期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 50, 期 4, 页码 1464-1466出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.06099-11
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资金
- NIAID
- NIH
To assess prospects for early diagnosis of prion disease based on prion seeding activity in cerebrospinal fluid (CSF), we measured the activity over time in scrapie-infected hamsters by real-time quaking-induced conversion (RT-QuIC). After intracerebral inoculation, activity appeared in CSF within 1 day and plateaued weeks before the onset of clinical signs. However, after intratongue inoculation, activity first appeared in CSF with the onset of clinical signs, well after higher-level accumulation of seeding activity in brain.
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