Article
Rheumatology
Kai-di Wang, Xiang Ding, Nan Jiang, Chao Zeng, Jing Wu, Xian-yi Cai, Aubryanna Hettinghouse, Asya Khleborodova, Zi-Ning Lei, Zhe-Sheng Chen, Guang-hua Lei, Chuan-ju Liu
Summary: Through screening of FDA-approved drug library, studying the chondroprotective effects of digoxin in vitro, defining the therapeutic effects of digoxin in a surgically-induced OA model, conducting a cohort study to examine the relationship between digoxin use and OA-associated joint replacement risk, identifying digoxin's binding to LRP4, and using various assays including CRISPR-Cas9 genome editing to study the dependence of digoxin regulation on chondrocytes on LRP4.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Engineering, Chemical
Doraiswami Ramkrishna, Richard Braatz
Summary: This article discusses whether the attention to core areas in chemical engineering should be preserved while pursuing frontier areas. The article points out that chemical engineering had a strong core base during the latter half of the 20th century, and the involvement in areas outside of the traditional one has led to researchers confronting more application-related questions.
Article
Economics
Raul Sanchez de la Sierra
Summary: The study found that the implementation of formal contracts is influenced by social factors, especially benefiting merchants favored by the state; the impact of contracts on buyer choices and payment incentives depends on whether the parties belong to different state-favored ethnic groups.
Review
Biochemistry & Molecular Biology
Asra Nasir Khan, Rizwan Hasan Khan
Summary: This passage discusses the importance of proteins in cell functions and the potential consequences of protein misfolding and aggregation. It also highlights the current limitations in therapeutic approaches for protein misfolding diseases and the recent development of new treatment strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Oncology
Susmita Parashar, Nausheen Akhter, Elisavet Paplomata, Islam Y. Elgendy, Deepa Upadhyaya, Marielle Scherrer-Crosbie, Tochukwu M. Okwuosa, Rupa M. Sanghani, Eva Chalas, Kathryn J. Lindley, Susan Dent
Summary: Advances in early detection and treatment of gynecologic malignancies have led to an increased number of survivors at risk of long-term cardiac complications from cancer treatment. Multimodality therapies for gynecologic malignancies can cause cancer therapy-related cardiovascular toxicity, but this potential adverse effect has been less recognized compared to female predominant cancers like breast cancer. This review provides a comprehensive overview of cancer therapeutic agents used in gynecologic malignancies, associated cardiovascular toxicities, risk factors for cardiotoxicity, cardiac imaging, and prevention strategies.
JACC: CARDIOONCOLOGY
(2023)
Editorial Material
Plant Sciences
Nicholas J. Kruger, R. George Ratcliffe
Summary: Stable isotope labeling experiments provide opportunities for probing metabolic pathways, and metabolic flux analysis (MFA) is commonly used in prokaryotes but more challenging in plants. Constrains-based modeling for simulating network fluxes offers a versatile approach for exploring network capabilities, while MFA can be best utilized to probe interesting features revealed by simulation.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Psychology, Multidisciplinary
Kaitlyn M. Werner, Michael Inzlicht, Brett Q. Ford
Summary: Inhibition plays a crucial role in goal pursuit, but its definition lacks consensus. We propose a new framework where inhibition is seen as the outcome of a goal, rather than the process to achieve it. By actively regulating impulses and desires, individuals can achieve inhibition goals.
CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE
(2022)
Article
Engineering, Biomedical
Ching-Wei Wang, Kun-Lin Lin, Hikam Muzakky, Yi-Jia Lin, Tai-Kuang Chao
Summary: Overexpression of HER2/ERBB2 is important for prognosis and treatment selection in metastatic breast cancer. The Brightfield DISH method recently authorized by the FDA faces challenges due to cell segmentation difficulty and variations in cell appearance. To address these issues, a two-stage weakly supervised deep learning framework is proposed for accurate and robust assessment of ERBB2 overexpression.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2023)
Review
Geriatrics & Gerontology
Michael R. Duggan, Anne Lu, Thomas C. Foster, Mathieu Wimmer, Vinay Parikh
Summary: Aging is a significant risk factor for cognitive decline, but the extent and underlying neurobiology can vary between individuals. Recent developments in analyzing exosomes have improved our understanding of the molecular and cellular mechanisms contributing to cognitive variation in aging. It holds promise for predicting cognitive trajectories and improving functional outcomes for the elderly.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Evie C. Landry, Mirre Scholte, Matthew P. Su, Yvette Horstink, Rishi Mandavia, Maroeska M. Rovers, Anne G. M. Schilder
Summary: This study utilizes health economic modeling to assess the cost-effectiveness of novel hearing therapeutics for age-related sensorineural hearing loss. The results indicate that these novel treatments may be cost-effective under current willingness-to-pay thresholds, providing better outcomes and cost savings compared to the current standard of care.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Lirong Lin, Wei Tan, Xianfeng Pan, En Tian, Zhifeng Wu, Jurong Yang
Summary: Metabolic syndrome (MetS) is a disease that includes visceral obesity, hyperglycemia, dyslipidemia, and hypertension. It has a high prevalence and is an important risk factor for chronic kidney disease. This article compares different diagnostic criteria for MetS and discusses interventions and underlying mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Nanette Santoro
Summary: The field of embryo and gamete cryopreservation is facing potential challenges and liabilities due to increased utilization and changing legal landscape. Clinics should pay attention to the current state of the science, potential legal ramifications, and long-term ethical implications.
FERTILITY AND STERILITY
(2022)
Review
Genetics & Heredity
Mariana K. Najjar, Sara G. Manore, Angelina T. Regua, Hui-Wen Lo
Summary: HER2 overexpression is associated with poor prognosis in breast cancer, with HER2-targeted therapies, such as antibody-drug conjugates (ADCs), showing promising results in treating HER2-positive breast cancer. The development of ADCs leveraging the high specificity of HER2-targeted monoclonal antibodies with cytotoxic small molecules represents a significant advancement in the management of the disease.
Review
Biochemistry & Molecular Biology
Chiedozie Kenneth Ugwoke, Erika Cvetko, Nejc Umek
Summary: Myofascial disease is a major complication of obesity and a leading cause of physical disability worldwide. Obesity affects the properties and functions of the fascial extracellular matrix, leading to the development of myofascial disorders. Understanding the pathological importance of hyaluronan and other components of the fascial connective tissue matrix in obesity may provide insights into the etiology of associated myofascial disorders and guide treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Sonali Nashine
Summary: This article discusses the contribution of aging to ocular diseases such as AMD, and introduces potential therapeutic candidates for AMD along with their known mechanisms of cytoprotection.