Article
Multidisciplinary Sciences
Arturo Sanchez-Perez, Ana Nicolas-Silvente, Carmen Sanchez-Matas, Silvia Molina-Garcia, Carlos Navarro-Cuellar, Georgios E. Romanos
Summary: The study results show that implant design does not significantly affect primary and secondary stability, bone level, and PES/WES evaluation outcomes. Good osseointegration, stability, maintenance of crestal bone, and appropriate PES/WES scores were achieved in immediate implant placement. Criteria for selecting the ideal patient for immediate implant placement are essential.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Rania Nassar, Mahmood Hachim, Mohannad Nassar, Eleftherios G. Kaklamanos, Mohamed Jamal, David Williams, Abiola Senok
Summary: Bacterial biofilms are microbial lifestyles found in all environments, with urgent need for novel antibiofilm strategies. Analysis of S. aureus biofilm transcriptomic data identified potential new targets for more effective treatment strategies against biofilm-associated infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sanako Makishi, Taisuke Watanabe, Kotaro Saito, Hayato Ohshima
Summary: This study aimed to analyze the effects of HA/beta-TCP on osseointegration at the bone-implant interface after immediately placed implants in the maxillae of 4-week-old mice. The lack of HA/beta-TCP on the implant surface affects the OPN immunoreactivity at the bone-implant interface and the rate of direct osteogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Analytical
Noemi Poma, Federico Vivaldi, Andrea Bonini, Pietro Salvo, Arno Kirchhain, Zeliha Ates, Bernardo Melai, Daria Bottai, Arianna Tavanti, Fabio Di Francesco
Summary: Future strategies for detecting and monitoring biofilm formation in both industry and human health are crucial due to the negative impact of biofilms. Various electrochemical techniques including potentiometric, voltammetric, and impedance-based sensors are being used to provide an overview of biofilm detection and monitoring processes.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Erica Tambone, Emiliana Bonomi, Paolo Ghensi, Devid Maniglio, Chiara Ceresa, Francesca Agostinacchio, Patrizio Caciagli, Giandomenico Nollo, Federico Piccoli, Iole Caola, Letizia Fracchia, Francesco Tessarolo
Summary: The study demonstrates that R89 biosurfactant is effective in reducing the formation of Staphylococcus biofilms on titanium surfaces. The anti-biofilm properties of R89 can be achieved on various commercially available implant surfaces.
Article
Dentistry, Oral Surgery & Medicine
William Johnston, Bob T. Rosier, Miguel Carda-Dieguez, Michael Paterson, Paddy Watson, Krystyna Piela, Marilyn Goulding, Gordon Ramage, Divyashri Baranyia, Tsute Chen, Nezar N. Al-Hebshi, Alex Mira, Shauna Culshaw
Summary: This study investigated the early and later changes in subgingival biofilm following periodontal treatment and found that hand and ultrasonic instruments had similar impacts on the composition of the subgingival plaque microbiome. There were marked changes in biofilm composition in the early stages after treatment, but limited evidence of these changes being associated with treatment outcomes.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
T. Chen, P. D. Marsh, N. N. Al-Hebshi
Summary: A subgingival microbial dysbiosis index (SMDI) was developed based on machine learning analysis of published periodontitis/health 16S microbiome data, demonstrating high diagnostic accuracy in identifying periodontitis patients/sites and assessing microbial response to treatment. The index can also be used as a quantitative tool in microbiome modulation studies.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sanako Makishi, Tomohiko Yamazaki, Hayato Ohshima
Summary: This study analyzed the effects of various OPN modified protein/peptides coatings on the healing patterns of the bone-implant interface. The results showed that rOPN coated implant enhances direct osteogenesis during osseointegration following implantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Ryan P. Bos, Drishti Kaul, Erik R. Zettler, Jeffrey M. Hoffman, Christopher L. Dupont, Linda A. Amaral-Zettler, Tracy J. Mincer
Summary: Little is known about the dynamics and changes of early plastic biofilm assemblages over time. Gene catalogues were constructed to compare the metabolic differences between early and mature biofilm communities. Early colonization was dominated by Alteromonadaceae and had higher proportions of genes associated with adhesion, biofilm formation, chemotaxis, hydrocarbon degradation and motility. Mature biofilms were composed of predominantly Rhodobacteraceae and displayed higher proportions of carbohydrate hydrolysis enzymes and genes for photosynthesis and secondary metabolism.
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Caroline Dini, Raphael Cavalcante Costa, Martinna Bertolini, Jamil Awad Shibli, Magda Feres, Marlise Inez Klein, Erica Dorigatti de Avila, Joao Gabriel Silva Souza, Valentim Adelino Ricardo Barao
Summary: This study successfully developed a clinically relevant oral polymicrobial biofilm model that mimics the microbial composition of implant-related infections. The results showed that the biofilm developed from patients' biofilm inoculum had a microbial composition more similar to the clinical subgingival biofilm of patients with peri-implantitis.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Francesco Bennardo, Selene Barone, Camillo Vocaturo, Ludovica Nucci, Alessandro Antonelli, Amerigo Giudice
Summary: This systematic review examined the use of magnetic mallet in oral and implant surgery procedures and found that the current evidence is insufficient to establish its effectiveness.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jing Zhao, Yuan Zhang, Yongfeng Cheng, Si Xie, Dian-Dian Li, Peng-Fei Zhang, Xiu-Yun Ren, Xing Wang
Summary: The objective of this study was to evaluate the effect of flap design for impacted mandibular third molar extraction on the distal periodontal tissue of adjacent second molars clinically, immunologically, and microbiologically. The results showed that after 1 and 4 weeks, the distal periodontal conditions of adjacent second molars deteriorated, along with an increase in subgingival microbiota and inflammatory factors in both groups. Compared to the triangular flap group, the modified triangular flap group significantly increased the presence of Prevotella intermedia. The study suggests that within 4 weeks, the modified triangular flap is better for the distal periodontal health of adjacent second molars.
Article
Infectious Diseases
Johannes-Simon Wenzler, Felix Krause, Sarah Boecher, Wolfgang Falk, Axel Birkenmaier, Georg Conrads, Andreas Braun
Summary: Subgingival air-polishing devices can effectively reduce periopathogenic bacteria, with glycine-based and trehalose-based powders showing significant reductions in bacterial load compared to other treatment groups.
Review
Environmental Sciences
Sunanda Mishra, Debasis Dash, Alok Prasad Das
Summary: Personal protective equipment made from plastic is widely used during pandemics. However, the improper disposal of these plastic products has led to a large amount of plastic waste entering the oceans each year. Recycling these wastes can bring economic benefits and contribute to a cleaner environment.
GEOMICROBIOLOGY JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Clemens Raabe, Fabrice Alain Dulla, Burak Yilmaz, Vivianne Chappuis, Samir Abou-Ayash
Summary: Through experiments on bone models, it was found that drilling sequence, guide-hole design, and alveolar ridge morphology have an impact on the accuracy of implant placement via static computer-assisted implant surgery (sCAIS). Using minimum drilling sequence (MDS) and sleeveless (SL) guide-hole design resulted in more accurate implant positions and shorter surgery time.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Biochemical Research Methods
A. Wylleman, F. Vuylsteke, C. Dekeyser, W. Teughels, M. Quirynen, I Laleman
Summary: The study found that the effectiveness of alternative therapies for intra-oral halitosis is uncertain, with significant variations in results, and currently there is insufficient evidence to prove the added value of alternative therapies in the treatment of halitosis.
JOURNAL OF BREATH RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ana B. Castro, Jeroen Van Dessel, Andy Temmerman, Reinhilde Jacobs, Marc Quirynen
Summary: The study aimed to evaluate dimensional changes in the alveolar ridge and bone structure after tooth extraction using L-PRF or A-PRF+ compared to unassisted socket healing. The results showed no significant reduction in dimensional changes after multiple tooth extractions with the use of PRF matrices in the premaxilla, but both PRF matrices exhibited a significant superiority for socket fill after 3 months of healing. Histologically, PRF accelerated new bone formation without significant differences between the two types of PRF.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Ana B. Castro, C. Andrade, X. Li, N. Pinto, W. Teughels, M. Quirynen
Summary: This study compared the characteristics of three types of PRF membranes and found that the timing of centrifugation had a significant impact on the final membrane properties, while adjustments in RCF had minimal effect on the characteristics of the PRF membranes.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Karel Missinne, Joke Duyck, Ignace Naert, Marc Quirynen, Sabine Bertrand, Katleen Vandamme
Summary: The study evaluated the clinical performance of oral implant restorations placed by undergraduate students at KU Leuven in terms of function and esthetics. Most patients were satisfied with the restorations, although complications occurred in 18.9% of cases.
INTERNATIONAL JOURNAL OF PROSTHODONTICS
(2021)
Article
Multidisciplinary Sciences
Tim Verspecht, Wannes Van Holm, Nico Boon, Kristel Bernaerts, Carlo A. Daep, Naiera Zayed, Marc Quirynen, Wim Teughels
Summary: The study found that NADM has effects on multi-species oral biofilms beyond composition changes, including metabolism, virulence, and inflammatory potential. The presence and orientation of the N-acetyl group in NADM play a role in influencing these effects, with different outcomes at varying concentrations.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Catherine X. Andrade, Marc Quirynen, David R. Rosenberg, Nelson R. Pinto
Summary: This study evaluated the interaction between 5 different dental implant surfaces and liquid fibrinogen, revealing significant differences in the initial contact between implant surfaces and the fibrin network among different implant brands. Further studies are necessary to explore the clinical impact of these observations on the osseointegration process of dental implants.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Catherine Andrade Aldana, Antonio Sanz Ruiz, David Rosenberg Messina, Marc Quirynen, Nelson Pinto Carrasco
Summary: This study aimed to compare the efficacy of L-PRF and CTG in the treatment of localized gingival recessions. Both treatments were effective, with CTG achieving higher root coverage and esthetic results, while L-PRF resulted in lower postoperative pain and complications.
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Pierre Lahoud, Siebe Diels, Liselot Niclaes, Stijn Van Aelst, Holger Willems, Adriaan Van Gerven, Marc Quirynen, Reinhilde Jacobs
Summary: This study developed and validated a novel AI-driven tool for fast and accurate mandibular canal segmentation on CBCT scans. Using a deep learning algorithm trained on 235 CBCT scans, the automated segmentation demonstrated high precision and speed, providing a potential solution to relieve practitioners from manual segmentation tasks.
JOURNAL OF DENTISTRY
(2022)
Article
Multidisciplinary Sciences
S. A. M. Siawasch, C. Andrade, A. B. Castro, W. Teughels, A. Temmerman, M. Quirynen
Summary: This study evaluated the effect of local and systemic administration of antimicrobials to leukocyte- and platelet-rich fibrin (L-PRF). The results showed that incorporating metronidazole solution can enhance the antibacterial capacity of L-PRF against periodontal pathogens without affecting the release of growth factors.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Fabio Rodriguez Sanchez, Tim Verspecht, Ana B. Castro, Martine Pauwels, Carlos Rodriguez Andres, Marc Quirynen, Wim Teughels
Summary: L-PRF exudate exhibits antimicrobial activity against P. gingivalis by releasing hydrogen peroxide and antimicrobial peptides. In developing multi-species biofilms, its antimicrobial effect is blocked only by peroxidase, leading to an increase in P. gingivalis growth.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mihai Tarce, Joe Merheb, Marc Meeus, Karla de Faria Vasconcelos, Marc Quirynen
Summary: This study validates a novel method for bone augmentation of horizontal alveolar bone defects using a surgical guide. The use of the guide resulted in improved accuracy of the resulting graft shape, reduced amount of graft material outside the planned volume, and increased surgical time.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Anna Ockerman, Amber Hendrickx, Wouter Willekens, Heleen Fehervary, Julie Vastmans, Wim Coucke, Peter Verhamme, Constantinus Politis, Thomas Vanassche, Annabel Braem, Marc Quirynen, Reinhilde Jacobs
Summary: The study found that L-PRF membranes from patients on anticoagulants were weaker, less stretchable, and contained fewer leukocytes compared to those from patients not taking these drugs.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Rutger Dhondt, Marc Quirynen, Mihai Tarce, Wim Teughels, Andy Temmerman, Reinhilde Jacobs
Summary: The objective of this review was to assess the accuracy of available means of determining the buccal bone thickness and/or level. The study included clinical, in vitro, and animal trials examining the buccal bone plate at oral implants. The results indicated a significant underestimation of buccal bone thickness by CBCT in vitro studies.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mihai Tarce, Alexander de Greef, Pierre Lahoud, Karla de Faria Vasconcelos, Reinhilde Jacobs, Marc Quirynen
Summary: This study assessed the factors influencing implant blooming using a human-like imaging phantom and 3D-printed mandibles. The results showed that implant diameter, presence of a cover screw, implant design/material, implant position, and the presence of additional implants all affected the extent of implant blooming. The study also found that the effect of implant diameter was more pronounced for zirconium implants.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Microbiology
Tim Verspecht, Wannes Van Holm, Nico Boon, Kristel Bernaerts, Carlo A. Daep, James G. Masters, Naiera Zayed, Marc Quirynen, Wim Teughels
Summary: This study examined the modulation effects of four new potential prebiotic substrates on oral biofilms, finding that they could make the biofilms more host-compatible at different concentrations, resulting in decreased pathogens, virulence gene expression, and inflammatory potential.
JOURNAL OF ORAL MICROBIOLOGY
(2021)