4.7 Letter

In early-stage breast cancer, the estrogen receptor interacts with correlation between human epidermal growth factor receptor 2 status and age at diagnosis, tumor grade, and lymph node involvement

期刊

JOURNAL OF CLINICAL ONCOLOGY
卷 26, 期 10, 页码 1768-1769

出版社

AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.2007.15.6141

关键词

-

类别

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Oncology

Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results of the phase II PRIMMO study

Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stephanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwe, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frederic Amant, Katrien Vandecasteele, Hannelore G. Denys

Summary: The PRIMMO study conducted a phase II trial on patients with pretreated persistent/recurrent/metastatic cervical or endometrial cancer. The study found that pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail had modest but durable antitumor activity, with acceptable but not negligible toxicity.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

Review Surgery

An Algorithm for Labia Minora Reduction Based on a Review of Anatomical, Configurational, and Individual Considerations

Maurits Lange, J. Joris Hage, Refaat B. Karim, Frederic Amant

Summary: Various techniques have been introduced for reduction labiaplasty, but there is no single technique that is optimal for every patient. The choice of technique should be based on anatomical, configurational, and technical considerations, as well as the patient's personal preferences. An algorithm has been developed to guide the choice of technique, considering factors such as resection or retention of the labial free rim, required labial width reduction, labial vascular status, prevention of iatrogenic labial thickening, and preservation of labial sensibility. The choice of techniques includes edge trimming, central spindle form de-epithelialization or full-thickness resection, and modifications of the wedge resection or de-epithelialization technique.

ARCHIVES OF PLASTIC SURGERY-APS (2023)

Article Environmental Sciences

Characterization of the genotoxic profile of antineoplastic drugs using the cytokinesis-block micronucleus cytome assay

Ilana Struys, Eline Verscheure, Liesbeth Lenaerts, Frederic Amant, Lode Godderis, Manosij Ghosh

Summary: Due to the genotoxic consequences of antineoplastic agents on non-cancerous tissue, it is crucial to understand their effects. This study aimed to characterize the genotoxic profile of different classes of antineoplastic drugs using a cell line assay. The results showed increased micronucleus formation with all tested drugs, as well as specific abnormalities for each drug class. These findings can aid in interpreting genotoxic aberrations in patients treated with these drugs.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2023)

Article Oncology

Psychological impact of referral to an oncology hospital on patients with an ovarian mass

Pien Lof, Ellen G. Engelhardt, Mignon D. J. M. van Gent, Constantijne H. Mom, Fleur M. F. Rosier-van Dunne, W. Marchien van Baal, Harold R. Verhoeve, Brenda B. J. Hermsen, Marjolijn B. Verbruggen, Majoie Hemelaar, Jojanneke M. G. van de Swaluw, Haye C. Knipscheer, Judith A. F. Huirne, Steven M. Westenberg, Willemien J. van Driel, Eveline M. A. Bleiker, Frederic Amant, Christianne A. R. Lok

Summary: This study evaluated cancer-specific distress and treatment satisfaction in patients with an ovarian mass. It found that many patients experienced high cancer-specific distress during the work-up process. However, patients were generally satisfied with their treatment regardless of the diagnosis and treatment location. This suggests that patients' preferences should be considered when developing risk assessment strategies.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2023)

Article Health Care Sciences & Services

Minimum sample size for developing a multivariable prediction model using multinomial logistic regression

Alexander Pate, Richard D. Riley, Gary S. Collins, Maarten van Smeden, Ben Van Calster, Joie Ensor, Glen P. Martin

Summary: Multinomial logistic regression models are used to predict the risk of a categorical outcome with more than two categories. Researchers need to ensure that the number of participants is appropriate relative to the number of events and predictor variables for each category. This study proposes three criteria to determine the minimum required sample size, aiming to minimize overfitting, difference between observed and adjusted R-2 Nagelkerke, and ensure accurate estimation of overall risk. The criteria were evaluated through simulation study and applied to a worked example, with code provided for implementation in R and Stata.

STATISTICAL METHODS IN MEDICAL RESEARCH (2023)

Article Pharmacology & Pharmacy

Predicting Chemotherapy Distribution into Breast Milk for Breastfeeding Women Using a Population Pharmacokinetic Approach

David Damoiseaux, Daniel Centanni, Jos H. Beijnen, Frederic Amant, Alwin D. R. Huitema, Thomas P. C. Dorlo

Summary: Information on the distribution of chemotherapeutic drugs to breast milk is limited, and our study aimed to predict chemotherapy distribution in a more realistic breastfeeding population and evaluate the effect of discarding breast milk on potential chemotherapy exposure in infants.

CLINICAL PHARMACOKINETICS (2023)

Article Oncology

Improving Endometrial cancer assessment by combining the new techniqUe of GENomic profiling with surgical Extra uterIne disEase assessment (EUGENIE)

Jenneke C. Kasius, Rita Trozzi, Johanna Pijnenborg, Thais Baert, Annouschka Laenen, Anne-Sophie Van Rompuy, Ignacio Zapardiel, Giuseppe Vizzielli, Jure Knez, Francesco Fanfani, Frederic Amant

Summary: The study aims to determine the association between molecular classification and disease stage in endometrial cancer, in order to guide surgical approach. 1000 female patients aged 18 or above will be enrolled, and results on staging and oncological outcomes are expected in 2027 and 2029 respectively.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2023)

Letter Multidisciplinary Sciences

University vice-chancellor responds

Ben Van Calster

NATURE (2023)

Article Health Care Sciences & Services

Perspectives on validation of clinical predictive algorithms

Anne A. H. de Hond, Vaibhavi B. B. Shah, Ilse M. J. Kant, Ben Van Calster, Ewout W. Steyerberg, Tina Hernandez-Boussard

Summary: The generalizability of predictive algorithms is crucial for their application in clinical practice. This article provides an overview of three types of generalizability, namely temporal, geographical, and domain generalizability, based on existing literature. These types of generalizability are associated with their respective goals, methodology, and stakeholders.

NPJ DIGITAL MEDICINE (2023)

Article Oncology

Predicting resectable disease in relapsed epithelial ovarian cancer by using whole-body diffusion-weighted MRI

Sander Dumont, Vincent Vandecaveye, Raphaela Carmen Dresen, Els Van Nieuwenhuysen, Thais Baert, Frederic Amant, Valerie Broeckhoven, Toon Van Gorp

Summary: This study aimed to evaluate the diagnostic value of whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) in predicting resectable disease during secondary cytoreductive surgery for relapsed epithelial ovarian cancer. The study found that WB-DWI/MRI accurately predicted resectable disease and was associated with improved progression-free and overall survival of the patients.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2023)

Letter Computer Science, Artificial Intelligence

The TRIPOD-P reporting guideline for improving the integrity and transparency of predictive analytics in healthcare through study protocols

Paula Dhiman, Rebecca Whittle, Ben Van Calster, Marzyeh Ghassemi, Xiaoxuan Liu, Melissa D. McCradden, Karel G. M. Moons, Richard D. Riley, Gary S. Collins

NATURE MACHINE INTELLIGENCE (2023)

Letter Multidisciplinary Sciences

Provide public access to ethics-approved study protocols

Ben Van Calster

NATURE (2023)

Article Health Care Sciences & Services

Multiclass risk models for ovarian malignancy: an illustration of prediction uncertainty due to the choice of algorithm

Ashleigh Ledger, Jolien Ceusters, Lil Valentin, Antonia Testa, Caroline Van Holsbeke, Dorella Franchi, Tom Bourne, Wouter Froyman, Dirk Timmerman, Ben Van Calster

Summary: Assessing the malignancy risk of ovarian tumors is crucial for selecting appropriate management. In this study, six algorithms were compared to estimate the probabilities of different types of ovarian tumors. The models developed showed good performance, but individual probability estimates varied substantially.

BMC MEDICAL RESEARCH METHODOLOGY (2023)

Article Obstetrics & Gynecology

A blended preconception lifestyle programme for couples undergoing IVF: lessons learned from a multicentre randomized controlled trial

Tessy Boedt, Eline Dancet, Diane De Neubourg, Sofie Vereeck, Jan Seghers, Katleen van der Gucht, Ben Van Calster, Carl Spiessens, Sharon Lie Fong, Christophe Matthys

Summary: This randomized controlled trial aimed to assess the impact of a blended preconception lifestyle programme on reproductive and lifestyle outcomes of couples undergoing IVF. However, the trial was prematurely stopped due to the Covid-19 pandemic and the results indicate that the programme did not have a meaningful effect on time to ongoing pregnancy or other reproductive and lifestyle outcomes.

HUMAN REPRODUCTION OPEN (2023)

Article Obstetrics & Gynecology

Effects of chemotherapy on ovaries of pregnant mice

Teska Schuurman, Ji-Ying Song, Vera Wolters, Marieke van de Ven, Nienke van Trommel, Ina Beerendonk, Frederic Amant, Christianne Lok

Summary: This study found that chemotherapy can cause damage to the maternal ovaries during pregnancy, and the extent of this damage depends on the type of chemotherapy and the duration of exposure. Short-term exposure leads to more severe damage, but it might be temporary. Chemotherapy also results in the loss of primordial follicles and DNA damage, with paclitaxel causing the least damage.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2023)

暂无数据