Article
Clinical Neurology
Joseph H. Garcia, Ramin A. Morshed, Jason Chung, Miguel A. Millares Chavez, Vivek Sudhakar, Satvir Saggi, Lauro N. Avalos, Aaron Gallagher, Jacob S. Young, Mariza Daras, Michael W. McDermott, Paul A. Garcia, Edward F. Chang, Manish K. Aghi
Summary: The authors analyzed a large surgical cohort of patients with brain metastases to examine risk factors associated with preoperative and postoperative seizures and to better understand the seizure risk factors of metastatic brain tumors. The study found that frontal lobe metastases and hemorrhagic tumors were associated with a higher risk of preoperative seizures, while checkpoint inhibitor use and parietal lobe tumors appeared to be associated with seizures at 6 months postoperatively.
JOURNAL OF NEUROSURGERY
(2023)
Article
Geriatrics & Gerontology
Tiantian Chu, Zongfang Wu, Aijun Xu
Summary: This study investigated preoperative hypokalemia in elderly patients and its effect on postoperative complications. The results showed that female gender, pre-existing hypokalemia at admission, and oral laxative twice or more were independent risk factors for preoperative hypokalemia in elderly patients. However, there was no increase in postoperative complications and 30-day mortality, which may be attributed to the monitoring of blood gas analysis and prompt correction of potassium levels during surgery.
Article
Gastroenterology & Hepatology
Revanth S. Kosaraju, Daniel J. Wong, Eve M. Roth, Thomas E. Cataldo, Anne C. Fabrizio, Kristen T. Crowell, Joseph D. Feuerstein, Evangelos Messaris
Summary: This study compared the colectomy and postoperative complication rates in hospitalized patients with severe ulcerative colitis receiving standard infliximab induction therapy and dose-intensified regimens. The results showed no significant difference in colectomy rates between the two treatment approaches, and dose-intensified regimens were not associated with a greater risk of perioperative complications.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Multidisciplinary Sciences
Caleb R. Matthews, Timothy Hartman, Mackenzie Madison, Nicolas W. Villelli, Niharika Namburi, Cameron L. Colgate, Zainab Faiza, Lawrence S. Lee
Summary: Based on the review of data from 2011-2017, it appears that the timing of cardiac surgery after stroke does not impact postoperative stroke or mortality rates. However, if postoperative stroke does occur, the mortality rate related to the stroke is high. Similar 30-day mortality and postoperative stroke rates were observed across different timing groups for both endocarditis and non-endocarditis patients.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Mei Su, Wei Lin, Qi Xu, Buqing Ni, Xilong Zhang, Shijiang Zhang, Ning Ding
Summary: The aim of this study was to evaluate the effects of 1-week perioperative auto-continuous positive airway pressure (CPAP) treatment on postoperative heart and pulmonary outcomes in patients with obstructive sleep apnea (OSA) and valvular heart disease. The results showed that preoperative use of auto-CPAP for OSA significantly decreased the duration of mechanical ventilation, as well as postoperative stays in the ICU and hospital compared to the non-CPAP treatment group.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Tomoko Tanaka, Toby Bradford, N. Scott Litofsky
Summary: The study found that patients with poorly controlled diabetes mellitus are at a higher risk of postoperative complications after spine surgery. Smoking was not found to be a significant factor associated with complications. Preoperative HbA1c can be used to assess the risk of postoperative spine surgery complications.
WORLD NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Juan Carlos Celis-Pinto, Adela Alonso Fernandez-Velasco, Maria Daniela Corte-Torres, Jorge Santos-Juanes, Noelia Blanco-Agudin, Kelvin Manuel Pina Batista, Jesus Merayo-Lloves, Luis M. Quiros, Ivan Fernandez-Vega
Summary: The study investigated the expression of PTEN-induced kinase-1 (PINK1) in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver. The results showed that positive PINK1 expression was observed in all tumoral tissues, and there were no differences between different CRCs. However, a significant under-expression of PINK1 was found in CRLMs derived from the rectum compared to other sites. Altered PINK1 expression in CRCs was associated with worse overall survival due to abnormal mitophagy function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Tatsuo Matsuda, Yuzo Umeda, Tadakazu Matsuda, Yoshikatsu Endo, Daisuke Sato, Toru Kojima, Kenta Sui, Masaru Inagaki, Tetsuya Ota, Masayoshi Hioki, Masahiro Oishi, Masashi Kimura, Toshihiro Murata, Nobuhiro Ishido, Takahito Yagi, Toshiyoshi Fujiwara
Summary: The study identified the prognostic nutritional index (PNI) as a useful indicator for predicting postoperative complications and prognosis in patients with intrahepatic cholangiocarcinoma. Patients with a low PNI had higher rates of complications and worse overall survival outcomes.
Article
Medicine, General & Internal
Jae Hong Park, Yei Heum Park, Byeongcheol Lee, Sung Hyun Shin, Daeseok Oh, Sung Ho Moon, Myoung Jin Ko
Summary: Preoperative echocardiography does not affect postoperative outcomes, but it has the potential to affect intraoperative anesthetic management such as invasive hemodynamic monitoring during surgery.
Article
Cardiac & Cardiovascular Systems
Philip Allen, Brett R. Anderson, Emile Bacha, Damien J. LaPar
Summary: This study assessed the impact of trisomy 21 on morbidity, mortality, and resource use in patients with cavopulmonary connections. The results showed that patients with T21 had significantly higher rates of adverse events and resource utilization compared to non-T21 patients after Glenn and Fontan procedures.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Jun Han Tang, Bei Wang, Jie Ling Jaclyn Chow, Priscilla M. Joseph, Jia Ying Chan, Nursharazilla Abdul Rahman, Yi Hui Low, Yen Pin Tan, Vishalkumar G. Shelat
Summary: This study successfully increased the postoperative day 2 mobilisation rate for patients undergoing elective major hepatopancreatobiliary surgery through a multidisciplinary team clinical practice improvement project, reducing hospital length of stay and achieving potential cost savings.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Ryota Matsui, Noriyuki Inaki, Toshikatsu Tsuji, Ryo Momosaki, Tetsu Fukunaga
Summary: This study investigated whether preoperative low-handgrip strength could predict postoperative outcomes in patients with gastric cancer. The results showed that low-handgrip strength was associated with infectious complications, and chronic kidney disease and diabetes were independent risk factors for infectious complications in patients with low-handgrip strength.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mercedes Fernandez-Castro, Jose-Maria Jimenez, Belen Martin-Gil, Maria-Fe Munoz-Moreno, Ana-Belen Martin-Santos, Isaias del Rio-Garcia, Natan Redondo-Perez, Maria Lopez
Summary: This study aims to explore the relationship between preoperative anxiety levels and postoperative pain in cardiac surgery patients. It found that higher levels of preoperative anxiety were associated with increased postoperative analgesic requirements, while the amount of analgesics needed decreased with age.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Jing-Yong Xu, Xiao-Dong Tian, Yin-Mo Yang, Jing-Hai Song, Jun-Min Wei
Summary: The study demonstrates that preoperative anemia is associated with higher rates of severe postoperative complications and increased costs in patients undergoing open pancreatoduodenectomy. Identifying and treating preoperative anemia is crucial for improving postoperative outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Yangchun Xiao, Xin Cheng, Lu Jia, Yixin Tian, Jialing He, Miao He, Lvlin Chen, Pengfei Hao, Tiangui Li, Weelic Chong, Yang Hai, Chao You, Liyuan Peng, Fang Fang, Yu Zhang
Summary: This study found that moderate to severe anemia and polycythemia are independently associated with increased postoperative mortality in patients undergoing craniotomy for brain tumor resection, emphasizing the importance of identifying and managing abnormal hematocrit values before surgery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Caroline K. Fiser, Joshua P. Kronenfeld, Sophia N. Liu, Neha Goel, Wrood Kassira, John C. Oeltjen, Susan B. Kesmodel
Summary: Prior cosmetic breast surgery does not increase the risk of complications or reconstruction loss in patients undergoing skin-sparing or nipple-sparing mastectomy with immediate breast reconstruction. Mastectomy and immediate breast reconstruction can be safely performed in appropriately selected patients with prior cosmetic breast surgery.
CLINICAL BREAST CANCER
(2022)
Article
Gastroenterology & Hepatology
Elias Orouji, Ayush T. Raman, Anand K. Singh, Alexey Sorokin, Emre Arslan, Archit K. Ghosh, Jonathan Schulz, Christopher Terranova, Shan Jiang, Ming Tang, Mayinuer Maitituoheti, Scot C. Callahan, Praveen Barrodia, Katarzyna Tomczak, Yingda Jiang, Zhiqin Jiang, Jennifer S. Davis, Sukhen Ghosh, Hey Min Lee, Laura Reyes-Uribe, Kyle Chang, Yusha Liu, Huiqin Chen, Ali Azhdarinia, Jeffrey Morris, Eduardo Vilar, Kendra S. Carmon, Scott E. Kopetz, Kunal Rai
Summary: Enhancer aberrations are key epigenetic features in colorectal cancers, with active enhancer dynamics underlying tumor progression and potential for precision combination therapy. By mapping chromatin profiles and identifying distinct enhancer subtypes, combinatorial therapeutic strategies targeting specific pathways based on enhancer patterns have been proposed for different CRC subgroups, potentially improving patient outcomes.
Article
Gastroenterology & Hepatology
Yoshikuni Kawaguchi, Scott Kopetz, Elena Panettieri, Hyunsoo Hwang, Xuemei Wang, Hop S. Tran Cao, Ching-Wei D. Tzeng, Yun Shin Chun, Thomas A. Aloia, Jean-Nicolas Vauthey
Summary: Survival in patients undergoing resection of colorectal liver metastases has improved over the past 20 years, associated with the introduction of irinotecan- and/or oxaliplatin-containing regimens, molecular targeted therapy, and multigene alteration testing. Liver resectability indications expanded over time, with a significantly better 5-year overall survival rate in 2006-2014 compared to 2001-2005. RAS alteration was associated with worse survival outcomes, while multigene alteration testing proved useful for prognostication and identification of potential therapeutic targets.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Editorial Material
Oncology
Michael S. Lee, Scott Kopetz
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Review
Oncology
David G. Menter, Vahid Afshar-Kharghan, John Paul Shen, Stephanie L. Martch, Anirban Maitra, Scott Kopetz, Kenneth Honn, Anil K. Sood
Summary: We have expertise in studying the role of platelets in cancer biology. In this article, we explore the connection between platelets and the thrombotic events and immunologic disorders caused by SARS-CoV-2 infections. Platelets play a central role in hemostasis, immunity, and adaptive phylogeny, and their evolutionary changes have influenced the interaction with viruses. Platelets have various responses to contain virus spread and stimulate immune cells and tissue repair.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Oncology
Nicolette Taku, Y. Nancy Yi-Qian, George J. Chang, Ethan B. Ludmir, Kanwal Pratap Singh Raghav, Miguel A. Rodriguez-Bigas, Emma Brey Holliday, Grace L. Smith, Bruce D. Minsky, Michael J. Overman, Craig Messick, David Boyce-Fappiano, Albert C. Koong, John Michael Skibber, Eugene Jon Koay, Arvind Dasari, Cullen M. Taniguchi, Brian K. Bednarski, Van K. Morris, Scott Kopetz, Prajnan Das
Summary: Young adult patients below 45 years old who undergo long course chemoradiation and surgery have lower rates of pathological complete response, nodal downstaging, and disease-free survival compared to those above 45 years old. Age is an important factor that affects treatment outcomes.
CLINICAL COLORECTAL CANCER
(2022)
Meeting Abstract
Oncology
Scott Kopetz, Danielle A. Murphy, Jie Pu, Rona Yaeger, Fortunato Ciardiello, Jayesh Desai, Eric Van Cutsem, Harpreet Singh Wasan, Takayuki Yoshino, Elena Elez, Adele Golden, Zhou Zhu, Xiaosong Zhang, Josep Tabernero
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Caio Max Sao Pedro Rocha Lima, Greg Yothers, Samuel A. Jacobs, Hanna Kelly Sanoff, Deirdre Jill Cohen, Katherine A. Guthrie, Norah Lynn Henry, Patricia A. Ganz, Scott Kopetz, Peter C. Lucas, Charles David Blanke, Norman Wolmark, Howard S. Hochster, Thomas J. George, Michael J. Overman
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Scott Kopetz, Axel Grothey, Rona Yaeger, Fortunato Ciardiello, Jayesh Desai, Tae Won Kim, Tim Maughan, Eric Van Cutsem, Harpreet Singh Wasan, Takayuki Yoshino, Michelle L. Edwards, Adele Golden, Ashwin Gollerkeri, Josep Tabernero
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Melanie Nicole Woods, Vincenzo De Falco, Claudia Prisco, Giulia Martini, Luigi Pio Guerrera, Valentina Belli, Teresa Troiani, Van K. Morris, John Paul Y. C. Shen, Hey Min Lee, Oscar Villarreal, Alexey Sorokin, Preeti Kanikarla Marie, Fortunato Ciardiello, Scott Kopetz, Stefania Napolitano
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Kanwal Raghav, Fang-Shu Ou, Alan P. Venook, Federico Innocenti, Ryan Sun, Heinz-Josef Lenz, Scott Kopetz
Summary: Clinical trial updates allow for dissemination of additional results from studies where the primary end point has already been reported. This study aimed to determine the prevalence of acquired genomic alterations (Acq-GAs) on anti-EGFR-chemotherapy compared to anti-VEGF-chemotherapy and later-line anti-EGFR-antibody therapy in metastatic colorectal cancer (mCRC). The findings indicate divergent resistance mechanisms with rare occurrence of Acq-GAs with up-front use of anti-EGFR-chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Veronika Fedirko, Scott Kopetz, Carrie R. Daniel
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Editorial Material
Oncology
Madhulika Eluri, Scott Kopetz, Christine M. Parseghian
Summary: The use of serial ctDNA in metastatic colorectal cancer has the potential to refine patient selection, reduce chemotherapy toxicity, and assess emerging resistance mechanisms for novel therapeutic strategies. However, important questions remain regarding its validation as a predictive biomarker of treatment response.
CLINICAL CANCER RESEARCH
(2023)
Letter
Oncology
Kanwal Raghav, Scott Kopetz, Ying Yuan
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Blessie Elizabeth Nelson, Apostolia M. Tsimberidou, Xueyao Fu, Siqing Fu, Vivek Subbiah, Anil K. Sood, Jordi Rodon, Daniel D. Karp, George Blumenschein, Scott Kopetz, Shubham Pant, Sarina A. Piha-Paul
Summary: This study evaluated the combination of bevacizumab, temsirolimus, and valproic acid in patients with advanced malignancies and found modest efficacy but significant toxicity. The study is the first to evaluate this combination and suggests potential for anticancer activity, but careful management of toxicity is necessary for future development.