Article
Clinical Neurology
Jia Huang, Yiyun Cai, Yousong Su, Min Zhang, Yifan Shi, Na Zhu, Feng Jin, Daihui Peng, Yiru Fang
Summary: The study found that over 70% of depressive episode patients have gastrointestinal symptoms, and a higher frequency of these symptoms is associated with suicide ideation, anxiety, insomnia, and body pain. There are moderate but significant associations between gastrointestinal symptoms and psychological characteristics.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Shu-Juan Liu, Zhen-Zhen Liu, Ze-Ying Wang, Bao-Peng Liu, Shuo Cheng, Xianchen Liu, Cun-Xian Jia
Summary: The study found that symptoms of sleep disordered breathing (SDB) are an independent and significant predictor of depressive symptoms in adolescents. 4.5% of adolescents had persistent depressive symptoms, and the incidence rate of depressive symptoms at 1-year follow-up was 6.5%. Elevated frequency of any SDB symptoms was significantly associated with incident depressive symptoms after adjusting for potential confounders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Christine M. Ramsey, Kevin G. Lynch, Philip R. Gehrman, Srinivasan Vairavan, Vaibhav A. Narayan, Qingqin S. Li, David W. Oslin
Summary: This study examines the association between daily step count and depressive symptoms in outpatients with moderate-to-severe depression. The findings provide a metric for individuals with clinically significant MDD and can inform future trials aiming to determine the amount of daily activity needed to improve symptoms in individuals with MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Esmee A. Bickel, Anouk M. Auener, Adelita Ranchor, Joke Fleer, Maya J. Schroevers
Summary: The study found that cancer patients' perceptions of depressive symptoms play a mediating role in the relationship between depressive symptoms and perceived need for psychological care. Specifically, cognitive perceptions had a significant impact on care needs.
Article
Biochemistry & Molecular Biology
Neza Brezovec, Katja Perdan-Pirkmajer, Blaz Burja, Ziga Rotar, Josko Osredkar, Snezna Sodin-Semrl, Katja Lakota, Sasa Cucnik
Summary: The balance between reactive oxygen species and antioxidant defense is disrupted in oxidative stress. This study examined the oxidative balance in systemic sclerosis (SSc) patients and healthy controls, and found high levels of reactive oxidative metabolites (ROMs) in both groups. However, SSc patients had significantly higher total antioxidant capacity (TAC) and oxidative stress index, indicating an increased antioxidant capacity. Although there was no difference in lipid peroxidation or oxidative DNA damage, SSc patients had more leukocyte DNA breaks, especially those treated with immunosuppressives.
Article
Clinical Neurology
Lei Hu, Zhen-Zhen Liu, Zi-Yang Wang, Cun-Xian Jia, Xianchen Liu
Summary: In Chinese adolescents, there is a significant association between headache, stomachache, and other nonspecific pain with depressive symptoms. Increased pain frequencies are significantly linked to higher prevalence and incidence rates of depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Xiaoya Fu, Yudan Ding, Jindong Chen, Feng Liu, Huabing Li, Jingping Zhao, Wenbin Guo
Summary: This study revealed the influence of comorbid gastrointestinal symptoms on functional asymmetry in major depressive disorder (MDD) patients. Increased parameter of asymmetry (PAS) scores in the left inferior frontal gyrus (IFG) and superior medial prefrontal cortex (MPFC) might represent an unbalanced regulation of brain over gastrointestinal function and could be regarded as distinctive features related to functional gastrointestinal symptoms in MDD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Adriana Munhoz Carneiro, Danilo Assis Pereira, Fernando Fernandes, Makilim Nunes Baptista, Andre Russowsky Brunoni, Ricardo Alberto Moreno
Summary: This study investigates the mediating role of distorted thoughts in Major Depressive Disorder (MDD) and its impact on perceptions of depression severity and treatment response.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Article
Psychology, Multidisciplinary
Liisa Lehtonen, Siri Lillieskold, Kris De Coen, Liis Toome, Ana Gimeno, Sylvia Caballero, Rasa Tameliene, Sabine Laroche, Jana Retpap, Hege Grundt, Marie-Rose Van Hoestenberghe, Caryl Skene, Bernd Pape, Anna Axelin
Summary: This study aimed to assess the association between early parent-infant closeness and later depressive symptoms among parents of preterm infants. The results showed no significant association between the duration of parent-infant closeness in the neonatal unit and parents' depressive symptoms.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Xueling Ren, Shengshu Wang, Yan He, Junsong Lian, Qian Lu, Yanhong Gao, Yuling Wang
Summary: The study found that patients with chronic lung diseases are more likely to experience depressive symptoms, with a higher incidence rate of the disease. Additionally, individuals who smoke, are male, live in rural areas, have dyslipidemia, and suffer from comorbidities are also more likely to experience depressive symptoms.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Xiaosi Huang, Shunkai Lai, Xiaodan Lu, Ying Wang, Yiliang Zhang, Guanmao Chen, Pan Chen, Kaiwei Ye, Manying Duan, Kailin Song, Shuming Zhong, Yanbin Jia
Summary: This study reveals the features and correlation between cognitive impairments and brain biochemical abnormalities in depressed patients with gastrointestinal symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pediatrics
Laura Bechtiger, Annekatrin Steinhoff, Jessica M. Dollar, Susan D. Calkins, Susan P. Keane, Lenka Shriver, Laurie Wideman, Lilly Shanahan
Summary: The study found that maternal depressive symptoms in early, middle, and adolescence stages are directly and indirectly associated with adolescents' unhealthy behaviors. Promoting mothers' mental health is crucial for promoting children's health behaviors and overall health.
Article
Geriatrics & Gerontology
Ying Lian, Gang-Pu Wang, Guo-Qiang Chen, Cun-Xian Jia
Summary: This study found bidirectional associations between handgrip strength and depressive symptoms, showing a dose-response pattern. Decreased handgrip strength was related to increased risk of depressive symptoms, while depressive symptoms were associated with decreased handgrip strength.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Psychology, Developmental
Tom ter Bogt, William W. Hale, Natale Canale, Massimiliano Pastore, Alessio Vieno
Summary: Identification with Goth youth culture has been linked to higher levels of depression, self-harm, and suicide ideation. However, it may be challenging to assess this identification due to the stigma surrounding Goth culture. Adolescents who like Goth music have been found to experience increased levels of depressive symptoms as they age, suggesting that music preferences can serve as an early indicator of potential depressive symptoms in adolescents. The mechanisms behind how music preferences may contribute to or sustain depressive symptoms are also discussed in the study.
JOURNAL OF YOUTH AND ADOLESCENCE
(2021)
Article
Psychiatry
Huijie Lei, Qinghua Zhang, Zhi Wang, Jingjin Shao
Summary: The study found that there was no linear change in depressive symptoms among Chinese left-behind children, but there was a linear decrease in delinquency over time. The patterns of change in delinquency varied across parental migration status and gender, with left-behind children whose mothers migrated showing higher initial symptoms.
PSYCHIATRY RESEARCH
(2021)
Review
Health Care Sciences & Services
Mohamed Abdelaal, Jonathan Avery, Ronald Chow, Nasreen Saleem, Rouhi Fazelzad, Pamela Mosher, Breffni Hannon, Camilla Zimmermann, Ahmed Al-Awamer
Summary: This scoping review examined the palliative and end-of-life care needs and experiences of adolescents and young adults with advanced life-limiting illnesses. The findings highlight the differences in palliative care experiences and knowledge gaps for this underserved patient population, emphasizing the need for further research and tailored palliative care programs.
PALLIATIVE MEDICINE
(2023)
Article
Oncology
Jeff Dunn, Gary Rodin
Summary: This Special Issue focuses on challenges and opportunities in providing psychosocial care to patients in low and middle-income countries (LMICs). It aims to highlight disparities in care and showcase efforts to address this gap. The papers in this issue emphasize research and interventions to improve the psychological well-being and quality of life of cancer patients and their families in LMICs.
Review
Oncology
Jacqueline Alcalde Castro, Breffni Hannon, Camilla Zimmermann
Summary: While the benefits of early palliative care are clear, current evidence is limited to resource-rich urban areas in high-income countries, which cannot be scaled internationally. In order to provide support to all patients with advanced cancer, family physicians and oncology clinicians, in addition to specialist palliative care clinicians, need training and mentorship. Care models that ensure seamless palliative care across settings and clear communication between clinicians are crucial. Further exploration of the unique needs of patients with hematological malignancies and modification of existing palliative care models is necessary. Equitable and culturally sensitive care delivery is important, requiring the development of context-specific palliative care models worldwide.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Rachel Sue-A-Quan, Anna Sorensen, Samantha Lo, Ashley Pope, Nadia Swami, Gary Rodin, Breffni Hannon, Kirsten Wentlandt, Camilla Zimmermann
Summary: Canadian palliative care physicians believe that providing early palliative care requires clear role delineation, needs-dependent shared care, adequate resource support, and addressing misconceptions about palliative care. Changes are needed at the level of referral systems, healthcare providers, resources, and policies to enable the implementation of early palliative care.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Tadahiro Yamazaki, Seraki Miyamoto, Toshio Matsubara, Hiroshi Yamagata, Hiroshi Kobo, Makoto Otani, Hiroaki Abe, Masahiko Sumitani, Ken Shimizu, Gary Rodin, Kazuhiro Yoshiuchi
Summary: The study tested the reliability and validity of the Japanese translated version of QUAL-EC (QUAL-EC-J) for assessing the quality of life for cancer patients near the end of life. The QUAL-EC-J showed a three-factor structure with acceptable reliability and sufficient validity.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Kirsten Wentlandt, Kayla T. Wolofsky, Andrea Weiss, Lindsay Hurlburt, Eddy Fan, Camilla Zimmermann, Sarina R. Isenberg
Summary: This study describes the delivery of palliative care by primary providers (PP) and specialist providers (SP) to hospitalized patients with COVID-19. The results show that PP and SP provide support in care discussions, symptom management, end-of-life care, and care withdrawal. There are differences in their approach to symptom management, which may impact the consistency and quality of care.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Oncology
Ronald Chow, Jean J. Mathews, Emily YiQin Cheng, Samantha Lo, Joanne Wong, Sorayya Alam, Breffni Hannon, Gary Rodin, Rinat Nissim, Sarah Hales, Dio Kavalieratos, Kieran L. Quinn, George Tomlinson, Camilla Zimmermann
Summary: This study examined the effectiveness of interventions offering support for caregivers of patients with advanced cancer on caregiver quality of life (QOL) and mental health outcomes. The findings suggest that interventions targeting caregivers, dyads, or patients and families can lead to improvements in caregiver QOL and mental health.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Camilla Zimmermann, Ashley Pope, Breffni Hannon, Philippe L. Bedard, Gary Rodin, Neesha Dhani, Madeline Li, Leonie Herx, Monika K. Krzyzanowska, Doris Howell, Jennifer J. Knox, Natasha B. Leighl, Srikala Sridhar, Amit M. Oza, Stephanie Lheureux, Christopher M. Booth, Geoffrey Liu, Jacqueline Alcalde Castro, Nadia Swami, Rachel Sue-A-Quan, Anne Rydall, Lisa W. Le
Summary: This study reports preliminary findings of a mixed methods study involving a randomized controlled trial (RCT) of Symptom screening with Targeted Early Palliative care (STEP) and qualitative interviews. The results showed that STEP was more effective in providing palliative care and improving patient-reported outcomes of quality of life, symptom control, and satisfaction with care compared to usual care.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Health Care Sciences & Services
James H. B. Im, Ronald Chow, Madison Novosel, Jenny Xiang, Michael Strait, Vinay Rao, Jennifer Kapo, Camilla Zimmermann, Elizabeth Prsic
Summary: This study aimed to explore the association between receiving an inpatient palliative care consultation and hospital outcomes, including in-hospital death, ICU use, discharge to hospice, 30-day readmissions, and 30-day ED visits. A retrospective chart review was conducted on medical oncology admissions at Yale New Haven Hospital, with and without palliative care consultations. The results showed that receiving more palliative care consultations was associated with higher odds of hospital death and discharge to hospice, and lower odds of ICU admission, but had no significant association with 30-day readmissions or ED visits.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Health Care Sciences & Services
Mirza Jacqueline Alcalde Castro, Shenhab Zaig, Rinat Nissim, Brenda O'Connor, Jenny Lau, Ernie Mak, Camilla Zimmermann, Breffni Hannon
Summary: This study aimed to explore the most appropriate model of care for in-person versus telehealth visits in outpatient palliative care settings from the perspective of patients. The results indicated that participants endorsed a flexible hybrid approach that incorporates both in-person and telehealth visits.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Health Care Sciences & Services
Michael Bonares, Lisa W. Le, Camilla Zimmermann, Kristen Wentlandt
Summary: Although patients with nonmalignant diseases have similar palliative care needs to cancer patients, they are less likely to receive specialist palliative care. This study compared referral practices to specialist palliative care among cardiologists, respirologists, and oncologists, and found that the perceived availability of specialist palliative care services was higher for cancer patients compared to non-cancer patients.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Denis Qeska, Ronald Chow, Tracy A. Balboni, Jennifer Kapo, Camilla Zimmermann, Elizabeth Prsic
Summary: This study aimed to assess the association between advance care planning (ACP) and outcomes of in-hospital mortality, 30-day hospital readmission, and 30-day emergency department visits among patients with cancer. The study found that patients with documented ACP had lower rates of readmission and ED visits within 30 days. This association was independent of hospice utilization.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Oncology
Joshua D. D. Rosenblat, Froukje E. E. deVries, Zoe Doyle, Roger S. S. McIntyre, Gary Rodin, Camilla Zimmermann, Ernie Mak, Breffni Hannon, Christian Schulz-Quach, Aida Al Kindy, Zeal Patel, Madeline Li
Summary: Ketamine administered through intranasal spray has shown rapid and sustained antidepressant effects in advanced cancer patients suffering from moderate to severe depression. The treatment was well-tolerated with minimal side effects. Further larger-scale controlled trials are needed to confirm these promising findings.