Article
Oncology
Annelien L. van Binsbergen, Valerie de Haas, Vincent H. J. van der Velden, Hester A. De Groot-Kruseman, Marta F. Fiocco, Rob Pieters
Summary: This study analyzed the outcomes of children treated with HR blocks, showing a high survival rate and lower relapse rates for patients with negative or low MRD levels. However, a considerable number of patients still died from toxicity. It is important to search for more effective treatment strategies to reduce both leukemia relapse and toxicity-related deaths.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Maxime Caru, Caroline Laverdiere, Valerie Lemay, Simon Drouin, Laurence Bertout, Maja Krajinovic, Gregor Andelfinger, Daniel Sinnett, Daniel Curnier
Summary: The study demonstrated that childhood ALL survivors exposed to chemotherapy can achieve a safe maximal CPET without long-term complications. Regression analysis showed a significant association between the cumulative dose of doxorubicin and VO(2)peak.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Oncology
Marina Oldenburg, Nadine Ruechel, Stefan Janssen, Arndt Borkhardt, Katharina L. Goessling
Summary: The concept of holobionts emphasizes the complex interactions between a host and other species, which, if disturbed may lead to disease and premature aging. The impact of chemotherapy on the microbiome and long-term dysbiosis in survivors of acute lymphoblastic leukemia requires further research.
Article
Oncology
Gloria Heredia, Rafael Gonzalez-Manzanares, Soledad Ojeda, Jose R. Molina, Consuelo Fernandez-Aviles, Francisco Hidalgo, Jose Lopez-Aguilera, Manuel Crespin, Dolores Mesa, Manuel Anguita, Juan C. Castillo, Manuel Pan
Summary: Childhood cancer survivors have an increased risk of right ventricular dysfunction, especially in obese or smoking individuals. Cardiac ultrasound and assessment of free-wall strain can be effective in monitoring these survivors. Therefore, incorporating right ventricular strain assessment into routine cardiac surveillance and promoting healthy lifestyle habits is crucial for these patients.
Article
Medicine, Research & Experimental
Yizhen Li, Wentao Yang, Meenakshi Devidas, Stuart S. Winter, Chimene Kesserwan, Wenjian Yang, Kimberly P. Dunsmore, Colton Smith, Maoxiang Qian, Xujie Zhao, Ranran Zhang, Julie M. Gastier-Foster, Elizabeth A. Raetz, William L. Carroll, Chunliang Li, Paul P. Liu, Karen R. Rabin, Takaomi Sanda, Charles G. Mullighan, Kim E. Nichols, William E. Evans, Ching-Hon Pui, Stephen P. Hunger, David T. Teachey, Mary Relling, Mignon L. Loh, Jun J. Yang
Summary: Genetic alterations in the RUNX1 gene are associated with various blood disorders, especially those of the megakaryocyte and myeloid lineages. Germline RUNX1 variants have different effects on B-ALL and T-ALL, with the latter showing severe damaging effects. Additionally, JAK3 mutation is a common somatic genomic abnormality in T-ALL with germline RUNX1 variants.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Shawn H. R. Lee, Federico Antillon-Klussmann, Deqing Pei, Wenjian Yang, Kathryn G. Roberts, Zhenhua Li, Meenakshi Devidas, Wentao Yang, Cesar Najera, Hai Peng Lin, Ah Moy Tan, Hany Ariffin, Cheng Cheng, William E. Evans, Stephen P. Hunger, Sima Jeha, Charles G. Mullighan, Mignon L. Loh, Allen E. J. Yeoh, Ching-Hon Pui, Jun J. Yang
Summary: This study examines the association of genetic ancestry with childhood acute lymphoblastic leukemia (ALL) molecular subtypes and treatment outcomes. The results suggest that genetic ancestry is associated with ALL molecular subtypes and prognosis, potentially providing a genetic basis for racial and ethnic disparities in ALL. Therefore, personalized treatment based on molecular subtypes is needed to address the gaps in outcomes between different racial and ethnic groups.
Review
Biochemistry & Molecular Biology
Princess D. Rodriguez, Hana Paculova, Sophie Kogut, Jessica Heath, Hilde Schjerven, Seth Frietze
Summary: Studies have shown that non-coding RNAs (ncRNAs) play central roles in the pathogenesis of B-cell acute lymphoblastic leukemia (B-ALL), providing new insights into the molecular mechanisms of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yuting Zhu, Xiaopeng Ma, Heng Zhang, Yijun Wu, Meiyun Kang, Yongjun Fang, Yao Xue
Summary: The study revealed that circADD2 is down-regulated in ALL, and its overexpression inhibits cell proliferation while promoting apoptosis. circADD2 functions by directly sponging miR-149-5p.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Chih-Hsiang Yu, Shiann-Tarng Jou, Ying-Hui Su, Elane Coustan-Smith, Gang Wu, Chao-Neng Cheng, Meng-Yao Lu, Kai-Hsin Lin, Kang-Hsi Wu, Shu-Huey Chen, Fang-Liang Huang, Hsiu-Hao Chang, Jinn-Li Wang, Hsiu-Ju Yen, Meng-Ju Li, Shu-Wei Chou, Wan-Ling Ho, Yen-Lin Liu, Chia-Ching Chang, Ze-Shiang Lin, Chien-Yu Lin, Hsuan-Yu Chen, Yu-Ling Ni, Dong-Tsamn Lin, Shu-Wha Lin, Jun J. Yang, Yen-Hsuan Ni, Ching-Hon Pui, Sung-Liang Yu, Yung-Li Yang
Summary: This study analyzed data from two consecutive protocols to determine the clinical impact of minimal/measurable residual disease (MRD) and tumor genetic subtypes in newly diagnosed pediatric acute lymphoblastic leukemia (ALL) patients. The results showed that MRD-directed therapy improved outcomes for pediatric ALL, especially for standard-risk patients. This study provides important data to inform the design of future clinical trials in Taiwan.
Article
Psychology, Developmental
Marita Partanen, Sean Phipps, Kathryn Russell, Doralina L. Anghelescu, Joshua Wolf, Heather M. Conklin, Kevin R. Krull, Hiroto Inaba, Ching-Hon Pui, Lisa M. Jacola
Summary: Most children with acute lymphoblastic leukemia (ALL) have stable neurocognitive profiles, but a small proportion exhibit significant impairments or worsening performance over time. Older age, female sex, and experiencing sepsis are associated with worsening attention problems, while lower baseline IQ is linked to improved memory and fewer attention issues over time.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2021)
Article
Hematology
Lili Song, Bo Yu, Yi Yang, Jianwei Liang, Yingwen Zhang, Lixia Ding, Tianyi Wang, Xinyu Wan, Xiaomin Yang, Jingyan Tang, Shengyue Wang, Benshang Li, Yanxin Li, Haizhong Feng
Summary: The study identified the R209C mutation of GNAO1 as a new ALL risk loci and revealed its cooperative mechanism with E/R fusion, suggesting GNAO1 as a potential therapeutic target for leukemia.
Review
Medicine, General & Internal
Maria Kourti, Michalis Aivaliotis, Emmanouel Hatzipantelis
Summary: Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and risk-directed therapy based on clinical, biologic and genetic features has played a significant role in its treatment. Despite improvement in survival rates, ALL remains a leading cause of cancer-related deaths. Proteomics is a cutting-edge technology that aims to understand the impact of the proteome on leukemia subtypes and identify new biomarkers and targets for therapy.
Article
Oncology
Marco Severgnini, Mariella D'Angio, Silvia Bungaro, Giovanni Cazzaniga, Ingrid Cifola, Grazia Fazio
Summary: In this study, RNA-seq technology was used to comprehensively profile the transcriptional landscape of childhood BCP-ALL cases. The analysis revealed a subset of conjoined genes (CGs) that were exclusively expressed in leukemic cases, suggesting a potential novel mechanism of transcriptional regulation in childhood leukemia and potential leukemia-specific biomarkers.
Article
Oncology
Rosangela Aparecida Mendes Silva, Regina Maria Holanda de Mendonca, Simone dos Santos Aguiar, Julia Cervellini Yajima, Fernando Augusto Lima Marson, Silvia Regina Brandalise, Carlos Emilio Levy
Summary: BSI is a frequent event in ALL patients during the induction phase, and is significantly associated with variables such as protocol for Derived T Protocol, oral manifestations, central venous catheter, and bladder catheter. Identifying these factors can help in the development and improvement of strategies for supportive care, prevention, and rapid treatment of infections.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Clinical Neurology
Rui Li, Ji-Hong Tang, Bing-Bing Zhang, Xiao-Yan Shi, Yuan-Yuan Dai, Rui Qu
Summary: The clinical characteristics of epileptic seizures in children with acute lymphoblastic leukemia (ALL) during treatment were analyzed. Epileptic seizures mainly occurred in the induction remission period, maintenance treatment period, and after bone marrow transplantation. The common causes were MTX-related demyelinating encephalopathy and reversible posterior encephalopathy syndrome (PRES). Convulsion was the first symptom. Early neuroimaging and EEG examination are important for early diagnosis and treatment.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Candace A. Frerich, Hailey N. Sedam, Huining Kang, Yoshitsugu Mitani, Adel K. El-Naggar, Scott A. Ness
Article
Biochemical Research Methods
Hui Yu, Shilin Zhao, Scott Ness, Huining Kang, Quanhu Sheng, David C. Samuels, Olufunmilola Oyebamiji, Ying-yong Zhao, Yan Guo
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Li Luo, Huining Kang, Xichen Li, Scott A. Ness, Christine A. Stidley
Article
Oncology
Limin Jiang, Fei Guo, Jijun Tang, Shuguan Leng, Scott Ness, Fei Ye, Huining Kang, David C. Samuels, Yan Guo
Article
Substance Abuse
Mate Fischer, Praveen Chander, Huining Kang, Nikolaos Mellios, Jason P. Weick
Summary: The study used an in vitro human pluripotent stem cell-based model to investigate the effects of early, chronic intermittent alcohol exposure on cortical neurons. Results showed that alcohol exposure significantly altered a small number of biological pathways, including cell-type specification, axon guidance, synaptic function, and regional patterning, with a notable upregulation of WNT signaling-associated transcripts.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Filip Matthijssens, Nitesh D. Sharma, Monique Nysus, Christian K. Nickl, Huining Kang, Dominique R. Perez, Beatrice Lintermans, Wouter Van Loocke, Juliette Roels, Sofie Peirs, Lisa Demoen, Tim Pieters, Lindy Reunes, Tim Lammens, Barbara De Moerloose, Filip Van Nieuwerburgh, Dieter L. Deforce, Laurence C. Cheung, Rishi S. Kotecha, Martijn D. P. Risseeuw, Serge Van Calenbergh, Takeshi Takarada, Yukio Yoneda, Frederik W. van Delft, Richard B. Lock, Seth D. Merkley, Alexandre Chigaev, Larry A. Sklar, Charles G. Mullighan, Mignon L. Loh, Stuart S. Winter, Stephen P. Hunger, Steven Goossens, Eliseo F. Castillo, Wojciech Ornatowski, Pieter Van Vlierberghe, Ksenia Matlawska-Wasowska
Summary: The study demonstrates that the upregulation of RUNX2 acts as a dependency factor in high-risk subtypes of human T-ALL by regulating tumor metabolism and leukemic cell migration simultaneously.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemical Research Methods
Quanhu Sheng, Hui Yu, Mingrui Duan, Scott Ness, Jiapeng He, Huining Kang, Limin Jiang, John J. Wyrick, Peng Mao, Yan Guo
Summary: UV radiation can lead to skin cancers by causing DNA damage, and the CPD-Seq technique provides a high-throughput method to study the mutagenesis mechanisms associated with UV damage. CPDSeqer protocol has been developed to assist researchers in processing CPD-Seq data efficiently and effectively.
Article
Biochemical Research Methods
Yan Guo, Hui Yu, Haocan Song, Jiapeng He, Olufunmilola Oyebamiji, Huining Kang, Jie Ping, Scott Ness, Yu Shyr, Fei Ye
Summary: The MetaGSCA tool allows for comprehensive meta-analyses of gene set differential coexpression data, identifying relevant pathways and visualizing them. The tool demonstrated its effectiveness in case studies of chronic kidney disease and non-small cell lung cancer, as well as in a pan-cancer analysis of 11 cancer types. Analysis with randomly generated gene sets showed low false positive rates, indicating the tool's specificity.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Oncology
Philip E. Castle, Walter K. Kinney, Lu Chen, Jane J. Kim, Steven Jenison, Giovanna Rossi, Huining Kang, Jack Cuzick, Cosette M. Wheeler
Summary: In 2019, only 12.7% of women aged 30-64 underwent cotesting and 27.7% underwent cytology at the recommended interval. The observed under- and overscreening could result in increases in cervical cancer incidence and harms and costs, respectively.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Neurosciences
Shuhua Yuan, Weili Li, Chengbei Hou, Huining Kang, Qingfeng Ma, Xunming Ji, Zhifeng Qi, Ke Jian Liu
Summary: Serum occludin level and baseline NIHSS score are independently associated with hemorrhagic transformation (HT) in acute ischemic stroke patients with reperfusion therapy. The combination of these two variables significantly improves the accuracy of HT prediction.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Qi Jin, Tawny W. Boyce, Huining Kang, Laura Nervi, Andrew L. Sussman, Dolores D. Guest
Summary: By using individualized SMS and phone calls, it was found that Spanish-speaking community-dwelling Hispanics can increase their daily intake of fruits and vegetables as well as physical activity. The SMS + PC group was the most effective intervention, showing improvements in both physical activity and vegetable intake among respondents. This demonstrates the feasibility and acceptability of using remote access platforms for health communication strategies with Spanish-speaking participants.
HISPANIC JOURNAL OF BEHAVIORAL SCIENCES
(2021)
Article
Environmental Sciences
Elizabeth M. Harding, Ann L. Gibson, Huining Kang, Micah N. Zuhl, Harsh Sharma, Cindy K. Blair
Summary: The study found that older cancer survivors self-select a faster walking cadence to meet their daily step goals during a light-intensity physical activity intervention, leading to increased steps taken in moderate-intensity physical activity cadence bands.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cell Biology
Huining Kang, Jakub Fichna, Ksenia Matlawska-Wasowska, Damian Jacenik
Summary: ADGRF5 is overexpressed in the colons of patients with CRC, and the higher expression is associated with more advanced stages of CRC. The expression of ADGRF5 is correlated with multiple signaling pathways and tumor-infiltrating immune cells in the colon, and high expression of ADGRF5 is associated with lower overall survival and disease-free survival.
Article
Oncology
Kathryn J. Brayer, Huining Kang, Adel K. El-Naggar, Simon Andreasen, Preben Homoe, Katalin Kiss, Lauge Mikkelsen, Steffen Heegaard, Daniel Pelaez, Acadia Moeyersoms, David T. Tse, Yan Guo, David Y. Lee, Scott A. Ness
Summary: Adenoid cystic carcinoma (ACC) is a distinct tumor that mainly occurs in salivary or lacrimal glands, but can also develop in other tissues. ACC tumors from different organs have remarkably similar gene expression profiles, indicating a dominant ACC phenotype induced by genetic and epigenetic regulatory events. A gene expression biomarker was validated in a new cohort of ACC tumors, correctly identifying 98% of the patients with poor survival, suggesting the need for a clinical test to identify high-risk patients.
Article
Oncology
Cindy K. Blair, Elizabeth Harding, Charles Wiggins, Huining Kang, Matthew Schwartz, Amy Tarnower, Ruofei Du, Anita Y. Kinney
Summary: A home-based mHealth program to disrupt and replace sedentary time with stepping was feasible among and acceptable to older cancer survivors.