into the connections between genes, the environment, and behavior. The ENIGMA Bipolar Disorder Working Group is a collaborative effort that aims to generate consensus findings and improve the replicability of studies on BD. Through large-scale neuroimaging studies, the working group has discovered patterns of brain alterations associated with BD, as well as the effects of medications and clinical risk profiles.
HUMAN BRAIN MAPPING
(2022)
Editorial Material
Psychiatry
Rodrigo Machado-Vieira, Joao Quevedo, Lokesh Shahani, Jair C. Soares
BRAZILIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Z. M. Lobato, A. C. Almeida da Silva, S. M. Lima Ribeiro, M. M. Biella, A. Santos Silva Siqueira, T. Correa de Toledo Ferraz Alves, R. Machado-Vieira, M. K. Borges, R. C. Oude Voshaar, Ivan Aprahamian
Summary: The study aims to evaluate the prevalence of malnutrition in depressed older inpatients and determine which indices of malnutrition predict adverse health outcomes in late-life depression.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Review
Chemistry, Medicinal
Courtney M. Vecera, Gabriel R. Fries, Lokesh R. Shahani, Jair C. Soares, Rodrigo Machado-Vieira
Summary: Studies suggest that the therapeutic efficacy of lithium in treating BD may be related to genetic variations, gene regulation, and stress responses, providing new directions for personalized treatment of BD patients.
Article
Clinical Neurology
M. G. Soeiro-de-Souza, E. Scotti-Muzzi, F. Fernandes, R. T. De Sousa, C. C. Leite, M. C. Otaduy, R. Machado-Vieira
Summary: The study longitudinally assessed H-1-MRS metabolites in the ACC of BDep patients and found higher levels of mI/Cr and Cho/Cr compared to healthy controls at baseline. After treatment, levels of mI/Cr or Cho/Cr in euthymic patients were similar to controls, while non-responders still had elevated Cho/Cr levels. This suggests a critical regulatory effect of lithium on the PI cycle involved in mood regulation.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Antonio L. Teixeira, Trudy Millard Krause, Lopita Ghosh, Lokesh Shahani, Rodrigo Machado-Vieira, Scott D. Lane, Eric Boerwinkle, Jair C. Soares
Summary: This study found that patients with schizophrenia, mood disorders, and anxiety disorders are more likely to test positive for COVID-19 and have a higher risk of mortality compared to a reference group without major psychiatric conditions, after controlling for various demographic and comorbid factors.
Article
Clinical Neurology
Gregory Jones, Carola Rong, Courtney M. Vecera, Christopher Gurguis, Roshan Chudal, Rushaniya Khairova, Edison Leung, Ana C. Ruiz, Lokesh Shahani, Marcus Zanetti, Rafael T. de Sousa, Geraldo Busatto, Jair Soares, Wagner F. Gattaz, Rodrigo Machado-Vieira
Summary: Lithium may play an important role in treating comorbid anxiety in bipolar disorder, both as adjunct and monotherapy. Lower doses of lithium may provide equivalent efficacy and enhance tolerability and compliance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Gustavo C. Medeiros, Todd D. Gould, William L. Prueitt, Julie Nanavati, Michael F. Grunebaum, Nuri B. Farber, Balwinder Singh, Sudhakar Selvaraj, Rodrigo Machado-Vieira, Eric D. Achtyes, Sagar V. Parikh, Mark A. Frye, Carlos A. Zarate, Fernando S. Goes
Summary: (R,S)-ketamine and (S)-ketamine have rapid and substantial antidepressant effects, but there is no well-accepted method to differentiate responders from non-responders. The association between blood-based biomarkers and response to ketamine was examined in a systematic review/meta-analysis, revealing limited evidence of a consistent relationship.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Gregory Jones, Robert Suchting, Marcus Zanetti, Edison Leung, Sabrina Correa da Costa, Rafael T. de Sousa, Geraldo Busatto, Jair Soares, Maria C. Otaduy, Wagner F. Gattaz, Rodrigo Machado-Vieira
Summary: The study found that positive adaptations with lithium can be observed throughout the brain after only six weeks of low-therapeutic serum levels of monotherapy. These results remove confounders seen in prior studies and support the extensive evidence for long-term lithium therapy in bipolar disorder, suggesting its potential use in wider demographics.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2022)
Article
Multidisciplinary Sciences
Antonio L. Teixeira, Regina M. Hansen, Joseph S. Wozny, Caroline M. Schaefer, Rodrigo Machado-Vieira, Lokesh Shahani, Scott D. Lane, Jair C. Soares, Trudy M. Krause
Summary: The COVID-19 pandemic has had a significant impact on mental health outcomes, and individuals with COVID-19 are more likely to be diagnosed with new psychiatric disorders.
Letter
Biochemistry & Molecular Biology
Gregory Jones, Rodrigo Machado-Vieira
MOLECULAR PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Krista Wartchow, Giselli Scaini, Tina Li, Giovana Zunta-Soares, Rodrigo Machado-Vieira, Jair Soares, Joao Quevedo
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Cell Biology
Gregory H. Jones, Courtney M. Vecera, Omar F. Pinjari, Rodrigo Machado-Vieira
Summary: Bipolar disorder is a heterogeneous and multifactorial disease, where inflammation plays a significant role in affecting various systems. Understanding the role of inflammation in connecting these systems is crucial for identifying promising future targets for therapeutic development and screening.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)