Article
Clinical Neurology
Jennifer R. Miller, Silvia Chapman, Daniella Iglesias Hernandez, Keith Radler, Nikki Delgado, Edward D. Huey, Elan D. Louis, Stephanie Cosentino
Summary: This study aimed to investigate whether depressive symptoms can predict cognitive decline in older adults with essential tremor (ET). The results showed that depressive symptoms were associated with faster memory decline, but not with changes in overall cognition or executive functioning.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Madiha Rasheed, Rabia Asghar, Sundas Firdoos, Nadeem Ahmad, Amina Nazir, Kakar Mohib Ullah, Noumin Li, Fengyuan Zhuang, Zixuan Chen, Yulin Deng
Summary: This systematic review explores the role of circulatory microRNAs (cimiRNAs) as biomarkers for the diagnosis of major depressive disorder (MDD). The study identifies dysregulated cimiRNAs in MDD patients and analyzes their involvement in molecular pathways and co-regulation with transcription factors. However, further research is needed to determine the clinical significance and therapeutic implications of these cimiRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Olusegun Adebayo Adeoluwa, Juliet Nneda Olayinka, Gladys Onyinye Adeoluwa, Elizabeth Toyin Akinluyi, Funmilayo Racheal Adeniyi, Adedamola Fafure, Kate Nebo, Edem Ekpenyong Edem, Anthony Taghogho Eduviere, Badamasi Abubakar
Summary: This study evaluated the antidepressant effect of quercetin on LPS-induced depression in rats. The results showed that quercetin can alleviate depressive symptoms induced by LPS and reduce inflammatory response. This suggests that quercetin may exert its antidepressant effects by inhibiting neuro-inflammatory signaling pathways.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Martino Belvederi Murri, Luigi Grassi, Rosangela Caruso, Maria Giulia Nanni, Luigi Zerbinati, Sylke Andreas, Berta Ausin, Alessandra Canuto, Martin Haerter, Manuel Munoz Lopez, Kerstin Weber, Hans-Ulrich Wittchen, Jana Volkert, George S. Alexopoulos
Summary: Late-life depression presents with diverse and heterogeneous clinical features, which were identified in this study as eight symptom complexes through network psychopathology. The study found reciprocal interactions between different symptom complexes, providing potential targets for personalized treatment and biomarker research in late-life depression.
MOLECULAR PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Jennifer M. Kirk, Jay Magaziner, Michelle D. Shardell, Alice S. Ryan, Ann L. Gruber-Baldini, Denise Orwig, Marc C. Hochberg, Alan M. Rathbun
Summary: Four patterns of depressive symptoms were identified among older adults after hip fracture: asymptomatic, somatic, melancholic, and anhedonic. Somatic symptoms were associated with difficulties in concentration and reduced energy and movement, while anhedonic symptoms were linked to the inability to experience pleasure. Melancholic symptoms corresponded to anhedonia, decreased physical activity, and other psychological and somatic complaints.
Article
Clinical Neurology
Yajun Shang, Xinjie Chen, Mingda Ai, Xiaoran Gao, Shujuan Dai, Mingjie Zhao, Cen Yang, Liangfeng Wang, Junyan Zhang, Lianmei Zhong, Tianhao Bao, Xiaolei Liu
Summary: This meta-analysis found that cognitive impairments and affective disorders are common in patients with essential tremor (ET). Patients with ET showed lower scores on Mini-Mental State Examination (MMSE) and higher scores on depressive and anxiety symptoms scale compared to non-ET group. The risk for dementia and affective disorders was significantly higher in individuals with ET. However, the causal relationship between ET and dementia, depression, and anxiety remains unclear.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychiatry
Zsofia Csajbok, Zuzana Sterbova, Peter K. Jonason, Pavla Cermakova, Adam Doka, Jan Havlicek
Summary: The occurrence of depression is influenced by social relationships, and this study found that depressive symptoms of couples evolve over time. The study identified four distinct classes of couples based on their trajectories of depressive symptoms, with different implications for relationship stability and overall well-being.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Sjors M. M. Lange, Frederike Schirmbeck, Max L. Stek, Yentl R. Murk Jansen, Geeske van Rooijen, Lieuwe de Haan, Brenda W. J. H. Penninx, Didi Rhebergen
Summary: More than half of SSD patients show considerable depressive symptoms, with a relative preponderance of somatic/vegetative symptoms compared to MDD. Further research could explore potential biological dysregulations associated with depressive symptom profile in SSD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Health Care Sciences & Services
Natalia Chechko, Susanne Stickel, Elena Losse, Aliaksandra Shymanskaya, Ute Habel
Summary: This study assessed postpartum mood and mother-child attachment in a cohort of 598 young mothers and found multiple distinct patterns. Most women with postpartum depression showed deteriorating behavior, while adjustment disorder cases showed improving behavior. Higher EPDS levels were associated with higher risk factors, while lower EPDS levels were associated with better mother-child attachment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychology, Clinical
Marcelo T. Berlim, Stephane Richard-Devantoy, Nicole Rodrigues dos Santos, Gustavo Turecki
Summary: The study found that the psychopathological network structure of major depressive disorder changed after 8 weeks of antidepressant treatment, showing increased interconnectedness. Throughout the treatment process, the core symptoms of major depressive disorder include depressed mood, fatigue, and cognitive/psychomotor disturbance.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Neuroimaging
Patrick Bedard, Pattamon Panyakaew, Hyun-Joo Cho, Mark Hallett, Silvina G. Horovitz
Summary: This study aimed to understand the differential pathophysiology of essential tremor and dystonic tremor. The results showed altered functional connectivity in the cerebellum for essential tremor patients, higher fractional anisotropy in the middle cerebellar peduncle for dystonic tremor patients, and reduced mean diffusivity in the cerebellum for both tremor groups. The findings suggest that the cerebellum is affected differently in both essential tremor and dystonic tremor.
NEUROIMAGE-CLINICAL
(2022)
Article
Oncology
Kate Oppegaard, Joosun Shin, Carolyn S. Harris, Alejandra Schimmel, Steven M. Paul, Bruce A. Cooper, Jon D. Levine, Yvette P. Conley, Marilyn Hammer, Laura Dunn, Kord M. Kober, Christine Miaskowski
Summary: The study aims to identify subgroups of oncology patients with distinct depressive symptom profiles and evaluate the differences in demographic and clinical characteristics, levels of stress and resilience, and the severity of common co-occurring symptoms. The findings suggest that inter-individual variability in depressive symptoms is associated with various factors, such as demographic and clinical characteristics, stress levels, resilience, and severity of co-occurring symptoms.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
Article
Psychology, Clinical
Bradley S. Jermy, Saskia P. Hagenaars, Kylie P. Glanville, Jonathan R. I. Coleman, David M. Howard, Gerome Breen, Evangelos Vassos, Cathryn M. Lewis
Summary: This study used factor analysis to derive continuous depression phenotypes from symptom-level data in the UK Biobank and found an association between polygenic risk for major depression and continuous depressive symptoms. The analysis on case- and control-only subsets showed a stronger association within cases, suggesting the importance of within-group variation in understanding major depression.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Luca Angelini, Giulia Paparella, Alessandro De Biase, Annalisa Maraone, Matteo Panfili, Isabella Berardelli, Antonio Cannavacciuolo, Antonella Di Vita, Roberta Margiotta, Giovanni Fabbrini, Alfredo Berardelli, Matteo Bologna
Summary: This study investigated the progression of Essential Tremor (ET) manifestations through clinical and neurophysiological evaluation. The results showed that ET progression is characterized by the spread of tremor in multiple body segments and the emergence of soft signs. Female sex, absence of family history, and rest tremor at baseline were identified as predictive factors of worse disease progression.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yifan Shi, Daihui Peng, Chen Zhang, David Mellor, Huaning Wang, Yiru Fang, Zhiguo Wu
Summary: Objective of this study was to explore the clinical characteristics and symptomatology of major depressive disorder with atypical features based on DSM criteria or only reversed vegetative symptoms. A total of 3187 patients with MDD were enrolled, and the findings supported the validity of DSM defined atypical depression and the clinical utility of the simplified approach of defining atypical features based on only reversed vegetative symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Gang Deng, Ran Tao, Dai-Shi Tian, Jun-Li Liu
Summary: This case report presents a rare case of LC with cauda equina involvement, emphasizing the importance of employing a multimodal strategy in diagnosing PCNSL, including multimodal magnetic resonance, cerebral spinal fluid cytology, flow cytometry and fluorodeoxyglucose positron emission tomography/computed tomography.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Review
Immunology
Hai-Han Yu, Chuan Qin, Shuo-Qi Zhang, Bo Chen, Xue Ma, Ran Tao, N. Chen, Yun-Hui Chu, Bi-Tao Bu, Dai-Shi Tian
Summary: This study conducted a meta-analysis to evaluate the efficacy of plasma exchange (PE) therapy in acute attacks of neuromyelitis optica spectrum disorders (NMOSD). The results showed that PE was an effective therapeutic method, both as a rescue therapy and as a first-line therapy, in reducing EDSS score and improving patient response rates during acute attacks of NMOSD. Subgroup analysis also indicated that earlier PE initiation and AQP4-IgG seronegative patients may have a superior response to PE therapy.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Review
Immunology
Tingjun Chen, Dale B. Bosco, Yanlu Ying, Dai-Shi Tian, Long-Jun Wu
Summary: NMO is an autoantibody-triggered neuro-inflammatory disease that mainly affects the spinal cord and optic nerve. Studies have shown significant microglial activation in NMO lesions, indicating a potential role for microglia in NMO pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Su-Ya Qiao, Ke Shang, Yun-Hui Chu, Hai-Han Yu, Xin Chen, Chuan Qin, Deng-Ji Pan, Dai-Shi Tian
Summary: This meta-analysis confirmed the association between APOE gene epsilon 4 mutation and ischemic stroke, showing a dose-response correlation in the risk of IS. Additionally, similar conclusions were drawn in the small artery disease subtype.
Article
Immunology
Bo Chen, Dai-Shi Tian, Bi-Tao Bu
Summary: The study found that in patients with antibody-mediated autoimmune encephalitis, factors such as severe disability on admission, low lymphocyte count, and elevated neutrophil levels can predict poor prognoses. Patients with poor outcomes in autoimmune encephalitis have distinct immunological features compared to those with good recoveries.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Bo Chen, Meng-Cui Gui, Su-Qiong Ji, Yi Xie, Dai-Shi Tian, Bi-Tao Bu
Summary: The study revealed differences in immunological features between NMOSD, MS, and MOGAD, with potential biomarkers serving as classifiers in clinical settings. By analyzing data from 50 patients, distinct patterns were observed in T-lymphocyte subsets and cytokine profiles for each disorder.
NEUROIMMUNOMODULATION
(2022)
Article
Neurosciences
Bo Chen, Dai-Shi Tian, Bi-Tao Bu
Summary: In Chinese patients, a combination of onset age and IgG index can serve as an alternative to differentiate between RRMS and NMOSD, showing slightly better sensitivity than the CSF-OCB model.
Article
Immunology
Ming-Hao Dong, Luo-Qi Zhou, Yue Tang, Man Chen, Jun Xiao, Ke Shang, Gang Deng, Chuan Qin, Dai-Shi Tian
Summary: The genetically predicted increase in CSF sTREM2 levels is causally associated with a higher risk of multiple sclerosis, while no causal relationship was found with other neurological disorders.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Clinical Neurology
Jingfei Yang, Jie Jing, Shiling Chen, Xia Liu, Yingxin Tang, Chao Pan, Zhouping Tang
Summary: This article reviews the changes in cerebral blood flow and DWI lesions after ICH, and discusses the risk factors and possible mechanisms associated with the occurrence of DWI lesions, providing potential therapeutic interventions for improving long-term recovery in patients with ICH.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Clinical Neurology
Bo Chen, Su-Qiong Ji, Fan Shen, Dai-Shi Tian, Bi-Tao Bu
Summary: In patients with relapsing-onset multiple sclerosis (MS), progression independent of relapse activity (PIRA) is the major contributor to irreversible disability accrual throughout the disease course, although relapse-associated worsening (RAW) also plays a role during the early stage. Clinical attack number partly mediates the relationship between disease duration and neurological disability in the early phase. Onset age and sex have varying correlations with the disabled outcome in different phases.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Editorial Material
Cell Biology
Chuan Qin, Yun-Hui Chu, Luo-Qi Zhou, Ming-Hao Dong, Wei Wang, Dai-Shi Tian
Summary: The autophagic-lysosomal pathway in microglia is crucial for removing myelin debris in white matter damage. However, the regulation of this pathway and maintaining lipid metabolism balance are still unclear. Excessive activation of autophagy causes lipid overload and accumulation in lysosomes and lipid droplets, leading to microglial dysfunction and secondary white matter damage. Suppression of autophagic activation in the acute phase of demyelination benefits microglia by restoring lipid metabolism balance and promoting myelin debris removal. Neuroprotective effects of microglial autophagy regulation may involve intracellular linoleic acid (LA) production and activation of the PPARG pathway.
Review
Neurosciences
Yunjie Li, Xia Liu, Shiling Chen, Jingyi Wang, Chao Pan, Gaigai Li, Zhouping Tang
Summary: Antiplatelet medications are increasingly used for the prevention of ischemic stroke, but they may also increase the risk of intracerebral hemorrhage (ICH). Restarting antiplatelet therapy after ICH is a complex decision that depends on the individual patient's risks of both thrombotic events and bleeding. More research is needed to determine the optimal timing for restarting antiplatelet therapy and to provide evidence-based guidelines for clinical decision-making.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cell Biology
Luwei Nie, Dabao Yao, Shiling Chen, Jingyi Wang, Chao Pan, Dongcheng Wu, Na Liu, Zhouping Tang
Summary: Due to the limited capacity of the adult mammalian brain to self-repair and regenerate, neurological diseases, such as neurodegenerative disorders and stroke, are often considered as refractory diseases. Neural stem cells (NSCs) have the potential to differentiate into specific neural cell types and offer new approaches for the treatment of neurological diseases. This review outlines the advances in generating different neuronal lineage subtypes from NSCs and summarizes their therapeutic effects in neurological disease models, focusing on Parkinson's disease and ischemic stroke. The strengths and weaknesses of different sources of NSCs and methods of directed differentiation are compared, and future research directions for NSCs in regenerative medicine are proposed.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Chuan Qin, Dai-Shi Tian, Luo-Qi Zhou, Ke Shang, Liang Huang, Ming-Hao Dong, Yun-Fan You, Jun Xiao, Ying Xiong, Wen Wang, Hao Pang, Jing-Jing Guo, Song-Bai Cai, Di Wang, Chun-Rui Li, Min Zhang, Bi-Tao Bu, Wei Wang
Summary: CAR T-cell therapy targeting BCMA shows manageable safety profile and therapeutic potentials for patients with relapsed/refractory AQP4-IgG seropositive NMOSD. Ongoing clinical trial results demonstrate positive outcomes in improving patients' disabilities and quality of life.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Dai-Shi Tian, Chuan Qin, Luo-Qi Zhou, Sheng Yang, Man Chen, Jun Xiao, Ke Shang, Dale B. Bosco, Long-Jun Wu, Wei Wang
Summary: This study investigates the role of revascularization and angiogenesis in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) by analyzing plasma protein profiles and transcriptomic data. The findings suggest that FSAP may serve as a potential biomarker for collateral status after LVO and a promising therapeutic target for stroke treatment. The study also demonstrates the involvement of the Wnt signaling pathway in FSAP-mediated endothelial dysfunction and neurological deficits.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
