Review
Immunology
Aida Karachi, Farhad Dastmalchi, Saina Nazarian, Jianping Huang, Elias J. Sayour, Linchun Jin, Changlin Yang, Duane A. Mitchell, Maryam Rahman
Summary: Evading T cell surveillance is a key aspect of cancer development. Patients with solid tissue malignancies like glioblastoma often experience immune dysfunction, particularly in T cell function. Standard treatments can worsen T cell dysfunction, but strategies like adoptive T cell transfer, including CAR T cells, offer potential for reinvigorating immune responses against cancer. However, there are risks of depletion and dysfunction in these adoptively transferred T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lena Haensch, Matthias Peipp, Maximilian Mastall, Danielle Villars, Renier Myburgh, Manuela Silginer, Tobias Weiss, Dorothee Gramatzki, Flavio Vasella, Markus G. Manz, Michael Weller, Patrick Roth
Summary: In this study, CD317 was identified as a novel target antigen for CAR T cell therapy against glioblastoma. CD317-CAR T cells showed strong anti-tumor activity in vitro and in vivo, demonstrating the potential of CD317-CAR T cell therapy for glioblastoma treatment. Further evaluation and translation of this immunotherapeutic strategy into clinical neuro-oncology is warranted.
Article
Multidisciplinary Sciences
Ken Miyaguchi, Hongqiang Wang, Keith L. Black, Stephen L. Shiao, Rongfu Wang, John S. Yu
Summary: Efficient activation of T cells with tumor-associated antigens (TAAs) to glioblastoma (GBM) stem cells was achieved through the use of three different antigen sources loaded onto dendritic cells (DCs). An activated T cell (ATC) protocol was developed and optimized for a phase I clinical trial to target GSCs. The synthetic peptide pool loading method showed significantly increased cytotoxicity towards target cells.
SCIENTIFIC REPORTS
(2023)
Article
Dermatology
Marjorie Heim, Marie Irondelle, Luc Duteil, Nathalie Cardot-Leccia, Stephane Rocchi, Thierry Passeron, Meri K. Tulic
Summary: Psoriasis is a chronic inflammatory disease that is difficult to control in the long term. The combination of topical treatment with steroids and vitamin D analogue foam has been shown to be efficient in managing the disease and reducing relapses. This study focuses on the effect of topical therapies on cellular infiltrate and cytokine profile in the lesional skin of psoriasis patients. The findings suggest that the combined Calcipotriol/Betamethasone foam treatment is effective in reducing cellular influx into lesional skin and is superior to other treatments.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Cell Biology
Noha Attia, Mohamed Mashal, Sudhakar Pemminati, Adekunle Omole, Carolyn Edmondson, Will Jones, Priyanka Priyadarshini, Temoria Mughal, Pauline Aziz, Blesing Zenick, Ambar Perez, Morgan Lacken
Summary: Glioblastoma is an aggressive primary tumor with a low survival rate. Cell-based therapy shows potential in clinical trials, but has limitations. Novel techniques such as biomaterials, scaffolds, and nanoparticles combined with cell-based therapy may have promising future applications.
Article
Oncology
Yue Ming, Chunyuan Luo, Beihong Ji, Jian Cheng
Summary: This study revealed that the high expression level of ARPC5 may serve as a promising prognostic biomarker and be associated with tumor immunity in glioma.
Article
Pharmacology & Pharmacy
Xusheng Tu, He Huang, Shilei Xu, Caifei Li, Shaoning Luo
Summary: In this study, hub genes related to immune cell infiltration in sepsis were explored using data from the GEO database. CD28, CD3D, CD2, CD4, IL7R, LCK, and CD3E were identified as hub genes with decreased expression in sepsis samples. Animal experiments confirmed the significant differences in the concentration and expression of these immune factors.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
David Eisenbarth, Y. Alan Wang
Summary: Glioblastoma (GBM) is a highly deadly and treatment-resistant cancer due to its heterogeneity at both cellular and microenvironmental levels. The recent advancements in sequencing technologies have revealed the diversity of cell states in GBM, which hampers accurate classification and effective treatments for the disease. Moreover, GBM heterogeneity is influenced by both intrinsic factors and differs between new and recurrent cases, as well as treatment-naive and experienced patients. Understanding and unraveling the complex cellular network underlying GBM heterogeneity is essential for developing new strategies to combat this deadly disease.
Article
Cell Biology
Ting Sun, Yanyan Li, Ying Yang, Bin Liu, Yufei Cao, Wei Yang
Summary: A different strategy was developed in this study to enhance the persistence and efficacy of CAR-T cells by increasing immunogenic cell death. Multispecific CAR-T cells prepared through elevated cell death suppressed tumor growth, and radiation and CD39 inhibition-induced cell death as a vaccine improved the antitumor effect of CAR-T cells.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Defne Bayik, Cynthia F. Bartels, Katreya Lovrenert, Dionysios C. Watson, Duo Zhang, Kristen Kay, Juyeun Lee, Adam Lauko, Sadie Johnson, Alice Lo, Daniel J. Silver, Mary McGraw, Matthew Grabowski, Alireza M. Mohammadi, Filippo Veglia, Yi Fan, Michael A. Vogelbaum, Peter Scacheri, Justin D. Lathia
Summary: The study revealed that the enhanced cell adhesion ability of mMDSC in the GBM microenvironment is linked to tumor promotion, and targeting Integrin (31) and DPP-4 to interfere with mMDSC may be an effective way to alleviate immune suppression driven by myeloid cells in GBM.
Article
Immunology
Hayat Miftah, Oumayma Naji, Saadia Ait Ssi, Amina Ghouzlani, Abdelhakim Lakhdar, Abdallah Badou
Summary: This study systematically explored the clinical characteristics and biological functions of NR2F6 in gliomas and found that NR2F6 is significantly associated with high tumor aggressiveness and poor outcomes for glioma patients. Functional enrichment analysis showed that NR2F6 is associated with biological processes related to glioma progression and immune-related functions. Additionally, NR2F6 was found to be significantly correlated with stromal and immune infiltration in gliomas. The results suggest that targeting NR2F6 in immune cells, tumor cells, and stromal cells may be a promising immunotherapeutic strategy for glioma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Adrianne L. Jenner, Munisha Smalley, David Goldman, William F. Goins, Charles S. Cobbs, Ralph B. Puchalski, E. Antonio Chiocca, Sean Lawler, Paul Macklin, Aaron Goldman, Morgan Craig
Summary: This study investigated the therapeutic efficacy of herpes simplex virus in glioblastoma using an ex vivo tumor model and a computational model. The findings suggest that stromal density plays a crucial role in determining the success of oncolytic virus therapy, and this was validated in patient samples.
Review
Biochemistry & Molecular Biology
Andrea Bianconi, Giuseppe Palmieri, Gelsomina Aruta, Matteo Monticelli, Pietro Zeppa, Fulvio Tartara, Antonio Melcarne, Diego Garbossa, Fabio Cofano
Summary: Glioblastoma (GBM), the most common and aggressive central nervous system tumor, is difficult to treat due to its malignant behavior and infiltrative growth pattern. Although immunotherapeutic strategies hold promise for the fight against GBM, immune resistance and the immunosuppressive environment pose challenges. New therapeutic strategies targeting the immune system, such as immune checkpoint inhibitors and chimeric antigen receptor T cell therapy, have been explored, but significant results have not been achieved. The future direction of GBM therapy may involve a combined approach that includes multifaceted immunotherapy to directly kill tumor cells and activate the immune response.
Review
Immunology
Isidora Panez-Toro, Dominique Heymann, Francois Gouin, Jerome Amiaud, Marie-Francoise Heymann, Luis A. Cordova
Summary: This review discusses the role of non-myelomonocytic cells in periprosthetic tissues exposed to wear particles. T cells and B cells are found to coexist with multinucleated giant cells in periprosthetic membranes infiltrated by polyethylene and metallic particles.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Amin Daei Sorkhabi, Aila Sarkesh, Hossein Saeedi, Faroogh Marofi, Mahnaz Ghaebi, Nicola Silvestris, Behzad Baradaran, Oronzo Brunetti
Summary: Virus infection plays an important role in gliomas, and enhancing the anti-tumor immune response through immune therapy may be an effective treatment strategy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
John P. Sheppard, Carlito Lagman, Thien Nguyen, Hana Yokoi, Stacy H. Jeong, Peter Luong, Cheng Hao Jacky Chen, Vera Ong, Alexis French, Alyssa M. Franks, Isabelle Kwan, Mahlet Mekonnen, Edwin Ng, Audree Evans, Komal Preet, Methma Udawatta, Isaac Yang
Summary: The volume of academic publications among successful neurosurgery applicants in the U.S. has increased over the years, with a positive association with the reputation of matched residency programs. Men, PhD-holders, graduates from top 20 and top 40 U.S. medical schools, and IMGs generally had higher pre-residency publication counts. However, after stratifying by match cohort, gender did not have a significant effect on pre-residency publications.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Emily A. Sloan, Jason Chiang, Javier E. Villanueva-Meyer, Sanda Alexandrescu, Jennifer M. Eschbacher, Wesley Wang, Manuela Mafra, Nasir Ud Din, Emily Carr-Boyd, Michael Watson, Michael Punsoni, Angelica Oviedo, Ahmed Gilani, Bette K. Kleinschmidt-DeMasters, Dylan J. Coss, M. Beatriz Lopes, Corey Raffel, Mitchel S. Berger, Susan M. Chang, Alyssa Reddy, Biswarathan Ramani, Sean P. Ferris, Julieann C. Lee, Jeffrey W. Hofmann, Soo-Jin Cho, Andrew E. Horvai, Melike Pekmezci, Tarik Tihan, Andrew W. Bollen, Fausto J. Rodriguez, David W. Ellison, Arie Perry, David A. Solomon
Summary: This study comprehensively analyzed 20 patients with intracranial mesenchymal tumors harboring FET-CREB fusion, showing diverse clinical and genetic characteristics including various fusion gene types. These tumors, distinct from typical intracranial neoplasms, exhibit unique morphology and immunophenotype profiles.
Review
Oncology
Ansley Unterberger, Thien Nguyen, Courtney Duong, Aditya Kondajji, Daniel Kulinich, Isaac Yang
Summary: This study examined the impact of adjuvant radiotherapy (ART) on survival outcomes for high-grade meningiomas post-surgery compared to surgery alone. The results suggest that (surgery+ART) may increase progression free survival, overall survival, and tumor control rates in high-grade meningiomas. Further studies involving surgery+ ART are needed to fully evaluate the ideal radiosurgical candidate, modality, and dosage.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Review
Clinical Neurology
Nolan J. Brown, Bayard Wilson, Shane Shahrestani, Elliot H. Choi, Brian Lien, Anushka Paladugu, Katelynn Tran, Seth C. Ransom, Ali R. Tafreshi, Ryan Chase Ransom, Ronald Sahyouni, Alvin Y. Chan, Isaac Yang
Summary: This article conducts a bibliometric analysis of the 100 most-cited articles on medulloblastoma, identifying key contributions to the understanding of this common pediatric brain tumor. The results provide insights into the histopathologic and molecular classification of medulloblastoma, as well as the efficacy of therapeutic interventions.
WORLD NEUROSURGERY
(2021)
Review
Clinical Neurology
John P. Andrews, Rushikesh S. Joshi, Matheus P. Pereira, Taemin Oh, Alexander F. Haddad, Kaitlyn M. Pereira, Robert C. Osorio, Kevin C. Donohue, Zain Peeran, Sweta Sudhir, Saket Jain, Angad Beniwal, Ashley S. Chopra, Narpal S. Sandhu, Tarik Tihan, Lewis Blevins, Manish K. Aghi
Summary: This study reviewed clinical data on PP1 and SS3 adenomas, finding that PP1 tumors are not necessarily more aggressive than non-PP1 tumors. Further research is needed to identify consistently more clinically aggressive subtypes of pituitary adenomas.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Cathra Halabi, Erika K. Williams, Ramin A. Morshed, Mauro Caffarelli, Christine Anastasiou, Tarik Tihan, Daniel Cooke, Adib A. Abla, Christopher F. Dowd, Vinil Shah, Sharon Chung, Megan B. Richie
Summary: Heterogeneous CNS neurologic manifestations of PAN are often overlooked, with a wide range of pathology including mononeuritis multiplex and rare brain and spinal cord vascular manifestations. Early recognition and treatment are crucial for improving patient outcomes.
Article
Oncology
Kimberly D. Miller, Quinn T. Ostrom, Carol Kruchko, Nirav Patil, Tarik Tihan, Gino Cioffi, Hannah E. Fuchs, Kristin A. Waite, Ahmedin Jemal, Rebecca L. Siegel, Jill S. Barnholtz-Sloan
Summary: Brain and other CNS tumors are highly fatal cancers in the United States, with different incidence rates and survival rates among different races and age groups. Survival disparities, especially in childhood tumors, highlight the importance of providing more resources to advance research and understand the reasons behind differences in brain tumor occurrence, especially among rarer subtypes and understudied populations.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Multidisciplinary Sciences
Melike Pekmezci, Ramin A. Morshed, Pranathi Chunduru, Balaji Pandian, Jacob Young, Javier E. Villanueva-Meyer, Tarik Tihan, Emily A. Sloan, Manish K. Aghi, Annette M. Molinaro, Mitchel S. Berger, Shawn L. Hervey-Jumper
Summary: The study showed that fiber-laser based stimulated Raman histology (SRH) can identify residual microscopic tumor at the infiltrative glioma margin, potentially enhancing the extent of resection. Intraobserver agreements were confirmed, demonstrating the effectiveness of SRH.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Wei Gu, Andreas M. Rauschecker, Elaine Hsu, Kelsey C. Zorn, Yasemin Sucu, Scot Federman, Allan Gopez, Shaun Arevalo, Hannah A. Sample, Eric Talevich, Eric D. Nguyen, Marc Gottschall, Bardia Nourbakhsh, Carl A. Gold, Bruce A. C. Cree, Vanja C. Douglas, Megan B. Richie, Maulik P. Shah, S. Andrew Josephson, Jeffrey M. Gelfand, Steve Miller, Linlin Wang, Tarik Tihan, Joseph L. DeRisi, Charles Y. Chiu, Michael R. Wilson
Summary: This study demonstrates the importance of CSF mNGS in diagnosing CNS malignant neoplasms, showing low false-positive rates for patients with negative results from CSF cytologic testing and flow cytometry.
Article
Clinical Neurology
Emily A. Sloan, Rohit Gupta, Christian Koelsche, Jason Chiang, Javier E. Villanueva-Meyer, Sanda Alexandrescu, Jennifer M. Eschbacher, Wesley Wang, Manuela Mafra, Nasir Ud Din, Emily Carr-Boyd, Michael Watson, Michael Punsoni, Angelica Oviedo, Ahmed Gilani, Bette K. Kleinschmidt-DeMasters, Dylan J. Coss, M. Beatriz Lopes, Alyssa Reddy, Sabine Mueller, Soo-Jin Cho, Andrew E. Horvai, Julieann C. Lee, Melike Pekmezci, Tarik Tihan, Andrew W. Bollen, Fausto J. Rodriguez, David W. Ellison, Arie Perry, Andreas von Deimling, Susan M. Chang, Mitchel S. Berger, David A. Solomon
Summary: Intracranial mesenchymal tumor, FET-CREB fusion-positive can be categorized into two distinct epigenetic subgroups with unique clinical and molecular features, as well as different survival outcomes. This may assist in more accurate diagnosis and treatment of this unique tumor entity.
Review
Oncology
Ashley B. B. Zhang, Khashayar Mozaffari, Brian Aguirre, Victor Li, Rohan Kubba, Nilay C. Desai, Darren Wei, Isaac Yang, Madhuri Wadehra
Summary: Glioblastoma, the most common malignant primary brain tumor, has a poor prognosis despite advancements in treatment. Angiogenesis, particularly involving vascular endothelial growth factor-A (VEGF-A), plays a critical role in the growth and invasion of glioblastoma cells. Bevacizumab, a medication targeting VEGF-A, has been approved for recurrent glioblastoma but has not significantly improved survival. Other agents with similar mechanisms of action have also shown unfavorable results. This review explores the current state and future potential of anti-angiogenesis therapeutic agents.
Editorial Material
Clinical Neurology
M. E. Buckland, C. Sarkar, V. Santosh, M. Al-Hussaini, S. H. Park, T. Tihan, H. K. Ng, T. Komori
Article
Clinical Neurology
Sen Gao, Jeffrey Nelson, Shantel Weinsheimer, Ethan A. Winkler, Caleb Rutledge, Adib A. Abla, Nalin Gupta, Joseph T. Shieh, Daniel L. Cooke, Steven W. Hetts, Tarik Tihan, Christopher P. Hess, Nerissa Ko, Brian P. Walcott, Charles E. McCulloch, Michael T. Lawton, Hua Su, Ludmila Pawlikowska, Helen Kim
Summary: This study confirmed the high prevalence of somatic KRAS mutations in sporadic BAVM lesions and identified several candidate somatic variants in other MAPK pathway genes. These somatic variants may contribute to understanding the etiology of sporadic BAVM and the clinical characteristics of patients with this condition.
JOURNAL OF NEUROSURGERY
(2022)
Review
Clinical Neurology
Prasanth Romiyo, Kevin Ding, Dillon Dejam, Alyssa Franks, Edwin Ng, Komal Preet, Alexander M. Tucker, Tianyi Niu, Daniel T. Nagasawa, Shayan Rahman, Isaac Yang
Summary: This study identified ideal predictive models for spinal surgeries and emphasized the importance of using reliable variables and larger prospective databases for future optimization. These models showed promise in evaluating patients as candidates for spinal procedures.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Surgery
Michael Johanis, Russell De Jong, Tyler Miao, Leslie Hwang, Meachelle Lum, Taranjit Kaur, Shelby Willis, John J. Arsenault, Courtney Duong, Isaac Yang, Quinton Gopen
Summary: Superior semicircular canal dehiscence (SSCD) and endolymphatic hydrops (EH) have overlapping symptoms but result from different pathophysiologies and require different interventions. Concurrent SSCD and EH is rare but can be treated with medications and hearing aids. Post-surgical persistence of shared symptoms is a key indicator for physicians to investigate for concurrent EH and consider ordering an MRI.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)