Article
Health Care Sciences & Services
Indranil Mallick, Saheli Saha, Moses A. Arunsingh
Summary: Traditional methods of treatment planning and plan evaluation involve generic dose-constraints, but this study aimed to build a web-based application for personalized dose-constraints and plan evaluation against a library of prior approved plans. By building a library of plan DVHs and comparing the newly created plan with similar patients' plans, it demonstrated that simple freely available tools can be used for planning and review based on a library.
JOURNAL OF MEDICAL SYSTEMS
(2021)
Article
Oncology
Jacob G. Scott, Geoff Sedor, Jessica A. Scarborough, Michael W. Kattan, Jeffrey Peacock, G. Daniel Grass, Eric A. Mellon, Ram Thapa, Michael Schell, Anthony Waller, Sean Poppen, George Andl, Jamie K. Teer, Steven A. Eschrich, Thomas J. Dilling, William S. Dalton, Louis B. Harrison, Tim Fox, Javier F. Torres-Roca
Summary: This research suggests that radiation oncology may be operating under an outdated hypothesis and proposes a genomic-adjusted radiation dose method for personalized RT treatment, aiming to optimize tumor control and reduce toxicity. By developing a competing hazards model, it reveals the biological imprecision of one-size-fits-all RT dosing schemes and the potential for improvement through personalized dosing.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Oncology
P. Diez, G. G. Hanna, K. L. Aitken, N. van As, A. Carver, R. J. Colaco, J. Conibear, E. M. Dunne, D. J. Eaton, K. N. Franks, J. S. Good, S. Harrow, P. Hatfield, M. A. Hawkins, S. Jain, F. McDonald, R. Patel, T. Rackley, P. Sanghera, A. Tree, L. Murray
Summary: The use of SABR in the UK has expanded over the past decade, and multiple UK centres are currently working to develop new SABR services. A review and update of the previous consensus is necessary and significant for promoting safe and consistent SABR practice.
Article
Oncology
Jorge Gomez-Alvarez, Santiago Martin Pastor, Marta Gimeno, Jose Lamo-Espinosa, Luis Ramos, Mauricio Cambeiro, Luca Tagliaferri, Gyoergy Kovacs, Vratislav Strnad, Mikel San-Julian, Rafael Martinez-Monge
Summary: This study analyzed the complications of wound healing, osteoradionecrosis, and nerve damage in adult patients with soft tissue sarcomas of the extremities and the superficial trunk who underwent surgery and perioperative high dose rate brachytherapy. The results showed that the incidence of these complications was 38.8%, 5.0%, and 19.4% in previously unirradiated patients, and 63.3%, 3.3%, and 23.3% in previously irradiated patients, respectively. The analysis suggests that modifying treatment factors can reduce the occurrence of these complications.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bibi Martens, Gregor Jost, Casper Mihl, Estelle C. Nijssen, Joachim E. Wildberger, Bernhard Schmidt, Thomas Flohr, Hubertus Pietsch
Summary: This study aimed to evaluate the feasibility of optimizing radiation or contrast media dose in abdominal imaging compared with a combined approach. The results showed that personalized adjustment of radiation or contrast media dose can reduce radiation exposure or contrast media usage without compromising image quality.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kent Wallner, Kathleen E. Kearney, Jasleen Tiwana, Nicole Pristera, Edward Y. Kim, Lorenzo Azzalini, George Sandison, William L. Lombardi, Creighton Don, Minsun Kim
Summary: This study examines the use of a 34 Gy prescription dose at 2 mm from the source center and its potential toxicity in patients with restenosis. The results suggest that this prescription dose does not lead to increased toxicity.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Medicine, Research & Experimental
Adam J. Luginbuhl, Kealan Hobelmann, Julianna Rodin, Sanket Shukla, Ulrich Rodeck, Alban Linnenbach
Summary: The study demonstrates that administering RTA-408 during radiation treatment in a rat model can mitigate the toxic effects of radiation, preserving capillary networks and improving flap survival and tissue healing. Transcriptome analysis reveals robust activation of antioxidant pathways and induced expression of genes associated with hypoxia and angiogenesis.
Article
Oncology
Christopher Herpel, Franz Sebastian Schwindling, Thomas Held, Leo Christ, Kristin Lang, Martha Schwindling, Julius Moratin, Karim Zaoui, Tracy Moutsis, Peter Plinkert, Klaus Herfarth, Christian Freudlsperger, Peter Rammelsberg, Jurgen Debus, Sebastian Adeberg
Summary: The 3D-printed tooth-borne TRDs simplified the manufacturing process and improved adaptability and tolerance. This technology helped reduce patient treatment time and enhance the effectiveness of oral radiation therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Till Tobias Boehlen, Jean-Francois Germond, Jean Bourhis, Marie-Catherine Vozenin, Esat Mahmut Ozsahin, Francois Bochud, Claude Bailat, Raphael Moeckli
Summary: This study evaluated the magnitude of normal tissue sparing provided by the FLASH effect and parameterized its relationship with dose. The results showed that the magnitude of tissue sparing decreases as the dose increases and is dependent on the irradiated tissue.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Health Care Sciences & Services
Prabal Subedi, Maria Gomolka, Simone Moertl, Anne Dietz
Summary: This review aimed to examine the association between changes in protein expression induced by radiation in normal tissues and radiosensitivity, incorporating 28 studies. Most studies demonstrated increased DNA damage in radiosensitive individuals, with several proteins identified to be connected to radiosensitivity, providing a direction for further investigation into the mechanisms of radiosensitivity.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Computer Science, Interdisciplinary Applications
Kelsey Maass, Minsun Kim, Aleksandr Aravkin
Summary: Fluence map optimization for intensity-modulated radiation therapy planning is a large-scale inverse problem with competing objectives and constraints. However, current clinically relevant dose-volume constraints are nonconvex, making standard convex problem algorithms inapplicable. This study proposes a novel relaxation approach to handle nonconvex dose-volume constraints, demonstrating its application in radiation treatment planning.
INFORMS JOURNAL ON COMPUTING
(2022)
Article
Energy & Fuels
Sophie Duzellier, Thierry Nuns, Romain Rey, Claude Pons, Soufian Yjjou, Athina Varotsou, Carsten Baur, Christel Noemayr, Ana Gras, Ainhoa Martinez de Olcoz
Summary: This paper presents extensive irradiation test campaigns conducted on triple-junction solar cells to compare the degradation caused by different configurations of irradiation. The results support the validation of a new tool developed to optimize the accuracy of solar cell degradation prediction. The study addresses the equivalence of degradation induced by electrons, protons, and combined electrons and protons, taking into account local shielding.
PROGRESS IN PHOTOVOLTAICS
(2023)
Review
Health Care Sciences & Services
Anne Dietz, Maria Gomolka, Simone Moertl, Prabal Subedi
Summary: This study aims to investigate the relationship between ionizing radiation effects on human normal tissue proteome and radiosensitivity, providing insights for radiation therapy decisions. The research will follow the guidelines established by NTP/OHAT, and will be registered in PROSPERO to ensure transparency and traceability.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Engineering, Electrical & Electronic
Sadik Ilik, Mustafa Berke Yelten
Summary: This paper discusses the impact of TID on basic amplifier stages biased near the device threshold voltages. Circuit simulations were performed using existing TID degradation-aware transistor models. The simulation methodology accounts for operating currents comparable to TID-induced leakage currents. It is found that at certain TID levels, a specific DC input voltage can maintain the performance characteristics such as voltage gain before and after irradiation.
IEEE TRANSACTIONS ON DEVICE AND MATERIALS RELIABILITY
(2023)
Article
Medicine, General & Internal
Wei Wei, Shi-Geng Wang, Jing-Yi Zhang, Xiao-Yu Togn, Bei-Bei Li, Xin Fang, Ren-Wang Pu, Yu-Jing Zhou, Yi-Jun Liu
Summary: This study explores the feasibility of using individualized low-dose CT-guided hook wire localization to reduce radiation exposure. The results show that low-dose CT significantly reduces the radiation dose and effective dose compared to standard-dose CT. Despite inferior image quality, it is still clinically acceptable for hook wire localization.
Article
Oncology
Nikki de Rouw, Rene J. Boosman, Jacobus A. Burgers, Alwin D. R. Huitema, Anne-Marie C. Dingemans, Hieronymus J. Derijks, David M. Burger, Berber Piet, Lizza E. L. Hendriks, Bonne Biesma, Melinda A. Pruis, Daphne W. Dumoulin, Sander Croes, Ron H. J. Mathijssen, Michel M. van den Heuvel, Rob ter Heine
Summary: This study compared optimized dosing of pemetrexed to standard body surface area-based dosing in patients with non-small cell lung cancer and mesothelioma. The results showed no superiority of optimized dosing in terms of pharmacokinetic endpoint, safety, or quality of life.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Oncology
Daan A. C. Lanser, Simon P. de Leeuw, Esther Oomen-de Hoop, Peter de Bruijn, Marthe S. Paats, Daphne W. Dumoulin, Stijn L. W. Koolen, Anne -Marie C. Dingemans, Ron H. J. Mathijssen, Marijn Veerman
Summary: This study investigated the influence of different diets on the exposure of alectinib in ALK+ NSCLC patients. The results showed that low-fat yogurt significantly reduced the exposure of alectinib compared to other diets, while a self-chosen lunch did not change the exposure. Therefore, patients and physicians should be cautious about the food-drug interaction between alectinib and low-fat yogurt, as it may lead to reduced exposure.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Oncology
Simon P. de Leeuw, Melinda A. Pruis, Barend J. Sikkema, Mostafa Mohseni, G. D. Marijn Veerman, Marthe S. Paats, Daphne W. Dumoulin, Egbert F. Smit, Annemie M. W. J. Schols, Ron H. J. Mathijssen, Elisabeth F. C. van Rossum, Anne-Marie C. Dingemans
Summary: Alectinib, a standard treatment for metastatic ALK+ NSCLC, can lead to weight gain in approximately 10% of patients. This study analyzed body composition changes in patients treated with alectinib and found increases in waist circumference, visceral adipose tissue, subcutaneous adipose tissue, and skeletal muscle. Furthermore, in-depth analysis of four patients with significant weight gain revealed increased appetite and metabolic syndrome. These findings suggest that alectinib can cause abdominal obesity and various metabolic, physical, and mental disturbances.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Adrianus Johannes de Langen, Melissa L. Johnson, Julien Mazieres, Anne -Marie C. Dingemans, Giannis Mountzios, Miklos Pless, Jurgen Wolf, Martin Schuler, Herve Lena, Ferdinandos Skoulidis, Yasuto Yoneshima, Sang-We Kim, Helena Linardou, Silvia Novello, Anthonie J. van der Wekken, Yuanbin Chen, Solange Peters, Enriqueta Felip, Benjamin J. Solomon, Suresh S. Ramalingam, Christophe Dooms, Colin R. Lindsay, Carlos Gil Ferreira, Normand Blais, Cynthia C. Obiozor, Yang Wang, Bhakti Mehta, Tracy Varrieur, Gataree Ngarmchamnanrith, Bjorn Stollenwerk, David Waterhouse, Luis Paz-Ares
Summary: This study compared the efficacy and safety of Sotorasib with standard-of-care treatment in patients with non-small-cell lung cancer (NSCLC) with the KRASG12C mutation. The results showed that compared to docetaxel, Sotorasib significantly increased progression-free survival and had a more favorable safety profile.
Article
Oncology
Anita J. W. M. Brouns, Lizza E. L. Hendriks, Iris J. Robbesom-van den Berge, Annemariek J. H. M. Driessen, Guido M. J. M. Roemen, Britt L. . J. van Herpen, Zoe Dekkers, Bas Heitzer, Daphne J. G. Leunissen, Laura Moonen, Ragnar Lunde, Marcel Westenend, Marjolein van Driel, Ernst-Jan M. Speel, Anne-Marie C. Dingemans
Summary: Bone metastases are common in NSCLC patients and are associated with increased RANKL gene expression and RANKL/OPG gene ratio.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Puneeth Iyengar, Sean All, Mark F. Berry, Thomas P. Boike, Lisa Brad fi Eld, Anne -Marie C. Dingemans, Jill Feldman, Daniel R. Gomez, Paul J. Hesketh, Salma K. Jabbour, Melenda Jeter, Mirjana Josipovic, Yolande Lievens, Fiona Mcdonald, Bradford A. Perez, Umberto Ricardi, Enrico Ruffini, Dirk De Ruysscher, Hina Saeed, Bryan J. Schneider, Suresh Senan, Joachim Widder, Matthias Guckenberger
Summary: This guideline aims to review the use of local therapy in the management of extracranial oligometastatic non-small cell lung cancer (NSCLC) and provide recommendations. Currently, data is limited, but with increasing evidence supporting the use of local therapy in NSCLC, this guideline attempts to provide recommendations based on the quality of available data.
PRACTICAL RADIATION ONCOLOGY
(2023)
Letter
Oncology
S. F. Oosting, A. A. M. van der Veldt, R. S. N. Fehrmann, A. Bhattacharya, R. S. van Binnendijk, C. H. GeurtsvanKessel, A. -M. C. Dingemans, E. F. Smit, T. J. N. Hiltermann, G. den Hartog, M. Jalving, T. T. Westphal, F. de Wilt, S. M. Ernst, A. Boerma, L. van Zijl, G. F. Rimmelzwaan, P. Kvistborg, C. A. C. M. van Els, N. Y. Rots, D. van Baarle, J. B. A. G. Haanen, E. G. E. de Vries
Article
Imaging Science & Photographic Technology
Rihab Hami, Sena Apeke, Pascal Redou, Laurent Gaubert, Ludwig J. Dubois, Philippe Lambin, Dimitris Visvikis, Nicolas Boussion
Summary: The effectiveness of radiotherapy depends on various factors, and the tumor response to radiation varies among patients. This study developed a multi-scale model that integrated five major biological concepts in radiotherapy to predict the effects of radiation on tumor growth. The model considered factors such as oxygen level, cell cycle position, cellular sensitivity, and repair, providing a basis for a more personalized clinical tool.
JOURNAL OF IMAGING
(2023)
Letter
Oncology
Daan A. C. Lanser, Anne-Marie C. Dingemans, Ron H. J. Mathijssen, G. D. Marijn Veerman
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Letter
Oncology
Anne-Marie C. Dingemans, Ron H. J. Mathijssen, Elisabeth F. C. van Rossum
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Christi M. J. Steendam, Sophie M. Ernst, Sushil K. Badrising, Marthe S. Paats, Joachim G. J. V. Aerts, Adrianus J. de Langen, Anne-Marie C. Dingemans
Summary: This study evaluated the efficacy of chemotherapy regimens after progression on EGFR-TKI in patients with EGFR-mutated NSCLC. The results showed substantial benefit of different chemotherapy regimens, particularly in patients treated with PP and CPBA as first-line chemotherapy, and PB in further lines of chemotherapy.
Article
Oncology
Deirdre M. H. J. ten Berge, Ronald A. M. Damhuis, Joachim G. J. V. Aerts, Anne -Marie C. Dingemans
Summary: In patients with ROS1 rearrangement in the Netherlands, only half received primary treatment with TKI and the treatment outcomes were disappointing, mainly due to brain metastasis. Therefore, performing brain MRI as part of the standard diagnostic work up in patients with ROS1+ NSCLC is crucial.
Article
Oncology
F. Akram, J. L. Wolf, T. E. Trandafir, Anne-Marie C. Dingemans, A. P. Stubbs, J. H. von der Thusen
Summary: A statistical model was developed to predict the recurrence of lung adenocarcinoma after surgical resection, and an artificial intelligence (AI) classification model based on convolutional neural networks (CNNs) was trained using transfer learning. Both models were validated using the same biopsy dataset, and the AI classification model outperformed the statistical model in predicting recurrence.
Article
Respiratory System
Iris G. van der Sar, Marlies S. Wijsenbeek, Gert-Jan Braunstahl, Jason O. Loekabino, Anne-Marie C. Dingemans, Johannes C. C. M. In't Veen, Catharina C. Moor
Summary: The study used eNose technology to analyze patients' breath profiles and found that the breath of ILD patients was significantly different from patients with other respiratory diseases, indicating high potential for accurately distinguishing ILD patients with this technology.
RESPIRATORY RESEARCH
(2023)
Article
Microbiology
Yanchao Zhang, Aleksandra M. Kubiak, Tom S. Bailey, Luuk Claessen, Philip Hittmeyer, Ludwig Dubois, Jan Theys, Philippe Lambin
Summary: Clostridium species have gained attention in industrial and medical applications, with the development of genetic tools enabling the advancement of the CRISPR-Cas systems. This study demonstrated the establishment of a CRISPR-Cas12a system in clostridia with two different cas12a genes, allowing for efficient and rapid genome modification. The results showed that the CRISPR-FnCas12a system offers flexible target selection in clostridia, with a specific folding pattern of the precursor crRNA being important for high mutation generation efficiency.
MICROBIOLOGY SPECTRUM
(2023)