4.7 Meeting Abstract

Final results from PRIME: Randomized phase III study of panitumumab (pmab) with FOLFOX4 for first line metastatic colorectal cancer (mCRC)

期刊

JOURNAL OF CLINICAL ONCOLOGY
卷 29, 期 15, 页码 -

出版社

AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/jco.2011.29.15_suppl.3510

关键词

-

类别

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Surgery

Prognostic Significance of Negative Lymph Node Long Axis in Esophageal Cancer Results From the Randomized Controlled UK MRC OE02 Trial

Maximilian Kloft, Jessica E. Ruisch, Gayatri Raghuram, Jake Emmerson, Matthew Nankivell, David Cunningham, William H. Allum, Ruth E. Langley, Heike I. Grabsch

Summary: This study analyzed the relationship between negative lymph node size and overall survival in esophageal cancer patients. It found that large negative lymph node size is associated with better survival and may serve as a new prognostic biomarker. Further studies are needed to confirm these findings and explore the underlying biological mechanisms.

ANNALS OF SURGERY (2023)

Article Oncology

The Cancer Hub Approach for Upper Gastrointestinal Surgery During COVID-19 Pandemic: Outcomes from a UK Cancer Centre

Joseph P. Doyle, Pranav H. Patel, Sophie L. F. Doran, Long R. Jiao, David Cunningham, David Nicol, Vasileios K. Mavroeidis, William H. Allum, Asif M. Chaudry, Ricky H. Bhogal, Sacheen Kumar

Summary: This article describes the operational set-up and outcomes for upper gastrointestinal cancer resections performed during the COVID-19 pandemic. The study shows that the RM Partners Cancer Hub approach is a safe strategy for continuing upper gastrointestinal resectional surgery during periods of healthcare service disruption, with good short-term survival outcomes.

ANNALS OF SURGICAL ONCOLOGY (2023)

Editorial Material Oncology

The Cancer Hub Approach for Upper Gastrointestinal Surgery During COVID-19 Pandemic: Outcomes from a UK Cancer Centre

Joseph P. Doyle, Pranav H. Patel, Sophie L. F. Doran, Long R. Jiao, David Cunningham, David Nicol, Vasileios K. Mavroeidis, William H. Allum, Asif M. Chaudry, Ricky H. Bhogal, Sacheen Kumar

ANNALS OF SURGICAL ONCOLOGY (2023)

Editorial Material Hematology

A rare case of primary cutaneous-anaplastic large cell lymphoma (PC-ALCL) localized to the eyelid

Bambang Atmaja, Thomas Millard, Andrew Wotherspoon, Ayoma D. Attygalle, David Cunningham, Bhupinder Sharma

BRITISH JOURNAL OF HAEMATOLOGY (2023)

Article Oncology

Pathological regression of primary tumour and metastatic lymph nodes following chemotherapy in resectable OG cancer: pooled analysis of two trials

Avani Athauda, Matthew Nankivell, Rupert Langer, Susan Pritchard, Ruth E. Langley, Katharina von Loga, Naureen Starling, Ian Chau, David Cunningham, Heike I. Grabsch

Summary: No definitive largescale data exist evaluating the role of pathologically defined regression changes within the primary tumour and lymph nodes (LN) of resected oesophagogastric (OG) adenocarcinoma following neoadjuvant chemotherapy and the impact on survival.

BRITISH JOURNAL OF CANCER (2023)

Letter Oncology

Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer

Mary Y. Wu, Scott T. C. Shepherd, Annika Fendler, Edward J. Carr, Lewis Au, Ruth Harvey, Giulia Dowgier, Agnieszka Hobbs, Lou S. Herman, Martina Ragno, Lorin Adams, Andreas M. Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Nicola O'Reilly, Philip Bawumia, Callie Smith, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Stephanie Hepworth, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Bryan Williams, Michael Brown, Simon Caidan, Mike Gavrielides, James I. MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O'Flaherty, Sanjay Popat, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J. S. Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L. V. Bauer, George Kassiotis, Michael Howell, Susanna Walker, Emma Nicholson, James Larkin, Emma C. Wall, Samra Turajlic

CANCER CELL (2023)

Article Surgery

The influence of procedural volume on short-term outcomes for robotic pancreatoduodenectomy-a cohort study and a learning curve analysis

Michal Kawka, Tamara M. H. Gall, Fiona Hand, Scarlet Nazarian, David Cunningham, David Nicol, Long R. Jiao

Summary: This study retrospectively analyzed 60 cases of robotic pancreatoduodenectomy (RPD) and found a significant decrease in operative time after 21 RPD cases. This suggests that technical proficiency in RPD improves after a certain number of procedures have been performed.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2023)

Article Oncology

Individual Participant Data Network Meta-Analysis of Neoadjuvant Chemotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal Junction Carcinoma

Matthieu Faron, Maurice Cheugoua-Zanetsie, Jayne Tierney, Pierre Thirion, Matthew Nankivell, Kathryn Winter, Hong Yang, Joel Shapiro, Dewi Vernerey, B. Mark Smithers, Thomas Walsh, Guillaume Piessen, Magnus Nilsson, Jurjen Boonstra, Marc Ychou, Simon Law, David Cunningham, Florent de Vathaire, Michael Stahl, Susan Urba, Michele Valmasoni, Daniele Williaume, Janine Thomas, Florian Lordick, Joel Tepper, Jack Roth, Val Gebski, Bryan Burmeister, Xavier Paoletti, Johanna van Sandick, Jianhua Fu, Jean-Pierre Pignon, Michel Ducreux, Stefan Michiels

Summary: This study conducted an individual participant data network meta-analysis to determine the optimal neoadjuvant treatment for resectable carcinoma of the thoracic esophagus or gastroesophageal junction. The results showed that chemotherapy or chemoradiotherapy had better outcomes compared to upfront surgery alone, with variations in treatment effects observed based on tumor location and histology subgroups.

JOURNAL OF CLINICAL ONCOLOGY (2023)

Article Oncology

Pathologic Lymph Node Regression After Neoadjuvant Chemotherapy Predicts Recurrence and Survival in Esophageal Adenocarcinoma: A Multicenter Study in the United Kingdom

Jonathan L. Moore, Michael Green, Aida Santaolalla, Harriet Deere, Richard P. T. Evans, Mona Elshafie, Anita Lavery, Damian T. McManus, Andrew McGuigan, Rosalie Douglas, Joanne Horne, Robert Walker, Hira Mir, Monica Terlizzo, Sivesh K. Kamarajah, Mieke Van Hemelrijck, Nick Maisey, Ailsa Sita-Lumsden, Sarah Ngan, Mark Kelly, Cara R. Baker, Sacheen Kumar, Jesper Lagergren, William H. Allum, James A. Gossage, Ewen A. Griffiths, Heike I. Grabsch, Richard C. Turkington, Tim J. Underwood, Elizabeth C. Smyth, Rebecca C. Fitzgerald, David Cunningham, Andrew R. Davies

Summary: This study aimed to evaluate the influence of lymph node (LN) regression on survival after surgery for esophageal adenocarcinoma. The results showed that patients with complete LN regression, partial LN regression, or negative LNs had a lower mortality rate compared to those with poor/no LN regression.

JOURNAL OF CLINICAL ONCOLOGY (2023)

Article Medicine, General & Internal

Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C

Marwan G. Fakih, Lisa Salvatore, Taito Esaki, Dominik P. Modest, David P. Lopez-Bravo, Julien Taieb, Michalis V. Karamouzis, Erika Ruiz-Garcia, Tae-Won Kim, Yasutoshi Kuboki, Fausto Meriggi, David Cunningham, Kun-Huei Yeh, Emily Chan, Joseph Chao, Yaneth Saportas, Qui Tran, Chiara Cremolini, Filippo Pietrantonio

Summary: In this study, the combination of KRAS G12C inhibitor sotorasib and EGFR inhibitor panitumumab showed longer progression-free survival compared to standard treatment in patients with chemorefractory metastatic colorectal cancer.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

Article Oncology

PARP inhibition utilized in combination therapy with Olaparib-Temozolomide to achieve disease stabilization in a rare case of BRCA1-mutant, metastatic myxopapillary ependymoma

Preethika Mahalingam, Sam Smith, Juanita Lopez, Rajaei K. Sharma, Thomas Millard, Khin Thway, Cyril Fisher, David A. Reardon, Robin Jones, Andrew G. Nicholson, David Cunningham, Liam Welsh, Bhupinder Sharma

Summary: Myxopapillary ependymoma (MPE) is a primary CNS tumor characterized by its indolent malignancy involving the spinal conus medullaris, Filum terminale or cauda equina. We report a rare case of MPE recurring in the pelvic soft tissue and metastasizing to the pleura and lungs. Despite resistance to multiple treatments, including surgery, radiotherapy, chemotherapy, and temozolomide, the combination regimen of olaparib-temozolomide (OT) targeting somatic BRCA1 mutations has achieved stable disease after 10 cycles.

RARE TUMORS (2023)

Meeting Abstract Oncology

Clonal mutation burden and evolutionary dynamics analysis in metastatic gastro-esophageal adenocarcinoma (GEA) by error corrected whole-exome circulating tumor DNA sequencing

Neil McCafferty, Caroline Fong, Louise J. Barber, Andrew Woolston, Dimitrios Kleftogiannis, Taqia Rana, Susan Cromarty, Shannon Kidd, Ruwaida Begum, Ian Chau, Naureen Starling, David Cunningham, Marco Gerlinger

CANCER RESEARCH (2023)

Meeting Abstract Oncology

Circulating tumor DNA for recurrence prediction and efficacy analysis in the ICONIC trial of peri-operative FLOT and avelumab (PD-L1) in localized esophago-gastric adenocarcinoma

Marco Gerlinger, Anderley Gordon, Louise J. Barber, Georgios Laliotis, Avani Athauda, Benjamin Challoner, Andrew Woolston, Sonia Mansukhani, Matt Dunstan, Nikoletta Petrou, Komel Khabra, Retchel Lazaro-Alcausi, Richard Crux, Victoria Borja, Ruwaida Begum, Isma Rana, Charuta Palsuledesai, Meenakshi Malhotra, Minetta Liu, Adham Jurdi, Shruti Sharma, Sheela Rao, Sacheen Kumar, David Cunningham, Ian Chau, Naureen Starling, M. Asif Chaudry

CANCER RESEARCH (2023)

Article Engineering, Biomedical

Robotic versus freehand CT-guided radiofrequency ablation of pulmonary metastases: a comparative cohort study

Edward W. Johnston, Jodie Basso, Francisca Silva, Arafat Haris, Robin L. Jones, Nasir Khan, Helen Lawrence, Jakob Mathiszig-Lee, James McCall, David C. Cunningham, Nicos Fotiadis

Summary: The purpose of this study was to evaluate the feasibility, safety, and accuracy of robotic radiofrequency ablation (RFA) for pulmonary metastases compared to conventional freehand placement. The study found that robotic RFA was technically successful with high accuracy and fewer manipulations, leading to improved safety and reduced complications compared to freehand placement.

INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY (2023)

Article Oncology

MicroRNAs as biomarkers for trastuzumab-based therapy in HER2-positive advanced oesophago-gastric cancer patients

Hazel Lote, Florentia Mousoullou, George Vlachogiannis, Andrea Lampis, Laura Satchwell, Clare Peckitt, Caroline Fong, Ruwaida Begum, Shannon Kidd, Susan Cromarty, Anderley Gordon, Charlotte Fribbens, Sheela Rao, Naureen Starling, Ian Chau, David Cunningham, Nicola Valeri

Summary: This study identified miR-148a-3p as a potential biomarker for trastuzumab-based therapy in HER2-positive oesophago-gastric cancer patients. The results showed that the expression level of miR-148a-3p is associated with patient survival and progression rates.

FRONTIERS IN ONCOLOGY (2023)

暂无数据