期刊
JOURNAL OF CLINICAL NEUROSCIENCE
卷 18, 期 9, 页码 1154-1157出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2011.02.007
关键词
Freezing of gait; Parkinson's Disease; Pathophysiological mechanism
Freezing of gait is a paroxysmal phenomenon most commonly found in patients with advanced Parkinson's Disease. The pathophysiological mechanisms underlying this behaviour remain uncertain despite a well-characterised phenotype. Freezing behaviour extends beyond gait to affecting speech and upper limb function, suggesting that there is likely to be a universal mechanism underlying the phenomenon. This paper identifies the essential features required for a comprehensive model of freezing and evaluates a number of hypotheses that seek to explain the phenomenon. It appears likely that the pathophysiology of freezing involves context-dependant dysfunction across multiple levels of the neurological system, including cortical, subcortical and brainstem regions. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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