Article
Neurosciences
Faraz Sadrzadeh-Afsharazar, Alexandre Douplik
Summary: This study investigated the use of Non-Invasive Transcranial Alternating Current Stimulation (NITACS) to induce and map phosphenes in healthy individuals. The study identified optimal stimulation parameters for reliable phosphene induction without skin irritation or pain. The findings suggest that NITACS can be a valuable tool for studying the relationship between facial stimulation location and phosphene localization, and raise questions about the origin of phosphenes generated through NITACS.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Joel E. Pellot-Cestero, Eric Z. Herring, Emily L. Graczyk, William D. Memberg, Robert F. Kirsch, A. Bolu Ajiboye, Jonathan P. Miller
Summary: Functional electrical stimulation (FES) shows promise in improving rehabilitation outcomes for individuals with paralysis caused by central nervous system pathology. Despite advancements in technology, there are still challenges in translating this technology into widespread clinical use.
Article
Engineering, Electrical & Electronic
Paul Cvancara, Giacomo Valle, Matthias Mueller, Inga Bartels, Thomas Guiho, Arthur Hiairrassary, Francesco Petrini, Stanisa Raspopovic, Ivo Strauss, Giuseppe Granata, Eduardo Fernandez, Paolo M. Rossini, Massimo Barbaro, Ken Yoshida, Winnie Jensen, Jean-Louis Divoux, David Guiraud, Silvestro Micera, Thomas Stieglitz
Summary: This study successfully provided sensory feedback to amputees using hand prostheses through direct stimulation of peripheral nerves with implantable electrodes. The longevity of the electrodes was improved for permanent implant systems, making thin-film electrodes applicable.
NPJ FLEXIBLE ELECTRONICS
(2023)
Article
Multidisciplinary Sciences
Emanuel Gunnarsson, Kristian Rodby, Fernando Seoane
Summary: Electro-stimulation has been used successfully for years to alleviate spasticity, pain, and increase mobility. The Mollii-suit by Inerventions utilizes dry conductive rubber electrodes, eliminating the need for frequent replacement. However, fitting the garment on the body is cumbersome. This paper presents the possibility of using knitted dry electrodes instead, which have lower skin friction and can easily be fitted to the body. Through validating the performance of the garment using electrical parameters, it is concluded that knitting techniques can produce a seamlessly integrated garment with beneficial manufacturing and comfort perspectives.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Canran Wang, Xing Jiang, Han-Jun Kim, Shiming Zhang, Xingwu Zhou, Yi Chen, Haonan Ling, Yumeng Xue, Zhaowei Chen, Moyuan Qu, Li Ren, Jixiang Zhu, Alberto Libanori, Yangzhi Zhu, Heemin Kang, Samad Ahadian, Mehmet R. Dokmeci, Peyman Servati, Ximin He, Zhen Gu, Wujin Sun, Ali Khademhosseini
Summary: A flexible electrical patch (ePatch) made with conductive hydrogel as electrodes was developed to improve wound management. The ePatch showed significant benefits in promoting wound re-epithelization, enhancing angiogenesis, mediating immune response, and preventing infection. In vitro and in vivo studies demonstrated the effectiveness of electrical stimulation in promoting cell proliferation and migration, and in accelerating wound closure.
Article
Clinical Neurology
William H. Bosking, Denise N. Oswalt, Brett L. Foster, Ping Sun, Michael S. Beauchamp, Daniel Yoshor
Summary: This study investigated the perception of phosphenes evoked by multi-electrode stimulation in the visual cortex of human epilepsy patients. The results showed that simultaneous stimulation of multiple electrodes resulted in varying patterns of phosphenes, with significant variations in location, size, and orientation. While the multi-electrode stimulation did not produce recognizable forms, subjects were able to use the pattern of phosphenes for simple discriminations.
Article
Engineering, Biomedical
Gerwin Dijk, Jolien Pas, Katarina Markovic, Janez Scancar, Rodney Philip O'Connor
Summary: The use of PEDOT:PSS coating can protect the electrode and improve neural stimulation. In the study, it was found that the PEDOT:PSS coating prevents electrode corrosion and extends cell survival time, and it has a good response to high charge density stimulation.
APL BIOENGINEERING
(2023)
Article
Neurosciences
Alex R. Gogliettino, Sasidhar S. Madugula, Lauren E. Grosberg, Ramandeep S. Vilkhu, Jeff Brown, Huy Nguyen, Alexandra Kling, Pawel Hottowy, Wladyslaw Dabrowski, Alexander Sher, Alan M. Litke, E. J. Chichilnisky
Summary: Electrical stimulation of retinal ganglion cells (RGCs) with electronic implants can provide artificial vision, but current devices lack precision. This study examines the neural code and effectiveness of focal epiretinal stimulation in the central macaque retina, and suggests the possibility of reproducing high-resolution visual signals with an epiretinal implant.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Engineering, Environmental
Yanping Zhang, Alice Le Friec, Di Sun, Menglin Chen
Summary: The development of flexible electronics with adjustable performance offers a promising approach for treating cardiac diseases, overcoming the limitations of conventional electronic systems due to biomechanical mismatches. By exploring the natural flow behavior of polymer melt in Melt electrowriting (MEW), researchers created a fibrous mesh electrode with a sinusoidal anisotropic structure resembling the collagen fiber architecture in the heart. This anisotropic, stretchable electrode mesh demonstrated the ability to synchronize cardiomyocyte beating through its biomimetic viscoelastic behavior and fine-tuned electrical properties, offering great potential for cardiac repair.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Arman Ahnood, Andre Chambers, Amy Gelmi, Ken-Tye Yong, Omid Kavehei
Summary: The advent of electronic technology for neural interfacing in the past 50 years has transformed medicine and biology. Devices like deep brain stimulators and cochlear implants have revolutionized the treatment of previously untreatable conditions. Semiconducting electrodes have advanced neural interfacing technologies, enabling high precision sensing and stimulation in electrical, biochemical, and optical domains. This emerging class of electrodes offers new opportunities for research and treatment.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Santiago Velasco-Bosom, Johannes Gurke, Sanggil Han, Michael C. Lee, George G. Malliaras
Summary: In this study, flexible and adhesive interdigitated electrodes were developed with a PEDOT:PSS coating, which improved the safety and selectivity of electrical stimulation. The effectiveness of the device was demonstrated through experiments, showing its potential as a diagnostic and monitoring tool for SFN.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Engineering, Biomedical
Jay Shah, Christopher Quinkert, Brett Collar, Michael Williams, Ethan Biggs, Pedro Irazoqui
Summary: We introduce a wireless, fully implantable device for peripheral nerve stimulation, encapsulated in biocompatible silicone. The device can be powered by a wireless RF signal and offers a wide range of selectable stimulation parameters. In animal experiments, the device demonstrated long-term efficacy.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2022)
Article
Multidisciplinary Sciences
Patrick Pearce, Kristian Bulluss, San San Xu, Boaz Kim, Marko Milicevic, Thushara Perera, Wesley Thevathasan
Summary: The study evaluated the accuracy of STN-DBS electrode implantation in PD patients and found that electrode location errors were highly variable. Factors such as brain shift and microelectrode trajectory shifts did not significantly impact location error. The study suggests that more accurate methods are needed for implanting STN-DBS electrodes.
Article
Engineering, Biomedical
Andrea Corna, Poornima Ramesh, Florian Jetter, Meng-Jung Lee, Jakob H. Macke, Guenther Zeck
Summary: This study investigated the discrimination of simple objects using sinusoidal stimulation in retinal neuroprosthetics. The results showed that spatially displaced objects could be classified based on distinct spiking activity of selected RGCs under low stimulation threshold conditions, and stimulation with low artificial contrast encoded by different stimulus amplitudes also generated RGC activity in the retina.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Assraa Hassan Jassim, McKay Cavanaugh, Jessica Stukel Shah, Rebecca Willits, Denise M. Inman
Summary: Transcorneal electrical stimulation (TES) can improve retinal or optic nerve pathology in a mouse model of glaucoma and serve as a minimally invasive treatment option. The study found that TES resulted in RGC axon protection, reduced inflammation and activation of inflammatory cells, improved energy homeostasis, and decreased cell death-associated factors.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Ophthalmology
Minas T. Coroneo, Hans-Walter Roth, Ezra Maguen
Summary: The development of contact lenses in the late 1940s allowed both ametropes to be less dependent on glasses and to change their eye color using colored contact lenses. This had a significant impact on facial and ocular cosmesis, particularly for public figures like actors. Measurements of contact lenses and casts suggest that they were made for Marilyn Monroe, who may have been myopic, used colored contact lenses, and experienced contact lens overwear syndrome. The importance of ocular cosmesis is often overlooked in ophthalmic practice, but it is of great interest and importance to patients, as reflected in current techniques aimed at improving cosmesis.
Article
Ophthalmology
Gareth Lingham, Jason Kugelman, Jason Charng, Samantha S. Y. Lee, Seyhan Yazar, Charlotte M. McKnight, Minas T. Coroneo, Robyn M. Lucas, Holly Brown, Louis J. Stevenson, David A. Mackey, David Alonso-Caneiro
Summary: This study used a deep learning-based tool to assess the change in conjunctival ultraviolet autofluorescence (CUVAF) area in young adults over an 8-year period and found that wearing sunglasses was associated with a faster reduction in CUVAF area. The results of this study are important for understanding the damage caused by ultraviolet radiation exposure to the eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Kyoko Miura, Minas Coroneo, Jean Claude Dusingize, Catherine M. Olsen, Rick Tinker, Ken Karipidis, Ian Hosegood, Adele C. Green
Summary: This study estimated the prevalence of cataract in pilots by analyzing medical records of commercial airline pilots diagnosed with cataract between 2011 and 2016. The results showed that the prevalence of cataract in pilots aged 60 and above was 11.6%, while it was only 0.5% in pilots aged below 60. The study also found that there was no significant difference in cataract prevalence based on the ambient ultraviolet radiation levels, although the lowest prevalence was observed in the low-UV state of Victoria. Furthermore, cataracts in pilots aged 60 and above were mostly bilateral and mild, while cataracts in pilots below 60 were more likely to be unilateral and severe.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2023)
Article
Ophthalmology
Rene Cheung, Angelica Ly, Paula Katalinic, Minas Theodore Coroneo, Andrew Chang, Michael Kalloniatis, Michele C. Madigan, Lisa Nivison-Smith
Summary: This review discusses the challenges in assessing and documenting peripheral retinal degenerations due to difficulties in visualizing the peripheral retina. It provides a series of clinical examples visualized with ocular imaging technologies and offers a concise guide for clinical practice.
SEMINARS IN OPHTHALMOLOGY
(2022)
Article
Oncology
Abbas Habibalahi, Alexandra Allende, Jesse Michael, Ayad G. Anwer, Jared Campbell, Saabah B. Mahbub, Chandra Bala, Minas T. Coroneo, Ewa M. Goldys
Summary: This study introduces an imaging-based method for screening ocular surface squamous neoplasia, which will reduce pressure on health resources and potentially eliminate the need for eye biopsy in suspected cases.
Article
Ophthalmology
Jerome Ozkan, Mark Willcox, Minas Coroneo
Summary: This review investigates the similarities and differences of microbiomes on the human face across different biogeographies, as well as discussing the potential pathways for microbial circulation within individuals and populations to maintain microbiome niches and diversity.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Ophthalmology
Brendon W. H. Lee, Amitouj S. Sidhu, Ian C. Francis, Minas T. Coroneo
Summary: Pterygium is a UV-related disease characterized by aberrant wound healing process. 5-Fluorouracil (5-FU) as an antimetabolite agent shows suboptimal efficacy when used in pterygium surgery, but post-operative intralesional injections of 5-FU are promising in arresting progression. Additionally, 5-FU as a treatment modality without surgery effectively arrests progression in primary and recurrent pterygia.
Article
Cell & Tissue Engineering
M. Domdey, M. A. Kluth, C. Masslo, C. Ganss, M. H. Frank, N. Y. Frank, M. T. Coroneo, C. Cursiefen, M. Notara
Summary: This study reports the expression of ABCB5 in pterygium stem cell activity and EMT-related events. It demonstrates the involvement of limbal stem cells in pterygium pathogenesis and suggests that UV-induced EMT in limbal epithelial cells contributes to pterygium development. The findings provide insights for identifying novel treatments against pterygium growth and recurrence.
STEM CELL RESEARCH
(2022)
Article
Ophthalmology
Lloyd R. Kopecny, Joanna M. Biazik, Minas T. Coroneo
Summary: This study analyzed the microtopography and elemental composition of 5 reusable Drysdale nucleus manipulator (DNM) paddled tips, revealing sharp defects that may cause posterior capsule rupture. Therefore, it is recommended to develop a quality, reliable single-use alternative instrument and carefully inspect the sharp edges of reusable instruments before use.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Psychiatry
Gordon Parker, Minas Coroneo
Summary: This study presents exemplars of pseudo-hallucinations experienced by individuals with bipolar disorder, suggesting their overrepresentation in this condition and arguing that their presence does not indicate psychosis. The historical definitions of pseudo-hallucinations are reviewed, and six profiles are presented, considering manifestations, sequencing, and response to medication in bipolar disorder patients. The findings indicate the richness of expression, variable time course, and response to medication of pseudo-hallucinations in individuals with bipolar disorder.
AUSTRALASIAN PSYCHIATRY
(2023)
Review
Ophthalmology
Erica Darian-Smith, Steven G. Safran, Minas T. Coroneo
Summary: The purpose of this article was to investigate the pathophysiology behind ZACB insufficiency and propose a classification system for its causes. It also discussed dystrophic bag syndrome, its clinical cases, and its position within the ZACB spectrum.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Review
Ophthalmology
Lloyd R. Kopecny, Brendon W. H. Lee, Minas T. Coroneo
Summary: Rho kinase inhibitors have the potential to promote corneal endothelial healing and stimulate the inner limbal stem cell niche. However, the mechanism of action of these inhibitors is still not fully understood.
Article
Materials Science, Multidisciplinary
Gulab Malunjkar, Hieu McElroy, Mirella Coroneo, Adebola O. Ogunniyi
Summary: Metal-faced sandwich panels with a rigid polyurethane foam core, known as insulated metal panels (IMPs), are produced through the injection of a reacting PU mixture in a closed cavity. However, this injection process often leads to defects and non-uniform foam distribution, negatively impacting the panel's performance. To address this issue, a Finite Element Method model was developed to simulate and optimize the foam injection and expansion processes, aiming to achieve defect-free products.
Article
Microbiology
Rachel Xuan, Sheng Chiong Hong, Tanya Trinh, Minas T. Coroneo, Constantinos Petsoglou
Summary: The article presents six cases of rare fungal keratitides, including two previously undocumented cases. The patients were managed at a quaternary eye referral unit in Sydney Eye Hospital, Australia using a combination of medical and surgical interventions. Vigilant monitoring of patient symptoms and correlation with clinical signs is essential for guiding antifungal therapy, even in the presence of confirmed culture and sensitivity results.
Article
Ophthalmology
Jerome Ozkan, Marwan E. Majzoub, Minas Coroneo, Torsten Thomas, Mark Willcox
Summary: This study compared the microbiomes of the conjunctiva and eyelid margin in individuals with mild and moderate dry eye disease (DED) and controls. The study found significant differences in the microbial communities of the conjunctiva and eyelid margin between the DED/MGD groups and the control group, and also observed lower microbial diversity in females.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)