Article
Psychiatry
Akiko Mizuno, Helmet Talib Karim, Maria J. Ly, Brian J. Lopresti, Ann D. Cohen, Areej A. Ali, Chester A. Mathis, William E. Klunk, Howard J. Aizenstein, Beth E. Snitz
Summary: The study aimed to explore the symptoms of subjective cognitive decline (SCD) using fMRI brain activity and investigate the association with amyloid-beta (Ass) load. The results showed that SCD severity was associated with lower dorsomedial thalamus activation.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Marianna Tsatali, Eleni Poptsi, Despina Moraitou, Christina Agogiatou, Evaggelia Bakoglidou, Moses Gialaouzidis, Chrysa Papasozomenou, Aikaterini Soumpourou, Magdalini Tsolaki
Summary: The study found that DSST had excellent discriminant potential in distinguishing SCD and ADD patients, but lacked the ability to differentiate between SCD and aMCI groups.
Article
Psychiatry
Roger S. Mclntyre, Orl Lipsitz, Nelson B. Rodrigues, Mehala Subramanipillai, Flora Nasri, Yena Lee, Ben Fehmert, James King, Lambros Chrones, Kevin Kratiuk, Sharif Uddin, Joshua D. Rosenbhat, Rodrigo B. Mansur, Maggie McCue
Summary: The study evaluated the use of a smartphone-delivered app-based version of the established Cognition Kit Digit Symbol Substitution Test (DSST) neurocognitive assessment compared to a traditional paper-and-pencil version. The results showed that the app-based DSST had high correlation with the standard test and was positively evaluated by patients as being user-friendly and preferable over the paper-and-pencil version.
JMIR MENTAL HEALTH
(2022)
Article
Behavioral Sciences
Guy A. Higgins, Matt Brown, Cam MacMillan, Leo B. Silenieks, Sandy Thevarkunnel
Summary: In this study, the effects of AMP and ATX were compared in different tasks, with ATX showing a reducing effect on impulsive behavior but no significant impact on impulsive choice and risky decision making, while AMP affecting choice preference and discounting, but in a nuanced manner.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Psychiatry
Christopher S. Stauffer, Salem Samson, Alex Hickok, William F. Hoffman, Steven L. Batki
Summary: The increasing prevalence of illicit stimulant use poses a significant risk to public health, especially among those in opioid treatment programs. Oxytocin administration shows promise in enhancing treatment engagement among individuals with stimulant and opioid use disorders. However, it does not significantly affect stimulant use, craving, or therapeutic alliance.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Neurosciences
Charline Compagne, Juliana Teti Mayer, Damien Gabriel, Alexandre Comte, Eloi Magnin, Djamila Bennabi, Thomas Tannou
Summary: This review examines the adaptation of the Balloon Analog Risk Task (BART) to neuroimaging and identifies the most appropriate parameters for this adaptation. The study found that including a delay between trials, reducing the number of inflations, increasing the number of trials, providing explicit feedback, and using an outcome index can enhance the reliability of the BART in assessing risk-taking behavior. Additionally, increasing participant motivation and adjusting rewards based on risk level can improve the clinical utility of the BART.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Mengmeng Wang, Shunmin Zhang, Tao Suo, Tianxin Mao, Fenghua Wang, Yao Deng, Simon Eickhoff, Yu Pan, Caihong Jiang, Hengyi Rao
Summary: The Balloon Analog Risk Task (BART) has been widely used to assess risk-taking behavior and brain function. This study used activation likelihood estimation (ALE) meta-analysis and functional connectivity (FC) analysis to synthesize brain networks involved in risk-taking during the BART and compared differences between adults and adolescents. The results showed that reward, salience, and executive control networks play important roles in risk-taking during the BART, and adolescents exhibit greater activation compared to adults.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Stacy L. Andersen, Benjamin Sweigart, Nancy W. Glynn, Mary K. Wojczynski, Bharat Thyagarajan, Jonas Mengel-From, Stephen Thielke, Thomas T. Perls, David J. Libon, Rhoda Au, Stephanie Cosentino, Paola Sebastianion
Summary: By using digital technology to analyze DSST test results, the study identified different trajectories of thinking and writing time, which were associated with cognitive and physical function. The findings may provide information for the selection and timing of in-depth neuropsychological assessments as well as targeted interventions.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Yasue Uchida, Kazuyo Mise, Daiji Suzuki, Yoko Fukunaga, Nobuhiro Hakuba, Naoki Oishi, Takaki Ogawa, Mariko Takahashi, Yutaka Takumi, Shohei Fujimoto, Yukihide Maeda, Kazunori Nishizaki, Teppei Noda, Noritaka Komune, Nozomu Matsumoto, Takashi Nakagawa, Yukiko Nishita, Rei Otsuka, Azusa Maegawa, Tomomi Kimizuka, Akiko Miyata, Ayako Gonda, Kazuha Ishikawa, Yoshie Higashino, Shingo Murakami
Summary: The study found that the use of hearing aids in older individuals can lead to improvements in executive function and social interaction, with a significant increase in the number of relatives in the social network and improvements in family relationships.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Psychology, Clinical
Michael Williamson, Paul Maruff, Adrian Schembri, Hannah Cummins, Laura Bird, Emily Rosenich, Yen Ying Lim
Summary: The study validates the utility and validity of the DSST-Meds for measuring cognitive dysfunction in early Alzheimer's Disease.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2022)
Article
Psychology, Clinical
Cristina Lojo-Seoane, David Facal, Maria Luisa Delgado-Losada, Susana Rubio-Valdeita, Ramon Lopez-Higes, Belen Frades-Bueno, Arturo X. Pereiro
Summary: This paper presents normative data for attentional tests in middle-aged and older Spanish adults, taking into account age, education, and sex. The study included 2,597 participants aged 50 to 98 years old. The results provide clinically useful information for assessing cognitive impairment in the Spanish population.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Psychology, Biological
Roger C. McIntosh, Tasneem Khambaty, Maria M. Llabre, Krista M. Perreira, Hector M. Gonzalez, Mayank M. Kansal, Wassim Tarraf, Neil Schneiderman
Summary: Empirical evidence suggests that elevated vagal tone, indexed by heart rate variability (HRV), can mitigate the deleterious effects of chronic stress on prefrontal lobe functioning. The study assessed how HRV interacts with stress on cognitive performance and found that individuals with higher quartile of SDNN showed better cognitive performance under chronic stress.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2021)
Article
Psychology, Clinical
Johanna Perzl, Elisabeth Maria Riedl, Joachim Thomas
Summary: Mobile devices offer new opportunities to study cognitive performance in everyday situations. By adapting established cognitive tests for smartphone use and determining reliable and valid measurement durations, we gain insights into cognitive performance patterns in healthy adults.
Article
Psychology, Applied
Stjepan Sambol, Emra Suleyman, Michelle Ball
Summary: Affective decision-making is the ability to effectively reappraise stimuli during decisions to maximize long-term outcomes. Tasks such as BART and CCT may assess distinct decision-making constructs from ADM. The scoring method used in these tasks can influence the assessment of decision-making constructs.
JOURNAL OF BEHAVIORAL DECISION MAKING
(2023)
Article
Geriatrics & Gerontology
Anthony Campitelli, Sally Paulson, Josh L. Gills, Megan Jones, Erica N. Madero, Jennifer Myers, Jordan M. Glenn, Michelle Gray
Summary: This study aimed to assess the concurrent validity of a novel digital processing speed (PS) assessment. The results showed a significant moderate positive correlation between the novel assessment and the gold-standard measure, with no difference in mean scores between the two tests. The novel assessment displayed adequate agreement and equivalence with the gold-standard measure.
Article
Medicine, Research & Experimental
Christopher James Areephanthu, Raevti Bole, Terry Stratton, Thomas H. Kelly, Catherine P. Starnes, B. Peter Sawaya
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2015)
Article
Neurosciences
Jane E. Joseph, Xun Zhu, Christine R. Corbly, Stacia DeSantis, Dustin C. Lee, Grace Baik, Seth Kiser, Yang Jiang, Donald R. Lynam, Thomas H. Kelly
Article
Behavioral Sciences
Joshua A. Lile, Michael J. Wesley, Thomas H. Kelly, Lon R. Hays
BEHAVIOURAL PHARMACOLOGY
(2016)
Editorial Material
Substance Abuse
Thomas H. Kelly, Michael T. Bardo
DRUG AND ALCOHOL DEPENDENCE
(2016)
Article
Psychology, Biological
Arit Harvanko, Catherine Martin, Joshua Lile, Richard Kryscio, Thomas H. Kelly
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2016)
Article
Neurosciences
Jane E. Joseph, Xun Zhu, Donald Lynam, Thomas H. Kelly
Article
Behavioral Sciences
Ruolei Gu, Yang Jiang, Seth Kiser, Chelsea L. Black, Lucas S. Broster, Yue-jia Luo, Thomas H. Kelly
Article
Behavioral Sciences
Jessica S. Fogel, Thomas H. Kelly, Philip M. Westgate, Joshua A. Lile
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2017)
Article
Psychology, Clinical
Arit M. Haryanko, Andrea K. McCubbin, Kristin B. Ashford, Thomas H. Kelly
ADDICTIVE BEHAVIORS
(2018)
Article
Psychology, Biological
Michael J. Wesley, Philip M. Westgate, William W. Stoops, Thomas H. Kelly, Lon R. Hays, Joshua A. Lile
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2018)
Article
Substance Abuse
Arit Harvanko, Richard Kryscio, Catherine Martin, Thomas Kelly
DRUG AND ALCOHOL DEPENDENCE
(2019)
Article
Psychology, Biological
Joshua A. Lile, Joseph L. Alcorn, Lon R. Hays, Thomas H. Kelly, William W. Stoops, Michael J. Wesley, Philip M. Westgate
Summary: While early clinical trials showed potential effects of VDCC ligand gabapentin on reducing cannabis use in treatment seekers, further studies on non-treatment-seeking cannabis users with pregabalin did not support its efficacy as a standalone pharmacotherapy for cannabis use disorder.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Biological
Aaron P. Smith, Thomas H. Kelly, Joshua A. Lile, Catherine A. Martin, Miranda P. Ramirez, Michael J. Wesley
Summary: Recent advances in diagnostic research have shown that individuals with higher impulsivity and sensation-seeking scores tend to have more positive subjective responses to stimulant drugs. This study explored the relationship between personality traits and responses to stimulants, finding that differences in mesocorticolimbic circuitry may play a role in mediating this relationship. The study used fMRI scans to assess brain activity and found that amphetamine administration disrupted connectivity among brain regions, with associations between impulsivity and brain regions changing from negative to positive during placebo and amphetamine conditions. These results suggest that differences in mesocorticolimbic circuitry may be a potential target for diagnostic and treatment strategies for stimulant use disorders.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Sheri L. Robb, Thomas H. Kelly, Victoria L. King, Jason T. Blackard, Patricia C. McGuire
Summary: The CTSI Career Development Award (KL2) programs aim to provide protected time and multidisciplinary, mentored research training for junior faculty in clinical and translational science research. The KL2 Visiting Scholars Program was designed to promote collaborative training, leverage academic strengths, and support career development. Post-visit and outcomes surveys showed that most scholars found the program valuable for career and research development.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Communication
Lewis Donohew, Michelle DiBartolo, Xun Zhu, Chelsie Benca, Elizabeth Lorch, Seth M. Noar, Thomas H. Kelly, Jane E. Joseph
HEALTH COMMUNICATION
(2018)