Article
Oncology
Cristina Marenghi, Zhuyu Qiu, Jozien Helleman, Daan Nieboer, Jose Rubio-Briones, Peter R. Carroll, Lui Shiong Lee, Riccardo Valdagni, Paul C. Boutros, Nicola Nicolai
Summary: Active surveillance is a safe option for low-risk prostate cancer patients, and most patients do not show adverse pathological findings at surgery. However, wider entry criteria are associated with higher tumor extension and positive surgical margins.
Article
Urology & Nephrology
Jordan Nasri, Flora Barthe, Sneha Parekh, Parita Ratnani, Adriana M. Pedraza, Vinayak G. Wagaskar, Jonathan Olivier, Arnauld Villers, Ash Tewari
Summary: This study developed and validated a prediction model to assess the risk of adverse pathology outcome in low-risk prostate cancer patients. The model showed good accuracy in predicting adverse pathology outcomes and could aid in treatment decision-making for this patient population.
Article
Endocrinology & Metabolism
Ahmed Emam, Gregory Hermann, Kristopher Attwood, Wenyan Ji, Gaybrielle James, Michael Kuettel, James L. Mohler
Summary: The study compared the oncologic outcomes of radical prostatectomy (RP) and external beam radiotherapy (EBRT) + androgen deprivation therapy in high risk localized prostate cancer patients. The results showed that RP had higher rates of biochemical failure and adjuvant or salvage treatment, while EBRT trended towards benefit in metastasis-free survival. However, cancer-specific survival and overall survival remained high in both groups.
Article
Urology & Nephrology
Claudia Kesch, Vlad Pantea, Timo Soeterik, Alessandro Marquis, Giulia la Bombarda, Allesandro Morlacco, Francesco Barletta, Jan Philipp Radtke, Christopher Darr, Felix Preisser, Fabio Zattoni, Giancarlo Marra, Roderik C. N. van den Bergh, Boris Hadaschik, Giorgio Gandaglia, EAU-YAU Prostate Canc Working Party
Summary: Although active surveillance is recommended for low- to favorable intermediate-risk prostate cancer, the risk of upgrading at radical prostatectomy is still significant. This study aims to explore the rates and risk factors for adverse outcomes in patients with ISUP <= 2 PCa detected at MRI-targeted biopsy with concomitant systematic biopsy.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Lars Bjornebo, Henrik Olsson, Tobias Nordstrom, Fredrik Jaderling, Henrik Gronberg, Martin Eklund, Anna Lantz
Summary: The study aimed to evaluate clinical variables, including MRI, for predicting adverse pathology at RP in men initially enrolled in AS. Age, clinical T-stage, PSA, and PI-RADS score were found to be significantly associated with adverse pathology at RP.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Romain Diamand, Guillaume Ploussard, Mathieu Roumiguie, Marco Oderda, Daniel Benamran, Gaelle Fiard, Alexandre Peltier, Giuseppe Simone, Julien Van Damme, Bernard Malavaud, Christophe Iselin, Jean-Luc Descotes, Jean-Baptiste Roche, Thierry Quackels, Thierry Roumeguere, Simone Albisinni
Summary: The study shows that delaying surgery for several months did not have a negative impact on oncologic outcomes for intermediate and high-risk prostate cancer patients, aligning with the current recommendation of urologic societies.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Silvia Mora, Ji Qi, Todd M. Morgan, Christopher M. Brede, James Peabody, Arvin George, Brian R. Lane
Summary: This study investigated the outcomes of radical prostatectomy (RP) for high-risk (HR), very high-risk (VHR), or metastatic prostate cancer (CaP). The results showed that the majority of HR or higher-risk patients remained progression-free two years after RP, with acceptable perioperative outcomes. The progression-free survival rates were similar in metastatic and VHR patients, better in non-metastatic HR patients, indicating the limitations of conventional imaging modalities in clinical staging.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Surgery
Renaldi Prasetia, Mahyudin, Hermawan Nagar Rasyid
Summary: Neglected dislocations of the elbow are common in developing countries, with patients often seeking treatment from traditional bonesetters, which can exacerbate the problem. Surgical treatment for late-presenting, unreduced elbow dislocations is effective in restoring the joint to a painless, stable, and functional state.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Biophysics
Takaaki Konuma, Hidehiro Itonaga, Ken Ishiyama, Noriko Doki, Naoyuki Uchida, Masashi Sawa, Yuta Katayama, Masatsugu Tanaka, Yasunori Ueda, Makoto Onizuka, Shigesaburo Miyakoshi, Yukiyasu Ozawa, Takahiro Fukuda, Ken-ichi Matsuoka, Junji Tanaka, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta
Summary: HLA-matched sibling donors may not be the best choice for elderly patients with MDS undergoing allogeneic HCT.
BONE MARROW TRANSPLANTATION
(2023)
Article
Biotechnology & Applied Microbiology
Benedikt Ebner, Maria Apfelbeck, Nikolaos Pyrgidis, Tobias Nellessen, Stephan Ledderose, Paulo Leonardo Pfitzinger, Yannic Volz, Elena Berg, Benazir Enzinger, Severin Rodler, Michael Atzler, Troya Ivanova, Dirk-Andre Clevert, Christian Georg Stief, Michael Chaloupka
Summary: The aim of this study was to evaluate the impact of mpMRI fusion-guided biopsy (FBx) on adverse pathology after radical prostatectomy (RP) in low-risk prostate cancer patients. The results showed that introducing FBx did not lead to significant change in the ratio of adverse pathology after RP compared to systematic randomized biopsies (SBx) in a real-world setting.
BIOENGINEERING-BASEL
(2023)
Article
Pathology
Jeffrey Ordner, Abdallah Flaifel, Antonio Serrano, Rebecca Graziano, Jonathan Melamed, Fang-Ming Deng
Summary: The study aimed to determine the prognostic significance of the maximum allowable percentage of Gleason pattern 4 (GP4) at prostate biopsy compared with adverse pathology observed at radical prostatectomy (RP) to expand active surveillance eligibility among a cohort with intermediate risk of prostate cancer. The study found no statistically significant difference in adverse pathology at RP between the active surveillance-eligible control (GP4 0%) and the GP4 <= 5% subgroup, with 68.9% of the GP4 <= 5% subgroup showing favorable pathologic outcomes. Moreover, there was no statistical correlation between prebiopsy serum PSA levels or GP4 length and adverse pathology at RP in the GP4 <= 5% subgroup. Therefore, active surveillance may be a reasonable option for management of patients in the GP4 <= 5% group until long-term follow-up data become available.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Orthopedics
Matteo Innocenti, Francesco Muratori, Giacomo Mazzei, Davide Guido, Filippo Frenos, Ersilia Lucenteforte, Rodolfo Capanna, Domenico Andrea Campanacci
Summary: Burch-Schneider-like antiprotrusio cages remain helpful in addressing severe periacetabular bone losses, with higher failure and complication rates in revision THA patients compared to oncologic cases. Significant independent predictors for dislocations were the extended ileo-femoral approach and proximal femur replacement, while THA failures were predicted for infections. Surgeons should consider using less-invasive approaches to reduce dislocation rates in non-oncologic cases.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Oncology
Yoichiro Tohi, Ryou Ishikawa, Takuma Kato, Jimpei Miyakawa, Ryuji Matsumoto, Keiichiro Mori, Koji Mitsuzuka, Junichi Inokuchi, Masafumi Matsumura, Kenichiro Shiga, Hirohito Naito, Yasuo Kohjimoto, Norihiko Kawamura, Masaharu Inoue, Shusuke Akamatsu, Naoki Terada, Yoshiyuki Miyazawa, Shintaro Narita, Reiji Haba, Mikio Sugimoto
Summary: It is unclear what factors predict adverse pathology, such as intraductal carcinoma of the prostate and cribriform patterns, in men undergoing active surveillance for prostate cancer. In this study, we found that increasing age could be a predictive factor for adverse pathology. Older individuals may benefit from adhering to an active surveillance schedule.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Urology & Nephrology
Pan Song, Mengxuan Shu, Luchen Yang, Xiaoyu Di, Peiwen Liu, Zhenghuan Liu, Jing Zhou, Qiang Dong
Summary: For elderly men aged 70 and above with very high-risk prostate cancer, radical prostatectomy (RP) was associated with better overall survival (OS) and similar prostate cancer-specific survival (PCSS) compared to external beam radiotherapy plus brachytherapy (EBRT + BT). Both RP and EBRT + BT demonstrated better OS and PCSS outcomes than EBRT alone.
UROLOGIA INTERNATIONALIS
(2022)
Article
Oncology
Nathan Paulson, Tal Zeevi, Maria Papademetris, Michael S. Leapman, John A. Onofrey, Preston C. Sprenkle, Peter A. Humphrey, Lawrence H. Staib, Angelique W. Levi
Summary: In this study, a machine learning algorithm was used to predict adverse outcomes in patients undergoing radical prostatectomy using whole-slide images of prostate biopsies.
JCO CLINICAL CANCER INFORMATICS
(2022)