Article
Oncology
Edoardo Isnaldi, Francois Richard, Maxim De Schepper, Sophia Leduc, Marion Maetens, Tatjana Geukens, Karen Van Baelen, Ha-Linh Nguyen, Ghizlane Rouas, Gabriele Zoppoli, Fatima Cardoso, Christos Sotiriou, Denis Larsimont, Giuseppe Floris, Elia Biganzoli, Christine Desmedt
Summary: The impact of adiposity on the efficacy of endocrine treatment in patients with estrogen receptor positive breast cancer was investigated retrospectively. It was found that obesity and larger adipocyte diameter are associated with a higher likelihood of anti-proliferative response in neoadjuvant treatment.
Article
Medicine, General & Internal
Gabriel N. Hortobagyi, Salomon M. Stemmer, Howard A. Burris, Yoon-Sim Yap, Gabe S. Sonke, Lowell Hart, Mario Campone, Katarina Petrakova, Eric P. Winer, Wolfgang Janni, Pierfranco Conte, David A. Cameron, Fabrice Andre, Carlos L. Arteaga, Juan P. Zarate, Arunava Chakravartty, Tetiana Taran, Fabienne Le Gac, Paolo Serra, Joyce O'Shaughnessy
Summary: First-line therapy with ribociclib plus letrozole showed a significant overall survival benefit as compared with placebo plus letrozole in patients with HR-positive, HER2-negative advanced breast cancer. Median overall survival was more than 12 months longer with ribociclib than with placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Samuel G. Smith, Ivana Sestak, Michelle. A. Morris, Michelle Harvie, Anthony Howell, John Forbes, Jack Cuzick
Summary: The study found that higher BMI is associated with greater breast cancer risk in postmenopausal women at increased risk of the disease, but no effect was observed in premenopausal women. The lack of interaction between BMI and treatment group on breast cancer risk suggests women are likely to experience benefit from preventive therapy regardless of their BMI.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Nutrition & Dietetics
Vittoria D'Esposito, Michele Francesco Di Tolla, Manuela Lecce, Francesco Cavalli, Michele Libutti, Saverio Misso, Serena Cabaro, Maria Rosaria Ambrosio, Alessia Parascandolo, Bianca Covelli, Giuseppe Perruolo, Mario Sansone, Pietro Formisano
Summary: Age, BMI, smoking, physical activity, and dietary habits are associated with specific cytokines that may represent potential markers for low-grade chronic inflammation.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Sixten Harborg, Deirdre Cronin-Fenton, Maj-Britt Raaby Jensen, Thomas P. Ahern, Marianne Ewertz, Signe Borgquist
Summary: Clinical studies confirm that obesity is a risk factor for recurrence in postmenopausal women with hormone receptor-positive breast cancer. Evidence suggests that women with obesity do not obtain similar protection from aromatase inhibitors as women with healthy weight.
Article
Biochemistry & Molecular Biology
Mayuko Ikarashi, Junko Tsuchida, Masayuki Nagahashi, Shiho Takeuchi, Kazuki Moro, Chie Toshikawa, Shun Abe, Hiroshi Ichikawa, Yoshifumi Shimada, Jun Sakata, Yu Koyama, Nobuaki Sato, Nitai C. Hait, Yiwei Ling, Shujiro Okuda, Kazuaki Takabe, Toshifumi Wakai
Summary: Elevated plasma levels of S1P are associated with larger tumor size, lymph node metastasis, and advanced cancer stage in ER-positive breast cancer patients, indicating a role in cancer progression. Treatment with FTY720, a functional antagonist of S1P receptors, showed promising results in suppressing viability of hormone therapy-resistant cells, suggesting a potential new therapeutic strategy for ER-positive breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Lucia Del Mastro, Mauro Mansutti, Giancarlo Bisagni, Riccardo Ponzone, Antonio Durando, Laura Amaducci, Enrico Campadelli, Francesco Cognetti, Antonio Frassoldati, Andrea Michelotti, Silvia Mura, Ylenia Urracci, Giovanni Sanna, Stefania Gori, Sabino De Placido, Ornella Garrone, Alessandra Fabi, Carla Barone, Stefano Tamberi, Claudia Bighin, Fabio Puglisi, Gabriella Moretti, Grazia Arpino, Alberto Ballestrero, Francesca Poggio, Matteo Lambertini, Filippo Montemurro, Paolo Bruzzi
Summary: The study showed that extending letrozole treatment to 5 years in postmenopausal patients with breast cancer who had received 2-3 years of tamoxifen resulted in a significant improvement in disease-free survival compared to the standard 2-3 years of letrozole treatment.
Article
Nutrition & Dietetics
Erika Cortes-Macias, Marta Selma-Royo, Cecilia Martinez-Costa, Maria Carmen Collado
Summary: Breastfeeding plays a crucial role in neonatal microbial and immune system development, with pre-pregnancy BMI and weight gain during pregnancy affecting milk microbiota composition. Normal-weight women with exclusive breastfeeding habits showed higher abundance of Bifidobacterium genus and alpha-diversity in breast milk. Further research is needed to understand the potential impact of maternal factors on milk and infant development and health.
Article
Nutrition & Dietetics
Jordana Carolina Marques Godinho-Mota, Larissa Vaz-Goncalves, Isis Danyelle Dias Custodio, Jaqueline Schroeder de Souza, Joao Felipe Mota, Maria Cristina Gonzalez, Priscylla Rodrigues Vilella, Karine Anusca Martins, Yara Cristina de Paiva Maia, Sara Maria Moreira Lima Verde, Aline Porciuncula Frenzel, Patricia Faria Di Pietro, Eduarda da Costa Marinho, Ruffo Freitas-Junior
Summary: This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. The results showed that CT negatively impacted body composition and different regimens had different effects. The study highlights the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment.
Article
Nutrition & Dietetics
Reem Eltayeb, Naif K. Binsaleh, Ghaida Alsaif, Reem M. Ali, Amjad R. Alyahyawi, Ishag Adam
Summary: The association between hemoglobin level/anemia and obesity during pregnancy is not fully understood. A cross-sectional study was conducted in Saudi Arabia to assess this association. The study found that parity and BMI were negatively associated with hemoglobin level and that primiparity, increasing BMI, and obesity were associated with decreased odds of anemia.
Article
Biochemistry & Molecular Biology
Karen Savage, Lee Gogarty, Ana Lea, Saurenne Deleuil, Karen Nolidin, Kevin Croft, Con Stough
Summary: The increasing proportion of older citizens in society calls for a better understanding of the biological basis of mood as people age. This study examines the relationship between oxidative stress biomarkers and mood symptoms in healthy older adults. The findings suggest that elevated oxidative stress markers contribute to depressed mood and reduced general health in this population.
Article
Oncology
Ahmet Ozveren, Melis Ridvanogullari Donger, Sedat Motor, Gulcan Bulut
Summary: The study aimed to investigate the frequency of metabolic syndrome (MS) in early-stage breast cancer patients. 128 out of 207 patients (61.8%) had MS, which was more frequent in hormone receptor positive subgroup and recipients of adjuvant hormonotherapy. Significant differences were found in age, BMI, and estrogen/progesterone receptor status between patients with and without MS. There were no significant differences in terms of cancer stage, inflammatory markers, basal insulin and LDL levels, and tumor markers. It is important to emphasize lifestyle changes to improve obesity-related adverse outcomes in clinical practice.
INTEGRATIVE CANCER THERAPIES
(2023)
Review
Endocrinology & Metabolism
Sandra C. Naaman, Sherry Shen, Meltem Zeytinoglu, Neil M. Iyengar
Summary: Obesity is associated with an increased risk of postmenopausal, hormone receptor-positive breast cancer. Factors such as altered adipokine balance and chronic inflammation contribute to tumorigenesis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
G. Jerusalem, S. Farah, A. Courtois, J. Chirgwin, S. Aebi, P. Karlsson, P. Neven, E. Hitre, M. P. Graas, E. Simoncini, E. Abdi, C. Kamby, A. Thompson, S. Loibl, J. Gavila, K. Kuroi, C. Marth, B. Muller, S. O'Reilly, A. Gombos, T. Ruhstaller, H. J. Burstein, M. Rabaglio, B. Ruepp, K. Ribi, G. Viale, R. D. Gelber, A. S. Coates, S. Loi, A. Goldhirsch, M. M. Regan, M. Colleoni
Summary: The study found that extended adjuvant therapy with intermittent administration of letrozole did not improve 7-year disease-free survival compared to continuous treatment, despite the recovery of estrogen levels. Adverse events rates were similar in both groups.
ANNALS OF ONCOLOGY
(2021)
Letter
Medicine, General & Internal
David A. Gorelick
Summary: This comprehensive review of human adipose tissue fails to mention the role of the endocannabinoid system in fat metabolism. The endogenous cannabinoids and their receptors, found in both white and brown fat, have been recognized as key players in adipose tissue metabolism. Rimonabant, an inverse agonist of cannabinoid receptor type 1, has shown promising effects as a therapeutic target for obesity, dyslipidemia, and insulin resistance, although its clinical use was discontinued due to neuropsychiatric side effects.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
M. Jamal-Hanjani, R. A'Hern, N. J. Birkbak, P. Gorman, E. Groenroos, S. Ngang, P. Nicola, L. Rahman, E. Thanopoulou, G. Kelly, P. Ellis, P. Barrett-Lee, S. R. D. Johnston, J. Bliss, R. Roylance, C. Swanton
ANNALS OF ONCOLOGY
(2015)
Review
Cell Biology
Jonna Frasor, Lamiaa El-Shennawy, Joshua D. Stender, Irida Kastrati
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2015)
Article
Medicine, General & Internal
J. Mateo, S. Carreira, S. Sandhu, S. Miranda, H. Mossop, R. Perez-Lopez, D. Nava Rodrigues, D. Robinson, A. Omlin, N. Tunariu, G. Boysen, N. Porta, P. Flohr, A. Gillman, I. Figueiredo, C. Paulding, G. Seed, S. Jain, C. Ralph, A. Protheroe, S. Hussain, R. Jones, T. Elliott, U. McGovern, D. Bianchini, J. Goodall, Z. Zafeiriou, C. T. Williamson, R. Ferraldeschi, R. Riisnaes, B. Ebbs, G. Fowler, D. Roda, W. Yuan, Y. -M. Wu, X. Cao, R. Brough, H. Pemberton, R. A'Hern, A. Swain, L. P. Kunju, R. Eeles, G. Attard, C. J. Lord, A. Ashworth, M. A. Rubin, K. E. Knudsen, F. Y. Feng, A. M. Chinnaiyan, E. Hall, J. S. de Bono
NEW ENGLAND JOURNAL OF MEDICINE
(2015)
Article
Oncology
Federico Rojo, Abel Gonzalez-Perez, Jessica Furriol, Ma Jesus Nicolau, Jaime Ferrer, Octavio Burgues, MohammadA Sabbaghi, Irene Gonzalez-Navarrete, Ion Cristobal, Laia Serrano, Sandra Zazo, Juan Madoz, Sonia Servitja, Ignasi Tusquets, Joan Albanell, Ana Lluch, Ana Rovira, Pilar Eroles
BRITISH JOURNAL OF CANCER
(2016)
Article
Oncology
Roger P. A'Hern
JOURNAL OF CLINICAL ONCOLOGY
(2016)
Article
Oncology
M. Arnedos, S. Drury, M. Afentakis, R. A'Hern, M. Hills, J. Salter, I. E. Smith, J. S. Reis-Filho, M. Dowsett
ANNALS OF ONCOLOGY
(2014)
Article
Oncology
A. Sheri, I. E. Smith, S. R. Johnston, R. A'Hern, A. Nerurkar, R. L. Jones, M. Hills, S. Detre, S. E. Pinder, W. F. Symmans, M. Dowsett
ANNALS OF ONCOLOGY
(2015)
Article
Oncology
S. Irshad, C. Gillett, S. E. Pinder, R. P. A'Hern, M. Dowsett, I. O. Ellis, J. M. S. Bartlett, J. M. Bliss, A. Hanby, S. Johnston, P. Barrett-Lee, P. Ellis, A. Tutt
BREAST CANCER RESEARCH AND TREATMENT
(2014)
Article
Oncology
Charlotte K. Y. Ng, Britta Weigelt, Roger A'Hern, Francois-Clement Bidard, Christophe Lemetre, Charles Swanton, Ronglai Shen, Jorge S. Reis-Filho
Article
Oncology
Alexandra Leary, Abigail Evans, Stephen R. D. Johnston, Roger A'Hern, Judith M. Bliss, Rashmita Sahoo, Simone Detre, Benjamin P. Haynes, Margaret Hills, Catherine Harper-Wynne, Nigel Bundred, Gill Coombes, Ian Smith, Mitch Dowsett
CLINICAL CANCER RESEARCH
(2015)
Article
Oncology
R. P. A'Hern
Article
Cell Biology
Daniel Wetterskog, Paul M. Wilkerson, Daniel N. Rodrigues, Maryou B. Lambros, Karen Fritchie, Mattias K. Andersson, Rachael Natrajan, Arnaud Gauthier, Silvana Di Palma, Sami Shousha, Zoran Gatalica, Chantal Toepfer, Vesna Vukovic, Roger A'Hern, Britta Weigelt, Anne Vincent-Salomon, Goeran Stenman, Brian P. Rubin, Jorge S. Reis-Filho
Article
Oncology
Rachael Natrajan, Paul M. Wilkerson, Caterina Marchio, Salvatore Piscuoglio, Charlotte K. Y. Ng, Patty Wai, Maryou B. Lambros, Eleftherios P. Samartzis, Konstantin J. Dedes, Jessica Frankum, Ilirjana Bajrami, Alicja Kopec, Alan Mackay, Roger A'hern, Kerry Fenwick, Iwanka Kozarewa, Jarle Hakas, Costas Mitsopoulos, David Hardisson, Christopher J. Lord, Chandan Kumar-Sinha, Alan Ashworth, Britta Weigelt, Anna Sapino, Arul M. Chinnaiyan, Christopher A. Maher, Jorge S. Reis-Filho
JOURNAL OF PATHOLOGY
(2014)
Article
Health Care Sciences & Services
Roger P. A'Hern
Summary: Taking multiple synchronous samples can improve accuracy, with the effect depending on the intra-class correlation. Benefits of multiple samples include reducing the number of subjects, increasing power, and available alpha.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Article
Clinical Neurology
Maria F. Cordeiro, Eduardo M. Normando, M. Jorge Cardoso, Serge Miodragovic, Seham Jeylani, Benjamin M. Davis, Li Guo, Sebastien Ourselin, Roger A'Hern, Philip A. Bloom