Article
Oncology
Jemma M. Boyle, Angela Kuryba, Thomas E. Cowling, Jan van der Meulen, Nicola S. Fearnhead, Kate Walker, Michael S. Braun, Ajay Aggarwal
Summary: Completing all cycles of oxaliplatin-based adjuvant chemotherapy was associated with improved cancer-specific survival in real-world practice, but patients completing less than 50% of cycles had poor outcomes.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Ji Ha Lim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Jung Kyong Shin
Summary: This study compared the oncologic outcomes between patients with incomplete obstructive colon cancer (IOCC) and non-obstructive colon cancer (NOCC) according to tumor location. The results showed that patients with IOCC had significantly worse survival outcomes than those with NOCC. Stage II IOCC patients and stage III NOCC patients had similar survival rates. The location of the tumor, especially on the right side, affected the survival outcomes. These findings highlight the importance of considering incomplete obstruction and tumor location in assessing prognosis for colon cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Farah El-Sharkawy, Vadim Gushchin, Timothy A. Plerhoples, Chang Liu, Erica L. Emery, Devon T. Collins, Lana Bijelic
Summary: Minimally invasive surgery (MIS) is preferred for T1-T3 colon cancer resection due to better short and long-term outcomes, while recommendations for T4 cancers are still controversial. Studies show that MIS is associated with improved postoperative mortality, survival rates, and other outcomes for T4 colon cancer patients compared to open surgery (OS).
Article
Gastroenterology & Hepatology
Jacopo Crippa, Fabian Grass, Pietro Achilli, Kevin T. Behm, Kellie L. Mathis, Courtney N. Day, William S. Harmsen, Giulio M. Mari, David W. Larson
Summary: This study aimed to compare segmental resection versus extended colectomy for transverse colon cancer in terms of oncological outcomes. The results showed that extended colectomy did not provide a survival advantage compared with segmental resection, and was associated with slightly poorer survival in mid transverse cancers and locally advanced tumors.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Oncology
Atieh Akbari, Maryam Khayamzadeh, Reza Salmanian, Afshin Moradi, Mohammad Esmaeil Akbari
Summary: This study aimed to estimate the survival rate of cervical cancer (CC) and the reasons for its low survival rate based on the data retrieved from the Iranian National Cancer Registry System. The study found that the survival rate of CC in Iran is low and is related to biological factors, geographical, and sociodemographic indices. Effective screening based on cultural and sociodemographic issues is recommended.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Li-Chun Chang, Chia-Tung Shun, Been-Ren Lin, Silvia Sanduleanu, Weng-Feng Hsu, Ming-Shiang Wu, Han-Mo Chiu
Summary: A study conducted at the National Taiwan University Hospital from 2005 to 2014 compared the disease-free survival of T1 cancer arising from the rectum versus the colon. The results showed that T1 rectal cancer had a higher risk of recurrence compared to T1 colon cancer, with rectal location being an independent risk factor for recurrence. Further research is needed to explore whether adjuvant therapy or closer surveillance can reduce the risk of recurrence in T1 rectal cancer.
Article
Surgery
Rachel Gefen, Sameh Hany Emile, Nir Horesh, Zoe Garoufalia, Steven D. Wexner
Summary: By analyzing a large database, this study found age-related disparities in characteristics, treatments, and outcomes of colorectal cancer.
Article
Multidisciplinary Sciences
Taylor D. Ottesen, Blake N. Shultz, Alana M. Munger, Michael Amick, Courtney S. Toombs, Gary E. Friedaender, Jonathan N. Grauer
Summary: This study analyzed the long-term survival and treatment outcomes of chondrosarcoma patients using the National Cancer Database. The results showed that appendicular chondrosarcoma patients had higher survival rates compared to axial chondrosarcoma patients. Surgical treatment remains the mainstay for both types of chondrosarcoma, although there has been insignificant improvement in survival over the last decade.
Article
Oncology
Nicola Hodges, Hugh Mackenzie, Nigel D'Souza, Gina Brown, Danilo Miskovic
Summary: This study evaluated 5-year overall survival in patients operated on for potentially curable right versus left-sided colon cancer and rectal cancer in England. The results showed a significant difference in survival between patients with right and left-sided colon cancers, with superior overall survival for patients with left-sided colon cancer across all stages.
Article
Oncology
Saeed Nemati, Elnaz Saeedi, Fereshte Lotfi, Azin Nahvijou, Elham Mohebbi, Zahra Ravankhah, Abbas Rezaeianzadeh, Majid Yaghoobi-Ashrafi, Habbiballah Pirnejad, Arash Golpazir, Roya Dolatkhah, Saba Alvand, Seyed Vahid Ahmadi-Tabatabaei, Maria Cheraghi, Elisabete Weiderpass, Freddie Bray, Michel P. Coleman, Arash Etemadi, Ardeshir Khosravi, Farid Najafi, Mohammad Ali Mohagheghi, Gholamreza Roshandel, Reza Malekzadeh, Kazem Zendehdel
Summary: A national cancer survival study in Iran revealed that Iranian cancer patients have relatively low 5-year survival rates compared to high-income countries. Breast and prostate cancers had the highest survival rates, while pancreatic, lung, liver, stomach, and esophageal cancers had very low survival rates.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Chien-Yi Yang, Min-Hsuan Yen, Kee-Thai Kiu, Yu-Ting Chen, Tung-Cheng Chang
Summary: This study compared the outcomes of right-sided colon cancer (RCC) and left-sided colon cancer (LCC). The results showed no significant difference in overall survival or time to recurrence between patients with RCC and LCC. However, in stage II colon cancer patients, RCC was associated with shorter time to recurrence.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Thais Reif de Paula, Deborah S. Keller
Summary: This study aimed to evaluate the use of adjuvant chemotherapy and its impact on overall survival in pT4N0M0 colon cancer patients. The study found that although adjuvant chemotherapy is associated with improved overall survival, its compliance is low. There is a complex relationship between payor, income, comorbidity, and adjuvant chemotherapy receipt.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Otorhinolaryngology
Alex Yang, Priscilla Tanamal, Kathleen Tibbetts, Baran Sumer, James-Michael Blackwell, Kelly Schostag, David Sher, Andrew Day
Summary: The incidence of laryngeal cancer is increasing in young patients, and there are differences in characteristics and outcomes compared to older patients. Female young patients and those with high-risk HPV-positive tumors have a higher proportion. Higher income in female patients is associated with a decreased risk of overall mortality. Patients with high-risk HPV-positive tumors have a reduced risk of all-cause mortality.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Han-Ching Chan, Chi-Cheng Huang, Ching-Chieh Huang, Amrita Chattopadhyay, Kuan-Hung Yeh, Wen-Chung Lee, Chun-Ju Chiang, Hsin-Ying Lee, Skye Hung-Chun Cheng, Tzu-Pin Lu
Summary: Colon cancer is the third most incident and life-threatening cancer in Taiwan. This study developed accurate prognostic models for colon cancer patients using clinicopathological variables. The proposed models showed robust prediction performance and could potentially improve treatment plans for colon cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Chang Woo Kim, Seung Yoon Yang, Hyuk Hur
Summary: This study compared the long-term postoperative and oncologic outcomes as well as perioperative outcomes between single-incision laparoscopic surgery (SILS) and conventional laparoscopic surgery (CLS) for colon cancer. The results showed that SILS appeared to be safe and effective compared to CLS, with shorter total incision length, less postoperative pain, and similar rates of incisional hernia. The 7-year overall and disease-free survival rates were also similar between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Harry H. Yoon, David Tougeron, Qian Shi, Steven R. Alberts, Michelle R. Mahoney, Garth D. Nelson, Suresh G. Nair, Stephen N. Thibodeau, Richard M. Goldberg, Daniel J. Sargent, Frank A. Sinicrope
CLINICAL CANCER RESEARCH
(2014)
Article
Oncology
Dan Sha, Adam M. Lee, Qian Shi, Steven R. Alberts, Daniel J. Sargent, Frank A. Sinicrope, Robert B. Diasio
CLINICAL CANCER RESEARCH
(2014)
Article
Oncology
Jocelin Huang, Suresh G. Nair, Michelle R. Mahoney, Garth D. Nelson, Anthony F. Shields, Emily Chan, Richard M. Goldberg, Sharlene Gill, Morton S. Kahlenberg, James T. Quesenberry, Stephen N. Thibodeau, Thomas C. Smyrk, Axel Grothey, Frank A. Sinicrope, Thomas A. Webb, Gist H. Farr, Barbara A. Pockaj, Jeffrey L. Berenberg, Margaret Mooney, Daniel J. Sargent, Steven R. Alberts
CLINICAL COLORECTAL CANCER
(2014)
Article
Medicine, Research & Experimental
Ming-Wen An, Sumithra J. Mandrekar, Martin J. Edelman, Daniel J. Sargent
CONTEMPORARY CLINICAL TRIALS
(2014)
Article
Oncology
Yan Liu, Saskia Litiere, Elisabeth G. E. de Vries, Daniel Sargent, Lalitha Shankar, Jan Bogaerts, Lesley Seymour
EUROPEAN JOURNAL OF CANCER
(2014)
Article
Oncology
Saskia Litiere, Elisabeth G. E. de Vries, Lesley Seymour, Dan Sargent, Lalitha Shankar, Jan Bogaerts
EUROPEAN JOURNAL OF CANCER
(2014)
Article
Pharmacology & Pharmacy
Sin-Ho Jung, Daniel J. Sargent
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2014)
Article
Oncology
Sumithra J. Mandrekar, Ming-Wen An, Jeffrey Meyers, Axel Grothey, Jan Bogaerts, Daniel J. Sargent
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Article
Oncology
Dan Rosmarin, Claire Palles, David Church, Enric Domingo, Angela Jones, Elaine Johnstone, Haitao Wang, Sharon Love, Patrick Julier, Claire Scudder, George Nicholson, Anna Gonzalez-Neira, Miguel Martin, Daniel Sargent, Erin Green, Howard McLeod, Ulrich M. Zanger, Matthias Schwab, Michael Braun, Matthew Seymour, Lindsay Thompson, Benjamin Lacas, Valerie Boige, Nuria Ribelles, Shoaib Afzal, Henrik Enghusen, Soren Astrup Jensen, Marie-Christine Etienne-Grimaldi, Gerard Milano, Mia Wadelius, Bengt Glimelius, Hans Garmo, Milena Gusella, Thierry Lecomte, Pierre Laurent-Puig, Eva Martinez-Balibrea, Rohini Sharma, Jesus Garcia-Foncillas, Zdenek Kleibl, Alain Morel, Jean-Pierre Pignon, Rachel Midgley, David Kerr, Ian Tomlinson
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Article
Health Care Sciences & Services
Jeff A. Sloan, Daniel J. Sargent, Paul J. Novotny, Paul A. Decker, Randolph S. Marks, Heidi Nelson
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2014)
Article
Oncology
Xavier Paoletti, Koji Oba, Yung-Jue Bang, Harry Bleiberg, Narikazu Boku, Olivier Bouche, Paul Catalano, Nozomu Fuse, Stefan Michiels, Markus Moehler, Satoshi Morita, Yasuo Ohashi, Atsushi Ohtsu, Arnaud Roth, Philippe Rougier, Junichi Sakamoto, Daniel Sargent, Mitsuru Sasako, Kohei Shitara, Peter Thuss-Patience, Eric Van Cutsem, Tomasz Burzykowski, Marc Buyse
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2013)
Article
Multidisciplinary Sciences
Hanna K. Sanoff, Lindsay A. Renfro, Pradeep Poonnen, Pratibha Ambadwar, Daniel J. Sargent, Richard M. Goldberg, Howard McLeod
Article
Mathematical & Computational Biology
A. S. C. Conlon, J. M. G. Taylor, D. J. Sargent
STATISTICS IN MEDICINE
(2014)
Article
Computer Science, Interdisciplinary Applications
L. A. Renfro, Q. Shi, Y. Xue, J. Li, H. Shang, D. J. Sargent
COMPUTATIONAL STATISTICS & DATA ANALYSIS
(2014)
Article
Oncology
Thierry Andre, Timothy Iveson, Roberto Labianca, Jeffrey A. Meyerhardt, Ioannis Souglakos, Takayuki Yoshino, James Paul, Alberto Sobrero, Julien Taieb, Anthony F. Shields, Atsushi Ohtsu, Axel Grothey, Daniel J. Sargent
CURRENT COLORECTAL CANCER REPORTS
(2013)