Article
Biochemistry & Molecular Biology
Joanna K. Bujak, Daria Kosmala, Kinga Majchrzak-Kuligowska, Piotr Bednarczyk
Summary: The study confirmed the expression of the TRPV1 ion channel on both mRNA and protein levels in canine PBMC, and indicated that the ion channel is functional.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Elena O. Gracheva, Sviatoslav N. Bagriantsev
Summary: David Julius and Ardem Patapoutian were awarded this year's Nobel Prize in Physiology or Medicine for explaining the molecular basis for sensing heat, cold and mechanical force, marking the end of a scientific journey to identify the mechanisms in the somatosensory system mediating the detection of internal and external environments.
Article
Pharmacology & Pharmacy
Amalia Mira, Marta Rubio-Camacho, David Alarcon, Enrique Rodriguez-Canas, Asia Fernandez-Carvajal, Alberto Falco, Ricardo Mallavia
Summary: Electrospun fibers from PMVEMA and menthol solutions were characterized, showing higher encapsulation efficiency and stability of menthol in P139 fibers compared to P119 fibers. The morphology and size of the fibers were analyzed, and in vitro biological assays demonstrated no cytotoxicity induction.
Article
Biochemistry & Molecular Biology
Greg L. McKie, Kyle D. Medak, Hesham Shamshoum, David C. Wright
Summary: Topical application of the TRPM8 agonist L-menthol (MNTH) can stimulate BAT thermogenesis and attenuate weight gain in mice without affecting energy intake.
Article
Biochemistry & Molecular Biology
Yin-Zi Ye, Hao Zhang, Jiameng Li, Ren Lai, Shilong Yang, Wei-Guo Du
Summary: Temperature sensing is crucial for living organisms' survival, and turtle embryos exhibit thermotaxic behavior by activating two heat-sensitive ion channels, MrTRPA1 and MrTRPV1. These TRP channels play a key role in controlling the thermal behavior of turtle embryos through a delicate functional balance.
Article
Biochemistry & Molecular Biology
Enkelejda Goci, Entela Haloci, Antonio Di Stefano, Annalisa Chiavaroli, Paola Angelini, Ajkuna Miha, Ivana Cacciatore, Lisa Marinelli
Summary: The study aimed to prepare a pharmaceutical Carbopol-based formulation containing capsaicin and evaluate its in vitro release and antimicrobial and antifungal properties. The results showed that approximately 50% of capsaicin was released within 52 hours from the formulation, and it significantly enhanced the antimicrobial effects of capsaicin against various bacteria and fungi strains.
Article
Biochemistry & Molecular Biology
Nathalie M. Malewicz, Zahra Rattray, Sebastian Oeck, Sebastian Jung, Vicente Escamilla-Rivera, Zeming Chen, Xiangjun Tang, Jiangbing Zhou, Robert H. LaMotte
Summary: This study demonstrates the potential of capsaicin-loaded PLGA nanoparticles in reducing pain and itch associated with histamine-independent pruritic diseases. The controlled release of capsaicin from the nanoparticles led to desensitization of superficial nociceptors, resulting in decreased nociceptive and pruritic sensations. The nanoparticles exhibited good release profiles and showed promising results in both mouse and human experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Emergency Medicine
Hamzah M. Yusuf, Curtis Geier, Alex Staidle, Juan Carlos C. Montoy
Summary: The study found no association between topical capsaicin and shorter length of stays in CHS patients, but patients who received capsaicin earlier during an ED visit had a significantly shorter length of stay compared to those who received it later.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Ralitza Gueorguieva, Elizabeth K. C. Schwartz, R. Ross MacLean, Elise E. DeVito, Tore Eid, Ran Wu, Stephanie S. O'Malley, Mehmet Sofuoglu
Summary: This study aimed to determine if plasma menthol glucuronide (MG) concentrations can predict changes in subjective drug effects, urges to smoke, and heart rate following concurrent inhaled menthol and intravenous nicotine. The results showed that changes in plasma MG concentrations were proportional to menthol concentration in e-liquids, and were predictive of cooling effect in menthol smokers without active nicotine infusion.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Emergency Medicine
Vivian Kuma, Adrienne Bell, Wei Fang, Elizabeth VanWert
Summary: This study aimed to evaluate the efficacy of topical capsaicin in pediatric and adult patients presenting to the emergency department with suspected or confirmed CHS. Results showed that patients who received capsaicin were more likely to achieve efficacy compared to those who did not.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Rheumatology
Bjoern Anders, Malte Anders, Matthias Kreuzer, Sebastian Zinn, Lukas Fricker, Christoph Maier, Miriam Wolters, Michaela Kohm, Frank Behrens, Carmen Walter
Summary: This study aimed to examine the long-term inflammatory effects of rheumatoid arthritis (RA) on pain sensation and neuropathy development. The results showed that the application of capsaicin cream had a stronger effect on healthy subjects than on RA patients. There were contrary effects observed in terms of changes in CHEPs. The findings suggest the existence of sensitization in RA patients caused by chronic inflammation and that capsaicin could act as a marker for the extent of sensitization and neuropathic symptoms.
CLINICAL RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Guillermo Burillo-Putze, David Trujillo-Burillo, Jose Carlos Garcia-Hernandez, M. Angeles Lopez-Hernandez, Ivan Hernandez-Ramos, Isabel Ramos-Suarez, John R. Richards
Summary: There is limited research on cannabinoid hyperemesis syndrome (CHS) and the use of topical capsaicin as a treatment in Spain. This retrospective study analyzed CHS patients seen in a hospital emergency department between 2018 and 2019. The study found that CHS has a low incidence in the emergency department in Spain, but patients have a high recurrence rate. The use of capsaicin ointment was found to be efficient and safe for CHS treatment.
Review
Oncology
Christian Maihoefner, Ingo Diel, Hans Tesch, Tamara Quandel, Ralf Baron
Summary: Cancer diagnosis and treatment are significant events with potential severe side effects, including chemotherapy-induced peripheral neuropathy (CIPN). Some patients may face chronic symptoms, highlighting the importance of prevention and treatment strategies. Improved survival rates for cancer patients may lead to an increased incidence of CIPN in the future.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Anesthesiology
Polina Shabes, Daniela C. Rosenberger, Florian Henrich, Wolfgang Greffrath, Rolf-Detlef Treede, Ulf Baumgaertner, Walter Magerl
Summary: In this study, acute sensitization of the skin with topical capsaicin was found to enhance the sustained phase of pain in a noninvasive surrogate model of intraoperative pain. Capsaicin increased the pain magnitude and duration induced by the blade, but did not fully match the sustained duration of incisional pain. The blade model showed similarities to incisional pain in normal skin and acquired a more capsaicin-like pain descriptor pattern in capsaicin-treated skin, possibly due to peripheral sensitization of the TRPV1 receptor.
Article
Immunology
Sabrina Qader Kudsi, Caren Tatiane de David Antoniazzi, Camila Camponogara, Graziela Moro Meira, Marcella de Amorim Ferreira, Ana Merian da Silva, Diessica Padilha Dalenogare, Rubya Zaccaron, Carolina dos Santos Stein, Paulo Cesar Lock Silveira, Rafael Noal Moresco, Sara Marchesan Oliveira, Juliano Ferreira, Gabriela Trevisan
Summary: Musculoskeletal pain, especially after traumatic muscle injury, is a common and poorly managed public healthcare issue. This study found that the transient receptor potential ankyrin 1 (TRPA1) may be a promising anti-inflammatory and antinociceptive target in treating pain after traumatic muscle injury.
INFLAMMOPHARMACOLOGY
(2023)
Article
Anesthesiology
Andrew S. C. Rice, Robert H. Dworkin, Nanna B. Finnerup, Nadine Attal, Praveen Anand, Roy Freeman, Alessandro Piaia, Francesca Callegari, Christie Doerr, Subhayan Mondal, Nisha Narayanan, Laurent Ecochard, Yanina Flossbach, Shaloo Pandhi
Summary: The analgesic efficacy and safety of EMA401 in patients with postherpetic neuralgia and painful diabetic neuropathy were assessed in two phase 2b studies, showing consistent clinical improvement in pain intensity reduction. However, premature termination of the studies prevented definitive conclusions from being drawn.
Article
Biochemical Research Methods
Peter K. Koo, Antonio Majdandzic, Matthew Ploenzke, Praveen Anand, Steffan B. Paul
Summary: Deep neural networks show improved performance in predicting DNA and RNA binding protein sequence specificities compared to previous methods, but interpreting the predictions remains challenging. Global importance analysis (GIA) is introduced as a model interpretability method to quantify the effect size of putative patterns on model predictions at a population level. GIA can be used to test hypotheses of patterns and interactions, revealing that deep learning models not only learn sequence motifs, but also consider motif number, spacing, and sequence context.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Review
Health Care Sciences & Services
Rosario Privitera, Praveen Anand
Summary: The Capsaicin 8% patch is an effective and safe treatment option for neuropathic pain associated with CIPN, providing long-lasting pain relief and minimal transient side-effects.
CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE
(2021)
Article
Multidisciplinary Sciences
Beena E. Thomas, Kannan Thiruvengadam, S. Raghavi, Sudha Rani, S. Vetrivel, Vikas Gangadhar Rao, Rajiv Yadav, J. Bhat, Vijayachari Paluru, Anil Jacob Purthy, Tahziba Hussain, Anil Kumar Indira Krishna, Alex Joseph, Avi Kumar Bansal, Praveen Anand, Pradeep Das, K. R. John, Rekha K. Devi, P. Sunish, Rony Moral, S. Azhagendran, V. Chandrasekaran, G. S. Toteja, Madhuchhanda Das, A. M. Khan, Harpreet Kaur
Summary: Understanding the care-seeking behavior among tribal populations with symptoms of TB is crucial for early diagnosis and treatment, with gender-specific interventions needed to address differences in symptoms prompting care-seeking.
Article
Multidisciplinary Sciences
Beena E. Thomas, Kannan Thiruvengadam, Chandrasekaran Vedhachalam, A. Srividya, V. G. Rao, Paluru Vijayachari, Yadav Rajiv, V Raghavi, Avi Kumar Bansal, Anil Kumar Indira Krishna, Alex Joseph, Anil J. Purty, Tahziba Hussain, Praveen Anand, Pradeep Das, K. R. John, Rekha K. Devi, P. Sunish, S. Azhagendran, Azger Dusthakeer, J. Bhat, Vineet K. Chadha, G. S. Toteja, Dasarathy Raghunath, Madhuchhanda Das, A. M. Khan, Hapreet Kaur
Summary: This study found a high prevalence of pulmonary tuberculosis among tribal populations in India, with older age, underweight individuals, a history of anti-tuberculosis treatment, smoking, and alcohol consumption being associated with a higher risk of bacteriologically positive pulmonary tuberculosis.
Article
Clinical Neurology
Praveen Anand, Rosario Privitera, Philippe Donatien, V. Peter Misra, David R. Woods
Summary: Neuropathic pain associated with Non-freezing Cold Injury (NFCI) is a major burden to military service personnel. Capsaicin 8% patch has been shown to be well-tolerated and effective for reducing neuropathic pain in NFCI patients, with regeneration and restoration of nerve fibres, in addition to pain relief.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Uma Anand, Barbara Pacchetti, Praveen Anand, Mikael Hans Sodergren
Summary: The study reviews the potential synergistic and entourage effects of cannabinoids in pain relief, emphasizing the complex interactions between the compounds found in cannabis. Further clinical trials and in vitro studies are needed to validate these effects.
Meeting Abstract
Hematology
Valeriya Dimitrova, Noori Sotudeh, Anna Montanaro, Huiyoung Yun, Sayalee V. Potdar, Alexandria Van Scoyk, Shruti Bhatt, Praveen Anand, Antonis Kokkalis, Jake A. Kloeber, Julia Frede, Johannes M. Waldschmidt, Anthony G. Letai, David M. Weinstock, Jens G. Lohr, Birgit Knoechel
Article
Oncology
Johannes M. Waldschmidt, Andrew J. Yee, Tushara Vijaykumar, Ricardo A. Pinto, Julia Frede, Praveen Anand, Giada Bianchi, Guangwu Guo, Sayalee Potdar, Charles Seifer, Monica S. Nair, Antonis Kokkalis, Jake A. Kloeber, Samantha Shapiro, Lillian Budano, Mason Mann, Robb Friedman, Brea Lipe, Erica Campagnaro, Elizabeth K. O'Donnell, Cheng-Zhong Zhang, Jacob P. Laubach, Nikhil C. Munshi, Paul G. Richardson, Kenneth C. Anderson, Noopur S. Raje, Birgit Knoechel, Jens G. Lohr
Summary: This study demonstrates that the detection of cfDNA positivity can predict disease progression and PFS in patients with multiple myeloma, providing an early identification of poor response to treatment.
Article
Clinical Neurology
Uma Anand, Christian Oldfield, Barbara Pacchetti, Praveen Anand, Mikael H. Sodergren
Summary: CBG, CBD, and THC individually demonstrated potent dose-related inhibition of capsaicin responses in DRG neurons in vitro, and their combination showed enhanced effectiveness. The high correlation between cannabinoid-mediated calcium influx and reduction of capsaicin responses suggests potential synergistic effects of CBG, CBD, and THC when applied together. Further studies are needed to explore the efficacy and tolerability of these combinations in vivo.
JOURNAL OF PAIN RESEARCH
(2021)
Meeting Abstract
Hematology
Valeriya Dimitrova, Noori Sotudeh, Birgit Knoechel, Jens G. Lohr, Anna Montanaro, Sayalee Potdar, Julia Frede, Alexandria Van Scoyk, Shruti Bhatt, Praveen Anand, Jon C. Aster, David M. Weinstock, Anthony G. Letai
Article
Engineering, Civil
Praveen Anand, Vivek Kumar
Summary: The objective of this study is to investigate and compare the effect of tunnelling on the response of a framed building on different types of foundations. The ovalling effect of a circular tunnel on the displacement of the building was analyzed using FEM-based software ABAQUS. The study considered three different types of foundations: isolated foundation, mat foundation, and pile foundation. The results showed that the maximum displacement of the building frame occurred when the tunnel was situated just below the center axis of the building frame for all types of foundations. Building constructed over isolated foundation showed the highest displacement compared to building constructed over mat foundation and pile foundation for all locations and sizes of tunnel.
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY-TRANSACTIONS OF CIVIL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Vivek Kumar, Praveen Anand
Summary: This paper investigates the effect of tunnelling on the response of a framed building on different types of foundations through shake table test. The results show that the ovalling effect of circular tunnel mainly affects the displacement of the building, and its influence diminishes as the distance between the building frame and tunnel increases. Furthermore, the type of foundation used for the building also has varying degrees of influence on the effect of the tunnel.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
Meeting Abstract
Hematology
Johannes M. Waldschmidt, Sankalp Arora, Tushara Vijaykumar, Noori Sotudeh, Praveen Anand, Hannah Stuart, Julia Frede, Tim Campbell, Shari M. Kaiser, Manisha Lamba, Nikhil C. Munshi, Kenneth C. Anderson, Andrew J. Yee, Birgit Knoechel, Jens G. Lohr, Noopur Raje
Article
Clinical Neurology
Pallai Shillo, Yiangos Yiangou, Philippe Donatien, Marni Greig, Dinesh Selvarajah, Iain D. Wilkinson, Praveen Anand, Solomon Tesfaye
Summary: The study found that epidermal nerve fiber density was significantly decreased in both painful diabetic peripheral neuropathy (DPN) and painless-DPN, with no significant differences in regenerating nerve fibers, CGRP, or vWF. Vascular density was significantly increased in painless-DPN and No-DPN groups compared to healthy volunteers, but it was significantly higher in the painful-DPN group. The ratio of CGRP:vWF in sub-epidermal nerve fibers showed a significant decrease in painful-DPN compared to painless-DPN, suggesting that increased dermal vasculature may differentiate painful-DPN from painless-DPN.
FRONTIERS IN PAIN RESEARCH
(2021)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
