Article
Multidisciplinary Sciences
Benjamin Nuerge, Alan Lennart Schulz, Daniel Kaemmerer, Joerg Saenger, Katja Evert, Stefan Schulz, Amelie Lupp
Summary: The complement component C5a and its receptor C5aR1 play crucial roles in the development of inflammatory diseases and are also widely expressed in various tumor entities, suggesting a potential as a future therapeutic target.
Article
Agriculture, Dairy & Animal Science
Ana R. Flores, Marisa Castro, Alexandra Rema, Joao R. Mesquita, Marian Taulescu, Fatima Gartner, Fernanda Seixas, Irina Amorim
Summary: Gastric carcinoma is a common malignancy in dogs, and the reduced expression of TFF1 protein may play a role in the development and progression of canine gastric cancer. Further studies are needed to determine the potential of TFF1 as a prognostic indicator in canine gastric carcinoma.
Article
Health Care Sciences & Services
Chia-Hsin Liu, Chi-You Liao, Ming-Hsin Yeh, James Cheng-Chung Wei
Summary: This study aimed to analyze the National Health Insurance Research Database (NHIRD) in Taiwan, investigate the association between human papillomavirus (HPV) infection and the risk of breast carcinoma. The findings revealed that patients with HPV had a higher risk of developing breast cancer, particularly in older age groups. Additionally, hypertension, chronic obstructive pulmonary disease, and diabetes mellitus were significant risk factors for breast cancer.
Article
Multidisciplinary Sciences
Masahiko Terajima, Yuki Taga, Becky K. Brisson, Amy C. Durham, Kotaro Sato, Katsuhiro Uzawa, Tomoaki Saito, Shunji Hattori, Karin U. Sorenmo, Mitsuo Yamauchi, Susan W. Volk
Summary: The study characterized the molecular and morphological phenotypes of type I collagen in canine mammary carcinoma, finding longer and wider collagen fibers as well as an increase in stable collagen cross-links in neoplastic samples. Mass spectrometric analyses revealed over-hydroxylation of lysine residues in malignant mammary tumor samples, potentially promoting tumor cell metastasis. Furthermore, expression levels of genes encoding lysyl hydroxylase 2 (LH2) and its molecular chaperone FK506-binding protein 65 were significantly increased in neoplastic samples, suggesting a role in LH2-mediated stable collagen cross-links in promoting tumor cell metastasis.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Brent C. Sterling, Mitra Mehrad, Kim A. Ely, James S. Lewis
Summary: This study aims to distinguish sinonasal papillomas from morphologically similar non-neoplastic lesions using CD163 immunostaining. It is found that sinonasal papillomas show extensive CD163 circle staining in the surface epithelium, which can be helpful in distinguishing diagnoses, particularly on small biopsies or equivocal specimens.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Adil Othman, Amer Goreal, Intisar Pity
Summary: This study investigated the prevalence and genotype distribution of Human Papilloma virus (HPV) in patients with different anogenital lesions. The results showed that HPV positivity was detected in various anogenital lesions and HPV16 was the most common high-risk genotype, while HPV6 was the most common low-risk genotype. These findings highlight the importance of HPV screening in preventing cancer development and planning for vaccine introduction.
Article
Optics
Mahmoud Al-Salihi, Rongxing Yi, Shiqi Wang, Qiang Wu, Fangrui Lin, Junle Qu, Liwei Liu
Summary: This paper introduces a method to distinguish neoplastic tissues from non-neoplastic tissues using calibration-free laser-induced breakdown spectroscopy (CF-LIBS). By analyzing the plasma emission lines of different elements, the study identified higher concentrations of major and trace elements in neoplastic tissues, especially in the early temporal observation windows. The results obtained from the CF-LIBS method were in good agreement with that of Inductive coupled plasma-optical emission spectroscopy (ICP-OES).
Article
Oncology
Karthikeyan Subbarayan, Kamatchi Ulagappan, Claudia Wickenhauser, Barbara Seliger
Summary: The study found a higher incidence of COVID-19 infection in cancer patients, specifically lung cancer patients, and demonstrated heterogeneous expression patterns of ACE2 and TMPRSS2 in healthy and malignant tissues. The differential expression and/or methylation profile of ACE2 and TMPRSS2 across various parameters may have implications for COVID-19 disease.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Medicine, General & Internal
Annalisa Palmieri, Dorina Lauritano, Agnese Pellati, Luca Scapoli, Claudio Arcuri, Luigi Baggi, Roberto Gatto, Francesco Carinci
Summary: Oral cavity and oropharynx cancer associated with human papilloma virus infection is a serious public health problem, especially in young people continuously exposed to the virus. Studies showed newly acquired oral oncogenic HPV infections in healthy population are rare, but more research is needed to clarify HPV infection prevalence and guide prevention efforts.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Anna-Sophia Lieselott Beyer, Daniel Kaemmerer, Joerg Saenger, Katja Evert, Amelie Lupp
Summary: FAM159B, an adaptor protein, plays crucial roles in various cell signalling pathways. Experimental validation showed its expression in neuronal and neuroendocrine tissues and high expression levels in different types of tumors, making the antibody HPA011778 a useful tool for researching and detecting FAM159B expression in tissue samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Tsegaw Biyazin, Aynalem Yetwale, Belete Fenta
Summary: This study aimed to assess the willingness to receive HPV vaccination among female high school students in Jimma town, Ethiopia. The study found that factors such as mother's education level, having an older sister, owning a smartphone, having good knowledge, and a positive attitude were significantly associated with willingness to accept HPV vaccine.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Mei-Hsuan Lee, Yu-Han Huang, Anna E. Coghill, Zhiwei Liu, Kelly J. Yu, Wan-Lun Hsu, Yin-Chu Chien, Cheng-Ping Wang, Tseng-Cheng Chen, Chien-Jen Chen, Allan Hildesheim
Summary: The study used a NPC risk prediction model and found an increased risk score in unaffected family members, suggesting the presence of genetic factors affecting EBV control and increasing the risk of nasopharyngeal carcinoma.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Engineering, Biomedical
Andy Hernandez-Montoto, M. Nieves Aranda, Isabel Caballos, Alba Lopez-Palacios, Maria Angeles Tormo-Mas, Javier Peman, Mireya Prieto Rodriguez, Carlos Picornell, Elena Aznar, Ramon Martinez-Manez
Summary: Fluorogenic probes based on oligonucleotide capped nanoporous anodic alumina films were developed for specific and sensitive detection of human papilloma virus (HPV) DNA. The probes showed high sensitivity and selectivity in detecting 14 different high-risk (hr) HPV types in clinical samples. The optimized synthesis protocol allowed for the production of sensors with high reproducibility and reliable fluorescence signal reading.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Shereen Fouad, Gabriel Landini, Max Robinson, Tzu-Hsi Song, Hisham Mehanna
Summary: The paper proposed an intelligent image analysis framework for determining HPV status in digitized samples of oropharyngeal cancer tissue micro-arrays (TMA). The method achieved a high accuracy of 91% by combining handcrafted feature extraction with deep learning.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2021)
Article
Biotechnology & Applied Microbiology
Vinodh Bhoopathi, Pradeep Bhagavatula, Maharaj Singh
Summary: This study examined the association between health literacy levels and receipt of at least one dose of HPV vaccination. The results showed that higher levels of health literacy were associated with a higher likelihood of receiving the vaccine. Age, gender, marital status, race/ethnicity, insurance status, and having regular access to a personal doctor were predictors of HPV vaccination status.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)