Article
Infectious Diseases
Yu Wang, Xiaofen Liu, Kun Li, Yaxin Fan, Jicheng Yu, Hailan Wu, Yi Li, Xiaojie Wu, Beining Guo, Xin Li, Jiali Hu, Jufang Wu, Guoying Cao, Jing Zhang
Summary: This study investigated the pharmacokinetics of doripenem in healthy Chinese subjects and evaluated the optimal dosage regimens. The findings showed linear pharmacokinetics of doripenem within a certain dose range and proposed optimal regimens based on different minimum inhibitory concentrations of pathogens. These results provide guidance for the appropriate use of doripenem.
Article
Infectious Diseases
Sonia Luque, Adela Benitez-Cano, Leire Larranaga, Luisa Sorli, Maria Eugenia Navarrete, Nuria Campillo, Jesus Carazo, Isabel Ramos, Ramon Adalia, Santiago Grau
Summary: In critically ill patients treated with meropenem by extended or continuous infusion, there were no significant differences in drug exposure levels between patients with low body weight and normal body weight. The only factor independently associated with supratherapeutic drug exposure was a baseline estimated glomerular filtration rate (eGFR) < 90 mL/min.
Article
Critical Care Medicine
Renata Cerna Parizkova, Jirina Martinkova, Eduard Havel, Petr Safranek, Milan Kaska, David Astapenko, Jan Bezouska, Jaroslav Chladek, Vladimir Cerny
Summary: This study showed that fluid overload in infected patients can significantly affect the pharmacokinetic/pharmacodynamic parameters of meropenem, but these effects can be mitigated over time with appropriate monitoring and dosing adjustments.
Article
Pharmacology & Pharmacy
M. G. Vossen, S. Pferschy, C. Milacek, M. Haidinger, Mario Karolyi, Zoltan Vass, Heinz Burgmann, Alexandra Maier-Salamon, S. G. Wicha, W. Jaeger, M. Zeitlinger, T. Stimpfl, T. Wittek, F. Thalhammer
Summary: In this study, a bovine blood based in vitro pharmacokinetic model was used to analyze the clearance of drugs during intermittent renal replacement therapy. The results showed that clearance values were heavily impacted by the choice of membrane material and flow rates. Gentamicin, doripenem, vancomicin, and teicoplanin exhibited varying clearance rates across different hemofilter models and flow rates, with clearance values corresponding well to previously published data from clinical pharmacokinetic trials.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Claudia Garcia Messiano, Ronaldo Morales Junior, Gabriela Otofuji Pereira, Elson Mendes da Silva Junior, David de Souza Gomez, Silvia Regina Cavani Jorge Santos
Summary: The purpose of this prospective cohort study was to evaluate the therapeutic target achievement of 3-hour extended infusion of meropenem in patients with septic burns in the early and late periods of septic shock. The study found that the therapeutic target was achieved when treating infections caused by gram-negative bacteria, such as Pseudomonas aeruginosa.
CLINICAL THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Francesco Venuti, Mattia Trunfio, Anne-Grete Martson, Filippo Lipani, Sabrina Audagnotto, Giovanni Di Perri, Andrea Calcagno
Summary: Consolidated data from pharmacokinetic and pharmacodynamic studies support the administration of beta-lactam antibiotics in prolonged infusion to optimize therapeutic efficacy. Novel beta-lactam/beta-lactamase inhibitor combinations have shown promising roles in treating MDR Gram-negative bacteria. This review summarizes available pharmacological and clinical data, future perspectives, and limitations of prolonged infusion of these novel protected beta-lactams.
Article
Pharmacology & Pharmacy
Susan J. Keam
Summary: This article summarizes the milestones in the development of Gepirone ER, leading to its first approval for the treatment of major depressive disorder in adults.
Article
Endocrinology & Metabolism
Amra Simic, Pernelle K. Schondorff, Tobias Stumpe, Matthias Heschel, Werner Regittnig, Tina Poettler, Daniela Ninaus, Thomas Augustin, Andrea Groselj-Strele, Thomas R. Pieber, Julia K. Mader
Summary: The study confirmed the efficacy and safety of the novel extended-wear infusion set over 7 days in adults with type 1 diabetes, showing that prolonged wear can improve the quality of life for insulin pump users.
DIABETES OBESITY & METABOLISM
(2021)
Article
Pediatrics
Agathe Debray, Delphine Callot, Deborah Hirt, Emmanuelle Bille, Sylvain Renolleau, Laurent Chouchana, Jean-Marc Treluyer, Mehdi Oualha, Agathe Beranger
Summary: This study assessed the pharmacokinetic exposure and clinical toxicity of three beta-lactams in critically ill children, depending on two lengths of infusion. Continuous infusion showed a higher probability of achieving optimal pharmacokinetic targets compared to intermittent infusion, but also carried a higher risk of overexposure. Regular therapeutic drug monitoring is recommended for critically ill children receiving beta-lactams, regardless of the length of infusion.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Tricia M. -M. Tan, James Minnion, Bernard Khoo, Laura-Jayne Ball, Reshma Malviya, Emily Day, Francesca Fiorentino, Charlie Brindley, Jim Bush, Stephen R. Bloom
Summary: The Phase 1 trial of the extended-release peptide YY analogue, Y14, demonstrated significant weight loss and reduced food intake, with good safety and tolerability profile, supporting its continued development as a novel treatment for obesity.
DIABETES OBESITY & METABOLISM
(2021)
Article
Infectious Diseases
Chailat Maluangnon, Surat Tongyoo, Chairat Permpikul
Summary: This study compared the benefits of continuous and intermittent vancomycin infusion. Continuous infusion was found to achieve therapeutic targets faster and have fewer subtherapeutic episodes compared to intermittent infusion. However, there was no significant difference in treatment success, mortality, or incidence of acute kidney injury between the two methods.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
Valentin al Jalali, Peter Matzneller, Beatrix Wulkersdorfer, Scharon Chou, Soma Bahmany, Birgit C. P. Koch, Markus Zeitlinger
Summary: This study investigated the pharmacokinetics of fosfomycin after continuous infusion and compared it with intermittent infusion in healthy volunteers. Continuous infusion resulted in higher steady-state concentration and drug exposure, achieving 100% time above MIC for certain MIC values. It showed improved pharmacokinetics and pharmacodynamic determinants compared to intermittent infusion in healthy volunteers.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Elisabeth Krogsgaard Petersen, Pelle Hanberg, Martin Knudsen, Sara Kousgaard Tostesen, Andrea Rene Jorgensen, Kristina Obrink-Hansen, Kjeld Soballe, Maiken Stilling, Mats Bue
Summary: This study compared the effects of continuous infusion (CI) and short-term intermittent infusion (STI) of piperacillin on the minimal inhibitory concentration time (fT > MIC) in porcine cervical spine tissue. The results showed that CI resulted in a significantly higher fT > MIC, indicating that CI should be considered for the treatment of spondylodiscitis cases requiring piperacillin.
Article
Pediatrics
Daniel Riggsbee, Samantha Engdahl, Rebecca S. Pettit
Summary: This study compared the incidence of acute kidney injury (AKI) in pediatric patients with cystic fibrosis (CF) receiving piperacillin-tazobactam (PZT) via extended infusion (EI) or traditional infusion (TI). The results showed no significant difference in AKI incidence between the two groups.
PEDIATRIC PULMONOLOGY
(2023)
Article
Chemistry, Medicinal
Monica R. Swinney, Amy L. Cox, Eric D. Hawkins, Jie Xue, Parag Garhyan, James R. L. Stanley, Shantanu Sule, Kofi Adragni, M. Dodson Michael
Summary: Prolonged wear of insulin infusion sets may increase the risk of unexplained hyperglycemia, potentially due to an inflammatory response to preservatives like m-cresol. However, exposure to m-cresol did not affect pharmacokinetics and pharmacodynamics endpoints, while the inflammatory response peaked at Day 7 and remained stable thereafter.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)