期刊
JOURNAL OF CLINICAL NEUROSCIENCE
卷 21, 期 1, 页码 189-190出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2013.03.012
关键词
Central nervous system neoplasms; Epidermal growth factor receptor; Glioblastoma; Immunotherapy; T-lymphocytes
资金
- National Institutes of Health [P50 NS020023-28, 3R01-CA-135272-02S1]
- [5P50-NS020023-29]
- [5R01-CA135272-0251]
- [5R01-CA134844-03]
- [5UL1-RR024128-05]
- [5R21-NS067980-02]
- [5R21-NS068057-02]
Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors. (C) 2013 Elsevier Ltd. All rights reserved.
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