Review
Oncology
Andrew D. J. Pearson, Susan L. Weiner, Peter C. Adamson, Dominik Karres, Gregory Reaman, Raphael Rousseau, Patricia Blanc, Koen Norga, Jeffrey Skolnik, Pam Kearns, Nicole Scobie, Elly Barry, Lynley Marshall, Leona Knox, Hubert Caron, Darshan Wariabharaj, Alberto Pappo, Steven G. DuBois, Lia Gore, Mark Kieran, Brenda Weigel, Elizabeth Fox, Karsten Nysom, Teresa de Rojas, Gilles Vassal
Summary: Rapid evaluation and regulatory approval of new drugs are crucial for improving survival and reducing side-effects for children and adolescents with cancer. ACCELERATE organization facilitates communication and collaboration among academia, industry, patient advocates, and regulators to prioritize drug development and promote a patient-centric approach.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Immunology
Tiina E. Kahkonen, Jussi M. Halleen, Gary MacRitchie, Ronnie M. Andersson, Jenni Bernoulli
Summary: Bone metastasis is a significant problem in breast, prostate, and other major cancers, causing high mortality and decreased quality of life. Immunotherapies have not been approved for treating bone metastasis, and the current approved immunotherapies show limited effectiveness. Understanding the tumor microenvironment in bone metastasis is crucial for developing novel therapies. The concept of osteoimmuno-oncology (OIO) emphasizes the interactions between tumor, immune, and bone cells, providing potential targets for bone metastasis. This review identifies 24 immunotherapies in preclinical or clinical development with evaluation in bone metastasis, offering insights into immuno-oncology drug development in the context of bone metastasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sarantos Kostidis, Elena Sanchez-Lopez, Martin Giera
Summary: Lipidomics, a new addition to the Omics landscape, is increasingly recognized as a valuable tool for identifying potential drug targets and biochemical markers. This review highlights recent advances in lipid analysis for drug discovery and development, including state-of-the-art technologies that continue to evolve for improved sensitivity and selectivity. The versatility of lipidomics analysis is demonstrated through important examples, and the integration of lipidomics with other Omics technologies, stem cell technologies, and metabolic flux analysis is expected to expand our understanding of pathophysiological mechanisms and lead to the discovery of novel targets and biomarkers.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xiwei Ji, Xiangrui Meng, Xiao Zhu, Qingfeng He, Yimin Cui
Summary: The outbreak of COVID-19 has emphasized the importance and urgency of developing therapeutic drugs, and China has made notable progress in this area. This article summarizes the anti-COVID-19 drugs and promising drug candidates developed in China, discussing their prospects, mechanisms of action, and advantages and disadvantages. It aims to contribute to the rational use of drugs in COVID-19 treatment and the development of new drugs against SARS-CoV-2 and its variants.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Huanhuan Pang, Zeping Hu
Summary: Emerging evidence has shown the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding of metabolism in biological systems. With advanced analytical techniques, metabolomics has significant value in basic drug research, including understanding disease mechanisms and identifying drug targets.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Oncology
Myung S. Kim, Vinay Prasad
Summary: The current indications for pembrolizumab are complex and may not capture all potential responders. Using pembrolizumab in any metastatic solid tumor may lead to better outcomes, considering the heterogeneity of response to checkpoint inhibitors and limited predictive biomarkers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Charles Oo, Barbara Ameer
Summary: Oncology is at the forefront of drug development, with a significant focus on molecularly targeted drugs in recent years. FDA approvals for novel oncology drugs from 2017 to 2020 span across diverse classes, signaling substantial progress in cancer treatment despite the limited potential for complete cure.
DRUG DISCOVERY TODAY
(2021)
Review
Oncology
Yajing Liu, Yanbing Zhou, Pu Chen
Summary: Lung cancer is a highly prevalent and deadly malignancy that requires personalized treatment strategies. Lung cancer organoids (LCOs) have the potential to faithfully replicate tumor characteristics and heterogeneity, providing a promising platform for anti-tumor drug discovery. Additionally, LCOs can enhance current precision medicine for lung cancer and overcome the limitations of current approaches.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Zhendong Liu, Zhishuai Ren, Cheng Zhang, Rongjun Qian, Hongbo Wang, Jialin Wang, Wang Zhang, Binfeng Liu, Xiaoyu Lian, Yanbiao Wang, Yuqi Guo, Yanzheng Gao
Summary: High expression of ELK3 in gliomas is associated with poor patient prognosis and serves as an independent biomarker. Overexpression of ELK3 promotes proliferation and migration of glioma cells, potentially by regulating the JAK-STAT signaling pathway to drive malignant progression.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Jitendra Gupta, Hussein Riyadh Abdul Kareem Al-Hetty, Murtadha Sh. Aswood, Abduladheem Turki Jalil, Maha Dhurgham Azeez, Zafar Aminov, Fahad Alsaikhan, Andres Alexis Ramirez-Coronel, Pushpamala Ramaiah, Bagher Farhood
Summary: Cancer is caused by defects in coding and non-coding RNAs. Duplicated biological pathways diminish the effectiveness of mono target cancer drugs. MiR-766 plays a crucial role in physiological processes and is overexpressed in diseases such as malignant tumors. It promotes therapeutic resistance pathways and has potential applications as a therapeutic target, diagnostic biomarker, and prognostic indicator in cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Julia Stephanie Bruno, Eduardo Rodrigues Fregnani
Summary: A growing number of studies have shown that there is a shift in oral bacteria in cancer patients, as well as enrichment of oral bacteria in distant tumors. These opportunistic oral bacteria are correlated with oral toxicities during cancer treatment. It is important to focus on identifying the most mentioned genera in recent studies and further investigating their roles in cancer.
CURRENT OPINION IN ONCOLOGY
(2023)
Article
Medical Informatics
Akari Tanaka, Hirofumi Suzuki, Satoshi Toyoshima, Naomi Nagai
Summary: In Japan, the co-development of companion diagnostics plays a significant role in oncology drug development, especially in reducing approval lag time and improving access to optimal treatment for patients.
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Alessandra Serra, Pavel Mozgunov, Thomas Jaki, Fabio Rigat
Summary: The identification and quantification of predictive biomarkers play a crucial role in personalized medicine and patient-centric clinical development. This study proposes a simple metric, called expected clinical benefit (ECB), to evaluate the clinical benefit of biomarker-informed clinical development programs. The results show that the ECB of biomarker-driven strategies is specific and sensitive, and the difference in ECB increases with the incremental efficacy driven by biomarkers and the population prevalence of biomarker-positive study participants.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2022)
Review
Chemistry, Medicinal
Grazyna Biala, Ewa Kedzierska, Marta Kruk-Slomka, Jolanta Orzelska-Gorka, Sara Hmaidan, Aleksandra Skrok, Jakub Kaminski, Eva Havrankova, Dominika Nadaska, Ivan Malik
Summary: The processes of discovering new drugs have recently experienced a renaissance, with the development of new techniques. Drug design and discovery, as well as the search for safe compounds, are significant challenges. The drug development process consists of drug discovery, preclinical development, and clinical trials.
Article
Gastroenterology & Hepatology
Tongqi Qian, Naoto Fujiwara, Bhuvaneswari Koneru, Atsushi Ono, Naoto Kubota, Arun K. Jajoriya, Matthew G. Tung, Emilie Crouchet, Won-Min Song, Cesia Ammi Marquez, Gayatri Panda, Ayaka Hoshida, Indu Raman, Quan-Zhen Li, Cheryl Lewis, Adam Yopp, Nicole E. Rich, Amit G. Singal, Shigeki Nakagawa, Nicolas Goossens, Takaaki Higashi, Anna P. Koh, C. Billie Bian, Hiroki Hoshida, Parissa Tabrizian, Ganesh Gunasekaran, Sander Florman, Myron E. Schwarz, Spiros P. Hiotis, Takashi Nakahara, Hiroshi Aikata, Eisuke Murakami, Toru Beppu, Hideo Baba, Rew Warren, Sangeeta Bhatia, Masahiro Kobayashi, Hiromitsu Kumada, Austin J. Fobar, Neehar D. Parikh, Jorge A. Marrero, Steve Hategekimana Rwema, Venugopalan Nair, Manishkumar Patel, Seunghee Kim-Schulze, Kathleen Corey, Jacqueline G. O'Leary, Goran B. Klintmalm, David L. Thomas, Mohammed Dibas, Gerardo Rodriguez, Bin Zhang, Scott L. Friedman, Thomas F. Baumert, Bryan C. Fuchs, Kazuaki Chayama, Shijia Zhu, Raymond T. Chung, Yujin Hoshida
Summary: This study developed a surrogate biomarker to predict liver fibrosis progression and evaluated the effectiveness of antifibrotic drugs. Results showed that a 20-gene surrogate biomarker could accurately predict fibrosis progression within 5 years. Furthermore, rational combination therapies based on epigallocatechin gallate were identified and validated for enhanced antifibrotic effect. This biomarker has potential clinical significance for the development of antifibrotics.
Article
Obstetrics & Gynecology
Shota Ogawa, Hiromitsu Shinozaki, Kunihiko Hayashi, Masahiro Itoh, Masayuki Soda, Takashi Kameda, Kiyoshi Ozawa, Hidemi Yokota, Kiyoshi Kamioka, Takashi Minegishi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2018)
Article
Multidisciplinary Sciences
Yuki Ideno, Kunihiko Hayashi, Junko Nakajima-Shimada, Yoko Onizuka, Mikiko Kishi, Tomomi Ueno, Shigeto Uchiyama
Article
Endocrinology & Metabolism
Kota Katanoda, Mitsuhiko Noda, Atsushi Goto, Hideki Mizunuma, Jung Su Lee, Kunihiko Hayashi
JOURNAL OF DIABETES INVESTIGATION
(2019)
Review
Nutrition & Dietetics
Yoshinobu Kondo, Atsushi Goto, Hisashi Noma, Hiroyasu Iso, Kunihiko Hayashi, Mitsuhiko Noda
Article
Public, Environmental & Occupational Health
Dongshan Zhu, Hsin-Fang Chung, Nirmala Pandeya, Annette J. Dobson, Rebecca Hardy, Diana Kuh, Eric J. Brunner, Fiona Bruinsma, Graham G. Giles, Panayotes Demakakos, Jung Su Lee, Hideki Mizunuma, Kunihiko Hayashi, Hans-Olov Adami, Elisabete Weiderpass, Gita D. Mishra
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Geriatrics & Gerontology
Toshiyuki Yasui, Yuki Ideno, Yoko Onizuka, Junko Nakajima-Shimada, Jung-Su Lee, Hiromitsu Shinozaki, Mikiko Kishi, Reiko Suzuki, Kunihiko Hayashi
Article
Medical Laboratory Technology
Yoko Onizuka, Kazue Nagai, Yuki Ideno, Yoshikazu Kitahara, Akira Iwase, Toshiyuki Yasui, Junko Nakajima-Shimada, Kunihiko Hayashi
CLINICAL BIOCHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Akashi Harada, Fuminori Taniguchi, Hiroki Amano, Youichi Kurozawa, Yuki Ideno, Kunihiko Hayashi, Tasuku Harada, Toshihiro Kawamoto, Yukihiro Ohya, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Hidekuni Inadera, Zentaro Yamagata, Chisato Mori, Shuichi Ito, Michihiro Kamijima, Takeo Nakayama, Hiroyasu Iso, Masayuki Shima, Yasuaki Hirooka, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh
Article
Public, Environmental & Occupational Health
Dongshan Zhu, Hsin-Fang Chung, Annette Dobson, Nirmala Pandeya, Graham G. Giles, Fiona Bruinsma, Eric Brunner, Diana Kuh, Rebecca Hardy, Nancy E. Avis, Ellen B. Gold, Carol A. Derby, Karen A. Matthews, Janet E. Cade, Darren C. Greenwood, Panayotes Demakakos, Daniel E. Brown, Lynnette L. Sievert, Debra Anderson, Kunihiko Hayashi, Jung Su Lee, Hideki Mizunuma, Therese Tiffin, Mette Kiidevxid Simonsen, Hans-Olov Adami, Elisa Bete Weiderpass, Gita D. Mishra
LANCET PUBLIC HEALTH
(2019)
Article
Medicine, General & Internal
Ayumi Ito, Kunihiko Hayashi, Shosuke Suzuki, Yuki Ideno, Takumi Kurabayashi, Toru Ogata, Atsushi Seichi, Masami Akai, Tsutomu Iwaya
Article
Public, Environmental & Occupational Health
Takumi Kurabayashi, Yuki Ideno, Kazue Nagai, Naho Maruoka, Kiyoshi Takamatsu, Toshiyuki Yasui, Kunihiko Hayashi
Summary: This study found that self-reported diagnoses of osteoporosis in young and middle-aged women had a high negative predictive value of 98.9%. However, the positive predictive value was slightly lower, suggesting that additional confirmation through a questionnaire could improve accuracy.
CLINICAL EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Kiyoshi Takamatsu, Yuki Ideno, Mami Kikuchi, Toshiyuki Yasui, Naho Maruoka, Kazue Nagai, Kunihiko Hayashi
Summary: The study aimed to validate self-reported diagnoses of gynaecological and breast cancers in a nationwide cohort study of nursing professionals. Results showed that gynaecological cancer cannot be accurately assessed by self-reporting alone, and the external validity of cancer incidence in this cohort was confirmed.
Article
Public, Environmental & Occupational Health
Toshiyuki Yasui, Yuki Ideno, Hiromitsu Shinozaki, Yoshikazu Kitahara, Kazue Nagai, Kunihiko Hayashi
Summary: This study accurately assessed the prevalence of exogenous hormone use in Japan, specifically oral contraceptives (OCs) and hormone replacement therapy (HRT), based on surveys conducted among female nurses. The lifetime prevalence of OC use was found to be 6.0% and HRT use was 13.8% in this study.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Chen Liang, Hsin-Fang Chung, Annette J. Dobson, Kunihiko Hayashi, Yvonne T. van der Schouw, Diana Kuh, Rebecca Hardy, Carol A. Derby, Samar R. El Khoudary, Imke Janssen, Sven Sandin, Elisabete Weiderpass, Gita D. Mishra
Summary: Infertility, recurrent miscarriage, and stillbirth are associated with an increased risk of stroke, with different risk patterns for different stroke subtypes. These findings contribute to the monitoring and prevention of stroke in women with a history of these conditions.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Medicine, Research & Experimental
Toshiyuki Yasui, Yuki Ideno, Yoko Onizuka, Junko Nakajima-Shimada, Hiromitsu Shinozaki, Kunihiko Hayashi
JOURNAL OF MEDICAL INVESTIGATION
(2019)
