Article
Oncology
Paul Girot, Nicolas Chapelle, Laetitia Aymeric, Anne Bessard, Alice Prigent, Yann Touchefeu, Christine Varon, Michel Neunlist, Emilie Duchalais, Tamara Matysiak-Budnik
Summary: Gastric cancer is a leading cause of cancer-related deaths globally. This study investigated the adhesion of gastric cancer cells to enteric neurons, and found that enteric neurons are a privileged site for gastric cancer cell adhesion, especially in diffuse-type gastric cancer. The adhesion was partially mediated by N-Cadherin, and blocking N-Cadherin significantly decreased the adhesion ability. These findings suggest a potential role of enteric neurons in the dissemination of gastric cancer cells.
Article
Biochemistry & Molecular Biology
Beiqin Yu, Wentao Dai, Li Pang, Qingqing Sang, Fangyuan Li, Junxian Yu, Haoran Feng, Jianfang Li, Junyi Hou, Chao Yan, Liping Su, Zhenggang Zhu, Yuan-Yuan Li, Bingya Liu
Summary: This study identified crucial transcription factors related to gastric cancer progression and proposed testable hypotheses on the differential regulation mechanisms of gastric carcinogenesis. Through cytological experiments and IHC staining, the dynamic changes of target genes regulated by one of the transcription factors were validated. The identified transcription factors and their targets may have potential therapeutic value.
MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Wenhao Shi, Yushen Wang, Chen Xu, Yan Li, Sai Ge, Bin Bai, Kecheng Zhang, Yunzhi Wang, Nairen Zheng, Juan Wang, Shiqi Wang, Gang Ji, Jipeng Li, Yongzhan Nie, Wenquan Liang, Xiaosong Wu, Jianxin Cui, Yi Wang, Lin Chen, Qingchuan Zhao, Lin Shen, Fuchu He, Jun Qin, Chen Ding
Summary: This research utilizes multilevel proteomic analyses to investigate the molecular differences between diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC) in Chinese patients. The analyses reveal an ARIDIA mutation with opposite prognostic effects, identify three subtypes for DGC and IGC based on distinct protein expression patterns, and demonstrate that disease progressions are regulated by specific transcription factor complexes. Furthermore, immune cell infiltration is shown to be an indicator for immunotherapeutic effectiveness. These results contribute to a better understanding of gastric cancer and have implications for precision medicine.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Chong Yu, Jin Wang
Summary: Gastric cancer is a significant disease affecting global health. This study explores the mechanism of intestinal-type gastric cancer and the influence of Helicobacter pylori infection on its progression through gene regulatory network analysis and simulation.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Yang Guo, Xue-Shan Cao, Meng-Ge Zhou, Bo Yu
Summary: Gastric cancer is a leading cause of cancer-related deaths worldwide. The gastric microbiota, including both Helicobacter pylori and non-H. pylori microbes, plays a critical role in the development of gastric cancer. Dysbiosis of the gastric microbiota, with a decrease in non-H. pylori microbes, occurs following H. pylori infection. As gastric lesions progress, there is a decrease in H. pylori and an increase in non-H. pylori microbes. The roles of H. pylori and non-H. pylori microbes differ at different stages of gastric carcinogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angela Saviano, Mattia Brigida, Carmine Petruzziello, Christian Zanza, Marcello Candelli, Maria Rita Morabito Loprete, Faiz Saleem, Veronica Ojetti
Summary: SARS-CoV-2 virus primarily infects and replicates in the gut epithelial cells through ACE2 receptors, leading to gastrointestinal symptoms. Moreover, it causes hyperactivation of platelets and cytokine storms in the bloodstream, resulting in gut-blood barrier damage, alteration of the gut microbiota, malabsorption, malnutrition, increased disease severity, and potential long-term effects.
Article
Medicine, General & Internal
Chao-Tao Tang, Si-Hai Chen
Summary: The study comprehensively analyzed early-onset early-stage gastric cancer, identifying intestinal type as a risk factor for lymph node metastasis and survival compared to the diffuse type. The oncogenic expression promoting the occurrence of LNM was different between intestinal and diffuse types, suggesting clinicians should focus more attention on intestinal-type EEGC.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Xinmei Zhang, Chao Li, Weijun Cao, Zhenyu Zhang
Summary: Microbial infections are known to contribute to gastric carcinogenesis, and changes in gastric microbiota may aid in early diagnosis of gastric cancer. This study aimed to characterize microbial changes and identify taxonomic biomarkers across stages of gastric carcinogenesis. The results showed that the richness and diversity of gastric microbiota did not show a gradual changing trend, with certain oral bacteria continuously enriching from superficial gastritis to gastric cancer. Patients with gastric cancer had enrichments of both oral and environmental bacteria, while those with gastric intraepithelial neoplasia had an enrichment of intestinal commensals. Gastric cardia cancer and non-cardia cancer patients had significantly different microbiota profiles, with a higher abundance of Helicobacter in the cardia cancer patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Zijing Xu, Ling Xiao, Shuaishuai Wang, Yuqin Cheng, Jianping Wu, Yufen Meng, Kaifan Bao, Junfeng Zhang, Chun Cheng
Summary: In this study, a rat model was used to investigate the biological mechanism of gastric intestinal metaplasia (GIM) induced by bile reflux. The results showed that GIM enhanced gastric fat digestion and absorption function, while impairing gastric acid secretion function. This effect might be mediated by the interactions among deoxycholic acid (DCA), Rikenellaceae RC9 gut group, RGD1311575 gene, and Fabp1 gene.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Hudson M. Holmes, Andre G. Jove, Mimi C. Tan, Hashem B. El-Serag, Aaron P. Thrift
Summary: The study found no association between the amount of alcohol consumed or specific beverage type and the risk of gastric intestinal metaplasia.
Article
Gastroenterology & Hepatology
Duochen Jin, Keting Huang, Miao Xu, Hongjin Hua, Feng Ye, Jin Yan, Guoxin Zhang, Yun Wang
Summary: This study reveals the mechanism by which bile acids promote gastric inflammation and carcinogenesis through the TGR5/STAT3/KLF5 pathway during the process of intestinal metaplasia. It also demonstrates that DCA disrupts the homeostasis of the gastric microbiome and bile acid metabolism during IM induction.
Article
Gastroenterology & Hepatology
Daisuke Douchi, Akihiro Yamamura, Junichi Matsuo, Yi Hui Melissa Lim, Napat Nuttonmanit, Mitsuhiro Shimura, Kazuto Suda, Sabirah Chen, ShuChin Pang, Kazuyoshi Kohu, Takaya Abe, Go Shioi, Guowei Kim, Asim Shabbir, Supriya Srivastava, Michiaki Unno, Jimmy Bok-Yan So, Ming Teh, Khay Guan Yeoh, Linda Shyue Huey Chuang, Yoshiaki Ito
Summary: The study investigates the cellular origin of metaplasia and cancer in the stomach using a Pgc-specific CreERT2 mouse model. It is found that PGC transcript-expressing cells could be responsible for the development of different stages of gastric cancer, from precancerous lesions to invasive and metastatic carcinoma. The Pgc-CreERT2 mouse model provides a valuable tool for studying the effects of oncogenic activation in the mouse corpus and observing the tumorigenesis process in the stomach.
Review
Oncology
Ting Liu, Xiaoying Zhou, Zhe Zhang, Yutao Qin, Rensheng Wang, Yanning Qin, Yuqi Huang, Yingxi Mo, Tingting Huang
Summary: Epstein-Barr virus (EBV) is a common virus that infects the majority of the global population and its role in EBVaGC tumorigenesis is not fully understood. Recent research has shown that EBV-encoded miRNAs play significant roles in various cellular processes and have both anti-apoptotic and pro-apoptotic functions in EBVaGC. However, the comprehensive mechanisms through which miRNAs contribute to EBVaGC are still not fully elucidated.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rachel Gingold-Belfer, Gania Kessler-Icekson, Sara Morgenstern, Lea Rath-Wolfson, Romy Zemel, Doron Boltin, Zohar Levi, Michal Herman-Edelstein
Summary: The study showed dysregulation of the POPDC1 and POPDC3 genes in the transition from intestinal metaplasia to gastric cancer, suggesting a role in tumor suppression and highlighting them as potential biomarkers and treatment targets for gastric cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hosne Ara, Utsab Subedi, Papori Sharma, Susmita Bhattarai, Sudha Sharma, Shrivats Manikandan, Xiuping Yu, Md. Shenuarin Bhuiyan, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam
Summary: Lysophosphatidic acid (LPA) plays a critical role in beta-catenin-mediated gastric cancer by promoting proliferation, migration, and invasion of cancer cells. LPA exposure increases beta-catenin expression and nuclear localization, phosphorylation of GSK-3 beta, and target gene expression. LPA also affects energy metabolism and contributes to gastric cancer initiation and progression.