Article
Biochemistry & Molecular Biology
Wenxiao Wu, Kun Song, Guangdong Chen, Ning Liu, Tongjun Cao
Summary: This study investigates the potential of Ganoderic acid A (GAA), extracted from Ganoderma mushrooms, for alleviating osteoarthritis (OA). The results show that GAA can improve OA by regulating the RANKL/OPG ratio to inhibit the secretion of MMP-13.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Public, Environmental & Occupational Health
Marwa A. Abdullameer, Ali A. Abdulkareem
Summary: Researchers have found that biomarkers in oral fluids, such as IL-17, RANKL, OPG, and RANKL/OPG, can accurately differentiate periodontal health and disease, as well as stable and unstable periodontitis.
HEALTH SCIENCE REPORTS
(2023)
Article
Biology
Reham AlJasser, Razan AlAqeely, Manal AlKenani, Sadeem AlQahtani, Afnan AlZahrani, Rhodanne Lambarte
Summary: The study found that oral Isotretinoin (INN) can reduce salivary flow rate but has anti-inflammatory effects on periodontal biomarkers, particularly positively correlated with elevated levels of salivary TIMP-1 and TIMP-2.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Xiangyu Zhang, Trent D. Evans, Sunny Chen, Ismail Sergin, Jeremiah Stitham, Se-Jin Jeong, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, In-Hyuk Jung, Abhinav Diwan, Joel D. Schilling, Oren Rom, Arif Yurdagul, Slava Epelman, Jaehyung Cho, Irfan J. Lodhi, Bettina Mittendorfer, Babak Razani
Summary: The mTOR pathway plays a significant role in atherosclerosis, with mTORC1 promoting lesion formation and mTORC2 inhibiting inflammatory response and regulating plaque complexity. The balanced and opposing roles of these two arms of mTOR signaling have important implications for plaque size and complexity.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Romaisa Arshad, Waleed A. Ismail, Batool Zara, Rabia Naseer, Sadia Minhas, Moeez Ansari, Fatema Akhter, Saria A. Khokhar, Abdullah Ali Alqahtani, Huda Abutayyem, Haytham Jamil Alswairki, Mohammad Khursheed Alam
Summary: Chronic periodontitis and diabetes mellitus have a two-way relationship through the inflammatory-mediated pathway, involving the release of various cytokines, including matrix metalloproteinase-9. This study found that the levels of matrix metalloproteinase-9 are significantly increased in type-II diabetes mellitus patients with chronic periodontitis. Additionally, the periodontal parameters were worse in diabetics with chronic periodontitis compared to systemically healthy subjects.
Article
Engineering, Biomedical
Lindsay Piraino, Chiao Yun Chen, Tracey Moyston, Yuanhui Song, Andrew Shubin, Catherine E. Ovitt, Jared A. Mereness, Lisa A. DeLouise, Danielle S. W. Benoit
Summary: We developed a salivary gland tissue mimetic (SGm) for high-throughput drug screening. By tuning biochemical cues within the hydrogel matrix, we improved the maintenance of acinar cell phenotype and function. Slow-degrading MMP-sensitive peptide crosslinkers and adhesive peptides enhanced the secretory response and stability of the SGm over 14 days of culture.
ACTA BIOMATERIALIA
(2023)
Article
Cell Biology
Jingya Guo, Yong Liang, Diyuan Xue, Jiao Shen, Yueqi Cai, Jiankun Zhu, Yang-Xin Fu, Hua Peng
Summary: A next-generation IL-15 cytokine has been developed in this study, which can be activated inside the tumor microenvironment without causing systemic toxicity by avoiding peripheral expansion of NK and T cells. The anti-tumor effect of pro-IL-15 depends on intratumoral CD8(+) T cells and IFN-gamma, and it helps overcome immune checkpoint blockade resistance and synergizes with current targeted-therapy. This novel IL-15 cytokine shows potent anti-tumor activity while minimizing severe toxicity.
Review
Biochemistry & Molecular Biology
Moataz Elgezawi, Rasha Haridy, Khalid Almas, Moamen A. Abdalla, Omar Omar, Hatem Abuohashish, Abeer Elembaby, Uta Christine Woelfle, Yasir Siddiqui, Dalia Kaisarly
Summary: This review article discusses the roles of Matrix metalloproteinases (MMPs) in dental and periodontal tissues, as well as their potential as biomarkers for diagnosis and treatment. The article provides insights into the involvement of MMPs in development, remodeling, degradation, and turnover of dental and periodontal tissues, and their signals in the pathogenesis and wound healing. The review identified 119 published papers, two textbooks, and two doctoral theses as the basis for the discussion. MMPs are seen as significant proteases with potential diagnostic and prognostic value. Understanding their role in dental and periodontal lesions and dentine-pulp wound healing is crucial for future diagnostic and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Qian Wang, Zhaoyang Chen, Xiaoping Peng, Zeqi Zheng, Aiping Le, Junjie Guo, Leilei Ma, Hongtao Shi, Kang Yao, Shuning Zhang, Zhenzhong Zheng, Jianbing Zhu
Summary: This study demonstrates the critical role of macrophage-derived NEU1 in pathological vascular remodeling of aortic dissection (AD). NEU1 exacerbates BAPN-induced pathological vascular remodeling and may represent a potential therapeutic target for the treatment of AD. By knocking out NEU1 in mice, improved aorta function and decreased mortality due to aortic rupture were observed, indicating the importance of NEU1 in maintaining vascular homeostasis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Nuralam Sam, Irawan Yusuf, Irfan Idris, Endy Adnan, Ratna Darjanti Haryadi, Firdaus Hamid, Andry Usman, Muhammad Phetrus Johan, Andi Alfian Zainuddin, Agussalim Bukhari
Summary: This study aimed to investigate the effect of prolotherapy on functional outcome improvements in frozen shoulder patients, as well as the ratio of matrix metalloproteinase-1 (MMP-1)/tissue inhibitor matrix metalloproteinase-1 (TIMP-1) as an indicator of tissue repair. The results showed a significant difference in the ratio of MMP-1/TIMP-1 level between the prolotherapy group and the normal saline group at week 6 and week 12. Both groups performed well in terms of the Numerical Rating Scale score and functional outcome. Prolotherapy changed the mean range of motion in flexion and internal rotation compared to the normal saline group.
Article
Medicine, General & Internal
Marta Relvas, Ricardo Silvestre, Maria Goncalves, Cristina Cabral, Ana Mendes-Frias, Luis Monteiro, Alexandra Viana da Costa
Summary: Periodontitis is a chronic disease characterized by immune-inflammatory pathways and biofilm changes leading to attachment loss. Salivary levels of IL-1 beta and RANK-L are associated with the severity and stage of periodontitis, suggesting their potential as diagnostic biomarkers. Higher levels of IL-1 beta and RANK-L were found in patients with advanced periodontitis, particularly in grade C patients. The correlation between IL-1 beta and PPD/CAL indices, as well as RANK-L and CAL, further supports their involvement in inflammation and bone loss events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Liangjun Jiang, Kunkun Sheng, Cong Wang, Deting Xue, Zhijun Pan
Summary: Recent studies have shown that MMP2-I1 plays a positive role in the osteogenesis of human bone marrow mesenchymal stem cells and angiogenesis of human vascular endothelial cells. It activates signaling pathways to promote osteogenesis and angiogenesis, and has been found to enhance bone formation and prevent bone loss in animal models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Ji-Youn Kim, Ki-Rim Kim, Han-Na Kim
Summary: The study identified IL-1α and IL-1β as significant biomarkers for periodontal disease by analyzing inflammatory cytokines in saliva, with IL-1β confirmed as a significant predictor for periodontitis with a sensitivity of 88.24% and specificity of 62.5%.
Article
Pharmacology & Pharmacy
N. Bayar Muluk, O. K. Arikan, P. Atasoy, R. Kilic, E. Tuna Yalcinozan
Summary: This study investigated the role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in the pathogenesis of nasal polyps (NP). The results showed that MMP2 and MMP9 were expressed at higher levels in granulocytes and mast cells compared to monocytes. Additionally, tissue inhibitor of metalloproteinase-1 (TIMP-1) was also expressed at higher levels in mast cells compared to granulocytes and monocytes. Excessive MMP2 and MMP9 in granulocytes and mast cells contribute to the degradation of the extracellular matrix, allowing inflammatory cells to pass through and causing polypoid degeneration.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Barczak, Mirona Palczewska-Komsa, Mariusz Lipski, Dariusz Chlubek, Jadwiga Buczkowska-Radlinska, Irena Baranowska-Bosiacka
Summary: The study investigated the effect of new silicate cement mineral trioxide aggregate (MTA Repair HP) on the inflammation process involving tooth and periodontal tissues. Results showed that the MTA Repair HP did not increase inflammatory response or affect the activity of MMP-2 and MMP-9 in monocytes/macrophages. This suggests that the new material may not interfere with the process of dentin regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)