期刊
JOURNAL OF CLINICAL NEUROSCIENCE
卷 17, 期 7, 页码 899-904出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2009.11.005
关键词
Alzheimer disease; Amyloid protein precursor; Apolipoprotein E; Ketogenic diet; Neurodegeneration; Obesity
Excess weight, particularly abdominal obesity, can cause or exacerbate cardiovascular and metabolic disease Obesity is also a proven risk factor for Alzheimer's disease (AD) Various studies have demonstrated the beneficial effects of a ketogenic diet (KD) in weight reduction and in modifying the disease activity of neurodegenerative disorders. including AD Therefore, in this study we examined the metabolic and neurodegenerative changes associated with obesity and the possible neuroprotective effects of a KD in obese adult rats Compared with obese rats fed a control diet. obese rats fed a KD showed significant weight loss, improvement in lipid profiles and insulin resistance, and upregulation of adiponectin mRNA expression in adipose tissue In addition, the KD triggered significant downregulation of brain amyloid protein precursor, apolipoprotein E and caspase-3 mRNA expression, and improvement of brain oxidative stress responses. These findings suggest that a KD has anti-obesity and neuroprotective effects (C) 2009 Elsevier Ltd All rights reserved
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