Article
Medicine, General & Internal
Consuelo Romero-Sanchez, Juliette De Avila, Alejandro Ramos-Casallas, Lorena Chila-Moreno, Nathaly Andrea Delgadillo, Philippe Chalem-Choueka, Cesar Pacheco-Tena, Juan Manuel Bello-Gualtero, Wilson Bautista-Molano
Summary: This study aimed to investigate the association between adipokine profile and disease activity, body mass index, and periodontal infection in early rheumatoid arthritis (RA) patients. The results showed that high levels of leptin were associated with greater clinical activity in RA patients who were overweight and had periodontal infection. This suggests a potential pathological mechanism involving adipokines in the relationship between RA, overweight, and periodontal infection.
Article
Dentistry, Oral Surgery & Medicine
Jacqueline Rodriguez, Gloria Ines Lafaurie, Wilson Bautista-Molano, Lorena Chila-Moreno, Juan Manuel Bello-Gualtero, Consuelo Romero-Sanchez
Summary: The study demonstrated an association between overweight or obesity and the diagnosis of eRA, with individuals with eRA exhibiting higher levels of leptin and vaspin. The presence of periodontitis and related markers only affected leptin levels in individuals with eRA.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Rheumatology
Vanessa L. Kronzer, Weixing Huang, Paul F. Dellaripa, Sicong Huang, Vivi Feathers, Bing Lu, Christine K. Iannaccone, Ritu R. Gill, Hiroto Hatabu, Mizuki Nishino, Cynthia S. Crowson, John M. Davis, Michael E. Weinblatt, Nancy A. Shadick, Tracy J. Doyle, Jeffrey A. Sparks
Summary: This study identified obesity, high CRP levels, poor functional status, and extensive smoking as novel risk factors for RA-ILD, which may be helpful for RA-ILD risk assessment and prevention. The overall predictive ability for RA-ILD remains modest.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Dimitra Karapetsa, Arianna Consensi, Giulia Castagnoli, Morena Petrini, Matteo Tonelli, Stefano Gennai, Laura Bazzichi, Filippo Graziani
Summary: The study found a high prevalence and severity of periodontitis among Italian patients with rheumatoid arthritis. Patients with both periodontitis and rheumatoid arthritis were more likely to have moderate to severe RA.
Article
Biochemistry & Molecular Biology
Benita Buragaite-Staponkiene, Adomas Rovas, Alina Puriene, Kristina Snipaitiene, Egle Punceviciene, Arunas Rimkevicius, Irena Butrimiene, Sonata Jarmalaite
Summary: This study aimed to identify specific miRNAs associated with periodontitis (PD) in gingival tissues and evaluate their levels in saliva and blood plasma among participants with and without rheumatoid arthritis (RA). Genome-wide miRNA expression analysis revealed 177 deregulated miRNAs in 16 gingival tissue samples. Validation in 80 samples confirmed higher expression of miR-140-3p and -145-5p and lower expression of miR-125a-3p in PD-affected tissues. Further analysis in a larger sample showed increased salivary levels of miR-145-5p associated with PD severity and higher plasma levels of miR-140-3p in PD participants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Health Care Sciences & Services
Zhain Mustufvi, Stefan Serban, James Chesterman, Kulveer Mankia
Summary: There is growing evidence of a link between periodontal disease and rheumatoid arthritis, with periodontal inflammation potentially preceding joint inflammation. Screening and early treatment of periodontal disease in individuals at risk for RA may help prevent the onset of the condition. Further research is needed to advance understanding of this disease association.
Review
Immunology
Yilin Li, Rui Guo, Patrick Kwabena Oduro, Tongke Sun, Hao Chen, Yating Yi, Weiqian Zeng, Qilong Wang, Ling Leng, Long Yang, Jun Zhang
Summary: This study conducted a meta-analysis to investigate the relationship between Porphyromonas gingivalis (P. gingivalis) exposure and the prevalence of rheumatoid arthritis (RA). The results showed a significant association between P. gingivalis exposure and an increased risk of developing RA, especially in European and North American populations.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tamseela Mumtaz, Ayesha Tahir, Maham Almas Tariq, Muhammad Amir Iqbal
Summary: The comparative toxicity of methotrexate and leflunomide on multiple organs in rheumatoid arthritis patients was evaluated in this study. While methotrexate had more harmful effects on the heart, blood vessels, and kidneys, leflunomide posed a greater risk to the liver.
Review
Immunology
Anna Krutyholowa, Karolina Strzelec, Agata Dziedzic, Grzegorz P. P. Bereta, Katarzyna Lazarz-Bartyzel, Jan Potempa, Katarzyna Gawron
Summary: The study explores the relationship between periodontitis and rheumatoid arthritis, highlighting the genetic and environmental risk factors underlying the development of both diseases, with a special focus on bacteria implicated in the pathogenicity of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Gerhard Schmalz, Markus Bartl, Jan Schmickler, Susann Patschan, Daniel Patschan, Dirk Ziebolz
Summary: This cross-sectional study aimed to investigate the potential associations between periodontal inflamed surface area (PISA) and tooth loss with disease-related parameters in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients. The study found that tooth loss is associated with disease activity, especially in RA individuals, while no associations were found between PISA and disease-related parameters in both groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mai Hussein, Youssef M. K. Farag, Stephen Sonis
Summary: This study aimed to investigate the association between periodontitis, tooth loss, and rheumatoid arthritis (RA) using a large national dataset. The results showed that RA was associated with a higher likelihood of having non-functional dentition, but there was no association with periodontitis after adjusting for confounding factors.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Medicine, General & Internal
Diana Marcela Castillo, Gloria Ines Lafaurie, Consuelo Romero-Sanchez, Nathaly Andrea Delgadillo, Yormaris Castillo, Wilson Bautista-Molano, Cesar Pacheco-Tena, Juan Manuel Bello-Gualtero, Philippe Chalem-Choueka, Jaime E. Castellanos
Summary: This study found that antibodies against arginine-gingipain A (RgpA) and the double positivity of RgpA and peptidyl arginine deiminase (PPAD) may serve as biomarkers for rheumatoid arthritis (RA), improving its diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Shuhei Ideguchi, Kazuko Yamamoto, Masahiro Tahara, Tomohiro Koga, Shotaro Ide, Tatsuro Hirayama, Takahiro Takazono, Yoshifumi Imamura, Taiga Miyazaki, Noriho Sakamoto, Shimpei Morimoto, Koichi Izumikawa, Katsunori Yanagihara, Kazuto Ashizawa, Takatoshi Aoki, Atsushi Kawakami, Kazuhiro Yatera, Hiroshi Mukae
Summary: The presence of Pseudomonas aeruginosa in the lower respiratory tract was associated with the subsequent incidence of pneumonia in patients with rheumatoid arthritis. Decision tree analysis indicated that P. aeruginosa and patient performance status were two important factors for predicting the incidence of pneumonia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jia Sun, Youli Zheng, Xiaowei Bian, Huijian Ge, Jun Wang, Zheng Zhang
Summary: The meta-analysis suggests that non-surgical periodontal treatment can significantly improve rheumatoid arthritis disease activity, particularly in terms of reducing disease activity score, joint counts, pain levels, and inflammatory markers.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Rheumatology
Jeffrey A. Sparks, Yinzhu Jin, Soo-Kyung Cho, Seanna Vine, Rishi Desai, Tracy J. Doyle, Seoyoung C. Kim
Summary: This study investigated the prevalence, incidence, and cause-specific mortality of RA-associated interstitial lung disease (RA-ILD) among older US patients with RA. The results showed that RA-ILD was present or developed in nearly 5% of patients, and RA-ILD was associated with excess total, respiratory, and cancer mortality compared with RA without ILD.
Article
Dentistry, Oral Surgery & Medicine
Isaac S. Gomes-Filho, Julita Maria F. Coelho, Samilly S. Miranda, Simone S. Cruz, Soraya C. Trindade, Eneida M. M. Cerqueira, Johelle S. Passos-Soares, Maria Conceicao N. Costa, Maria Isabel P. Vianna, Ana Claudia M. G. Figueiredo, Alexandre Marcelo Hintz, Amanda F. Coelho, Luiz Carlos S. Passos, Mauricio L. Barreto, Frank Scannapieco
JOURNAL OF PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Lewis Winning, Christopher C. Patterson, Katie Linden, Alun Evans, John Yarnel, Pascal P. McKeown, Frank Kee, Gerard J. Linden
JOURNAL OF CLINICAL PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Isaac Suzart Gomes-Filho, Izadora da S. C. E. Balinha, Simone S. da Cruz, Soraya C. Trindade, Eneida de M. M. Cerqueira, Johelle de S. Passos-Soares, Julita Maria F. Coelho, Ana Marice T. Ladeia, Maria Isabel P. Vianna, Alexandre M. Hintz, Teresinha C. de Santana, Pedro P. dos Santos, Ana Claudia M. G. Figueiredo, Ivana C. O. da Silva, Frank A. Scannapieco, Mauricio L. Barreto, Peter M. Loomer
Summary: The study found a positive association between moderate and severe periodontitis and metabolic syndrome, with adjusted measurements showing that individuals with moderate or severe periodontitis had around two times greater probability of having MetS compared to those without periodontitis, and the chance was greater among participants with severe periodontitis than those with moderate periodontitis.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Isaac Suzart Gomes-Filho, Michelle Teixeira Oliveira, Simone Seixas da Cruz, Eneida de Moraes Marcilio Cerqueira, Soraya Castro Trindade, Graciete Oliveira Vieira, Paulo Henrique Couto Souza, Luis Fernando Fernandes Adan, Alexandre Marcelo Hintz, Johelle de Santana Passos-Soares, Frank Andrew Scannapieco, Peter Michael Loomer, Gregory John Seymour, Ana Claudia Morais Godoy Figueiredo
Summary: The study found a positive association between moderate and severe periodontitis and dyslipidemia.
Article
Dentistry, Oral Surgery & Medicine
Isaac S. Gomes-Filho, Pedro N. P. Santos, Simone S. Cruz, Ana C. M. G. Figueiredo, Soraya C. Trindade, Ana M. Ladeia, Eneida M. M. Cerqueira, Johelle S. Passos-Soares, Julita M. F. Coelho, Alexandre M. Hintz, Mauricio L. Barreto, Ricardo G. Fischer, Peter M. Loomer, Frank A. Scannapieco
Summary: The study revealed a positive association between periodontitis and a TG/HDL-C ratio >= 2.3, suggesting a potential link to the severity of periodontal disease.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Frank A. Scannapieco, Anna Dongari-Bagtzoglou
Summary: Periodontal disease pathogenesis is dependent on microbial biofilms and host responses, different from microbial dysbiosis pattern observed in other diseases. The microbial diversity in periodontal disease is higher compared to other dysbiotic chronic diseases.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lewis Winning, Christopher C. Patterson, Katie Linden, Kathy M. Cullen, Frank Kee, Gerard J. Linden
Summary: The study found that edentulous or men with severe periodontitis in a group of men aged 58-72 in Northern Ireland had a significantly increased risk of all-cause mortality. However, systemic inflammation did not play a major explanatory mediator role in this association.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Niamh Kelly, Lewis Winning, Christopher Irwin, Fionnuala T. Lundy, Dermot Linden, Lorcan McGarvey, Gerard J. Linden, Ikhlas A. El Karim
Summary: This systematic review explores the association between poor periodontal health and frequency of COPD exacerbations. Research suggests that periodontal treatment can reduce exacerbation frequency in COPD patients, leading to improved quality of life.
Article
Microbiology
Izumi Mashima, Yu-Chieh Liao, Chieh-Hua Lin, Futoshi Nakazawa, Elaine M. Haase, Yusuke Kiyoura, Frank A. Scannapieco
Summary: The genus Veillonella in the oral microbiome includes eight species with important metabolic pathways utilizing lactate as an energy source. Through a comparative pan-genome analysis, it was found that these species have conserved pathways using carbohydrates other than lactate as an energy source, helping to understand the metabolic network in oral microbiomes.
Review
Oncology
Emily McIlvanna, Gerard J. Linden, Stephanie G. Craig, Fionnuala T. Lundy, Jacqueline A. James
Summary: There is a growing interest in the potential role inflammation plays in cancer initiation and progression, with examples such as Helicobacter pylori-mediated inflammation in gastric cancer and more recently, Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Recent studies have shown that Fusobacterium nucleatum can promote cancer through multiple mechanisms, including activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation, and immune evasion, leading to hypotheses about its potential role in oral cancer development.
Article
Dentistry, Oral Surgery & Medicine
Lewis Winning, Ikhlas A. El Karim, Gerard J. Linden, Christopher R. Irwin, Simon A. Killough, Fionnuala T. Lundy
Summary: This study aimed to investigate the regulation of neuropeptide receptor expression on STRO-1 +ve periodontal ligament stem cells (PDLSCs) in response to inflammatory cytokines and the potential osteogenic effect of neuropeptides. The results showed that neuropeptide Y had a modest osteogenic effect on STRO-1 +ve PDLSCs and its Y1 receptor gene expression was sensitive to local inflammatory cytokines.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Dian Baker, Karen K. Giuliano, Madhuli Thakkar-Samtani, Frank A. Scannapieco, Michael Glick, Marcos Restrepo, Lisa J. Heaton, Julie Frantsve-Hawley
Summary: In this 2019 study, hospital records were analyzed to examine the relationship between preventive dental treatment and periodontal therapy prior to hospitalization, and the risk of nonventilator hospital-acquired pneumonia. The results showed that both preventive dental treatment in the 12 months prior and periodontal therapy in the 6 months prior were associated with a reduced risk of NVHAP.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Letter
Dentistry, Oral Surgery & Medicine
Isaac Suzart Gomes-Filho, Simone Seixas da Cruz, Soraya Castro Trindade, Johelle de Santana Passos-Soares, Paulo Cirino Carvalho-Filho, Ana Claudia Morais Godoy Figueiredo, Amanda Oliveira Lyrio, Alexandre Marcelo Hintz, Mauricio Gomes Pereira, Frank Andrew Scannapieco
Review
Dentistry, Oral Surgery & Medicine
Frank A. Scannapieco
Summary: Mirdza E. (Mitzi) Neiders has had a diverse career at the University at Buffalo School of Dental Medicine, serving as a teacher, dentist, researcher, mentor, and role-model to thousands of faculty, students, and patients over the span of nearly 60 years. Being one of the first women on the dental school faculty, she has made significant contributions to dentistry and her community. This article highlights her journey and celebrates her retirement.
Review
Dentistry, Oral Surgery & Medicine
Ricardo Guimaraes Fischer, Isaac Suzart Gomes Filho, Simone Seixas da Cruz, Victor Bento Oliveira, Ronaldo Lira-Junior, Frank Andrew Scannapieco, Rodrigo Otavio Rego
Summary: Over the last five decades, significant progress has been made in understanding the relationship between periodontal diseases and systemic health conditions. This has led to increased interest in Periodontal Medicine and its potential impact on overall health. Further research is needed to explore the potential connections and implications for future advancements in this field.
BRAZILIAN ORAL RESEARCH
(2021)