Review
Cell Biology
Zhongju Shi, Shiyang Yuan, Linlin Shi, Jiahe Li, Guangzhi Ning, Xiaohong Kong, Shiqing Feng
Summary: Spinal cord injury (SCI) leads to functional deterioration due to cell death processes, including programmed cell death (PCD) like apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis, and paraptosis. PCD is an active cell death mediated by gene expression events, crucial for eliminating unnecessary and damaged cells and serves as a defense mechanism. Understanding the roles of PCD can enhance our knowledge of pathophysiological processes and improve functional recovery after SCI.
CELL PROLIFERATION
(2021)
Article
Clinical Neurology
Xuegang He, Bo Deng, Miao Ma, Keyao Wang, Ying Li, Yonggang Wang, Xuewen Kang
Summary: This study analyzed the expression levels of programmed cell death (PCD) and related differentially expressed genes (DEGs) in the development of spinal cord injury (SCI). The results showed different patterns of PCD in different stages of SCI and identified important genes related to cell death. The conclusions suggest that inhibiting specific cell death pathways and inducing autophagy may be therapeutic strategies for SCI, and important genes related to these cell death pathways may serve as therapeutic targets.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Lahanya Guha, Nidhi Singh, Hemant Kumar
Summary: Cell death is a complex process involving multiple pathways, some of which have been well-studied while others are still being explored. In neurological diseases, impairments in various programmed cell death signaling processes are observed. Spinal cord injury, characterized by the death of neuronal and glial cells, can be influenced by different cell death pathways. A better understanding of the molecular basis of these pathways may enhance neuronal and glial survival, promoting a curative path for spinal cord injury.
Review
Cell Biology
Xinli Hu, Yu Xu, Hui Xu, Chenqiang Jin, Haojie Zhang, Haohan Su, Yao Li, Kailiang Zhou, Wenfei Ni
Summary: Ferroptosis, a novel type of programmed cell death, has been found to be associated with acute central nervous system (CNS) trauma. The processes that induce ferroptosis include iron overload, imbalanced glutathione metabolism, and lipid peroxidation. Understanding the mechanism of ferroptosis is important for studying the pathophysiological process of CNS trauma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Elizabeth G. Ames, Jess G. Thoene
Summary: Cystinosis is a lethal genetic disease with specific treatments. The cellular mechanisms are still unknown, but programmed cell death and apoptosis may be involved. Studies have shown that apoptosis rate is increased in cystinosis, but can be partially reversed with cysteamine.
Article
Biochemistry & Molecular Biology
Rodrigo M. Maza, Maria Asuncion Barreda-Manso, David Reigada, Agata Silvan, Teresa Munoz-Galdeano, Altea Soto, Angela del Aguila, Manuel Nieto-Diaz
Summary: The downregulation of miR-138-5p after spinal cord injury (SCI) leads to the overexpression of pro-apoptotic genes, making neural cells more susceptible to harmful stimuli. MiR-138-5p was found to target apoptotic proteins, including CASP-3 and CASP-7, reducing their expression and enzymatic activity, and protecting cells from apoptosis.
Article
Chemistry, Multidisciplinary
Bin Zhu, Guangjin Gu, Jie Ren, Xiaomeng Song, Junjin Li, Chunyan Wang, Wencan Zhang, Yanqing Huo, Haifeng Wang, Lin Jin, Shiqing Feng, Zhijian Wei
Summary: Spinal cord injury (SCI) leads to permanent loss of sensory and motor function, but effective clinical treatments are lacking. This study developed a non-invasive composite patch that releases exosomes and methylprednisolone to the injured spinal cord. The patch showed good biocompatibility, promoted macrophage polarization, reduced neuronal apoptosis, and inhibited inflammation in vitro and in vivo. These therapeutic effects are attributed to specific pathways. The composite patch offers a potential non-invasive treatment for SCI.
Review
Multidisciplinary Sciences
Xinli Hu, Yu Xu, Haojie Zhang, Yao Li, Xiangyang Wang, Cong Xu, Wenfei Ni, Kailiang Zhou
Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Neurosciences
Narjes Shahsavani, Arsalan Alizadeh, Hardeep Kataria, Soheila Karimi-Abdolrezaee
Summary: Nrg-1131 provides early neuroprotection in SCI by reducing oxidative stress, lipid peroxidation, necrosis, and apoptosis. Mechanistically, it protects neurons from cell death by modulating mitochondrial-associated apoptotic cascades, MAP kinase, and AKT signaling pathways.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Neurosciences
Jian Yin, Ge Gong, Wenhui Wan, Xinhui Liu
Summary: Spinal cord injury (SCI) often leads to irreversible damage to neurons and glial cells, causing inflammation, ischemia, and cell death. Pyroptosis, a new form of regulated cell death, plays a vital role in SCI development. This review examines the evidence for pyroptosis in SCI, focusing on different cell types and their crosstalk. Additionally, the interaction between pyroptosis and other forms of cell death in SCI is discussed. The therapeutic strategies for inhibiting pyroptosis are summarized, providing novel insights for improving SCI outcomes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Sweata Hanson, Aiswarya Dharan, P. V. Jinsha, Sanjay Pal, Bipin G. Nair, Rekha Kar, Nandita Mishra
Summary: Programmed cell death (PCD) is a universal process that regulates cellular homeostasis and plays a crucial role in disease conditions, including cancer. Apoptosis is a major PCD, but cancer cells develop resistance to it, necessitating the search for alternative forms of programmed cell death such as paraptosis. Paraptosis is characterized by vacuolation and damage to cellular structures and has potential therapeutic implications in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kakali Bhadra
Summary: This article reviews the alternative pathways of cancer cell death targeted by anticancer drug molecules, providing a molecular basis for new strategies in cancer treatment. Many drugs can effectively induce cell death through targeting the caspase-independent cell death pathway, which is significant for cancer therapy.
Review
Cell Biology
Qi Zhang, Xin-xing Wan, Xi-min Hu, Wen-juan Zhao, Xiao-xia Ban, Yan-xia Huang, Wei-tao Yan, Kun Xiong
Summary: Stem cell therapies show promising effects in restoring damaged tissue, but multiple types of programmed cell death post-transplantation can compromise their efficiency. Understanding and targeting cell death signaling pathways are crucial for successful stem cell therapies in treating diabetes and related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xuchen Liu, Chengqiang Wang, Qingshan Peng, Birong Peng, Lixin Zhu
Summary: Pramipexole (PPX) has a neuroprotective effect in spinal cord injury (SCI) by inhibiting nerve cell apoptosis and regulating protein expression levels, which facilitates the recovery of motor function.
Review
Oncology
Yifan Cheng, Misha Mao, Yong Lu
Summary: YAP plays a critical role in regulating tumor progression and is closely related to programmed cell death (PCD). YAP activity can be regulated by kinase cascade pathways and other proteins. It has been found that YAP can affect multiple forms of PCD and act as a bridge between different forms of PCD in tumor development.
BIOMARKER RESEARCH
(2022)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
