Article
Oncology
Geon An, Stephen Ahn, Jae-Sung Park, Sin-Soo Jeun, Yong-Kil Hong
Summary: The study found that patients with thinner temporal muscle thickness (TMT) had shorter overall survival (OS) and progression-free survival (PFS) compared to those with thicker TMT. After propensity score matching, the negative associations with OS and PFS in thinner group were confirmed.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Loig Vaugier, Loic Ah-Thiane, Maud Aumont, Emmanuel Jouglar, Mario Campone, Camille Colliard, Ludovic Doucet, Jean-Sebastien Frenel, Carole Gourmelon, Marie Robert, Stephane-Andre Martin, Tanguy Riem, Vincent Roualdes, Loic Campion, Augustin Mervoyer
Summary: The study reviewed elderly patients with GBM referred for 6-week CRT, finding that CRT treatment was feasible for this population, even in the case of post-operative neurological disabilities. Age and neurological disabilities did not necessarily affect patient outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yanwei Liu, Shuai Liu, Guanzhang Li, Yanong Li, Li Chen, Jin Feng, Yong Yang, Tao Jiang, Xiaoguang Qiu
Summary: This study found that high-dose radiotherapy (>= 54 Gy) was associated with improved survival in patients with LGGs compared to low-dose radiotherapy. Patients with an IDH mutation/1p/19q noncodeletion or wild-type IDH may need to be considered for high-dose radiotherapy for better outcomes.
Article
Oncology
Daniela Pierscianek, Marvin Darkwah Oppong, Yahya Ahmadipour, Laurel Rauschenbach, Anna Michel, Sied Kebir, Philipp Dammann, Karsten H Wrede, Martin Glas, Joerg Hense, Christoph Poettgen, Ulrich Sure, Ramazan Jabbarli
Summary: This retrospective study found that hypochloremia is an independent prognostic factor for glioblastoma patients, associated with poorer survival rates.
Article
Clinical Neurology
Jodi Maple-Grodem, Ingvild Dalen, Ole-Bjorn Tysnes, Angus D. Macleod, Lars Forsgren, Carl E. Counsell, Guido Alves
Summary: The study found that carriers of GBA gene variants show a faster progression of motor symptoms in Parkinson's disease over a 7-year period compared to non-carriers. Recruiting only GBA carriers in clinical trials can significantly reduce trial size and improve trial design.
Article
Oncology
Emilie Le Rhun, Felix Boakye Oppong, Maureen Vanlancker, Roger Stupp, Burt Nabors, Olivier Chinot, Wolfgang Wick, Matthias Preusser, Thierry Gorlia, Michael Weller
Summary: Myelosuppression during temozolomide chemoradiotherapy is associated with the survival of patients with newly diagnosed glioblastoma. Female patients experience more marrow toxicity than males. Lymphopenia is related to the overall survival of patients.
Article
Medicine, General & Internal
Alain R. Thierry, Brice Pastor, Ekaterina Pisareva, Francois Ghiringhelli, Olivier Bouche, Christelle De La Fouchardiere, Julie Vanbockstael, Denis Smith, Eric Francois, Melanie Dos Santos, Damien Botsen, Stephen Ellis, Marianne Fonck, Thierry Andre, Emmanuel Guardiola, Faiza Khemissa, Benjamin Linot, J. Martin-Babau, Yves Rinaldi, Eric Assenat, Lea Clavel, Sophie Dominguez, Celine Gavoille, David Sefrioui, Veronica Pezzella, Caroline Mollevi, Marc Ychou, Thibault Mazard
Summary: This study found differences in tumor burden between patients diagnosed with mCRC before vs after the first COVID-19 lockdown in France. The findings suggest that colorectal cancer is a major area for intervention to minimize pandemic-associated delays in screening, diagnosis, and treatment.
Review
Oncology
Carlen A. Yuen, Marissa Barbaro, Aya Haggiagi
Summary: Management of elderly patients with newly diagnosed glioblastoma (eGBM) presents unique challenges. Although progress has been made in defining the optimal therapeutic approach for these patients, many questions remain unanswered.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Oncology
Stefanie Quach, Christoph Schwartz, Maximilian Aumiller, Marco Foglar, Michael Schmutzer, Sophie Katzendobler, Mohamed El Fahim, Robert Forbrig, Katja Bochmann, Rupert Egensperger, Ronald Sroka, Herbert Stepp, Adrian Ruehm, Niklas Thon
Summary: This study investigated the importance of innovative treatments for patients with glioblastoma (GBM). The results showed that interstitial photodynamic therapy (iPDT) as upfront local therapy can significantly improve survival rates and has good tolerability. Therefore, iPDT may be a feasible treatment option for GBM.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
A. Alafandi, K. A. van Garderen, S. Klein, S. R. van der Voort, D. Rizopoulos, L. Nabors, R. Stupp, M. Weller, T. Gorlia, J. -c. Tonn, M. Smits
Summary: This study retrospectively evaluated the association between postoperative pre-radiotherapy tumour burden and overall survival in patients with newly diagnosed glioblastoma. The results showed that pre-radiotherapy tumour volume was strongly associated with overall survival, while MGMT promoter methylation, age, and performance status were not.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Michelle M. Kim, Madhava P. Aryal, Yilun Sun, Hemant A. Parmar, Pin Li, Matthew Schipper, Daniel R. Wahl, Theodore S. Lawrence, Yue Cao
Summary: The study examined the efficacy of dose-intensified chemoRT on hypercellular and hyperperfused tumor regions in GBM patients, finding that patients in the trial group had significantly reduced tumor volumes and an increase in tumor volume was associated with worse survival.
Article
Medicine, General & Internal
Keisuke Natsume, Harutoshi Sakakima, Kentaro Kawamura, Akira Yoshida, Shintaro Akihiro, Hajime Yonezawa, Koji Yoshimoto, Megumi Shimodozono
Summary: This study investigated factors influencing ADL improvement in newly diagnosed GBM patients and found that factors such as motor paralysis improvement post-surgery, mild fatigue during radio and chemotherapy, and early walking training onset were associated with functional improvement. Patients in the good recovery group had significantly longer median overall survival compared to the deterioration group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Qingrong Pan, Yuan Jian, Yeqing Zhang, Wenkai Zhang, Zhe Chen, Yanna Yang, Aijun Liu, Guang Wang
Summary: This study revealed the association between low T3 syndrome and survival in multiple myeloma patients. Patients with low T3 syndrome showed significant differences in clinical characteristics, biochemical markers, and staging compared to the non-low T3 group. Low T3 syndrome was found to be an independent factor for predicting survival in multiple myeloma patients.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Oncology
Josef Vymazal, Tomas Kazda, Tomas Novak, Petr Slanina, Jan Sroubek, Jan Klener, Tomas Hrbac, Martin Syrucek, Aaron M. M. Rulseh
Summary: This study evaluated the efficacy of TTFields therapy in newly-diagnosed glioblastoma patients and found that it improved progression-free survival and overall survival compared to control patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Martin Stork, Sabina Sevcikova, Tomas Jelinek, Jiri Minarik, Jakub Radocha, Tomas Pika, Lenka Pospisilova, Ivan Spicka, Jan Straub, Petr Pavlicek, Alexandra Jungova, Zdenka Knechtova, Viera Sandecka, Vladimir Maisnar, Roman Hajek, Ludek Pour
Summary: This study aimed to define risk groups in newly diagnosed multiple myeloma (MM) patients with para-skeletal plasmacytomas (PS) and extramedullary plasmacytomas (EMD). The results showed that NDMM patients with low bone marrow plasma cell infiltration had an excellent prognosis in the case of PS plasmacytomas, while those with over 5% bone marrow plasma cells and 3 or more plasmacytomas had the worst prognosis.