Article
Pharmacology & Pharmacy
Chunnuan Wu, Bole Li, Shuai Meng, Linghui Qie, Jie Zhang, Guopeng Wang, Cong Cong Ren
Summary: The study successfully developed a PBPK model to predict optimal dosing regimens of pazopanib when co-administered with other drugs and administered in patients with hepatic impairment. The model matched well with clinical data and provided suitable dosage modifications in various situations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yi Li, Jianda Lu, Yue Kang, Xiaoyong Xu, Xin Li, Yuancheng Chen, Kun Wang, Xiaofen Liu, Yaxin Fan, Hailan Wu, Yu Wang, Jiali Hu, Jicheng Yu, Jufang Wu, Beining Guo, Yingyuan Zhang, Xin Zeng, Ming Zhao, Jun Xue, Jing Zhang
Summary: The optimal dosing regimen for patients with severe renal impairment was found to be 0.5 g nemonoxacin every 48 hours, which showed higher probability of target attainment and cumulative fraction of response against Streptococcus pneumoniae and Staphylococcus aureus. Other dosage regimens were found to be insufficient in covering the pathogens even if minimum inhibitory concentration was at 1 mg/L.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alaa Husni Qari, Raghad Mohammed Alharbi, Shahd Saud Alomiri, Banan Nasser Alandanusi, Lina Ayman Mirza, Mohammad Hasan Al-Harthy
Summary: The study compares the experience of patients seen using teledentistry with traditional Orofacial Pain and TMD visits. Results indicated a borderline difference in effectively using teledentistry for follow-ups among different age groups, but no significant differences were found in patients' experience between virtual and conventional visits. This suggests that high-quality dental care services can be provided remotely without adversely affecting patient experience or quality of care.
JOURNAL OF DENTISTRY
(2024)
Article
Oncology
Kyunghye Bang, Jaekyung Cheon, Jae Ho Jeong, Hyeon-Su Im, Kyu-pyo Kim, Baek-Yeol Ryoo, Changhoon Yoo
Summary: The study demonstrated that nal-IRI plus 5-FU/LV showed modest efficacy and manageable toxicities in patients with mPAC previously treated with conventional irinotecan-containing chemotherapy. The cumulative dose of prior conventional irinotecan therapy may be inversely correlated with the effectiveness of nal-IRI plus 5-FU/LV.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Article
Oncology
Seiichiro Mitani, Yosuke Kito, Kaori Hino, Kentaro Kawakami, Naoki Izawa, Fumiyasu Hanamura, Yoshiyuki Yamamoto, Hirokazu Shoji, Azusa Komori, Shogen Boku, Kenji Tsuchihashi, Kyoko Kato, Yoshikane Nonagase, Toshihiko Matsumoto, Mitsuhiro Furuta, Hisato Kawakami
Summary: This study aimed to evaluate the treatment outcomes of second-line or later chemotherapy for vulnerable patients with metastatic colorectal cancer (mCRC) in a real-world setting. The results showed that second-line chemotherapy for vulnerable patients with mCRC had clinically meaningful outcomes, but few patients received second-line therapy, and survival among patients who received best supportive care (BSC) was dismal.
Article
Psychology, Multidisciplinary
Freddie Lymeus, Mathew P. White, Per Lindberg, Terry Hartig
Summary: Restoration skills training (ReST) is a mindfulness-based course that helps participants improve their psychological functioning by combining natural practice settings and mindfulness training. This study found that ReST overcomes compliance problems in traditional mindfulness training and allows participants to sustain improvements in dispositional mindfulness and reduce cognitive lapses. ReST participants also had a higher rate of continued mindfulness practice, which was linked to sustained improvements.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Angelika M. Schwarz, Georg Lipnik, Gloria M. Hohenberger, Aurel Krauss, Michael Plecko
Summary: This study evaluated the findings of a mini-open procedure (MCTR) through a palmar approach and compared it to the conventional method (OCTR). The results showed that MCTR had comparable functional outcomes and lower scar sensibility compared to OCTR, making it a reliable and minimally-invasive procedure.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Chengjie Ke, Xiang You, Cuihong Lin, Jiarui Chen, Guimu Guo, Wanhong Wu, Lingling Ye, Pinfang Huang
Summary: A physiologically based pharmacokinetic (PBPK) model was developed to predict pregabalin (PGB) dosage for pediatric patients with renal impairment (RI). The model was validated and used to simulate the disposition of PGB in the healthy population and adults with RI. The results showed that the model accurately predicted the exposure to PGB in different populations and suggested optimal dosage regimens for pediatric patients with varying degrees of RI.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Medical Laboratory Technology
Sabrina Malvagia, Lorenzo Ferri, Maria Della Bona, Walter Borsini, Calogero Lino Cirami, Egrina Dervishi, Sandro Feriozzi, Serena Gasperini, Serena Motta, Renzo Mignani, Barbara Trezzi, Federico Pieruzzi, Amelia Morrone, Marta Daniotti, Maria Alice Donati, Giancarlo la Marca
Summary: This study compared LysoGb3 levels in dried blood spots (DBS) and plasma in patients with classic and late-onset phenotypes of Fabry disease. The results showed that DBS is an efficient method for measuring LysoGb3 levels, which is important for diagnosis, initial phenotypic assignment, and therapeutic monitoring in FD patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
Sabrina Malvagia, Lorenzo Ferri, Maria Della Bona, Walter Borsini, Calogero Lino Cirami, Egrina Dervishi, Sandro Feriozzi, Serena Gasperini, Serena Motta, Renzo Mignani, Barbara Trezzi, Federico Pieruzzi, Amelia Morrone, Marta Daniotti, Maria Alice Donati, Giancarlo la Marca
Summary: The study compared LysoGb3 levels in DBS and plasma in patients with different phenotypes of FD. The results showed that DBS provided a convenient, sensitive, and reproducible method for measuring LysoGb3 levels, which is suitable for diagnosis, initial phenotypic assignment, and therapeutic monitoring in FD patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Medicine, Research & Experimental
Chengyu Luo, Changsheng Wei, Wenbin Guo, Jie Yang, Qiuru Sun, Wei Wei, Shuhua Wu, Shubing Fang, Qingliang Zeng, Zhensheng Zhao, Fanjie Meng, Xuandong Huang, Xianlan Zhang, Ruihua Li, Xiufeng Ma, Chaoying Luo, Yun Yang
Summary: The study found that the use of MALND in breast cancer surgery can decrease relapse and arm complications, as well as improve long-term survival of patients.
ADVANCES IN THERAPY
(2022)
Article
Oncology
Sung Han Kim, Boram Park, Eu Chang Hwang, Sung-Hoo Hong, Chang Wook Jeong, Cheol Kwak, Seok Soo Byun, Jinsoo Chung
Summary: This study compared the cancer-specific survival and overall survival of patients with non-metastatic renal cell carcinoma who experienced disease recurrence in different scenarios. The findings indicated that the group with local recurrence had the worst survival outcomes compared to the other groups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Anouk Donners, Konrad van der Zwet, Antoine C. G. Egberts, Karin Fijnvandraat, Ron Mathot, Ilmar Kruis, Marjon H. Cnossen, Roger Schutgens, Rolf T. Urbanus, Kathelijn Fischer
Summary: Emicizumab effectively prevents bleeding in haemophilia A patients, but its high cost may limit access. This study aims to evaluate the non-inferiority of a lower dose targeting a trough concentration of 30 mu g/mL compared to conventional dosing, and assess the cost-effectiveness of the two dosing strategies.
Article
Environmental Sciences
Carlo Bassano, Paolo Nardi, Dario Buioni, Laura Asta, Calogera Pisano, Fabio Bertoldo, Claudia Altieri, Giovanni Ruvolo
Summary: This study compared the long-term outcomes of clampless off-pump coronary artery bypass grafting (C-OPCAB) and conventional on-pump double clamping coronary artery bypass grafting (C-CABG). The results showed no significant differences in overall survival and occurrence of adverse events between the two techniques after a follow-up of up to 14 years. Advanced age at operation and lower preoperative left ventricular ejection fraction were independent predictors of survival.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Corrado Tinterri, Damiano Gentile, Wolfgang Gatzemeier, Andrea Sagona, Erika Barbieri, Alberto Testori, Valentina Errico, Alberto Bottini, Emilia Marrazzo, Carla Dani, Beatrice Dozin, Luca Boni, Paolo Bruzzi, Bethania Fernandes, Davide Franceschini, Ruggero Spoto, Rosalba Torrisi, Marta Scorsetti, Armando Santoro, Giuseppe Canavese
Summary: The SINODAR-ONE trial aimed to assess whether SLN biopsy only would worsen the prognosis compared with ALND in patients with T1-2 breast cancer and one or two macrometastatic SLNs. The results showed that the 3-year survival and relapse rates of patients treated with SLNB only were not inferior to those treated with ALND.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Pathology
Louise-Marie Chevalier, Amandine Billaud, Christophe Passot, Adelaide Renoult, Frederic Bigot, Veronique Verriele, Alain Morel
ANNALES DE PATHOLOGIE
(2020)
Article
Genetics & Heredity
Louise-Marie Chevalier, Amandine Billaud, Sabrina Fronteau, Jonathan Dauve, Anne Patsouris, Veronique Verriele, Alain Morel
MOLECULAR DIAGNOSIS & THERAPY
(2020)
Article
Medicine, General & Internal
Amandine Billaud, Veronique Verriele, Jonathan Dauve, Louise-Marie Chevalier, Alain Morel
Review
Oncology
Amandine Billaud, Louise-Marie Chevalier, Mario Campone, Alain Morel, Frederic Bigot
BULLETIN DU CANCER
(2020)
Article
Oncology
Marie Selvy, Bruno Pereira, Nicolas Kerckhove, Jerome Busserolles, Fadila Farsi, Virginie Guastella, Patrick Merle, Denis Pezet, David Balayssac
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is challenging for oncologists, with high incidence and lack of effective preventive/management strategies. A survey of French oncologists revealed awareness of CIPN risks, but underestimation of incidence and poor adherence to ASCO recommendations for management. Prevention, diagnosis, and management of CIPN remain problematic in clinical practice in France.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Loig Vaugier, Xavier Mirabel, Isabelle Martel-Lafay, Severine Racadot, Christian Carrie, Veronique Vendrely, Marc-Andre Mahe, Helene Senellart, Jean-Luc Raoul, Loic Campion, Emmanuel Rio
Summary: The combination treatment of SBRT with irinotecan was well tolerated and showed promising results in improving local response for colorectal cancer patients, allowing for chemotherapy-free periods and potentially serving as an alternative regimen for tumors close to healthy tissues.
Article
Oncology
Ke Zhou, Audrey Blanc-Lapierre, Valerie Seegers, Michele Boisdron-Celle, Frederic Bigot, Marianne Bourdon, Hakim Mahammedi, Aurelien Lambert, Mario Campone, Thierry Conroy, Frederique Penault-Llorca, Martine M. Bellanger, Jean-Luc Raoul
Summary: COVID-19 symptoms differ in cancer patients and healthcare workers, with anosmia being strongly associated with the disease in cancer patients while dysgeusia/ageusia is not. Cancer patients may require tailored preventive measures due to their specific COVID-19 symptom pattern.
Article
Oncology
Jean-Luc Raoul, Julien Edeline, Victor Simmet, Camille Moreau-Bachelard, Marine Gilabert, Jean-Sebastien Frenel
Summary: Multikinase inhibitors and immune checkpoint inhibitors are major breakthroughs in cancer treatment, but the overuse of proton pump inhibitors may have detrimental effects on cancer patients' therapy and decrease the absorption of targeted therapies. Furthermore, long-term use of proton pump inhibitors alters the gut microbiome and suppresses the benefit of using immune checkpoint inhibitors.
Article
Oncology
Camille Moreau-Bachelard, Valentin Letailleur, Emmanuelle Bompas, Patrick Soulie, Julie Paul, Jean-Luc Raoul
Summary: This study retrospectively investigated the impact of combining proton pump inhibitors (PPIs) with pazopanib on the clinical efficacy and safety. The results showed that combining PPIs with pazopanib led to lower efficacy and decreased overall survival. The combination was associated with performance status, tumor location, hemoglobin level, and PMN/lymphocyte ratio. Dose reduction for toxicity and severe adverse events were less frequent in the combination group. Hence, the co-medication should be avoided.
Review
Oncology
Julien Edeline, Tim Meyer, Jean-Frederic Blanc, Jean-Luc Raoul
Summary: This review summarizes the data on a new treatment for hepatocellular carcinoma. Immunotherapy-based combination therapies have emerged as effective treatment options. The article discusses the challenges in selecting the most appropriate treatment, options after failure of these new treatments, and the future of drug development in advanced HCC.
Article
Oncology
Valerie Seegers, Guillaume Rousseau, Ke Zhou, Audrey Blanc-Lapierre, Frederic Bigot, Hakim Mahammedi, Aurelien Lambert, Camille Moreau-Bachelard, Mario Campone, Thierry Conroy, Frederique Penault-Llorca, Michele Boisdron-Celle, Martine Bellanger, Jean-Luc Raoul
Summary: This study demonstrates the importance of two doses of COVID-19 vaccines for cancer patients and healthcare workers. Despite a decline in post-vaccination antibody levels and some vaccine breakthrough infections, the vaccination was still effective for both populations studied.
Article
Medicine, General & Internal
Margaux Lelong, Jean-Luc Raoul, Yann Touchefeu, Jean-Marie Berthelot, Paul Arnolfo, Tamara Matysiak-Budnik, Helene Senellart
Summary: A 38-year-old man with a familial BRCA2 mutation presented with symptoms including skin erythema, polyarthritis, dactylitis, and febrile erythema nodosum. A biopsy of a liver metastasis revealed acinar cell carcinoma of the pancreas. After receiving FOLFIRINOX treatment followed by olaparib, the patient achieved a PS of 0 and became asymptomatic after 24 months.
CLINICAL CASE REPORTS
(2022)
Article
Oncology
Ke Zhou, Jean-Luc Raoul, Audrey Blanc-Lapierre, Valerie Seegers, Michele Boisdron-Celle, Marianne Bourdon, Hakim Mahammedi, Aurelien Lambert, Camille Moreau-Bachelard, Mario Campone, Thierry Conroy, Frederique Penault-Llorca, Martine M. Bellanger, Frederic Bigot
Summary: The COVID-19 infection rate in cancer patients is similar to that in healthcare workers, but the mortality rate related to clinical symptoms is lower. More than 40% of COVID (+) cancer patients are asymptomatic, while one-third of COVID (-) cancer patients have symptoms. Only geographic origin is associated with clinical presentation.
CLINICAL MEDICINE INSIGHTS-ONCOLOGY
(2022)
Article
Oncology
Loic Ah-Thiane, Jean-Luc Raoul, Sandrine Hiret, Helene Senellart, Frederic Dumont, Judith Raimbourg
Summary: Oxaliplatin, a platinum-based chemotherapeutic agent, is known to induce peripheral sensory neuropathy. This report presents two cases of sudden transient vision loss after oxaliplatin administration, likely reflecting optic neuritis.
CASE REPORTS IN ONCOLOGY
(2021)
Article
Oncology
Manon Baverez, Emilie Thibaudeau, Vincent Libois, Olivier Kerdraon, Helene Senellart, Jean-Luc Raoul
Summary: This case study details a 57-year-old woman with malignant transformation of a long-term preexisting retrorectal tailgut cyst, leading to mucinous adenocarcinoma invading the anal canal. Such progression is rare, highlighting the importance of preemptive surgical treatment for retrorectal cysts.
CASE REPORTS IN ONCOLOGY
(2021)