Article
Oncology
Jennifer Dalton, Pamela Rothpletz-Puglia, Joel B. Epstein, Shristi Rawal, Heidi Ganzer, Rebecca Brody, Laura Byham-Gray, Riva Touger-Decker
Summary: This study applied the Social Cognitive Transition (SCT) Model of Adjustment to investigate how head and neck cancer survivors transition in their eating experience, focusing on taste and oral function changes, weight loss concerns, and coping strategies that draw upon social and cultural dimensions. Results show that utilizing cognitive adaptation and coping strategies can support identity transition related to the eating experience following cancer therapy.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Kristian Hastoft Jensen, Ivan Vogelius, Claus Ernst Moser, Elo Andersen, Jesper Grau Eriksen, Jorgen Johansen, Mohammad Farhadi, Maria Andersen, Jens Overgaard, Jeppe Friborg
Summary: This study found that the risk of bloodstream infections (BSIs) in patients with head and neck squamous cell carcinoma undergoing radiotherapy or chemoradiation is associated with age, cancer stage, and performance status, with Staphylococcus aureus being a common pathogen. The 30-day post-BSI mortality rate was 26%, and BSIs contributed to 10% of early non-cancer deaths. Empiric antibiotic treatment should prioritize coverage for S. aureus in this population.
BRITISH JOURNAL OF CANCER
(2021)
Review
Health Care Sciences & Services
Martin Dolezel, Marek Slavik, Tomas Blazek, Tomas Kazda, Pavel Koranda, Lucia Veverkova, Petr Burkon, Jakub Cvek
Summary: Concurrent chemoradiotherapy is commonly used in the curative treatment of head and neck cancer patients, with locoregional failure being the main recurrence pattern. Tumor hypoxia is a major cause of treatment failure, and positron emission tomography (PET) has been extensively studied as a feasible method for detecting tumor hypoxia. Escalating the dose to hypoxic tumors has shown potential to improve outcomes. The optimization of radiotherapeutic plans has been well-documented, and there are two main approaches for defining the hypoxic tumor volume based on PET images.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
William Trung Le, Eugene Vorontsov, Francisco Perdigon Romero, Lotfi Seddik, Mohamed Mortada Elsharief, Phuc Felix Nguyen-Tan, David Roberge, Houda Bahig, Samuel Kadoury
Summary: In radiation oncology, predicting patient risk stratification using deep learning is important for improving patient outcomes. This study proposes a new deep learning model for predicting distant metastasis, locoregional recurrence, and overall survival probabilities in head and neck cancer patients. The model achieves high accuracy and can be applied to multi-center data.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Oncology
Heleen Bollen, Julie van der Veen, Annouschka Laenen, Sandra Nuyts
Summary: IMRT and VMAT have become standard of care in treating head and neck cancer. By analyzing treatment failure patterns, this study indirectly investigated the quality of target volume delineation and treatment delivery, which were performed accurately with few recurrences outside high-dose regions and no marginal failures observed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kelly Saesen, Julie van der Veen, Bertien Buyse, Sandra Nuyts
Summary: The study aimed to confirm the prevalence of obstructive sleep apnea (OSA) after radiotherapy for head and neck cancer, as well as investigate the risk factors for developing OSA in this population. The results showed that patients treated for head and neck cancer are at a higher risk of developing OSA, with referral to a sleep clinic recommended for those experiencing fatigue and sleeping problems. Further research is needed to identify potential risk factors and develop prevention and treatment strategies.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Sezin Yuce Sari, Melek Tugce Yilmaz, Burak Yasin Aktas, Sercan Aksoy, Ibrahim Gullu, Mustafa Cengiz, Gokhan Ozyigit, Gozde Yazici
Summary: The study found that concurrent stereotactic body radiotherapy and immunotherapy in patients with metastatic and recurrent head and neck cancer can achieve good treatment outcomes, with 6-month overall survival and progression-free survival rates of 93% and 86% respectively, and a 96% local control rate in SBRT sites.
Review
Oncology
Mischa de Ridder, Cornelis P. J. Raaijmakers, Frank A. Pameijer, Remco de Bree, Floris C. J. Reinders, Patricia A. H. Doornaert, Chris H. J. Terhaard, Marielle E. P. Philippens
Summary: MRI-guided radiotherapy has become more routine in the treatment of head and neck cancer. It provides superior anatomical imaging and functional information, while reducing radiation dose to organs at risk.
Article
Medicine, General & Internal
Ameeta Lubina Nayak, Arthur Travis Pickett, Megan Delisle, Brittany Dingley, Ranjeeta Mallick, Trevor Hamilton, Heather Stuart, Martha Talbot, Gregory Mckinnon, Evan Jost, Eva Thiboutot, Valerie Francescutti, Sal Samman, Alexandra Easson, Angela Schellenberg, Shaila Merchant, Julie La, Kaitlin Vanderbeck, Frances Wright, David Berger-Richardson, Pamela Hebbard, Olivia Hershorn, Rami Younan, Erica Patocskai, Samuel Rodriguez-Qizilbash, Ari Meguerditichian, Vanina Tchuente, Suzanne Kazandjian, Alex Mathieson, Farisa Hossain, Jessika Hetu, Martin Corsten, Angelina Tohme, Carolyn Nessim, Stephanie Johnson-Obaseki
Summary: This study, the largest Canadian evaluation of survival outcomes for head and neck MCC, found that disease staging and treatment modalities are associated with survival. Multimodal treatment is associated with higher survival rates across all stages of the disease.
Article
Psychology, Multidisciplinary
Fiona Menger, Jennifer Deane, Joanne M. M. Patterson, Peter Fisher, James O'Hara, Linda Sharp
Summary: This study explores the experiences of rumination among survivors of head and neck cancer, identifying four themes with linked subthemes on the content and process of rumination.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Oncology
Ling Zhou, Jia Chen, Chang-Juan Tao, Ming Chen, Zhong-Hua Yu, Yuan-Yuan Chen
Summary: Hypothyroidism after radiotherapy in head and neck cancer patients is influenced by factors such as radiation dose, treatment technique, thyroid volume, gender, and age. Incidence increases over time and a prospective large sample study is recommended for modeling complications related to radiation-induced hypothyroidism.
Article
Oncology
Sachin R. Jhawar, Marcelo Bonomi, Paul M. Harari
Summary: The Oncology Grand Rounds series aims to help readers apply the results of key studies in clinical practice, using case presentations, literature reviews, and treatment recommendations to enhance understanding of the latest developments in oncology.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Mariangela Massaccesi, Nicola Dinapoli, Valentina Fuga, Cosimo Rupe, Marco Panfili, Rosalinda Calandrelli, Stefano Settimi, Michela Olivieri, Francesco Beghella Bartoli, Ciro Mazzarella, Silvia Longo, Carlo Lajolo, Luca Boldrini, Maria Antonietta Gambacorta, Vincenzo Valentini, Francesco Micciche
Summary: This study developed a prediction model for trismus based on a multivariable analysis of dosimetric and clinical factors. By measuring the maximum interincisal opening and dosimetry of masticatory structures, it is possible to accurately predict whether patients will develop trismus after radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Louise Cunliffe, Helen Coulthard, Iain R. Williamson
Summary: Picky eating is a common behavior in childhood and is often associated with sensory processing difficulties. This study explored the experiences of parents or caregivers with children who have both sensory processing differences and picky eating behaviors. The findings emphasized the challenges faced by parents, including a lack of support and criticism from others. However, it was found that gradually accepting and adopting a positive attitude towards their child's eating allowed for positive interactions and activities centered around food.
MATERNAL AND CHILD NUTRITION
(2022)
Article
Oncology
Sandra Einarsson, Goran Laurell, Ylva Tiblom Ehrsson
EUROPEAN JOURNAL OF CANCER CARE
(2019)
Article
Oncology
Sandra Einarsson, Goran Laurell, Ylva Tiblom Ehrsson
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2020)
Article
Nutrition & Dietetics
Ylva Tiblom Ehrsson, Per Fransson, Sandra Einarsson
Summary: The study showed that nutrition status is closely related to health-related quality of life, anxiety, and depression in head and neck cancer patients. More patients reported anxiety at the beginning of treatment, while more reported depression at seven weeks. Targeted support is needed during care, and long-term survivors need strategies to cope with the consequences.
Article
Otorhinolaryngology
Constantina Nadia Christou, Ylva Tiblom Ehrsson, Erik Lampa, Ulf Riserus, Goran Laurell
Summary: This study aimed to explore the longitudinal changes in circulating fatty acid composition in patients with head and neck cancer. The results showed altered profiles of both saturated and unsaturated fatty acids, with certain fatty acids correlated with weight changes. Improved understanding of metabolic pathways in these patients could support better nutritional surveillance and treatment.
ACTA OTO-LARYNGOLOGICA
(2021)
Article
Oncology
Brith Granstrom, Thorbjorn Holmlund, Goran Laurell, Per Fransson, Ylva Tiblom Ehrsson
Summary: This prospective study aimed to assess the impact of nutritional symptoms on oral intake and weight loss in HNC patients. Swallowing problems, chewing difficulties, and loss of appetite were found to be the most significant symptoms interfering with oral intake. Factors such as pain, loss of appetite, feeling full, sore mouth, difficulty swallowing, taste changes, and dry mouth were associated with a higher risk of weight loss. Women tended to have higher symptom scores and interference with oral intake. In conclusion, this study emphasizes the importance of a holistic approach in addressing the nutritional issues of patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Ulrica Langegard, Asa Cajander, Maria Carlsson, Louise von Essen, Awais Ahmad, Goran Laurell, Ylva Tiblom Ehrsson, Birgitta Johansson
Summary: This study aims to develop an internet-based intervention to improve informal caregivers' ability to support individuals with head and neck cancer, and to test the feasibility and acceptability of the intervention.
Article
Oncology
Brith Granstrom, Joakim Isaksson, Nilla Westoo, Thorbjorn Holmlund, Krister Tano, Goran Laurell, Ylva Tiblom Ehrsson
Summary: This study aimed to explore how individuals treated for head and neck cancer perceive life one year after treatment and their experiences with supportive efforts from healthcare. A semi-structured interview study was conducted with 21 patients, focusing on physical, psychological, and return-to-work issues, as well as their experiences with rehabilitative efforts from healthcare and contact nurses. The results showed that one year after treatment, patients still experienced side effects and fear of recurrence, but they strived to live as they did before the cancer diagnosis. However, there was a lack of regular long-term follow-ups with contact nurses regarding rehabilitation needs. Improvement possibilities include clarifying the role of contact nurses and encouraging them to initiate contact with patients.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Oncology
Ylva Tiblom Ehrsson, Marta A. Kisiel, Yukai Yang, Goeran Laurell
Summary: The study found that advanced tumor stages were the main hindrance to returning to work within 3 months, while oral and larynx cancer posed difficulties for returning to work at 12 months; having a partner, white-collar job, and early tumor stages were identified as facilitators for returning to work.
Article
Nutrition & Dietetics
Sandra Einarsson, Hans-Emil Karlsson, Ove Bjor, Anna-Karin Haylock, Ylva Tiblom Ehrsson
CLINICAL NUTRITION ESPEN
(2020)
Article
Nutrition & Dietetics
Sandra Einarsson, Goran Laurell, Ylva Tiblom Ehrsson
CLINICAL NUTRITION ESPEN
(2020)
Article
Otorhinolaryngology
Thorsteinn Astradsson, Goran Laurell, Alexander Ahlberg, Polymnia Nikolaidis, Hemming Johansson, Ylva Tiblom Ehrsson
ACTA OTO-LARYNGOLOGICA
(2018)
Article
Otorhinolaryngology
Anna Holm, Urban Hellman, Claude Laurent, Goran Laurell, Karin Nylander, Katarina Olofsson
ACTA OTO-LARYNGOLOGICA
(2018)