Article
Oncology
Juan Du, Linxi Zhu, Huizi Sha, Zhengyun Zou, Jie Shen, Weiwei Kong, Lianjun Zhao, Qing Gu, Lixia Yu, Yudong Qiu, Baorui Liu
Summary: Individualized chemotherapy combined with sequential immunotherapy based on BRCA1 mRNA expression level can control the disease and have controllable adverse reactions in unresectable pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Optics
Jose Luis Vilas, Jose Maria Herrera-Fernandez
Summary: This paper focuses on achieving customized variable retarders in broad spectral ranges by optimizing the thicknesses and orientations of wave plates. The obtained results show deviations below 10% between the target and the desired retardation, making this research significant for fields and instruments where polarization control plays a fundamental role.
Article
Oncology
C. E. Geyer, J. E. Garber, R. D. Gelber, G. Yothers, M. Taboada, L. Ross, P. Rastogi, K. Cui, A. Arahmani, G. Aktan, A. C. Armstrong, M. Arnedos, J. Balmana, J. Bergh, J. Bliss, S. Delaloge, S. M. Domchek, A. Eisen, F. Elsafy, L. E. Fein, A. Fielding, J. M. Ford, S. Friedman, K. A. Gelmon, L. Gianni, M. Gnant, S. J. Hollingsworth, S-A Im, A. Jager, S. R. Lakhani, W. Janni, B. Linderholm, T-W Liu, N. Loman, L. Korde, S. Loibl, P. C. Lucas, F. Marme, E. Martinez de Duenas, R. McConnell, K-A Phillips, M. Piccart, G. Rossi, R. Schmutzler, E. Senkus, Z. Shao, P. Sharma, C. F. Singer, T. Spanic, E. Stickeler, M. Toi, T. A. Traina, G. Viale, G. Zoppoli, Y. H. Park, R. Yerushalmi, H. Yang, D. Pang, K. H. Jung, A. Mailliez, Z. Fan, I Tennevet, J. Zhang, T. Nagy, G. S. Sonke, Q. Sun, M. Parton, M. A. Colleoni, M. Schmidt, A. M. Brufsky, W. Razaq, B. Kaufman, D. Cameron, C. Campbell, A. N. J. Tutt, O. Th Johannsson
Summary: The OlympiA trial demonstrated that adjuvant therapy with the oral PARP inhibitor, olaparib, significantly improves overall survival in patients with gBRCA1/2pv-associated early breast cancer. The study also showed improvements in invasive disease-free survival and distant disease-free survival, with no new safety issues identified.
ANNALS OF ONCOLOGY
(2022)
Review
Immunology
Yan Lin, Huan-Wei Liang, Yang Liu, Xin-Bin Pan
Summary: Esophageal cancer is a common cancer worldwide, and neoadjuvant chemoradiotherapy followed by surgery is the standard treatment. However, most patients do not achieve complete response and have a poor prognosis. The latest trial shows that adjuvant therapy with nivolumab can improve survival in patients without complete response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daohan Jiang, Alexander L. Cope, Jianzhi Zhang, Matt Pennell
Summary: Variation in gene expression across lineages plays a crucial role in explaining phenotypic variation and adaptation. However, the assumption that mRNA levels can accurately represent protein levels has been challenged by studies showing weak correlations between the two measures across species. This discrepancy might be due to compensatory evolution between mRNA levels and translation regulation, but the conditions and strength of the correlation are still not well understood. A theoretical model of the coevolution of mRNA and protein levels reveals that compensatory evolution is common with stabilizing selection on protein levels, while under directional selection, mRNA levels and translation rates show negative correlations across lineages but positive correlations across genes. These findings offer insights into comparative studies of gene expression and provide a framework to distinguish biological and statistical hypotheses for the transcriptomic-proteomic mismatch.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Immunology
Xinyu Zhuang, Luer Chen, Songhui Yang, Shengnan Xia, Zhiqiang Xu, Tong Zhang, Boyu Zeng, Tong Yu, Ning Yu, Wei Wang, Huijun Lu, Mingyao Tian, Ningyi Jin
Summary: This study investigates the design strategy of mRNA vaccines against the H5N1 influenza virus. It suggests that incorporating ferritin into the vaccine can enhance the expression of target antigens, and the addition of adjuvants can improve the immune response in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jonas Herrmann, Helena Schmidt, Katja Nitschke, Cleo-Aron Weis, Philipp Nuhn, Jost von Hardenberg, Maurice Stephan Michel, Philipp Erben, Thomas Stefan Worst
Summary: Low expression of RAD52 is associated with decreased disease-free survival in patients with MIBC, especially in those treated with adjuvant cisplatin-based chemotherapy (ACBC), indicating its potential as a predictor for treatment response. Other DDRG genes such as BRCA2, ERCC2, and FOXM1 also showed an impact on DFS, with conflicting results in different patient cohorts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xianqing Xiong, Guozhen Lu, Danting Lu
Summary: This study conducted a standardized experimental study on children's solid wood furniture parts using group technology, analyzing three key structural features of the parts and classifying them to establish a children's solid wood furniture parts family. The optimization of part specifications greatly improved the standardization of solid wood parts.
APPLIED SCIENCES-BASEL
(2021)
Article
Genetics & Heredity
Zhouhuan Dong, Yun Wang, Jing Zhang, Fengwei Zhu, Zhiyuan Liu, Yajun Kang, Mingyuan Lin, Huaiyin Shi
Summary: In this study, the reliability of the Minigene Assay platform was verified, and the splicing effect of VUS in the BRCA1/2 genes was analyzed. The results showed that experimental splicing analysis was effective for VUS classification.
JOURNAL OF HUMAN GENETICS
(2023)
Review
Engineering, Biomedical
Adenilson de Souza da Fonseca, Eshilley de Souza Alves, Flavia de Paoli, Andre Luiz Mencalha
Summary: Evaluation of gene expression in cells and biological tissues using RT-qPCR after low-power laser exposure showed changes in mRNA levels of various genes related to molecular, cellular, and systemic processes. These findings contribute to a better understanding of the mechanisms involved in photobiomodulation and can enhance the efficacy and safety of clinical applications based on low-power lasers.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Lin Wang, Weizhong Geng, Kunjin He, Kaijin Guo
Summary: This study proposes a rapid design method for customized implants based on bionic vein structure features. By combining the traditional parametric deformation method with bionic vein structure features, the efficiency of customized implant design can be improved.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Javier Martin-Broto, Jeronimo Martinez-Garcia, David S. Moura, Andres Redondo, Antonio Gutierrez, Antonio Lopez-Pousa, Javier Martinez-Trufero, Isabel Sevilla, Roberto Diaz-Beveridge, Maria Pilar Solis-Hernandez, Amancio Carnero, Marco Perez, David Marcilla, Jesus Garcia-Foncillas, Pablo Romero, Javier Fernandez-Jara, Daniel Lopez-Lopez, Ivan Arribas, Nadia Hindi
Summary: Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors have shown activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS) with CDK4 amplification. CDK4 overexpression, rather than CDKN2A, was found to be the most consistent predictive factor for the efficacy of palbociclib in sarcomas. Palbociclib demonstrated activity in a variety of sarcoma subtypes with CDK4/CDKN2A amplification, suggesting its potential as a treatment option for sarcomas.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Pharmacology & Pharmacy
Juliana Popovitz, Rohit Sharma, Reyhane Hoshyar, Beob Soo Kim, Niren Murthy, Kunwoo Lee
Summary: The field of gene editing has been the subject of significant attention due to its potential for therapeutic applications. This review focuses on the use of mRNA delivery for gene editing therapeutics and discusses the engineering and improvement of gene editing technology. It also examines ex vivo and in vivo gene editing techniques and explores the future of CRISPR and base editing systems.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Oncology
T. Bosse, C. L. Creutzberg, E. J. Crosbie, K. Han, N. Horeweg, A. Leary, J. R. Kroep, J. N. McAlpine, M. E. Powell, F. Blanc-Durand, M. de Bruyn, D. N. Church, V. H. Koelzer, S. Kommoss, N. Singh, A. Bardet, N. Counsell, H. Putter, D. Tu, R. Edmondson, C. Gordon, J. Ledermann, P. Morice, H. MacKay, H. Nijman, R. A. Nout, V. T. H. B. M. Smit, H. White, J. Alexandre, S. M. de Boer, I Boere, R. Cooper, J. L. Ethier, J. S. Frenel, J. McGrane, A. Taylor, S. Welch, A. M. Westermann, H. Dijcker-van der Linden, L. Farrelly, A. Feeney, M. Kaya, W. Liu, A. Melis, F. Ngadjeua-Tchouatieu, W. Parulekar, K. Verhoeven-Adema, RAINBO Res Consortium
Summary: The RAINBO program aims to investigate molecular class-directed adjuvant treatment strategies for endometrial cancer, with the goal of improving clinical outcomes and reducing toxicity. It consists of four international clinical trials and an overarching research program to advance knowledge of predictive and prognostic markers.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Engineering, Civil
Dongfang Ma, Bo Fang, Weihao Ma, Xiaodong Wu, Sheng Jin
Summary: This study aims to identify spatial patterns of travel demands and extract potential customized bus routes using a clustering algorithm based on vehicle trajectory data. A comprehensive similarity (CS) method is proposed to evaluate multiple characteristics of vehicle trajectories. Density-based spatial clustering of applications with noise (DBSCAN) is used to divide trajectories into groups, and VIKOR is applied to determine trade-off parameters. A case study based on taxi trajectory data in Suzhou, China shows a coverage rate of 66.7% compared to existing bus routes. The proposed method has advantages in clustering algorithm and trajectory similarity measurement.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)