Editorial Material
Infectious Diseases
Katharina Bach, Birgit Edel, Steffen Hoering, Lucie Bartonickova, Stefan Gloeckner, Bettina Loeffler, Christina Bahrs, Juergen Roedel
Summary: The LAMP-based eazyplex(R) BloodScreen GN is a reliable molecular assay for rapid detection of frequent Gram-negatives directly from positive blood culture (BC) bottles. The assay demonstrated excellent sensitivity and specificity for various bacterial strains, with a quick turnaround time of 8 to 16 minutes plus sample preparation time of about 6 minutes.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Microbiology
Alecks Megxel S. Abordo, Mark B. Carascal, Roland Remenyi, Doralyn S. Dalisay, Jonel P. Saludes
Summary: In the clinically isolated Gram-negative bacilli in the Philippines, the co-occurrence of multiple β-lactamases, especially ESBL and metallo-β-lactamases, was observed. Through genetic analysis and phenotypic characterization, the presence of multi-class β-lactamases and cryptic metallo-β-lactamases in these resistant bacteria was revealed.
Article
Immunology
Ritu Banerjee, Lauren Komarow, Abinash Virk, Nipunie Rajapakse, Audrey N. Schuetz, Brenda Dylla, Michelle Earley, Judith Lok, Peggy Kohner, Sherry Ihde, Nicolynn Cole, Lisa Hines, Katelyn Reed, Omai B. Garner, Sukantha Chandrasekaran, Annabelle de St Maurice, Meganne Kanatani, Jennifer Curello, Rubi Arias, William Swearingen, Sarah B. Doernberg, Robin Patel
Summary: The study demonstrated that rapid organism identification and phenotypic AST can lead to faster antibiotic therapy adjustments for patients with gram-negative bloodstream infections (BSIs), ultimately improving treatment outcomes.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Viveka Nordberg, Aina Iversen, Annika Tidell, Karolina Ininbergs, Christian G. Giske, Lars Naver
Summary: This study in Stockholm, Sweden, found lower incidence of GNB sepsis in neonates compared to previous reports and low occurrence of antibiotic resistance. The in-hospital mortality and 5-day case fatality rate were higher in GNB late-onset sepsis compared to uninfected controls but not in comparison to suspected sepsis.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Microbiology
Clemence Beauruelle, Claudie Lamoureux, Arsid Mashi, Sophie Ramel, Jean Le Bihan, Thomas Ropars, Anne Dirou, Anandadev Banerjee, Didier Tande, Herve Le Bars, Genevieve Hery-Arnaud
Summary: The study on antibiotic susceptibility of Achromobacter isolates in PWCF showed that data on susceptibility to new antibiotics is still incomplete. Currently useful antibiotics for Achromobacter infections include Imipenem, Trimethoprim-sulfamethoxazole, Piperacillin, and Tigecycline, with Cefiderocol emerging as a promising therapeutic alternative. Further microbiological and clinical data are needed to determine the optimal treatment for Achromobacter infections.
Review
Medicine, General & Internal
Mohamed Aziz Daghmouri, Emmanuel Dudoignon, Mohamed Ali Chaouch, Josefine Baekgaard, Adrien Bougle, Marc Leone, Benjamin Deniau, Francois Depreta
Summary: This meta-analysis examined the impact of short-course and long-course antibiotic therapy on the recurrence and relapse of ventilator-associated pneumonia (VAP). The results showed that short-course antibiotic therapy did not increase the risk of VAP recurrence and relapse, and also increased the number of antibiotic-free days.
Article
Infectious Diseases
Kang Sun, Wangping Li, Yu Li, Guangyu Li, Lei Pan, Faguang Jin
Summary: This study developed a scoring model to predict antibiotic-associated bronchopneumonia caused by Gram-negative bacteria. The model was able to clearly differentiate low-risk, moderate-risk, and high-risk patients, and it was validated in a separate cohort.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Bianca Prajescu, Liana Gavriliu, Mara Ioana Iesanu, Andreea Ioan, Anca Andreea Boboc, Catalin Boboc, Felicia Galos
Summary: Antimicrobial resistance (AMR) is a growing concern in pediatric patients, and this study aimed to analyze the bacterial species isolated from patients in a tertiary hospital and their AMR profiles. The most frequently isolated bacteria were Escherichia coli, Staphylococcus aureus, Klebsiella species, and Pseudomonas species, all of which exhibited varying levels of resistance to commonly used antibiotics. Gram-negative bacteria, including ESBL-producing Escherichia coli and Klebsiella species, showed high rates of resistance, while methicillin-resistant Staphylococcus aureus was observed among Gram-positive bacteria. Effective antibiotic management programs and infection control measures are urgently needed to address the rising incidence of AMR in pediatric hospitals.
Article
Infectious Diseases
Isidoro Lopez, Fatima Otero, Rebeca Guillen, Maria del Carmen Fernandez, German Bou, Jaime Gosalvez, Jose Luis Fernandez
Summary: Trimethoprim-sulfamethoxazole is a well-known antibiotic that inhibits folic acid synthesis, a topic of renewed interest. Two morphological assays were performed in Escherichia coli and Klebsiella pneumoniae to quickly determine susceptibility to the antibiotic. The results show that this simple morphological procedure can be completed in a short amount of time and may provide a rapid and cost-effective method for selecting appropriate therapy.
Article
Infectious Diseases
Luis Fernandez-Espigares, Itahisa Hernandez-Chico, Manuela Exposito-Ruiz, Antonio Rosales-Castillo, Jose Maria Navarro-Mari, Jose Gutierrez-Fernandez
Summary: This study analyzed the epidemiology and antibiotic susceptibility of significant bacteriuria and found that the adoption of EUCAST criteria did not lead to a general change in resistance rates. The results showed stable resistance profiles for most antibiotics, with exceptions for levofloxacin and nitrofurantoin. The prevalence of methicillin-resistant Staphylococcus aureus was similar in hospital and community samples. The study suggests the need to revise certain empirical criteria for Enterococcus and community-origin S. aureus.
Review
Pharmacology & Pharmacy
Yasaman Taheri, Natasa Jokovic, Jelena Vitorovic, Oliver Grundmann, Alfred Maroyi, Daniela Calina
Summary: This study summarized the pharmacological properties of cefiderocol, focusing on its therapeutic efficacy, safety, and tolerability in treating Gram-negative bacterial infections. The results indicated that cefiderocol may provide clinical benefit in treating severe infections caused by Gram-negative aerobic microorganisms in adult patients with limited treatment options.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Infectious Diseases
Claudio Neidhoefer, Christina Berens, Marijo Parcina
Summary: Achromobacter spp. are multidrug-resistant microorganisms that can cause various types of infections. This study investigated a patient group and found important findings, such as the high prevalence in specific body sites and the variation in resistance rates among different sample types.
Article
Microbiology
Christian Buechler, Claudio Neidhoefer, Thorsten Hornung, Marcel Neuenhoff, Marijo Parcina
Summary: Bordetella trematum is a recently discovered Bordetella species predominantly found in chronic wounds, with varying susceptibility to different antibiotics, including resistance to some. It is important to be aware of the resistance patterns of B. trematum.
Article
Medicine, General & Internal
Gonzalo De-Las-Casas-Camara, Virginia Collados-Arroyo, Maria Carmen Garcia-Torrejon, Maria-Carmen Munoz-Egea, Maria Dolores Martin-Rios
Summary: This study evaluated the impact of removing sinks from ICU rooms on bronchoaspirate isolations in mechanically ventilated patients, finding that the intervention resulted in lower antibiotic consumption, days on antibiotics, MRB, and isolation days.
Review
Immunology
Jun Shinohara, Shogo Hanai, Jongtak Jung, Kyoung-Ho Song, Mitsunaga Iwata, Teruhiko Terasawa
Summary: Follow-up blood cultures (FUBCs) in patients with gram-negative bacilli (GNB) bacteremia are associated with reduced mortality but longer treatment duration and hospital stay. However, the studies reviewed in this systematic analysis were heterogenous and had a critical risk of bias.
OPEN FORUM INFECTIOUS DISEASES
(2022)
