Article
Clinical Neurology
George M. Anderson, Christine M. Ramsey, Kevin G. Lynch, Joel Gelernter, David W. Oslin
Summary: This study investigated the distribution of baseline platelet serotonin (5-HT) levels in depression patients seeking treatment and defined subgroups based on drug exposure. The bioeffect of 5-HT reuptake inhibitors (SRIs) and the relationship between demographic variables and platelet 5-HT concentration were also assessed. Data from a cross-sectional study of 1433 Veterans Administration (VA) patients were analyzed, revealing a bimodal distribution of platelet 5-HT levels and significant differences in population, sex, and age.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Medicine, General & Internal
Daniel Richter, Jeyanthan Charles James, Andreas Ebert, Aristeidis H. Katsanos, Lisa Mazul-Wach, Quirin Ruland, Ralf Gold, Georg Juckel, Christos Krogias
Summary: Early SSRI therapy is associated with a reduced risk of post-stroke depression, but increases the risk of bone fracture and nausea. Future research should focus on identifying high-risk individuals to improve the risk-benefit assessment of this therapy in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychology, Clinical
Chittaranjan Andrade
Summary: The exposure to antidepressants during pregnancy, especially SSRIs, is associated with a slightly increased risk of postpartum hemorrhage. However, the findings should be interpreted with caution, and precautionary measures are still recommended.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Oncology
Min-Jing Lee, Chien-Wei Huang, Yi-Lung Chen, Yao-Hsu Yang, Vincent Chin-Hung Chen
Summary: The study revealed an association between the use of SSRIs and decreased risk of kidney cancer, with citalopram and paroxetine showing protective effects in depressed patients with kidney cancer during a 2-year induction period.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Pharmacology & Pharmacy
Soobeen Hwang, Jong-Hui Kim, Su-Hyun Jo
Summary: Paroxetine can acutely and directly modulate human Kv1.3 channels, inhibiting channel activity by accelerating steady-state inactivation, thus revealing a possible mechanism for acute immunosuppression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Rafael R. Domingues, Hannah P. Fricke, Celeste M. Sheftel, Autumn M. Bell, Luma C. Sartori, Robbie S. J. Manuel, Chandler J. Krajco, Milo C. Wiltbank, Laura L. Hernandez
Summary: The effects of SSRI drugs on pregnancy and neonatal outcomes in mice were investigated. The study found that the high dose of fluoxetine led to a decrease in pregnancy rate and maternal weight gain, while both high and low doses of sertraline led to a decrease in the number of pups born and weaned. The study suggests that the effects of SSRI on neonatal mortality may be mediated by SSRI-induced placental insufficiency.
Review
Neurosciences
Robyn P. Thom, Michelle L. Palumbo, Claire Thompson, Christopher J. McDougle, Caitlin T. Ravichandran
Summary: The study found that the majority of adults with Down syndrome responded positively to a 12-week course of SSRI treatment for depression, with some experiencing adverse effects such as daytime sedation and anger. Controlled studies are needed to further evaluate the efficacy, tolerability, and safety of SSRIs in this population.
Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Pharmacology & Pharmacy
Juhee Lim, Yeojin Bang, Kyeong-Man Kim, Hyun Jin Choi
Summary: This study investigated the effects of differentiation on the serotonergic neuronal phenotype of the mouse hippocampal neuronal cell line HT22. The results showed that differentiation promoted neurite outgrowth and upregulation of N-methyl-D-aspartate receptor and choline acetyltransferase in HT22 cells. Furthermore, proteins required for serotonergic neurotransmission were significantly upregulated in differentiated HT22 cells. These findings suggest that differentiated HT22 cells have enhanced functional serotonergic properties and could be used for assessing the efficacy of antidepressant 5-HT reuptake inhibitors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Patryk Kubiszewski, Lansing Sugita, Christina Kourkoulis, Zora DiPucchio, Kristin Schwab, Christopher D. Anderson, M. Edip Gurol, Steven M. Greenberg, Anand Viswanathan, Jonathan Rosand, Alessandro Biffi
Summary: This study found that the use of selective serotonin reuptake inhibitors (SSRIs) among survivors of intracerebral hemorrhage (ICH) may increase the risk of ICH recurrence, but also alleviate depressive symptoms. The research suggests that clinicians can assess the suitability of SSRI use in ICH survivors by considering clinical history, neuroimaging data, and genetic biomarkers.
Article
Psychiatry
Lijun Liu, Xiaozhen Lv, Shuzhe Zhou, Qi Liu, Jing Wang, Hongjun Tian, Kerang Zhang, Jing Wei, Chuanyue Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Nan Zhang, Yu Huang, Tianmei Si, Xin Yu
Summary: The study aimed to explore the impact of SSRIs on cognitive function in depressed patients and identify factors associated with cognitive remission and nonremission. Results showed that most patients experienced improvements in cognitive function after treatment, but only a minority achieved cognitive remission.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Developmental
Lu Lu, A. Jeffrey Mills, Hailong Li, K. Heidi Schroeder, A. Sarah Mossman, T. Sara Varney, M. Kim Cecil, Xiaoqi Huang, Qiyong Gong, B. Laura Ramsey, P. Melissa DelBello, A. John Sweeney, R. Jeffrey Strawn
Summary: In adolescents with generalized anxiety disorder (GAD), escitalopram increased amygdala-prefrontal connectivity within the first 2 weeks of treatment, and the magnitude of this early change predicted subsequent clinical improvement.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Article
Gastroenterology & Hepatology
Patrick Starlinger, David Pereyra, Hubert Hackl, Gregor Ortmayr, Eva Braunwarth, Jonas Santol, Sina Najarnia, Michael R. Driedger, Lindsey Gregory, Roberto Alva-Ruiz, Amy Glasgow, Alice Assinger, David M. Nagorney, Elizabeth B. Habermann, Stefan Staetttner, Sean P. Cleary, Rory L. Smoot, Thomas Gruenberger
Summary: Perioperative intake of SSRIs/SNRIs is significantly associated with adverse postoperative outcomes after hepatic resection, indicating that these drugs should be avoided in patients undergoing liver resections.
Review
Pharmacology & Pharmacy
Hanying Duan, Lijun Zhu, Min Li, Xinyue Zhang, Beilin Zhang, Shaokuan Fang
Summary: This study conducted a network meta-analysis to compare the efficacy and acceptability of different selective serotonin reuptake inhibitor (SSRI) antidepressants for the treatment of binge eating disorder (BED). The results showed that fluoxetine might be the best choice, as it significantly reduced the frequency of binge eating and improved depressive symptoms.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Infectious Diseases
Jiawen Deng, Daniel Rayner, Harikrishnaa B. Ramaraju, Umaima Abbas, Cristian Garcia, Kiyan Heybati, Fangwen Zhou, Emma Huang, Ye-Jean Park, Myron Moskalyk
Summary: This study evaluated the efficacy and safety of selective serotonin reuptake inhibitors (SSRIs) in the treatment of acute COVID-19. It found that medium-dose fluvoxamine can reduce mortality and hospitalization, while low-dose fluvoxamine does not have this effect. Observational studies support the use of fluvoxamine and suggest fluoxetine as an alternative to SSRIs for COVID-19 treatment.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Psychology, Biological
Ruschelle M. Leone, Amber M. Jarnecke, Sudie E. Back, Kathleen T. Brady, Julianne C. Flanagan
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2020)
Article
Health Care Sciences & Services
Jenna L. McCauley, Joni D. Nelson, Gregg H. Gilbert, Valeria Gordan, Scott H. Durand, Rahma Mungia, Cyril Meyerowitz, Renata S. Leite, Roger B. Fillingim, Kathleen T. Brady
JOURNAL OF RURAL HEALTH
(2020)
Article
Public, Environmental & Occupational Health
Rochelle D. Jones, Jacquelyn Miller, C. Ann Vitous, Chris Krenz, Kathleen T. Brady, Ann J. Brown, Gail L. Daumit, Amelia F. Drake, Victoria J. Fraser, Katherine E. Hartmann, Judith S. Hochman, Susan Girdler, Adina L. Kalet, Anne M. Libby, Christina Mangurian, Judith G. Regensteiner, Kimberly Yonkers, Reshma Jagsi
JOURNAL OF WOMENS HEALTH
(2020)
Correction
Psychiatry
J. J. Prisciandaro, D. G. Brown, K. T. Brady, B. K. Tolliver
PSYCHIATRY RESEARCH
(2021)
Article
Neurosciences
Brian J. Sherman, Nathaniel L. Baker, Kathleen T. Brady, Jane E. Joseph, Lisa M. Nunn, Aimee McRae-Clark
PSYCHOPHARMACOLOGY
(2020)
Editorial Material
Psychiatry
Kathleen T. Brady
AMERICAN JOURNAL OF PSYCHIATRY
(2020)
Article
Medicine, Research & Experimental
Julianne C. Flanagan, Jennifer M. Mitchell, Nathaniel L. Baker, Joshua Woolley, Bethany Wangelin, Sudie E. Back, John R. McQuaid, Thomas C. Neylan, William R. Wolfe, Kathleen T. Brady
CONTEMPORARY CLINICAL TRIALS
(2020)
Article
Clinical Neurology
Xingbao Li, Karen J. Hartwell, Scott Henderson, Bashar W. Badran, Kathleen T. Brady, Mark S. George
Article
Substance Abuse
Julia P. Imperatore, Daniel M. McCalley, Jeffrey J. Borckardt, Kathleen T. Brady, Colleen A. Hanlon
Summary: For chronic pain patients with opiate misuse issues, transcranial magnetic stimulation may be more effective in reducing pain interference and opiate dependence. The study found that stimulation of the motor cortex showed more significant effects in reducing pain interference and urge to use opiates compared to stimulation of the dorsolateral prefrontal cortex.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Medicine, General & Internal
Katherine L. Mills, Emma Barrett, Sudie E. Back, Vanessa E. Cobham, Sarah Bendall, Sean Perrin, Kathleen T. Brady, Joanne Ross, Natalie Peach, Ivana Kihas, Joanne Cassar, Olivia Schollar-Root, Maree Teesson
Article
Substance Abuse
Shelly F. Greenfield, Kathleen T. Brady
AMERICAN JOURNAL ON ADDICTIONS
(2020)
Article
Emergency Medicine
Lindsey K. Jennings, Carolyn Bogan, Jenna J. McCauley, Angela Moreland, Suzanne Lane, Ralph Ward, Karen J. Hartwell, Louise Haynes, Kathleen T. Brady
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2020)
Article
Medicine, General & Internal
Constance Guille, Annie N. Simpson, Edie Douglas, Lisa Boyars, Kathryn Cristaldi, James McElligott, Donna Johnson, Kathleen Brady
Article
Psychology, Clinical
Angela Moreland, Jenna McCauley, Kelly Barth, Carolyn Bogdon, Therese Killeen, Louise Haynes, Lindsey Jennings, Constance Guille, Sara Goldsby, Kathleen Brady
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2020)
Article
Psychology, Clinical
Carolyn Bogan, Lindsey Jennings, Louise Haynes, Kelly Barth, Angela Moreland, Marla Oros, Sara Goldsby, Suzanne Lane, Chanda Funcell, Kathleen Brady
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2020)