4.7 Article

Spread of CTX-M-15 Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolates through Household Contact and Plasmid Transfer

期刊

JOURNAL OF CLINICAL MICROBIOLOGY
卷 52, 期 5, 页码 1783-1785

出版社

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.03342-13

关键词

-

资金

  1. Ministry of Education, Culture, Sports, Science and Technology of Japan [22591113]
  2. Grants-in-Aid for Scientific Research [25461524, 22591113] Funding Source: KAKEN

向作者/读者索取更多资源

We document the household spread of extended-spectrum beta-lactamase-producing Escherichia coli. One isolate belonged to sequence type 1193 and caused urinary tract infection in a 4-month-old female, and the other isolate belonged to sequence type 131 and colonized three family members, including the index patient. These isolates carried similar Inc-I1-I gamma plasmids, harboring bla(CTX-M-15).

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Infectious Diseases

Septic shock with emphysematous cholecystitis and disseminated infection caused by hypervirulent Klebsiella pneumoniae capsular genotype K2-ST65 in a Japanese man with diabetes mellitus: A case report

Yoshifumi Kubota, Haruhiko Ishioka, Sohei Harada, Masahiro Suzuki, Junji Shiotsuka, Alan Kawarai Lefor, Masamitsu Sanui

Summary: This study reported a case of rapidly developing emphysematous cholecystitis and disseminated infection caused by Klebsiella pneumoniae K2 strains, highlighting the need for clinicians in East Asia to be aware of fulminant infections caused by hypervirulent K2 strains, especially in patients with community-acquired K. pneumoniae infections. Further epidemiological studies are needed to understand the clinical features associated with virulence of K. pneumoniae K2 strains.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2021)

Article Cardiac & Cardiovascular Systems

Dynamic changes in fibrinogen and D-dimer levels in COVID-19 patients on nafamostat mesylate

Itsuki Osawa, Koh Okamoto, Mahoko Ikeda, Amato Otani, Yuji Wakimoto, Marie Yamashita, Takayuki Shinohara, Yoshiaki Kanno, Daisuke Jubishi, Makoto Kurano, Sohei Harada, Shu Okugawa, Yutaka Yatomi, Kyoji Moriya

Summary: A retrospective study analyzed COVID-19 patients treated with nafamostat mesylate, categorizing them into three subgroups based on different risk levels. The findings suggest that admission characteristics can predict the likelihood of subsequent coagulopathy in COVID-19 patients.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

Article Multidisciplinary Sciences

Clot waveform of APTT has abnormal patterns in subjects with COVID-19

Takuya Shimura, Makoto Kurano, Yoshiaki Kanno, Mahoko Ikeda, Koh Okamoto, Daisuke Jubishi, Sohei Harada, Shu Okugawa, Kyoji Moriya, Yutaka Yatomi

Summary: In COVID-19 patients, distinctive coagulation abnormalities were found in clot waveform analyses, showing specific patterns in APTT tests. These abnormal patterns, such as early shoulder type, late shoulder type, or biphasic type, were not seen in patients with disseminated intravascular coagulation, but were similar to patterns seen in patients with certain blood disorders. Plasma fibrinogen levels may play a role in these abnormal patterns, which were most frequent around 2 weeks post COVID-19 onset and not linked to disease severity.

SCIENTIFIC REPORTS (2021)

Article Infectious Diseases

Institutional outbreak involving multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 at a cancer center in Tokyo, Japan

Sohei Harada, Kotaro Aoki, Daisuke Ohkushi, Koh Okamoto, Kazumi Takehana, Tomomi Akatsuchi, Keito Ida, Daigo Shoji, Yoshikazu Ishii, Yohei Doi, Kyoji Moriya, Brian Hayama

Summary: Limited information has been available on the clinical and microbiological characteristics of IMP-producing Enterobacterales. Here, we report an institutional outbreak of IMP-producing Enterobacter cloacae complex (ECC) involving multiple clades of ECC sequence type (ST) 78 strains. Whole-genome sequencing analysis revealed three different clades of ST78 strains were responsible for the outbreak, with most IMP-producing ECC strains being susceptible to non-beta-lactam antibiotics and having relatively low minimum inhibitory concentrations to carbapenems, resulting in favorable treatment outcomes for patients compared to infections caused by other carbapenemase-producing Enterobacterales.

BMC INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Change in hepatitis C virus positivity among needle-stick injury source patients: a 10-year experience in a Japanese tertiary hospital

Kazuya Okushin, Rie Suzuki, Takeya Tsutsumi, Koh Okamoto, Kazuhiko Ikeuchi, Akira Kado, Chihiro Minatsuki, Yuka Minami-Kobayashi, Nobuhiko Satoh, Mahoko Ikeda, Sohei Harada, Kenichiro Enooku, Hidetaka Fujinaga, Hiroshi Yotsuyanagi, Kazuhiko Koike, Kyoji Moriya

Summary: This study found that the actual HCV RNA positivity rate in source patients of needle-stick injuries decreased after the emergence of interferon-free direct-acting antivirals (DAAs). It was also noted that HCV RNA-negative patients were predominant in departments not related to liver diseases in the era of interferon-free DAAs.

BMC INFECTIOUS DISEASES (2021)

Article Oncology

Clinical characteristics and risk factors associated with Pneumocystis jirovecii infection in patients with solid tumors: study of thirteen-year medical records of a large cancer center

Koichi Takeda, Sohei Harada, Brian Hayama, Kosuke Hoashi, Taisuke Enokida, Toshiharu Sasaki, Koh Okamoto, Kenji Nakano, Daisuke Ohkushi

Summary: The risk factors for Pneumocystis jirovecii pneumonia (PCP) in patients with solid tumors are not fully understood. Besides prolonged corticosteroid use, factors like lymphocytopenia and chest radiation therapy may contribute to the development of PCP. A method to estimate the likelihood of PCP in this patient population considering multiple factors is needed.

BMC CANCER (2021)

Article Multidisciplinary Sciences

Comparative performance and cycle threshold values of 10 nucleic acid amplification tests for SARS-CoV-2 on clinical samples

Miyuki Mizoguchi, Sohei Harada, Koh Okamoto, Yoshimi Higurashi, Mahoko Ikeda, Kyoji Moriya

Summary: A study compared the diagnostic performance of NAATs approved in Japan using frozen-stored clinical samples, revealing differences in sensitivity and specificity among the tests. A system is needed to ensure both rapid reagent supply and accurate diagnosis for diagnostic kits of emerging infectious diseases. Ct values obtained by different assays are not interchangeable.

PLOS ONE (2021)

Article Respiratory System

Diagnostic prediction of COVID-19 based on clinical and radiological findings in a relatively low COVID-19 prevalence area

Yosuke Amano, Hidenori Kage, Goh Tanaka, Wataru Gonoi, Yudai Nakai, Ryo Kurokawa, Shohei Inui, Koh Okamoto, Sohei Harada, Masato Iwabu, Yutaka Morizaki, Osamu Abe, Kyoji Moriya, Takahide Nagase

Summary: Distinguishing COVID-19 from other lung diseases using clinical data and CT images is challenging, but features such as close contact, loss of taste or smell, low white blood cell count, and high fibrinogen levels can help identify COVID-19 cases with typical CT findings. In regions with low prevalence, CT screening shows high sensitivity for detecting COVID-19 in patients with suspected symptoms.

RESPIRATORY INVESTIGATION (2021)

Article Infectious Diseases

Urine sediment findings were milder in patients with COVID-19-associated renal injuries than in those with non-COVID-19-associated renal injuries

Yoshifumi Morita, Makoto Kurano, Daisuke Jubishi, Mahoko Ikeda, Koh Okamoto, Masami Tanaka, Sohei Harada, Shu Okugawa, Kyoji Moriya, Yutaka Yatomi

Summary: This study compared urine sediment findings between COVID-19 patients and non-COVID-19 patients with acute renal injuries, and found that certain urine sediment particles and biochemical markers were associated with the severity of COVID-19.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Review Infectious Diseases

Infection with capsular genotype K1-ST23 hypervirulent Klebsiella pneumoniae isolates in Japan after a stay in East Asia: Two cases and a literature review

Keiji Nakamura, Hidetoshi Nomoto, Sohei Harada, Masahiro Suzuki, Keina Yomono, Ritsuko Yokochi, Noboru Hagino, Takato Nakamoto, Yuki Moriyama, Kei Yamamoto, Satoshi Kutsuna, Norio Ohmagari

Summary: This article reports two cases of K1-ST23 hvKp infections from East Asia, one of which experienced multiple organ involvement requiring surgical treatment, while the other only required antimicrobial therapy. Both cases were identified to have been infected with hvKp.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2021)

Editorial Material Dentistry, Oral Surgery & Medicine

Guide for surgical procedures in oral and maxillofacial areas during coronavirus disease 2019 pandemic

Kazuto Hoshi, Tetsuro Ikebe, Yoshihide Ota, Hiromitsu Kishimoto, Takeshi Kurata, Hiroshi Kurita, Kentaro Sakamaki, Toshihiko Takenobu, Sohei Harada, Toru Ogasawara, Kanchu Tei, Tadaaki Kirita

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY (2022)

Article Microbiology

Comparison of the Treatment Outcome of Piperacillin-Tazobactam versus Carbapenems for Patients with Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Escherichia coli in Areas with Low Frequency of Coproduction of OXA-1: a Preliminary Analysis

Kosuke Hoashi, Brian Hayama, Masahiro Suzuki, Aki Sakurai, Kazumi Takehana, Taisuke Enokida, Koichi Takeda, Daisuke Ohkushi, Yohei Doi, Sohei Harada

Summary: Piperacillin-tazobactam may be an effective option for treating ESBL-producing Escherichia coli bacteremia in areas with low frequency of OXA-1 co-production.

MICROBIOLOGY SPECTRUM (2022)

Article Microbiology

Accurate Identification of Klebsiella variicola by MALDI-TOF Mass Spectrometry in Clinical Microbiology Laboratories

Yuki Ohama, Yusuke Nomura, Miyuki Mizoguchi, Yoshimi Higurashi, Koh Okamoto, Sohei Harada

Summary: Recent use of bacterial whole-genome sequencing has led to the discovery of new bacterial species and reclassification of taxonomy. Accurate identification methods for bacterial species in clinical microbiology laboratories are limited. This study found that matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry can accurately identify Klebsiella variicola. Accurate identification will help in studying the clinical characteristics of K. variicola.

MICROBIOLOGY SPECTRUM (2022)

Article Infectious Diseases

Teicoplanin and vancomycin as treatment for glycopeptide-susceptible Enterococcus faecium bacteraemia: a propensity score-adjusted non-inferior comparative study

Ryo Yamaguchi, Takehito Yamamoto, Koh Okamoto, Sohei Harada, Miho Echizenya, Takeya Tsutsumi, Tappei Takada

Summary: This study assessed the effectiveness and safety of teicoplanin compared with vancomycin for treating glycopeptide-susceptible Enterococcus faecium (GSEF) bacteraemia. The results showed that teicoplanin is non-inferior to vancomycin in treating GSEF bacteraemia and significantly reduces the risk of acute kidney injury.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2023)

Article Immunology

COVID-19 and Fatal Sepsis Caused by Hypervirulent Klebsiella pneumoniae, Japan, 2020

Tomohiro Hosoda, Sohei Harada, Koh Okamoto, Sumire Ishino, Makoto Kaneko, Masahiro Suzuki, Ryota Ito, Miyuki Mizoguchi

Summary: In patients with coronavirus disease who deteriorate rapidly, co-infections by bacterial and fungal pathogens, including hypervirulent Klebsiella pneumoniae in eastern Asia, should be considered in the differential diagnosis.

EMERGING INFECTIOUS DISEASES (2021)

暂无数据