Review
Immunology
Mark Schmitt, Florian R. Greten
Summary: The research on colorectal cancer indicates the importance of an inflammatory microenvironment for tumorigenesis, which influences the activation of immune cells and stromal cells, as well as the role of intestinal microbiome in tumor development. Chronic inflammation can initiate tumorigenesis, and tumor-elicited and therapy-induced inflammation are also implicated in promoting colorectal cancer.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Oncology
Mohd Mughees, Jyoti Bala Kaushal, Gunjan Sharma, Saima Wajid, Surinder Kumar Batra, Jawed Akhtar Siddiqui
Summary: Chemokines play a crucial role in tumorigenesis and cancer progression, particularly in prostate cancer. Inflammatory processes and the secretion of chemokines and cytokines in the tumor microenvironment play a key role in cancer development and treatment resistance.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Gloria Maria Pontes-Quero, Lorena Benito-Garzon, Juan Perez Cano, Maria Rosa Aguilar, Blanca Vazquez-Lasa
Summary: The study encapsulated three hydrophobic anti-inflammatory drugs into core-shell terpolymer nanoparticles, reducing drug cytotoxicity and improving biocompatibility, demonstrating potential for treating inflammatory processes associated with osteoarthritis.
Article
Biochemistry & Molecular Biology
Evgenia Alpert, Armin Akhavan, Arie Gruzman, William J. Hansen, Joshua Lehrer-Graiwer, Steven C. Hall, Eric Johansen, Sean McAllister, Mittul Gulati, Ming-Fong Lin, Vishwanath R. Lingappa
Summary: The study explored the role of human prostatic acid phosphatase (PAcP) in prostate cancer using a proteomics tool called signal sequence swapping. It identified three forms of PAcP with distinct functions, subcellular locations, and properties, one of which (PAcP)-P-PL was found to be correlated with early prostate cancer in clinical specimens. This method demonstrates analytical power and suggests new therapeutic strategies for prostate cancer.
BIOSCIENCE REPORTS
(2021)
Article
Urology & Nephrology
Benjamin C. Fu, Fred K. Tabung, Claire H. Pernar, Weike Wanga, Amparo G. Gonzalez-Feliciano, Ilkania M. Chowdhury-Paulino, Steven K. Clinton, Edmund Folefac, Mingyang Song, Adam S. Kibel, Edward L. Giovannucci, Lorelei A. Mucci
Summary: The study found that a hyperinsulinemic diet was associated with an increased risk of advanced and fatal prostate cancer, while an inflammatory diet was linked to a higher risk of early-onset lethal prostate cancer. These dietary patterns may serve as potential mechanisms connecting diet with aggressive prostate cancer risk.
Review
Medicine, Research & Experimental
Vahid Karpisheh, Seyedeh Mahboubeh Mousavi, Parinaz Naghavi Sheykholeslami, Mehrdad Fathi, Mehran Mohammadpour Saray, Leili Aghebati-Maleki, Reza Jafari, Naime Majidi Zolbanin, Farhad Jadidi-Niaragh
Summary: Treg cells play a critical role in the progression of prostate cancer, with higher levels of Tregs associated with an increased risk of cancer recurrence. Suppressing Tregs or depleting Tregs may be an effective strategy for prostate cancer immunotherapy.
Review
Biochemistry & Molecular Biology
Ekaterina A. Sidorova, Yury V. Zhernov, Marina A. Antsupova, Kamilya R. Khadzhieva, Angelina A. Izmailova, Denis A. Kraskevich, Elena V. Belova, Anton A. Simanovsky, Denis V. Shcherbakov, Nadezhda N. Zabroda, Oleg V. Mitrokhin
Summary: Micro ribonucleic acids (microRNAs or miRNAs) are a subtype of non-coding RNA that play a significant role in regulating gene expression in mammalian cells. They bind to target messenger RNAs (mRNAs) and silence the genes involved, making them important regulators of gene expression. Dysregulation of microRNAs is known to contribute to cancer growth, and specific microRNAs have been identified as potential biomarkers for different types of cancer. This article reviews the roles of microRNAs in breast cancer and prostate cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Shangwei Zhong, Changhao Huang, Zhikang Chen, Zihua Chen, Jun-Li Luo
Summary: Castration-resistant prostate cancer (CRPC) develops from the transformation of androgen-dependent (AD) prostate cancer (PCa) to androgen-independent (AI) PCa under androgen deprivation therapy (ADT). This forced evolutionary process allows AI PCa cells to selectively and dominantly proliferate, making PCa cells and the tumor microenvironment (TME) adapt and reprogram under ADT. Currently, there are no effective therapeutic methods available for the treatment of CRPC, highlighting the importance of targeting inflammatory signaling for the emergence and maintenance of CRPC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Joseph M. Chan, Samir Zaidi, Jillian R. Love, Jimmy L. Zhao, Manu Setty, Kristine M. Wadosky, Anuradha Gopalan, Zi-Ning Choo, Sitara Persad, Jungmin Choi, Justin LaClair, Kayla E. Lawrence, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Irina Linkov, Shangqian Wang, Cindy Lee, Afsar Barlas, Michael J. Morris, Linas Mazutis, Ronan Chaligne, Yu Chen, David W. Goodrich, Wouter R. Karthaus, Dana Pe'er, Charles L. Sawyers
Summary: Drug resistance in cancer is often associated with tumor cell lineage plasticity. The molecular mechanisms driving this plasticity have not been fully understood. This study shows that prostate cancer plasticity is initiated in a population of cells with mixed luminal-basal phenotype and is dependent on increased JAK and FGFR activity. Single-cell analysis in patients with metastatic disease confirms the presence of mixed-lineage cells with increased JAK/STAT and FGFR signaling.
Article
Oncology
Zhenlin Huang, Bo Tang, Yinhui Yang, Zhaogang Yang, Lei Shi, Yang Bai, Binyuan Yan, R. Jeffrey Karnes, Jun Zhang, Rafael Jimenez, Liguo Wang, Qiang Wei, Jinjian Yang, Wanhai Xu, Zhankui Jia, Haojie Huang
Summary: The study identifies a previously unrecognized tumor suppressive role of the inflammation-activated MAP3K7-IKKβ axis in degrading AR protein. Additionally, the findings suggest that aberrant elevation of AR protein could serve as a prognostic biomarker and therapeutic target for MAP3K7-deficient prostate cancer.
Article
Biochemistry & Molecular Biology
Letizia Mezzasoma, Vincenzo Nicola Talesa, Egidia Costanzi, Ilaria Bellezza
Summary: Inflammation plays a key role in the progression of prostate cancer (PCa), with NOD-like receptor protein 3 (NLRP3)-inflammasome activation, interleukin-1 beta (IL-1 beta) secretion, and cancer cell-released extracellular vesicles (EVs) contributing to the establishment of tumor microenvironment. Endogenous biomolecules and Natriuretic Peptides (NPs) such as ANP and BNP have been shown to inhibit inflammasome activation in immune cells. This study demonstrated that exogenous ANP and BNP can modulate the inflammatory phenotype of PCa by reducing inflammasome activation and IL-1 beta secretion.
Article
Urology & Nephrology
Nicolo Pernigoni, Christina Guo, Lewis Gallagher, Wei Yuan, Manuel Colucci, Martina Troiani, Lei Liu, Luisa Maraccani, Ilaria Guccini, Denis Migliorini, Johann de Bono, Andrea Alimonti
Summary: The microbiota, a complex and dynamic population of microorganisms in the human body, has been found to play a role in the development and progression of prostate cancer. Specific microbial species in the urine and gut have been associated with an increased risk of prostate cancer, but the causal mechanisms are still not well understood. Mechanistic evidence suggests that bacterial generation of genotoxins and production of androgenic steroids by the gut microbiota may contribute to prostate carcinogenesis and therapeutic resistance. These findings open up potential avenues for the diagnosis and treatment of prostate cancer by profiling and modulating the host microbiota.
NATURE REVIEWS UROLOGY
(2023)
Review
Oncology
Mohammad Taheri, Elham Badrlou, Bashdar Mahmud Hussen, Amir Hossein Kashi, Soudeh Ghafouri-Fard, Aria Baniahmad
Summary: Long non-coding RNAs (lncRNAs) play essential roles in the pathogenesis of prostate cancer, acting as either oncogenic or tumor suppressor lncRNAs. Prominent oncogenic lncRNAs such as PCA3, DANCR, MALAT1, CCAT1, PVT1, TUG1, and NEAT1 have been identified. Conversely, tumor suppressor lncRNAs, including LINC00893, LINC01679, MIR22HG, RP1-59D14.5, MAGI2-AS3, NXTAR, FGF14-AS2, and ADAMTS9-AS1, have also been implicated. LncRNAs modulate androgen receptor signaling, AR degradation, and other signaling pathways in prostate cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Nabo Sun, Mohammad Javed Ansari, Andrew Ng Kay Lup, Masoud Javan, Alireza Soltani, Seyed Reza Khandoozi, Ali Arian Nia, Samaneh Tavassoli, Md Lutfor Rahman, Mohd Sani Sarjadi, Shaheen M. Sarkar, Chia-Hung Su, Hoang Chinh Nguyen
Summary: The study utilized theoretical calculations to predict the adsorption of anti-inflammatory drug celecoxib on zinc oxide and magnesium oxide nanoclusters, demonstrating the inhibitory potential of the CXB molecule against TNF-alpha, IL-1, and HER2. The results suggest that these nanoclusters could serve as effective carriers for CXB drug delivery.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Evanna L. Mills, Cathal Harmon, Mark P. Jedrychowski, Haopeng Xiao, Ryan Garrity, Nhien V. Tran, Gary A. Bradshaw, Accalia Fu, John Szpyt, Anita Reddy, Hannah Prendeville, Nika N. Danial, Steven P. Gygi, Lydia Lynch, Edward T. Chouchani
Summary: UCP1 plays a crucial role in reversing obesity and increasing thermogenesis, while also antagonizing liver inflammation, thus preventing diseases such as NAFLD that are associated with obesity.