Article
Medicine, General & Internal
Helena Merkel, Dirk Lindner, Khaled Gaber, Svitlana Ziganshyna, Jennifer Jentzsch, Simone Mucha, Thilo Gerhards, Sabine Sari, Annika Stock, Felicitas Vothel, Lea Falter, Ulf Quaeschling, Karl-Titus Hoffmann, Juergen Meixensberger, Dirk Halama, Cindy Richter
Summary: This study proposes a visual classification scheme for cerebral vasospasm that is suitable for endovascular treatment. The results show good agreement between mathematical clustering and physician scoring. Additionally, the study finds that a threshold-based criterion does not provide additional advantages, and automated vessel analysis is superior in research settings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Matthias Simon, Alexander Grote
Summary: IL-6 is a proinflammatory cytokine that may serve as a potential biomarker in SAH patients, although discrepancies in research findings and lack of defined clinical endpoints hinder its routine clinical use. Further research is needed to better understand the role of IL-6 and neuroinflammation in the pathophysiology of SAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
E. Francois Aldrich, Randall Higashida, Abdel Hmissi, Elizabeth J. Le, R. Loch Macdonald, Angelina Marr, Stephan A. Mayer, Sebastien Roux, Nicolas Bruder
Summary: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with significant morbidity and mortality. The presence of thick, diffuse subarachnoid blood may indicate a worse clinical course and outcome, independently of other known prognostic factors. Patients with thick and diffuse SAH have higher rates of mortality, vasospasm-related morbidity, and poor clinical outcomes compared to those without thick and diffuse SAH.
JOURNAL OF NEUROSURGERY
(2021)
Article
Biology
Jong Kook Rhim, Dong Hyuk Youn, Bong Jun Kim, Youngmi Kim, Sungeun Kim, Heung Cheol Kim, Jin Pyeong Jeon
Summary: Continuous monitoring of plasma copeptin levels facilitates the screening of DCI in poor-grade SAH patients, while the relationship between CRP levels and DCI is not significant. Additionally, predicting DCI by combining TCD with copeptin changes has a better outcome than using TCD alone.
Article
Medicine, General & Internal
Ali Khanafer, Pervinder Bhogal, Victoria Hellstern, Christoph Harmening, Hansjoerg Baezner, Oliver Ganslandt, Hans Henkes
Summary: This study analyzed the diagnosis and management of patients with aneurysmal subarachnoid hemorrhage who died from ischemic brain damage caused by vasospasm. It was found that early recognition of severe vasospasm is crucial for treatment, but aggressive treatment may not prevent death.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ramon Torne, Jhon Hoyos, Laura Llull, Ana Rodriguez-Hernandez, Guido Munoz, Ricard Mellado-Artigas, Daniel Santana, Leire Pedrosa, Alberto Di Somma, Luis San Roman, Sergio Amaro, Joaquim Ensenat
Summary: The study found that improvements in cerebral edema and consciousness level were not associated with the occurrence of CI in severe aSAH patients. Therefore, intensive monitoring should not be reduced even if these indicators show improvement during the first week after bleeding.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Pharmacology & Pharmacy
H-K Vo, V-T Le, V-L Nguyen, X-C Dao, D-H Duong, T-L Trinh, V-T Nguyen, H-L Vo, C-H Nguyen, V-L Tran, A-T Nguyen, V-T Hoang, T-A Truong, T-B Nguyen, B-C Chu, T-M Le, T-T-H Dao, T-H Duong, H-Q Ha, T-P-L Trinh, T-T Truong, V-D Phan, T-N-L Pham, T-H Phuong, Q-C Le
Summary: The objective of this study was to evaluate the value of transcranial Doppler (TCD) ultrasonography in diagnosing cerebral vasospasm in SAH patients in Vietnam. The results showed that TCD had a high accuracy in diagnosing vasospasm, with a high predictive diagnostic value. Hemiplegia was the clinical symptom with the highest diagnostic value.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Ling Chen, Yang Jin, Ling Wang, Kai Wei, Xin Li, Tao Jiang, Xiangyang Cao, Liujun Xue, Qiantao Cheng
Summary: This study investigated the impact of human serum albumin (HSA) levels on symptomatic cerebral vasospasm (SCVS) in patients with aneurysmal subarachnoid hemorrhage (aSAH). The results showed that HSA levels lower than the average and lowest levels were associated with the occurrence of SCVS, and the lowest HSA level was a better predictor for SCVS.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Tamara M. Mueller, Stephanie Gollwitzer, Ruediger Hopfengartner, Stephan Rampp, Johannes D. Lang, Jenny Stritzelberger, Dominik Madzar, Caroline Reindl, Maximilian Spruegel, Muejgan Dogan Onugoren, Iris Muehlen, Joji B. Kuramatsu, Stefan Schwab, Hagen B. Huttner, Hajo M. Hamer
Summary: The study compared the ability of qEEG and TCD/TCCS to early identify patients who will develop later manifest cerebral infarction, finding that qEEG could differentiate between patients with and without cerebral infarction while TCD/TCCS did not show significant differences.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Sepide Kashefiolasl, Matthias S. Leisegang, Valeska Helfinger, Christoph Schuermann, Beatrice Pflueger-Mueller, Voahanginirina Randriamboavonjy, Andrea E. Vasconez, Geert Carmeliet, Klaus Badenhoop, Gudrun Hintereder, Volker Seifert, Katrin Schroeder, Juergen Konczalla, Ralf P. Brandes
Summary: The study found that 1,25-VitD3 attenuates CVS after SAH by inducing SDF1 alpha. Plasma levels of vitamin D3 were inversely correlated with the severity of CVS.
Article
Clinical Neurology
Iori Ozono, Fusao Ikawa, Toshikazu Hidaka, Shingo Matsuda, Shinnichiro Oku, Nobutaka Horie, Isao Date, Michiyasu Suzuki, Hitoshi Kobata, Yuichi Murayama, Akira Sato, Yoko Kato, Hirotoshi Sano
Summary: This study aimed to investigate the differences in risk factors between cerebral infarction due to cerebral vasospasm (IVS) and symptomatic cerebral vasospasm (SVS). Through a registry study of 1863 cases of aneurysmal subarachnoid hemorrhage, it was found that age was a risk factor for IVS, while the Fisher scale was a risk factor for SVS.
WORLD NEUROSURGERY
(2023)
Review
Biochemistry & Molecular Biology
Jose Medina-Suarez, Francisco Rodriguez-Esparragon, Coralia Sosa-Perez, Sara Cazorla-Rivero, Laura B. Torres-Mata, Aruma Jimenez-O'Shanahan, Bernardino Clavo, Jesus Morera-Molina
Summary: This review discusses the main genetic single nucleotide polymorphisms (SNPs) associated with delayed cerebral ischemia (DCI) and vasospasm, two complications of subarachnoid hemorrhages (SAHs). SNPs of eNOS, asymmetric dimetilarginine, high-mobility group box 1, haptoglobin, endothelin-1 receptor, and angiotensin-converting enzyme have been found to have a relationship with DCI and/or vasospasm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Wang-Xia Wang, Joe E. Springer, Kevin W. Hatton
Summary: Aneurysmal subarachnoid hemorrhage is a serious hemorrhagic stroke affecting nearly 30,000 patients annually in the United States, with a high mortality rate. Studies have shown that miRNAs play an important role in this disease and its complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Elena Grossini, Teresa Esposito, Michela Viretto, Sakthipriyan Venkatesan, Ilaria Licari, Daniela Surico, Francesco Della Corte, Luigi Castello, Stefania Bruno, Marco Quaglia, Cristoforo Comi, Vincenzo Cantaluppi, Rosanna Vaschetto
Summary: This study reveals the potential role of circulating extracellular vesicles (EVs) in the onset of subarachnoid hemorrhage (SAH) complications, particularly vasospasm (VP). The EVs isolated from SAH patients express specific markers, have larger size and higher concentration compared to healthy controls. Moreover, these EVs adversely affect endothelial and smooth muscle cells, leading to endothelial damage and enhanced smooth muscle reactivity. These findings have significant implications for the use of EVs as potential diagnostic/prognostic markers and therapeutic tools in SAH management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)