Article
Clinical Neurology
Adeolu Funso Oladunjoye, Syed Zane Kaleem, Aishwarya Suresh, Vikram Sahni, Matthew J. Thoonkuzhy, Gibson Anugwom, Olubunmi Oladunjoye, David Otuada, Joseph Ikekwere, Eduardo D. Espiridion
Summary: This study used data from BD hospitalizations to investigate the association between Cannabis Use Disorder (CUD) and medication nonadherence in patients with Bipolar Disorder. The research found a significant relationship between CUD and medication noncompliance among BD patients, highlighting the importance of collaboration between psychiatric and addiction services in improving patient outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Julie Ramain, Philippe Conus, Philippe Golay
Summary: This study aimed to consolidate current knowledge on first-episode affective psychoses and identify areas for further investigation. The results showed heterogeneity in diagnosis-related grouping under the concept of affective psychoses, indicating a need for specialized intervention for patients with different psychopathological and neurocognitive profiles.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Hua-Meng Shi, De-Guo Jiang
Summary: This study found that mood-incongruent psychosis during the first manic episode of bipolar disorder appears to predict an increased likelihood of persistent psychotic symptoms over the subsequent 24 months. This persistence of psychosis is associated with a worse overall course of illness.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Eloi Gine-Serven, Maria Martinez-Ramirez, Ester Boix-Quintana, Eva Davi-Loscos, Nicolau Guanyabens, Virginia Casado, Desiree Muriana, Cristina Torres-Rivas, M. J. Cuesta, Javier Labad
Summary: This study found that thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis, including fewer prodromal symptoms, shorter duration of untreated psychosis, and sudden onset of psychosis. Additionally, thyroid hormone levels were also associated with affective psychosis diagnoses at the 12-month follow-up.
Article
Psychiatry
Juulia Poranen, Aura Koistinaho, Antti Tanskanen, Jari Tiihonen, Heidi Taipale, Markku Lahteenvuo
Summary: A study on the medication use patterns in patients newly diagnosed with bipolar disorder (BD) in Finland over the past 20 years showed that the use of antidepressants is too prevalent, the use of lithium is declining and needs to be increased, and long-acting injectable antipsychotics (LAI) are underutilized compared to their oral counterparts.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Multidisciplinary Sciences
Ashenafi Kibret Sendekie, Adeladlew Kassie Netere, Asmamaw Emagn Kasahun, Eyayaw Ashete Belachew
Summary: This study found that medication adherence was low and significantly associated with poor glycemic control in type 2 diabetes patients with comorbidity. The source of medication cost coverage, monthly income, self-monitoring of blood glucose practice, number of medications, and medical conditions were identified as important predictors of medication adherence.
Article
Psychiatry
Karim Abdel Aziz, Fadwa Al-Mugaddam, Subi Sugathan, Prashanth Saseedharan, Tarek Jouini, Mohamed Elhassan Elamin, Hamdy Moselhy, Dina Aly El-Gabry, Danilo Arnone, Sherif M. Karam
Summary: This study found that both acylated and total ghrelin levels were significantly reduced in bipolar disorder patients compared to healthy controls, and were positively correlated with markers of illness severity but negatively correlated with prescribed mood stabilizers, weight, and body mass index.
Article
Psychiatry
Ashok Malla, Srividya N. Iyer, Ridha Joober, Thara Rangaswamy, Padmavati Ramachandran, Norbert Schmitz, Aarati Taksal, Greeshma Mohan, Howard C. Margolese
Summary: This study investigated the impact of supervised antipsychotic medication discontinuation on clinical and functional outcomes in first-episode psychosis in two different cultural environments. The results showed that certain cultural environments and patient characteristics may facilitate supervised discontinuation of antipsychotic medication following treatment of a first-episode psychosis without negative consequences.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Psychiatry
Olivier Corbeil, Manuel Soulard, Maxime Huot-Lavoie, Laurent Bechard, Emilien Fournier, Sebastien Brodeur, Anne-Marie Essiambre, Charles Desmeules, Chantale Theriault, Amal Abdel-Baki, Christian Jacques, Isabelle Giroux, Michel Dorval, Marc-Andre Roy, Marie-France Demers
Summary: This study aims to identify risk factors for problem gambling among individuals with first-episode psychosis and document the effectiveness of standard treatment approaches. The results of this study will raise awareness and contribute to improved treatments for this neglected comorbidity.
Article
Clinical Neurology
Ziwei Teng, Lu Wang, Sujuan Li, Yuxi Tan, Yan Qiu, Chujun Wu, Kun Jin, Jindong Chen, Jing Huang, Hui Tang, Hui Xiang, Bolun Wang, Hui Yuan, Haishan Wu
Summary: The study found significantly lower BDNF levels in patients with Bipolar Type II disorder (BD II) compared to patients with Major Depressive Disorder (MDD) and healthy controls. BD II and MDD patients showed similar cognitive deficits in attention, delayed memory, and RBANS total score. BDNF levels were positively associated with visuospatial/constructional and Stroop color-word in the BD II group, and with language in the MDD group.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Huang Jia, Cai Yiyun, Wu Zhiguo, Su Yousong, Zhang Min, Shi Yifan, Zhu Na, Jin Feng, Fang Yiru, Peng Daihui
Summary: This study investigated the associations between gastrointestinal symptoms, medication use, and spontaneous drug discontinuation in patients with major depressive disorder (MDD). The results showed that GI symptoms were significantly associated with an increased risk of drug discontinuation in MDD patients. These findings have important implications for clinical treatment options and drug adherence management in MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Yongbo Hu, Shiyi Li, Jin Li, Youjin Zhao, Meiling Li, Weigang Cui, Xiaolong Peng, Zaiquan Dong, Lianqing Zhang, Haizhen Xu, Li Gao, Xiaoqi Huang, Weihong Kuang, Qiyong Gong, Hesheng Liu
Summary: Perceptual dysfunctions are fundamental causes of cognitive and emotional problems in patients with major depressive disorder. This study found that visual system impairment, including reductions in functional connectivities, can interfere with inhibition control in visual-motor processing in patients with major depressive disorder.
Review
Psychiatry
Parthasarathy Ramamurthy, Arya Jayasree, Susan Solomon, Vishnu V. Rudravaram, Vikas Menon, Pradeep Thilakan
Summary: Medication nonadherence is common among patients with psychiatric disorders in India, with approximately half of the patients being nonadherent. Negative attitude, polypharmacy, greater illness severity, lack of insight, and medication cost are associated with nonadherence.
INDIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Tian Qiu, Xiao Li, Wanjun Chen, Jinglan He, Lei Shi, Chenxi Zhou, Anhai Zheng, Zhongli Lei, Chenglu Tang, Qingchan Yu, Lian Du, Jiamei Guo
Summary: This study found that adolescent patients with MDD had lower levels of Maresin-1 and higher levels of IL-6 compared to the healthy control group. After anti-depressant treatment, Maresin-1 and IL-4 levels increased, while IL-6 and IL-1 beta levels significantly decreased. Furthermore, Maresin-1 levels were negatively correlated with depression severity.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Yi-Huan Chen, Hua-Ning Wang, Xiao-E Lang, Xiang -Yang Zhang
Summary: This study aimed to examine the prevalence and clinical correlates of abnormal glucose metabolism in young patients with first-episode medication-naive (FEMN) major depressive disorder (MDD). The results showed a high prevalence of comorbid glucose metabolism abnormalities in young FEMN MDD outpatients, with a rate of 12.57%. Thyroid stimulating hormone (TSH) levels and Hamilton Anxiety Rating Scale scores were associated with fasting blood glucose levels in patients with FEMN MDD, and TSH could differentiate patients with abnormal glucose metabolism.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Jean Addington, Lu Liu, Kali Brummitt, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, William Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Tyrone D. Cannon
Summary: This article provides an overview of the methodology of the third phase of the North American Prodrome Longitudinal Study (NAPLS) consortium, known as NAPLS-3, and presents the demographic information of 710 clinical high-risk participants in NAPLS-3.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychology, Clinical
Wisteria Deng, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Daniel H. Mathalon, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Scott W. Woods, Elaine F. Walker, Tyrone D. Cannon
Summary: This study found that there are different covariant trajectories of social anxiety and positive symptoms over time in individuals at clinical high-risk for psychosis. One subgroup showed sustained social anxiety despite moderate recovery in positive symptoms, while the other two subgroups showed recovery in both social anxiety and positive symptoms. The subgroup with sustained social anxiety had poorer long-term functional outcomes and higher levels of genetic and environmental risk factors for psychosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Olga Santesteban-Echarri, Danah Sandel, Lu Liu, Carrie E. Bearden, Kristin S. Cadenhead, Tyrone D. Cannon, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, William S. Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Jean Addington
Summary: Having a first-degree relative with a psychotic disorder significantly increases the severity of symptoms, lowers IQ scores, and increases the likelihood of experiencing trauma and abuse in individuals at risk for psychosis.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Katherine G. Welch, Bryan J. Stiles, Olafur S. Palsson, Piper S. Meyer-Kalos, Diana O. Perkins, Tate F. Halverson, David L. Penn
Summary: This study extends prior outcome research on I-CAT and suggests that diaries are a valuable method of data collection in FEP.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Benson S. Ku, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Tyrone D. Cannon, Michael T. Compton, Barbara A. Cornblatt, Benjamin G. Druss, Matcheri Keshavan, Daniel H. Mathalon, Diana O. Perkins, William S. Stone, Ming T. Tsuang, Scott W. Woods, Elaine F. Walker
Summary: This study found that area-level residential instability may be associated with reduced gray matter volumes in brain regions corresponding to urban upbringing. This association was observed in both individuals at high risk for psychosis and healthy controls.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Multidisciplinary Sciences
Clark D. Jeffries, John R. Ford, Jeffrey L. Tilson, Diana O. Perkins, Darius M. Bost, Dayne L. Filer, Kirk C. Wilhelmsen
Summary: Regularized regression analysis is a mature analytic approach used to identify weighted sums of variables predicting outcomes. This article presents a novel method called Coarse Approximation Linear Function (CALF) that selects important predictors and builds powerful predictive models using linear regression and nonzero weights. The study finds that CALF has advantages over other regression methods, especially when dealing with collinear or nearly collinear variables.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Benson S. Ku, Katrina Aberizk, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Tyrone D. Cannon, Ricardo E. Carrion, Michael T. Compton, Barbara A. Cornblatt, Benjamin G. Druss, Daniel H. Mathalon, Diana O. Perkins, Ming T. Tsuang, Scott W. Woods, Elaine F. Walker
Summary: This study found that higher levels of neighborhood poverty were associated with reduced hippocampal volume, and social engagement moderated this association.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Holly K. Hamilton, Brian J. Roach, Peter M. Bachman, Aysenil Belger, Ricardo E. Carrion, Erica Duncan, Jason K. Johannesen, Gregory A. Light, Margaret A. Niznikiewicz, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Thomas H. McGlashan, Diana O. Perkins, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Tyrone D. Cannon, Daniel H. Mathalon
Summary: This study found that deficits in mismatch negativity (MMN) amplitude were associated with future psychosis conversion among individuals at risk of CHR-P, particularly those not taking antipsychotic medication at baseline, although the associations were modest. MMN may provide novel risk information to multivariate prediction algorithms and serve as a translational neurophysiological target for novel treatment development in a subgroup of at-risk individuals.
Article
Psychiatry
Lauren N. N. Tronick, Heline Mirzakhanian, Jean Addington, Carrie E. E. Bearden, Tyrone D. D. Cannon, Barbara A. A. Cornblatt, Matcheri Keshavan, Daniel H. H. Mathalon, Thomas H. H. McGlashan, Diana O. O. Perkins, William Stone, Ming T. T. Tsuang, Elaine F. F. Walker, Scott W. W. Woods, Kristin S. S. Cadenhead
Summary: This study aims to explore the risk of violence in individuals at clinical high risk for psychosis (CHR) and its relationship with psychosis risk symptoms and global functioning. It shows that CHR individuals are at higher risk of violence compared to healthy individuals and that this risk is associated with greater severity of symptoms, poor functioning, and risk for conversion to psychosis.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Meghan A. Collins, Jie Lisa Ji, Yoonho Chung, Cole A. Lympus, Yvette Afriyie-Agyemang, Jean M. Addington, Bradley G. Goodyear, Carrie E. Bearden, Kristin S. Cadenhead, Heline Mirzakhanian, Ming T. Tsuang, Barbara A. Cornblatt, Ricardo E. Carrion, Matcheri Keshavan, Wiliam S. Stone, Daniel H. Mathalon, Diana O. Perkins, Elaine F. Walker, Scott W. Woods, Albert R. Powers, Alan Anticevic, Tyrone D. Cannon
Summary: Progressive grey matter loss has been observed among individuals who convert to psychosis, and this study found that accelerated cortical thinning precedes psychosis onset and can differentiate converters from non-converters. These findings highlight the importance of identifying neurobiological mechanisms prior to conversion for early intervention.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Esra Sefik, Michelle Boamah, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri S. Keshavan, Daniel H. Mathalon, Diana O. Perkins, William S. Stone, Ming T. Tsuang, Scott W. Woods, Tyrone D. Cannon, Elaine F. Walker
Summary: This study found clinically relevant deviations in cerebellar cortex and white matter structures among CHR individuals, highlighting the importance of considering the complex interplay between sex and age when studying the neuromaturational substrates of psychosis risk.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Mariapaola Barbato, Lu Liu, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, William Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Tyrone D. Cannon, Jean Addington
Summary: This study aimed to assess the impact of migrant status on clinical symptoms and functional outcome in individuals at clinical high risk (CHR) for psychosis. The results showed no significant differences in symptoms or functioning between different groups at any time point. However, significant improvements in symptoms and functioning were observed within each group over time. Transition rates did not differ across groups.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Katrina Aberizk, Esra Sefik, Jean Addington, Alan Anticevic, Carrie E. E. Bearden, Kristin S. S. Cadenhead, Tyrone D. D. Cannon, Barbara A. A. Cornblatt, Matcheri Keshavan, Daniel H. H. Mathalon, Diana O. O. Perkins, William S. S. Stone, Ming T. T. Tsuang, Scott W. W. Woods, Elaine F. F. Walker
Summary: This study found that reduced hippocampal volume is a brain morphological feature of psychiatric conditions. It also observed associations between hippocampal volume and hippocampal functional connectivity with the inferior parietal lobe and thalamus. The results suggest that the functional connectivity of the hippocampus with the temporoparietal junction within the default mode network is sensitive to hippocampal volume.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Meeting Abstract
Neurosciences
Kristin Cadenhead, Jean Addington, Carrie Bearden, Tyrone Cannon, Matcheri Keshavan, Daniel Mathalon, Diana Perkins, Elaine Walker, Scott Woods
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Psychiatry
B. Ku, J. Addington, C. Bearden, K. Cadenhead, T. Cannon, M. Compton, B. Cornblatt, B. Druss, M. Keshavan, D. Mathalon, T. Mcglashan, D. Perkins, L. Seidman, W. Stone, M. Tsuang, S. Woods, E. Walker
EUROPEAN PSYCHIATRY
(2022)
