期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 40, 期 12, 页码 1104-1111出版社
WILEY
DOI: 10.1111/jcpe.12160
关键词
anti-inflammatory; bone loss; periodontitis model; telmisartan
AimThe aim of this study was to evaluate the effect of telmisartan (TELM) on inflammation, oxidation and the expression of matrix metalloproteinases (MMPs) and the expression RANKL/RANK/OPG in the periodontal tissue of a rat model for ligature-induced periodontitis. Materials and methodsMale Wistar albino rats were randomly divided into five groups of 10 rats each: (i) non-ligated, given water; (ii) ligated, given water; (iii) ligated, given 1mg/kg TELM; (iv) ligated, given 5mg/kg TELM; and (v) ligated, given 10mg/kg TELM. All groups were treated with saline or TELM for 10days. Periodontal tissue was analysed by histopathology; by the immunohistochemical examination of COX-2, MMP-2, MMP-9 and the RANKL/RANK/OPG pathway; and by ELISA analysis of the levels of IL-1, IL-10, TNF-, myeloperoxidase (MPO), malonaldehyde (MDA) and glutathione (GSH). ResultsTreatment with 10mg/kg TELM resulted in reduced concentrations of MPO, MDA (p<0.05) and the pro-inflammatory cytokine IL-1 (p<0.05); reduced expression of MMP-2, MMP-9, RANK, RANKL and COX-2; and an increase in OPG. The levels of TNF- were significantly reduced in all TELM-treated groups. ConclusionsThese findings confirm the involvement of TELM in reducing the inflammatory response, oxidative stress and bone loss in ligature-induced periodontitis in rats.
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