Article
Nutrition & Dietetics
Ling-Jun Li, Ruochen Du, Marion Ouidir, Ruijin Lu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul S. Albert, Cuilin Zhang
Summary: Saturated fatty acids (SFAs) during pregnancy have an impact on metabolic programming and fetal growth. In this study, plasma phospholipid SFAs were measured in early pregnancy and fetal growth was monitored. It was found that even-chain and very long even-chain SFAs were negatively associated, while odd-chain SFAs were positively associated with fetal weight and size. Pentadecanoic acid (15:0) in the highest tertile showed a greater fetal weight and size compared to the lowest tertile. These findings suggest the potential use of an alternative high-fat diet rich in odd-chain SFAs for optimal fetal growth.
Article
Biochemistry & Molecular Biology
Qi Hui Sam, Hua Ling, Wen Shan Yew, Zhaohong Tan, Sharada Ravikumar, Matthew Wook Chang, Louis Yi Ann Chai
Summary: Short chain fatty acids (SCFA) and medium chain fatty acids (MCFA) have divergent immunomodulatory propensities, with SCFA down-attenuating pro-inflammatory response through the TLR4 pathway, while MCFA augmenting inflammation through TLR2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Muthu Thiruvengadam, Umadevi Subramanian, Baskar Venkidasamy, Prabhu Thirupathi, Ramkumar Samynathan, Mohammad Ali Shariati, Maksim Rebezov, Ill-Min Chung, Kannan R. R. Rengasamy
Summary: Understanding the gut microbiota has become crucial in maintaining human body's homeostasis and preventing disease development. Short-chain fatty acids, produced by gut microbiota fermentation of dietary fiber, play a significant role in modulating the tumor environment and binding to carcinogens for elimination. The gut microbiota may offer new approaches for cancer therapy in the future.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biotechnology & Applied Microbiology
Karolina Szacherska, Krzysztof Moraczewski, Sylwester Czaplicki, Piotr Oleskowicz-Popiel, Justyna Mozejko-Ciesielska
Summary: This study evaluated the use of short- and medium-chain fatty acids (SMCFAs) derived from acid whey fermentation for polyhydroxyalkanoate (PHA) production. Pseudomonas sp. GL06 showed the highest tolerance to SMCFAs and produced PHAs with the highest productivity. Further research revealed that PHA monomeric composition varied with bacterial strain and growth medium. The copolymer made of 3-hydroxybutyric, -hexanoic, -octanoic, -decanoic, and -dodecanoic exhibited promising properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Longying Pei, Wei Liu, Luping Liu, Xiaoyu Wang, Luxi Jiang, Zhaohui Chen, Qiquan Wang, Peng Wang, Heng Xu
Summary: This study investigated the effects of morel mushroom supplementation on the gut bacterial microbiota and short-chain fatty acids in healthy mice. The results showed that morel intervention altered the bacterial community composition, increased short-chain fatty acids levels, and was associated with weight loss. These findings contribute to the development of prebiotics for improving health and reducing obesity.
FRONTIERS IN NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Cristina Higueras, Ana I. Rey, Rosa Escudero, David Diaz-Reganon, Fernando Rodriguez-Franco, Mercedes Garcia-Sancho, Beatriz Agulla, Angel Sainz
Summary: Food-responsive enteropathy (FRE) is the most common diagnosis for dogs with chronic enteropathy, and there is currently no test that can replace treatment trials. This study found changes in the fatty acid profiles of plasma and feces in sick dogs, and high correlations between certain compounds and existing indices. Dogs with FRE had different fatty acid profiles compared to healthy dogs, both in plasma and feces. These findings highlight the importance of fatty acids, particularly fecal parameters, in diagnosing and evaluating the inflammatory status of dogs.
Article
Engineering, Chemical
Li-Jen Lin, Mukesh Saini, Chung-Jen Chiang, Yun-Peng Chao
Summary: In this study, a whole cell biocatalysis system was used to produce short-chain alcohols from fatty acids. Escherichia coli strain was reprogrammed to improve biocatalytic activity, resulting in successful production of 1-propanol and n-pentanol.
Article
Nutrition & Dietetics
Iris Trefflich, Stefan Dietrich, Annett Braune, Klaus Abraham, Cornelia Weikert
Summary: This study compared concentrations of SCFA, BCFA, ammonia, and fecal pH between vegans and omnivores, finding no significant differences in SCFA and BCFA concentrations but lower fecal pH and ammonia concentration in vegans. The results suggest that bacterial functionality may be adapted to varying nutrient availability in these diets.
Article
Agriculture, Multidisciplinary
Yang Lin, Oluyinka A. Olukosi
Summary: This study found that dietary fiber levels have a significant impact on the growth performance, nutrient utilization, oligosaccharide concentration, and cecal short-chain fatty acid profile in broilers. The combination of xylanase and protease enzymes can affect substrate generation, indicating strong digestive capacity in broilers fed with fibrous feedstuffs.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Engineering, Environmental
Hyeonho Lee, Sung-Ju Im, Chang-min Kim, Am Jang
Summary: The transport behavior difference between virgin and supported liquid membrane contactors and the selectivity of medium-chain fatty acids in the supported liquid membrane contactors were studied. The results showed that the transport flux and selectivity of medium-chain fatty acids were significantly improved in the supported liquid PVDF membrane.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Silke Matysik, Sabrina Krautbauer, Gerhard Liebisch, Hans-Frieder Schott, Louise Kjolbaek, Arne Astrup, Francois Blachier, Martin Beaumont, Max Nieuwdorp, Annick Hartstra, Simone Rampelli, Uberto Pagotto, Patricia Iozzo
Summary: This study quantified the concentrations of faecal sterol species, bile acids, and short-chain fatty acids in 165 study participants. Participants were classified as low or high converters based on their coprostanol/cholesterol ratio, with low converters excreting more straight-chain fatty acids and bile acids. Concentration ranges of 16 faecal metabolites were provided as reference values, showing significant differences in faecal metabolites between high and low sterol converter groups.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carmen Gonzalez-Bosch, Emily Boorman, Patricia A. Zunszain, Giovanni E. Mann
Summary: SCFAs, short-chain fatty acids derived from colonic bacteria and diet, have beneficial effects on human health related to their metabolic and signaling properties. They play a role in protecting against oxidative and mitochondrial stress, regulating metabolic pathways, and inducing signaling pathways such as Nrf2 to maintain redox homeostasis. Additionally, SCFAs may have potential as nutritional and therapeutic agents in various diseases including diabetes, neuropathologies, and cancer.
Article
Biochemistry & Molecular Biology
Chongyang Huang, Wenjun Deng, Huan-zhou Xu, Chen Zhou, Fan Zhang, Junfei Chen, Qinjia Bao, Xin Zhou, Maili Liu, Jing Li, Chaoyang Liu
Summary: Short-chain fatty acids (SCFAs) have anticancer activity in colon cancer. Acetate, propionate, and butyrate are the major SCFAs produced from dietary fiber by gut microbiota fermentation and have beneficial effects on human health. This study systematically analyzed the effects of acetate, propionate, and butyrate on ROS levels and metabolic and transcriptomic signatures in human colorectal adenocarcinoma cells, showing elevated levels of ROS and regulated signatures in pathways related to ROS production.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Cell Biology
Dan Zhang, Yong-Ping Jian, Yu-Ning Zhang, Yao Li, Li-Ting Gu, Hui-Hui Sun, Ming-Di Liu, Hong-Lan Zhou, Yi-Shu Wang, Zhi-Xiang Xu
Summary: Short-chain fatty acids (SCFAs) are metabolites produced by bacterial fermentation of dietary fiber in the gut. They are absorbed by substrate transporters and play important roles in cellular metabolism. SCFAs are vital fuels for intestinal epithelial cells (IECs) and influence molecular processes such as blood glucose regulation and IEC function. They also affect intestinal motility, barrier function, and host metabolism, and play regulatory roles in local and peripheral metabolism. Major SCFAs like acetate, propionate, and butyrate are involved in immunity, apoptosis, inflammation, and lipid metabolism. This review highlights the diverse functional roles of SCFAs and their impact on intestines, metabolism, and diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Medicine, General & Internal
Sara Deleu, Kathleen Machiels, Jeroen Raes, Kristin Verbeke, Severine Vermeire
Summary: Short-chain fatty acids play important roles in the gut microbiome and intestinal immune system, exerting various effects on host metabolism and immune system. Further research is needed on the cross-feeding mechanisms in the gut microbiome and the therapeutic potential of SCFAs in different disease models.
Article
Hematology
Susan P. Perrine, Serguei A. Castaneda, David H. K. Chui, Douglas V. Faller, Ronald J. Berenson, Noppadol Siritanaratku, Suthat Fucharoen
COOLEY'S ANEMIA: NINTH SYMPOSIUM
(2010)
Article
Hematology
Ali T. Taher, Khaled M. Musallam, Wassim Nasreddine, Susan P. Perrine, Taghrid I. El-Hajj, Ahmad Beydoun
BLOOD CELLS MOLECULES AND DISEASES
(2009)
Article
Hematology
Lillian McMahon, Hannah Tamary, Melissa Askin, Patricia Adams-Graves, Robert T. Eberhardt, Millicent Sutton, Elizabeth C. Wright, Serguei A. Castaneda, Douglas V. Faller, Susan P. Perrine
BRITISH JOURNAL OF HAEMATOLOGY
(2010)
Article
Pediatrics
Susan P. Perrine