Article
Genetics & Heredity
Jin Peng, Qingfeng Zhang, Fei Lin, Chao Ke, Wuguo Deng, Ankui Yang, Xuan Su
Summary: Using data from The Cancer Genome Atlas database, we identified significant CpGs associated with lymphatic metastasis in BRAF wild-type TC. A logistic regression model was developed to discriminate this type of metastasis, and TAGLN, MRPL4, CLDN10, and GRIK2 were identified as diagnostic markers. GRIK2, downregulated due to promoter hypermethylation, acts as a tumor suppressor.
Article
Biochemical Research Methods
Ruizheng Sun, Yaozhong Liu, Cheng Lei, Zhenwei Tang, Lixia Lu
Summary: This study proposed and validated a novel 7-RNA based signature to predict the prognosis of wild-type BRAF cutaneous melanoma (WT Bf-CM) patients. Functional analysis suggested that the predictive function of this signature might be related to the up-regulation of RNA splicing, transcription, and cellular proliferation in the high-risk group. Additionally, the study found that the prognosis of WT Bf-CM patients is highly related to the PI3K/Akt/mTOR pathway.
BIOLOGICAL PROCEDURES ONLINE
(2022)
Review
Oncology
Benoit Lhermitte, Thibaut Wolf, Marie Pierre Chenard, Andres Coca, Julien Todeschi, Francois Proust, Edouard Hirsch, Roland Schott, Georges Noel, Eric Guerin, Damien Reita, Agathe Chammas, Alexandra Salmon, Sophie Martin, Monique Dontenwill, Natacha Entz-Werle
Summary: Drugs targeting activating BRAF mutations have transformed the prognosis and treatment of MAPK-pathway-induced cancers. The better knowledge of the MAPK pathway's involvement in gliomagenesis offers hope in brain cancers where conventional therapies have produced disappointing results. This review summarizes the current literature regarding BRAF-altered gliomas, their molecular diagnosis, prognosis, associated molecular alterations, and potential treatment options.
Review
Oncology
Pilar Garcia-Alfonso, Astrid Lievre, Fotios Loupakis, Abir Tadmouri, Sadya Khan, Leticia Barcena, Sebastian Stintzing
Summary: Approximately 8-10% of metastatic colorectal cancer tumors have BRAF(V600E) mutations. Single-agent BRAF inhibitors have minimal efficacy, while combining BRAF inhibitors with anti-EGFR therapy improves outcomes. Patients with BRAF(V600E)-mutant mCRC have worse outcomes compared to those with BRAF wild-type mCRC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Dermatology
Samantha M. Guhan, Michael Shaughnessy, Anpuchchelvi Rajadurai, Michael Taylor, Raj Kumar, Zhenyu Ji, Sarem Rashid, Keith Flaherty, Hensin Tsao
Summary: Targeting transcriptional dependencies through selective inhibition of CDK9 is an effective method for suppressing therapeutically orphaned BRAF/NRAS/NF1 wild-type melanomas.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Economics
Daniel C. Miller, Stephanie Mansourian, Monica Gabay, Reem Hajjar, Pamela Jagger, Judith F. M. Kamoto, Peter Newton, Johan A. Oldekop, Onja H. Razafindratsima, Priya Shyamsundar, Terry Sunderland, Christoph Wildburger
Summary: Forests and trees play a critical role in global poverty alleviation efforts, but their benefits are unevenly distributed. While they can help rural poor communities face global challenges, poorly aligned policies may result in excessive costs for the poor. However, there are policy and management measures that can effectively address poverty goals with tailored solutions.
FOREST POLICY AND ECONOMICS
(2021)
Article
Biochemistry & Molecular Biology
Elena Lastraioli, Federico Alessandro Ruffinatti, Giacomo Bagni, Luca Visentin, Francesco di Costanzo, Luca Munaron, Annarosa Arcangeli
Summary: In melanoma, immune response and proteasome are associated with tumor development, while genes related to cytosolic ribosomes show a downregulated trend, and transcripts coding for mitoribosome proteins show the opposite trend.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Madiha Naseem, Shu Cao, Dongyun Yang, Joshua Millstein, Alberto Puccini, Fotios Loupakis, Sebastian Stintzing, Chiara Cremolini, Ryuma Tokunaga, Francesca Battaglin, Shivani Soni, Martin D. Berger, Afsaneh Barzi, Wu Zhang, Alfredo Falcone, Volker Heinemann, Heinz-Josef Lenz
Summary: In this study, the random survival forests (RSF) method was used to identify predictive markers of overall survival (OS) and progression-free survival (PFS) in mCRC patients treated with FOLFIRI/bevacizumab. The results show that SNPs in the Wnt/β-catenin and tumor associated macrophage pathways are strong predictors of OS and PFS in mCRC patients, regardless of KRAS status, while a SNP in the sex-differentiation pathway gene DMRT1 is strongly predictive of OS and PFS in KRAS mutant mCRC patients. RSF is highlighted as a useful method for identifying predictive SNPs in multiple pathways.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Wensheng Zhang, Kun Zhang
Summary: This study identified a 25-gene signature for BCR prediction in PCa patients with Gleason score >= 7, based on genes associated with TP53 mutation statuses. The signature showed promising predictive power in both the TCGA-PRAD dataset and five external datasets, indicating its potential for improving prognostic tools in PCa and other cancers.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Kuo-Hsing Chen, Chia-Lang Hsu, Yu-Li Su, Chang-Tsu Yuan, Liang-In Lin, Jia-Huei Tsai, Yi-Hsin Liang, Ann-Lii Cheng, Kun-Huei Yeh
Summary: This study found that the immune contexture in the tumor microenvironment is closely associated with prognosis in patients with metastatic BRAF V600E mutant colorectal cancer. High expression of immune genes and complement activation are correlated with poor prognosis, and the complement score is strongly correlated with tumor-associated macrophage M2 signatures.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Matthew C. Morris, Thomas M. Russell, Cole A. Lyman, Wesley K. Wong, Gordon Broderick, Maureen C. Ferran
Summary: This study investigates the role of the matrix (M) protein in infection and immune evasion of vesicular stomatitis virus (VSV). Different strains of VSV with wild-type (wt) or mutant M proteins were analyzed to understand their impact on immune response. The findings provide insights into the mechanisms of immune evasion by VSV.
Article
Oncology
Abigail L. Miller, Naiara Perurena, Alycia Gardner, Toshinori Hinoue, Patrick Loi, Peter W. Laird, Karen Cichowski
Summary: DAB2IP is a tumor suppressor that is mutated or silenced in colorectal cancers with KRAS or BRAF mutations. Its loss promotes tumor development by activating RAS proteins and triggering inflammatory mediators and protumorigenic macrophage recruitment.
Article
Microbiology
Tobias B. Alter, Lars M. Blank, Birgitta E. Ebert
Summary: Proteins play a crucial role in shaping microbial phenotypes, and optimal protein allocation is important for maximizing proliferation rates and adaptive responses to environmental changes. A protein allocation model (PAM) improves the predictability of metabolic responses to genetic perturbations and correctly reflects metabolic responses to changes in protein burden, advancing the accuracy of simulated phenotypes and intracellular flux distributions of E. coli. By integrating protein allocation constraints into classical constraint-based models, it enhances predictive capabilities and enables applications for strain analysis and metabolic engineering purposes.
Article
Oncology
Giulia Cerretti, Diego Cecchin, Luca Denaro, Mario Caccese, Marta Padovan, Vittorina Zagonel, Giuseppe Lombardi
Summary: This study reports a case of a 42-year-old patient with BRAF(V600E) mutant and SOX2 amplification glioblastoma who showed a radiologic and metabolic complete response to personalized treatment with dabrafenib, trametinib, and silybin. Personalized treatment with BRAF and MEK inhibitors showed promising activity in patients with BRAF(V600E) mutant glioblastoma, and silybin may play an important role in reducing drug resistance, especially in patients with SOX2 amplification.
Article
Biotechnology & Applied Microbiology
Xingguo Zhang, Manish K. Pandey, Jianping Wang, Kunkun Zhao, Xingli Ma, Zhongfeng Li, Kai Zhao, Fangping Gong, Baozhu Guo, Rajeev K. Varshney, Dongmei Yin
Summary: The study provides the first 3D genome architecture maps in wild type and mutant allotetraploid peanut lines, revealing A/B compartments and topologically associated domains (TADs). A specific TAD in the mutant line generates different chromatin loops, potentially regulating gene expression and leading to dwarfism in plants.
