☆ 4.6 Article

The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial

JOURNAL OF CLINICAL PERIODONTOLOGY (2012)

期刊

JOURNAL OF CLINICAL PERIODONTOLOGY

卷 39, 期 10, 页码 955-961

出版社

WILEY-BLACKWELL

DOI: 10.1111/j.1600-051X.2012.01932.x

关键词

Amoxicillin; generalized aggressive periodontitis; metronidazole; periodontal disease; periodontal treatment; scaling and root planing

类别

Dentistry, Oral Surgery & Medicine

资金

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Brazil) [2007/55291-9]

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Protocol

Reagent

摘要

Aim To evaluate the clinical effects of the adjunctive use of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of generalized aggressive periodontitis (GAgP). Methods Thirty subjects were randomly assigned to receive scaling and root planing (SRP) alone or combined with MTZ (400 similar to mg/TID) and AMX (500 similar to mg/TID) for 14 similar to days. Subjects were clinically monitored at baseline, 6 similar to months and 1 similar to year post-therapies. Results Both therapies led to a statistically significant improvement in all clinical parameters at 1 similar to year post-therapy (p similar to

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