Article
Oncology
Amanda L. Nash, Diane L. Bloom, Brittany M. Chapman, Stephanie B. Wheeler, Kandace P. McGuire, Clara N. Lee, Kevin Weinfurt, Donald L. Rosenstein, Jennifer K. Plichta, Julie C. Jacobson Vann, E. Shelley Hwang
Summary: This study explored the experiences of the partners of women who undergo CPM. Most partners hoped their wives would choose a bilateral mastectomy, but the final decision was up to the women. The male partners had difficulty understanding the physical and emotional changes of mastectomy, making communication about sexuality and intimacy challenging.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Alison S. Baskin, Ton Wang, Brooke C. Bredbeck, Brandy R. Sinco, Nicholas L. Berlin, Lesly A. Dossett
Summary: For women with small, unilateral breast cancer, most are suitable candidates for breast conserving surgery (BCS) but a significant portion opt for mastectomy, with a rising percentage choosing contralateral prophylactic mastectomy (CPM). Factors such as patient characteristics, tumor attributes, and facility features may influence the decision-making regarding CPM.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Oncology
Marjanka K. Schmidt, Jennifer E. Kelly, Anne Bredart, David A. Cameron, Jana de Boniface, Douglas F. Easton, Birgitte Offersen, Fiorita Poulakaki, Isabel T. Rubio, Francesco Sardanelli, Rita Schmutzler, Tanja Spanic, Britta Weigelt, Emiel J. T. Rutgers
Summary: After a unilateral breast cancer diagnosis, more and more patients are choosing to have contralateral prophylactic mastectomy (CPM), the removal of the healthy breast. Breast cancer specialists need to provide guidance to women considering CPM. This manifesto discusses the challenges of CPM and offers recommendations to improve outcomes for women with unilateral breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Anita Mamtani, Daniel D. D. Sjoberg, Alain Vincent, Behfar Ehdaie, Deepak Malhotra, Andrew Vickers, Monica Morrow
Summary: Despite the lack of oncologic benefit, the use of contralateral prophylactic mastectomy (CPM) among women with unilateral breast cancer is increasing. This trend is driven by patient fears of recurrence and desire for peace of mind. Traditional educational strategies have been ineffective in reducing CPM rates.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Surgery
Hannah Kapur, Rebecca Warburton, Jin-Si Pao, Carol Dingee, Leo Chen, Elaine McKevitt
Summary: Contralateral prophylactic mastectomy (CPM) is not recommended for average-risk women with breast cancer due to lack of evidence for survival benefit, yet recent studies demonstrate increasing CPM rates. Patients receiving CPMs tend to have higher reconstruction rates and be younger in age.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Akshara Singareeka Raghavendra, Hala F. Alameddine, Clark R. Andersen, Jesse C. Selber, Abenaa M. Brewster, Carlos H. Barcenas, Abigail S. Caudle, Banu K. Arun, Debu Tripathy, Nuhad K. Ibrahim
Summary: Partners, physicians, and the media significantly influence women with unilateral breast cancer's decision to undergo CPM surgery, with physicians having a greater influence and partners and the media having a lower influence compared to self-determination. Educational aids and programs are needed to help women make informed decisions regarding CPM efficacy.
Article
Oncology
Peter J. Krasniak, Minh Nguyen, Sarah Janse, Crystal Phommasathit, Kaleigh Clevenger, Savannah Renshaw, Doreen M. Agnese, Tasleem J. Padamsee, Clara N. Lee
Summary: The rate of contralateral prophylactic mastectomy (CPM) is increasing in the U.S. among patients with non-familial, unilateral breast cancer, despite no survival benefit. This study aimed to assess the impact of emotions on a patient's decision to undergo CPM.
Article
Oncology
Jennifer Q. Zhang, Carlos Henrique Dos Anjos, Varadan Sevilimedu, Angelena Crown, Kimberly A. Amoroso, Melissa L. Pilewskie, Mark E. Robson, Mary L. Gemignani
Summary: This study identified a high rate of contralateral prophylactic mastectomy (CPM) among breast cancer patients with ATM, CHEK2, and PALB2 gene alterations, including variants of uncertain significance (VUS). Premenopausal status and pathogenic alterations were associated with an increased use of CPM.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Surgery
Katherine B. Santosa, Jeremie D. Oliver, Adeyiza O. Momoh
Summary: Contralateral prophylactic mastectomy (CPM) rates in the United States have been on the rise, influenced by multiple factors. The authors have shed light on the current state and summarized the literature, outlining future directions for research and knowledge dissemination.
Review
Oncology
Josien C. C. Scheepens, Laura van 't Veer, Laura Esserman, Jeff Belkora, Rita A. Mukhtar
Summary: Research evaluates the evidence for contralateral prophylactic mastectomy (CPM), patient rationales for choosing CPM, and factors that may impact patient preferences. Studies indicate a significant gap between patient preferences for radical risk reduction with CPM and the current approaches recommended by important guidelines.
Article
Surgery
Meghana G. Shamsunder, Hina Panchal, Melissa Pilewskie, Clara Lee, Shantanu N. Razdan, Evan Matros
Summary: This study aimed to quantify preferences for aspects of contralateral prophylactic mastectomy (CPM) decision-making process among key stakeholders. Healthy volunteers, women with cancer, surgical oncologists, and plastic surgeons were surveyed. The results showed that the acceptability threshold for future cancer episodes and risk tolerance for complications varied by stakeholder.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Public, Environmental & Occupational Health
J. Jansen, A. Serafimovska, R. Glassey, N. Zdenkowski, C. Saunders, D. Porter, P. Butow
Summary: The study found that a decision aid about contralateral prophylactic mastectomy is feasible and acceptable, but there are questions regarding the role of decision aids in situations where one option has limited medical benefit. Some patients have a high need for information to make an informed decision, indicating a need for more support tools in these types of decisions.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Surgery
Amanda R. Sergesketter, Caitlin Marks, Gloria Broadwater, Ronnie L. Shammas, Rachel A. Greenup, Sharon Clancy, Jennifer K. Plichta, Scott T. Hollenbeck, Brett T. Phillips
Summary: For patients undergoing breast reconstruction after bilateral mastectomies, there is no significant difference in the risk of reconstructive complications between therapeutic mastectomy and contralateral prophylactic mastectomy sides.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Oncology
Baosheng Zhao, Mo Yi, Hong Lyu, Xiaoman Zhang, Yujie Liu, Xinhong Song
Summary: Currently, the choice of contralateral prophylactic mastectomy (CPM) for breast cancer patients is variable and controversial. This study aimed to conduct a meta-synthesis of qualitative studies on the decision-making experiences, real-life experiences, psychological feelings, and needs of breast cancer patients in CPM decision-making, with the aim of supporting the development of CPM practice decisions.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Surgery
Ayat ElSherif, Sherif Armanyous, Corey K. Gentle, Zahraa Al-Hilli, Stephanie A. Valente
Summary: This study found that age, BMI, genetic testing, and breast reconstruction are factors contributing to the decision of contralateral prophylactic mastectomy at the time of ipsilateral breast tumor recurrence.
AMERICAN JOURNAL OF SURGERY
(2022)
Editorial Material
Engineering, Biomedical
Demosthenes E. Ziogas, Ioannis D. Kyrochristos, Dimitrios H. Roukos
EXPERT REVIEW OF MEDICAL DEVICES
(2018)
Editorial Material
Oncology
Georgios K. Glantzounis, Ioannis D. Kyrochristos, Demosthenes E. Ziogas, Efstathios G. Lykoudis, Dimitrios H. Roukos
Editorial Material
Oncology
Ioannis D. Kyrochristos, Demosthenes E. Ziogas, Dimitrios H. Roukos
Editorial Material
Medicine, Research & Experimental
Ioannis D. Kyrochristos, Demosthenes E. Ziogas, Georgios K. Glantzounis, Dimitrios H. Roukos
BIOMARKERS IN MEDICINE
(2018)
Editorial Material
Medicine, Research & Experimental
Ioannis D. Kyrochristos, Demosthenes E. Ziogas, Efstathios G. Lykoudis, Dimitrios H. Roukos
BIOMARKERS IN MEDICINE
(2018)
Editorial Material
Oncology
Ioannis D. Kyrochristos, Dimitra V. Peristeri, Demosthenes E. Ziogas, Efstathios G. Lykoudis, Dimitrios H. Roukos
Review
Pharmacology & Pharmacy
Demosthenes E. Ziogas, Ioannis D. Kyrochristos, Dimitrios H. Roukos
DRUG DISCOVERY TODAY
(2018)
Editorial Material
Medicine, Research & Experimental
Demosthenes E. Ziogas, Ioannis D. Kyrochristos, Efstathios G. Lykoudis, Dimitrios H. Roukos
BIOMARKERS IN MEDICINE
(2018)
Review
Chemistry, Medicinal
Ioannis D. Kyrochristos, Demosthenes E. Ziogas, Dimitrios H. Roukos
MEDICINAL RESEARCH REVIEWS
(2019)
Editorial Material
Pharmacology & Pharmacy
Ioannis D. Kyrochristos, Demosthenes E. Ziogas, Dimitrios H. Roukos
PERSONALIZED MEDICINE
(2018)
Editorial Material
Pharmacology & Pharmacy
Ioannis D. Kyrochristos, Demosthenes E. Ziogas, Persefoni Antoniou, Michail Mitsis, Efstathios G. Lykoudis, Dimitrios H. Roukos
Review
Pharmacology & Pharmacy
Ioannis D. Kyrochristos, Demosthenes E. Ziogas, Dimitrios H. Roukos
DRUG DISCOVERY TODAY
(2019)
Review
Oncology
Ioannis D. Kyrochristos, Dimitrios H. Roukos
CANCER TREATMENT REVIEWS
(2019)
Article
Gastroenterology & Hepatology
Demosthenes E. Ziogas, Ioannis D. Kyrochristos, Georgios K. Glantzounis, Dimitrios Christodoulou, Evangelos Felekouras, Dimitrios H. Roukos
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2017)
Letter
Hematology
Alexandros Makis, Meropi Tzoufi, Eleni Pappa, Ioannis Kyrochristos, Anastasia Zikou, Vasileios Xydis, Maria I. Argyropoulou, Nikolaos Chaliasos
BLOOD CELLS MOLECULES AND DISEASES
(2017)
